Dr. Adeola O. OLOWOFOLAHAN

Profile

Resume

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Research

Current Research

1. Title: Antiproliferative potential of purified compounds from chloroform fraction of Drymaria cordata on uterine myoma cells and rat model
Funder: NIH
Nil Uterine myoma (UM) is the most frequent benign tumor in women and is responsible for menorrhagia and other forms of abnormal uterine disorder. The pathogenesis of UM may be related to sex hormones and their receptors, cell proliferation and apoptosis, abnormal signal transduction pathways, molecular genetics and other factors. Studies have shown that some bioactive agents isolated from natural sources elicit chemopreventive and therapeutic properties against tumors and cancers. Drymaria cordata (Caryophyllaceae) is a medicinal plant used in the traditional treatment of uterine fibroid and breast tumor in Nigeria. In our previous study, we found that methanol extract of Drymaria cordata and its various fractions induced mitochondrial-mediated apoptosis in rat model with the chloroform fraction being the most potent (Olowofolahan et al., 2015; Olowofolahan and Olorunsogo, 2018). Also, we have been able to demonstrate the antiproliferative potential of the methanol extract and chloroform fraction in monosodium glutamate-induced uterine hyperplasia (Olowofolahan et al., 2017). However, the putative compound(s) and the underlying mechanisms have not been fully explored; thus; the reason for this study.
Role: Investigator
Collaborators:

Completed Research

1. Effect of different fractions of methanol extract of Drymaria cordata on mitochondrial-mediated apoptosis

2. Ameliorative potential of methanol extract and chloroform fraction of Drymaria cordata on monosodium glutamate-induced uterine hyperplasia in female rats

Publications

Selected Publications

1. Olowofolahan, A.O., Adeoye, A.O., Offor, G.N., Adebisi, L.A. and Olorunsogo O.O.(2015). Induction of Mitochondrial Membrane Permeability Transition Pore and Cytohrome c Release by Different Fractions of Drymaria cordata. Archives of Basic and Applied Medicine. Vol 3: 135-144.
   
   
2. Olowofolahan, A.O Adeoye, Y.D. and Olorunsogo, O.O. (2017). Induction of Mitochondrial-Mediated Apoptosis by Solvent Fractions of Methanol Extract of Heliotropium indicum in Rat Liver Cells. Annual Research and Review in Biology. Vol 17 (2): 1-15.
   
   
3. Olowofolahan, A.O Aina, O.O., Hassan, E.T. and Olorunsogo, O.O. (2017). Ameliorative Potentials of Methanol Extract and Chloroform Fraction of Drymaria cordata on MSG-induced Uterine Hyperplasia in Female Wistar Rats. European Journal of Medicinal Plants. Vol 20 (4): 1-9
   
   
4. Olowofolahan, A.O and Olorunsogo, O.O. (2018). Induction of Apoptosis in Rat Liver Cells Via Caspase activation by Chloroform Fraction of Methanol Extract of Drymaria cordata. European Journal of Biomedical and Pharmaceutical Sciences. Vol. 5 (4): 73-83.
   
   
5. Olowofolahan, A.OAdeosun , O.A., Afolabi, O.T. and Olorunsogo, O.O. (2018). Effect of Methanol Extract of Mangifera indica on Mitochondrial Membrane Permeability Transition Pore in Normal Rat Liver and Monosodium Glutamate- induced Liver and Uterine Damage. Journal of Complementary and Alternative Medical Research. Vol 5(2):1-14.
   
   
6. Olowofolahan, A.O.Nwaokolo, E.N. and Olorunsogo, O.O. (2019). Effect of Methanol Leaf Extract of Blighia Sapida on Mitochondrial Membrane Permeability Transition Pore Opening and Blood Glucose Levels in Normal and Streptozotocin- Induced Diabetic Rats. Biomedical Journal of Scientific & Technical Research Vol. 19(1): 14047-14057.
   
   
7. Olowofolahan, A.O.,Adeosun,A.O., Olorunsogo, O.O. (2020). Monosodium Glutamate Induces Cytotoxicity in Rat Liver via Mitochondrial Permeability Transition Pore Opening. Cell Biochemistry and Biophysics Vol. 78:429–437
   
   
8. Olowofolahan, A.O,Bolarin, O.L. Olorunsogo, O.O. (2020). In vitro and in vivo effect of 3-Para-fluorobenzoyl-propionic acid on rat liver mitochondrial permeability transition pore opening and lipid peroxidation. Annals of Science and Technology. Vol 5 (1): 39-44.
   
   
9. Olowofolahan, A.O Akanji, B.A., Olorunsogo, O.O. (2020). 3-(Para-fluorobenzoyl)- propionic acid; a metabolite of haloperidol reversed oestradiol valerate-induced uterine hyperplasia via modulation of estrogen receptor signaling pathway in female Wistar rats. Journal of Basic and Clinical Physiology and Pharmacology. Vol. 31(4). DOI: 10.1515/jbcpp-2019-0119.
   
   
10. Olowofolahan, A.O,Ezekiel C.D., Olorunsogo O.O. (2020). Induction of Mitochondrial Membrane Permeability Transition Pore Opening and DNA fragmentation by Solvent Fractions of Mangifera indica. Archives of Basic and Applied Medicine. Vol. 7: 123–129.
    
    
11. Olowofolahan, A.O,Oyebode, O.T., Olorunsogo, O.O. (2020). GCMS analysis of partially purified chloroform sub fractions of methanol extract of Drymaria cordata (Linn) and their effects on mitochondrial membrane permeability transition pore. Arch. Bas. App. Med. Vol. 8: 3–11.
    
    
12. Olowofolahan, A.O., Olanlokun, J.O. and Olorunsogo, O.O.(2020). GCMS analysis and Phytoprotective effect of chloroform fraction of methanol leaf extract of Drymaria cordata against MSG-induced lesions in specific tissues. African Journal of Medicine and Medical Sciences. Vol. 49: 409-419.
    
    
13. Olowofolahan, A.O., Adeosun, O.A., Olorunsogo, O.O. (2020). Monosodium glutamate induces cytotoxicity in rat liver via mitochondrial permeability transition pore opening. Cell Biochemistry and Biophysics. Vol. 78:429–437.
    
14. , Olowofolahan, A.O., Oyebode, O.T., Olorunsogo, O.O. (2021). Methyl palmitate reversed estradiol benzoate-induced endometrial hyperplasia in female rats. Toxicology Mechanisms and Methods. Vol. 31(1): 43–52.
    
    
15. Olowofolahan, A.O.,and Olorunsogo, O.O. (2021). Effect of Gloriosa superba linn (EEGS) on mPT and monosodium glutamate-induced proliferative disorder using rat model. Journal of Ethnopharmacology Vol. 267: 113498.
    
    
16. Olowofolahan, A.O., and Olorunsogo, O.O. (2021). Fractions of Ageratum conyzoides L. (Compositae) induce mitochondrial-mediated apoptosis in rats: Possible option in monosodium glutamate-induced hepatic and uterine pathological disorder. Journal of Ethnopharmacology. Vol. 277: 114192.
    
    
17. , Olowofolahan, A.O.,Adewoye, F.O. and Olorunsogo, O.O. (2021). Modulatory effect of methanol extract of Annona muricata stem bark on mitochondrial membrane permeability transition pore in normal rat liver and monosodium glutamate-induced uterine hyperplasia. Journal of Complementary and Integrative Medicine. Vol. 18(2):355-361.
    
    
18. Olowofolahan, A.O.,Paulinus, O.B., Dare, H.M. and Olorunsogo, O.O. (2021). Metformin induces apoptosis via uterus mitochondrial permeability transition pore opening and protects against estradiol benzoate-induced uterine defect and associated pathophysiological disorder in female Wistar rats. Bulletin of the National Research Centre. Vol. 45:102.
    
    
19. Olowofolahan, A.O., Tobih S.E and Olorunsogo, O.O. (2021). Amelioration of oestradiol valerate-induced endometrial hyperplasia in female rats by methanol fraction of Mangifera indica Linn via modulation of estrogen receptor signaling pathway. Indian Journal of Physiology and Pharmacology. Vol. 65:2.
    
    
20. Olowofolahan, A.O., Dare, H.M., Adeoye, Y.D., Olorunsogo, O.O. (2022). Annona muricata Linn stem bark protects against uterine proliferative disorder induced by estradiol benzoate in female rat. European Journal of Medicinal Plants. Vol. 33(9): 48-61.

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Other Interest/Hobbies

I love playing keyboard and listening to music.