Prof. Fatai A. FEHINTOLA

Research focus/personal statement

The main thrust of my research is chemotherapy of acute uncomplicated malaria in children and pregnant women the two population groups most affected by this parasitic infection in endemic sub-Saharan Africa. I also researched into the determinants of successful chemotherapy in man. I have conducted many clinical trials on several notable antimalarial drugs used as monotherapy as well as when used in combination including the global gold standards – artemisinin-based combination therapy. These studies contributed to the body of knowledge on establishing the continued efficacy of ACTs in Nigeria.  Indeed, one of my publications is referenced in the 2011 National Malaria Control Programme of the Federal Government of Nigeria.  I have also devoted substantial efforts to the study of few pharmacodynamic drugs and I have paid due attention to aspects of pharmaco-epidemiology and pharmacovigilance over the years.

Cotrimoxazole is commonly used in the treatment of suspected upper respiratory tract infection and other bacterial infections in Nigeria. It is deductible from my studies that the relative slow evolution of drug resistance in malaria in Nigeria may be partly explained on the inadvertent combination therapy and use of resistance-reversing drugs like chlorpheniramine almost routinely and perhaps inadvertent combination therapy, by the use of chloroquine with cotrimoxazole.  Gametocytogenesis have been studied and being researched in the populations of pregnant women and children as means to reducing malaria-associated morbidity and mortality in Nigeria and globally.  


I am currently involved in elucidating further pharmacokinetic and pharmacodynamic interactions between antimalarial and anti-retroviral drugs.  The outcome of this study will improve the management of HIV/AIDS individuals whenever they require treatment with antimalarial drugs, thus global application.  


Curriculum Vitae