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Institute for Advanced Medical Research and Training

Institute for Advanced Medical Research and Training



Institute for Advanced Medical Research and Training


Profile of The Institute

The Postgraduate Institute for Advanced Medical Research and Training (PIMRAT) now the Institute for Advanced Medical Research and Training (IAMRAT) was established in 1980 as one of the academic divisions of the College of Medicine, University of Ibadan primarily for co-ordination of multidisciplinary research programmes in the College. The name of the Institute was changed in year 2000 to the Institute of Advanced Medical Research and Training (IAMRAT) for administrative purpose and recognition by National Universities Commission (NUC).

The Institute has 14 units which are: Ethics Committee (UI/UCHEC); Drug and Cancer Research Unit; Environmental Sciences & Toxicology; Genetics & Cancer; Molecular Entomology; Malaria Research; Pharmaceutical Research; Environmental Health; Bioethics; Epidemological Research Services; Neurodegenrative Unit; Palliative Care; HIV/AIDs and African Journal of Medicine and Medical Sciences. The Institute and her dedicated staffs are involved in research of international health related problems. The Institute is famous for its research in infectious diseases particularly malaria for which it was designated a centre of excellence in Africa and also in Genetics of non-communicable diseases for which it has been well acclaimed.

Over the years, the scope of the research activities of the Institute has increased tremendously. The facilities at the Institute are utilized by postgraduate and occasionally undergraduate students of the University of Ibadan and other Universities and Polytechnics in Nigeria. The Institute assists in training annually more than ten (10) Ph.D. and twenty (20) M.Sc. students registered in various departments of the University. The Institute also has postdoctoral scientists working as trainees and trainers as well as adjunct staff members from other Department within and outside University.

There is however, a growing need to strengthen the College of Medicine in the training of postgraduate students in contemporary biomedical and clinical research techniques such as molecular biology and biotechnology and complement training efforts of other departments in the University. It is therefore essential to promote both basic and operational medical research and contribute to evidence based National Health Policy Formulation. The Institute is being re-positioned so that it can achieve its full potentials. Research grants are attracted from donor agencies such as: World Health Organisation (WHO), National Institute of Health (NIH), Deutsche Volkswagen-Stiftung Foundation, European Commission, Welcome Trust, Alexander von Humboldt Foundation, European &Developing Countries Clinical Trials Partnership (EDCTP), Christopher Kolade Foundation and the University of Ibadan Senate Research Grants.

The main objectives of the Institute are to:

  1. Provide leadership and direction on basic/applied medical research and conduct multidisciplinary research in the College of Medicine and University in general

  2. Coordinate medical research activities and ensure adherence to standard ethical guidelines in the conduct of research involving human subjects.

  3. Provide avenue for the exchange of ideas among research investigators and policy makers

  4. Serve as a central research base and provide up to date facilities for training of postgraduate students and young scientists in modern biomedical research

  5. Organize training courses, workshops, seminars and symposium for the purpose of updating research Scientists and other interested individuals about contemporary research techniques and findings

  6. Attract Grants for research from both local and international funding agencies.



Staff List

Catherine O. Falade - Professor & Director MBBS (ib), MSc. FCMP, FWAP, FAS, FAAS

O.G Ogunmowo - Professor

B.Sc., M.Sc. (ib) Ph.D. (ib)

Patricia N. Okorie - Senior Research Fellow B.Sc. (Unizik) M. Phil (Legon) Ph.D(Wits)

R.O. Akinyemi - Senior Research Fellow MBBS (ib), MSc.(Ib), Ph.D. (Newcastle, UK), Neuroscience & Ageing Research

Olufunmilayo G. Oyero - Research Fellow I

BSc. MSc. (ib)

A.S. Bakarey - Research Fellow II

M.Sc. (ib) Ph.D.(Virology), (ib)

A.B. Odetunde - Chief Technologist

FIMLT (Nig.), FMLCN, M.Sc

O.O.Famuyiwa - Assistant Chief Technologist

BSc. (Hons) AIMLT Medical Microbiology

Adebola O. Oyewole - Senior Research Nurse

RN, RM, B.Sc., M.Sc. (ib)

M.K. Rafiu - Technologist II Cert in Sc. Lab, Dip Sc. Lab, Bsc Biochem(UNAAB)

A. Abioye - Technologist II (AISLT)

F.E. Ighaede - Snr. Lab. Supervisor SSCE, OND (NISLT)

Victoria A. Thomas - Snr. Lab. Supervisor

SSCE, OND (SLT)

A.T. Akindele - Principal Assistant Registrar/ B.A. (Hons) Ilorin, M.A. (ib), M. ANUPA Secretary to the Institute

Abiodun O. Franklin - Chief Personal Secretary/ Secretary to the Director

CSTC Sec. Admn. Cert. 50/120wpm,

Lond, Pitmans cert. 120wpm, Lond.

Pitmans Cert. (Shorthand) 140wpm.

Computer Operations & Appli. UI comp. Centre,

HRM, PR(ICM) UK

A.M. Sodiya - Data Analyst WAEC, 50wpm Typewriting, Dip. (Data Processing)

Joyce A. Arigbede - Data Analyst O level, Grd, 11, 50wpm, Cert in Computer



Adjunct Staff:

Dr. Ikeoluwapo Ajayi - Epidemiologist, Epid & Med. Statistics, UI

Professor A. Sowunmi - Pharmacology & Therapeutics

Professor Funmi O. Olapade - University of Chicago

Professor Sola Olapade - University of Chicago

Professor E.A. Bababunmi - ENHICA

Professor Catherine O. Falade - Pharmacology & Therapeutics

Professor Chinedum P. Babalola - Pharmaceutical Chemistry

Professor Edith O. Ajaiyeoba - Pharmacognosy

Professor Grace O. Gbotosho - Pharmacology & Therapeutics





RESEARCH UNITS IN THE INSTITUTE

The Institute has the following units which are headed by reputable academic staff. The overview of the activities of each unit is as highlighted:



DRUG AND CANCER RESEARCH UNIT

Head of Unit: Prof O.G. Ademowo



Activities of the Unit:

  1. Studies on Moleculat markers of resistance to antimalarial drugs such as Pfindr, Pfcrt, dhps etc. Factors affecting genetic associations with the resistance phenotype.

  2. Invivo and invitro evaluation of antimalarial activities of drups and natural products

  3. Outcome of drug treatment in patients with HIV, malaria and tuberculosis

  4. Effect of immune response to helminthes infection on outcome of treatment of HIV, malaria, TB

  5. Drug disposition and pharmacokinetics of antimalarial agents including chloroquine, amodiaquine, quinine and dihydro – artemisinim.

  6. Toxicological studies of novel and conventional antimalarial agents

  7. Development and evaluation of efficacy and safety of antimalarial drugs including artemisinin-based dr


GENETIC/HAEMOGLOBINOPATHY UNIT

Head of Unit: Professor Adeyinka G. Falusi


Activities of the Unit:

  1. Population genetics of sickle cell disease, the thalassaemias and factors which modify the pathology of the disease.

  2. Awareness programme of education, genetic counselling and diagnosis of genetic diseases such as the haemoglobinpathies


BREAST CANCER RESEARCH UNIT

Head of Unit: Professor Olufunmilayo Olopade


Activities of the Unit

  1. Epidemiology of genetic risk factors of BRCA I & II in breast cancer.

  2. Identification of genetic factors modifying the incidence and prognosis of hypertension, pre-eclampsia / eclampsia and diabetes



PHAMACOKINETICS/PHARMACY UNIT

Head of Unit: Prof Chinedum Peace Babalola


Activities of the Unit:

  1. These activities are carried out in collaboration with other departments within the University such as Medicine, Pharmacy, Institute of Child Health and other institutions.

  2. Clinical Trials evaluation of efficacy/safety of antimalarial drugs.

  3. Genetics of antimalarial drug kinetics


MOLECULAR ENTOMOLOGY

Head of Unit: Dr. Patricia N. Okorie


Activities of the unit:

1. Development of Nigeria Anopheles Vector Database: A comprehensive database comprising of Anopheles vectors of malaria and filariasis from 1900 to 2011 was collated. This collation resulted in a total of 110 publications, encompassing 484,747 Anopheles mosquitoes in 632 spatially unique descriptions at 142 georeferenced locations being identified across Nigeria from 1900 to 2010. Information on vector species composition, sampling/collection and species identification methods, distribution of Insecticide resistance and distribution of Plasmodium falciparum and W. Bancrofti.

2. Evaluation of the efficacy of LG ultrasonic device in effectively expelling and killing mosquito vectors of malaria in Nigeria. This study is to test the efficacy of LG ultrasonic device in effectively expelling and killings mosquito vectors in Nigeria. This study is in collaboration with Department of Epidemiology, Medical Statistics and Environmental

Health (EMSEH), Physics Department and LAMRAT

3. Insecticide resistance in Anopheles gambiae in Nigeria. The studies include insecticide resistance and susceptibility studies in field populations of Anopheles gambaie in Nigeria. 4. Lymphatic filariasis in Nigeria; micro-stratification overlap mapping (MOM)





MALARIA RESEARCH LAB (MRL)

Head of Unit: Prof A. Sowunmi

Professor Grace O. Gbotosho


Activities of the Unit:

  1. Development, evaluation and validation of diagnostic kits for drug resistant malaria

  2. Evaluation of new drug combinations in managing drug resistant malaria in African communities.

  3. Evaluation of Protocols for Home Management of Malaria.

  4. Identification and evaluation of active natural products for malaria therapy

These activities are carried out in collaboration with other departments' viz. Pharmacology & Therapeutics, Zoology, Public Health and other Research Institutes in Nigeria and in the United States of America, Malaysia and Ghana.


PHYTOMEDICINE RESEARCH UNIT

Head of Unit: Professor Edith O. Ajaiyeoba


Activities of the Unit:

  1. Establishment of standard Ethno-medical Herbarium.

  2. Extraction, isolation and development of pure compounds having anti-microbial, antitumor, anti-malaria and anti-viral properties from plants.

  3. Formulation of active compounds into dosage forms.

  4. Collaboration with the Faculty of Pharmacy and donor agencies both locally and internationally. The plan is to strengthen and expand our objectives and activities to enable the Institute attain its expected position as a National centre for research and training in the country


BIOETHICS

Head of Unit: Professor Sola Olopade


Activities of the Unit:

  1. The genetic arm undertakes genetics of disease prognosis and pharmacogenomics especially with respect to sickle cell disease, breastcancer, asthma and malaria. It is currently carrying out research in genetics of breast cancer and asthma, pharmacogenomics and pharmacokinetic research in sickle cell disease patients, HIV/AIDs patients and healthy individuals with respect to targeted enzymes.

  2. The bioethics unit undertakes bioethics research and training

EPIDEMIOLOGY AND BIO-STATISTICAL RESEARCH AND

SERVICES UNIT

Head of Unit: Dr. IkeOluwapo Ajayi


Activities of the Unit:

  1. Providing training programmes to help capacity building in research methodology, epidemiology, biostatistics and computing in medical sciences

  2. Providing consultancy services to Faculty members on the designs, conduct, analysis and interpretation of data on regular basis

  3. Conducting research in collaboration with other medical scientists on the development of morbidity and mortality indicators related to prevailing health problems in Nigeria and evaluation of health programmes.

  4. Carrying out research on the epidemiology of specific diseases of public health importance e.g. AIDS, asthma, malaria etc.


NEUROSCIENCES AND AGEING UNIT (NARU)

Head of Unit: Professor A. Ogunniyi

Senior Research Fellow: Dr. R. O. Akinyemi


Activities of the Unit:

In consonance with The Vision of the University of Ibadan "To be a world-class institution for academic excellence geared towards meeting societal needs" and the vision of the IAMRAT "To be a world – class institute with capacity to conduct high quality, cutting - edge and translatable research relevant to national and global issues, and train highly competent and innovative medical scientists' the Neurosciences and Ageing Research Unit (NARU) is inspired by the labour and accomplishments of our heroes past and present to pursue the:


The Mission:

To make significant contributions to knowledge through basic, clinical, epidemiological and translational ageing and brain research, and build the research capacity and translation - friendly clinical and public health practice, particularly in Africa of young scientists in a milieu of evidence-based and translation – friendly clinical and public health practice, particularly in Africa’

and

Broad Objectives:

  • Build local and international collaborations and networks in the research fields of ageing and ageing-associated degenerative and vascular disorders of the brain.

  • Pursue the establishment of new basic, clinical and translational research programmes in the aforementioned areas.

  • Collaborate with other neuroscientists to upgrade our 'brain cut up programme' to a modern world class Ibadan Brain Bank, the first of its kind in Sub- Saharan Africa.

  • To develop new programmes such as Master of Research (MRes), MSc and PhD programmes in Neurosciences in the University of Ibadan.

  • Strengthen the mentoring programme for medical and biomedical students, and early career researchers eg short- and medium- termattachments, fellowships and post-doc training opportunities in our unit.

  • Promote translation of research findings into practice, community impact and policy formulation (T1 - T4 Translational pipelines) through robust patient, policy maker and community engagement and advocacy programmes.


Research Interest

Ageing and ageing-associated vascular and degenerative brain disorders, Neuro-infections


Disease of Interest

Stroke, dementias and vascular cognitive impairment, Parkinson's disease, traumatic brain injury, NeuroAIDS


Research Themes

  • Disease epidemiology, including genetic and genomic epidemiology

  • Peculiarities of diseases in people of African ancestry

  • Cognitive dysfunction associated with vascular and degenerative brain disorders

  • Genomic, biological, biochemical, psychosocial, cultural and environmental determinants of ageing, degenerative and vascular brain disorders and their consequences

  • Ageing research: epidemiology and determinants of ageing in people of African ancestry

  • Cellular and molecular disease mechanisms, including animal experimentation and post-mortem human studies

  • Diagnostics and biomarkers development

  • Drug discovery and development

  • Clinical trials

  • Translational research (T1-T4)

  • Health systems research

  • Neuroadvocacy and neuroeducation


Research Methods

Qualitative methodologies

Epidemiological methods

Neuropsychological evaluation

Immunohistochemistry

Immunoblotting methods

Genomic analyses methods: genotyping, GWAS and NGS


Current Projects

  1. The Abeokuta Stroke Registry: FMC, Abeokuta, Nigeria (2010-till date)

  2. Cognitive Functions After Stroke - Nigeria (COGFAST-NG) (2010- till date)

  3. NIH-funded Tailored Hospital-based Risk Reduction to Impede Vascular Events after Stroke (THRIVES) study (2012-2016)

  4. The IDEA Project (Grand Challenges, Canada)

  5. NeuroAIDS Project (Forgarty International, NIH)

  6. MEPI and NUMERIC Projects (NIH)

  7. NIH-funded Stroke Investigative Research and Education Network (SIREN)

(2013-2017)

  1. Enhancing Stroke Education, Care, Documentation and Prevention in Nigeria; Project funded by the World Federation of Neurology (WFN) and World Stroke Organization (WSO) (2014-2015)


Collaborating Units/Departments/Institutions

  • Medical University of South Carolina, USA

  • University of Alabama at Birmingham, USA

  • Institute of Neuroscience, Newcastle University, UK

  • Northumbria Foundation NHS Trusts, North Shields, UK

  • Neurology Unit, Department of Medicine, University of Ibadan.

  • Department of Psychiatry, College of Medicine, University of

  • Federal Medical Centre Abeokuta, Nigeria

  • Lagos State University, Ojo - Lagos, Nigeria

  • Ladoke Akintola University of Technology, Ogbomoso, Nigeria


PALLIATIVE CARE UNIT

Head of Unit: Professor Olaitan A. Soyannwo


Activities of the Unit:

  1. Palliative Care Service is for any person (Adults and Children) who are suffering from Pain and other symptoms in persons with long-term Conditions and life limiting illnesses (e.g. Neurological diseases, Cancer, Sickle cell disease, other diseases and those nearing the End of Life).

  2. Catering for some needs of patients and their family members (this needs range from physical, social, psychological, mental, cultural, ethical, legal and spiritual care). This is done at UCH Hospice and Palliative care Unit, through 2 key programmes (Adult and Children day care forums), run fortnightly when funds are available, to offer care at the wards (in-patient), out-patient service and Home care service to patients suffering from Life limiting illnesses. s disease, motor neuron

  3. The Centre for Palliative Care, Nigeria (CPCN) which anchors the project with UCH Team was the first to introduce use of oral morphine for severe cancer pain management in the country as recommended by World Health Organization (WHO). CPCN works with Global Access to Pain Relief Initiative (GAPRI) and the Federal Ministry of