Name: Mayowa A. AJAYI Email:This email address is being protected from spambots. You need JavaScript enabled to view it. Biography: Dr Abayomi Mayowa Ajayi studied Biochemistry from Ahmadu Bello University, Zaria, and had both M.Sc and PhD in Pharmacology from the University of Ibadan. He was at some point an assistant lecturer in the Department of Pharmacology, Kampala International University-Western Campus, Uganda. There he spent six years training medical and pharmacy students from the East African region. His doctoral research under the supervision of Professor George Ademowo focused on the Pharmacological activity of Ocimum gratissimum leaf, an economically viable multipurpose herbaceous plant with longstanding successful use in ethnomedicine. Presently, a Senior Lecturer at the Department of Pharmacology and Therapeutics, University of Ibadan. A research scientist who is committed to research excellence and the attainment of quality knowledge in the life sciences. My long term research interest involve using new tools to understand how indigenous fruits, spices and herbs promote health and well-being for all at all ages. I have been involved in investigating how extracts or bioactive compounds prevent and or ameliorates behavioural derangement and underlying oxido-inflammatory processes as a result of repeated exposure to stress, chemical toxicants, high fat diet and malaria infection. The aim is to generate knowledge and provide basis for the uptake of such bio-functional extracts or compounds as sources for developing new nutraceuticals or herbal medicinal products. a. Completed 1. Neurotoxic, Hematologic and Metabolic Outcomes of Sub chronic Khat (Catha edulis) and Ethanol in a rat model. 2. Comparative Physicochemical, Phytochemical and Acute Toxicity Studies on Two Ocimum Species of Western Ugandan. 3. Evaluation of the anti-inflammatory activities of extracts and flavonoid-rich fraction from Ocimum gratissimum (Lamiaceae) Leaf. b. In progress 1. Health promoting properties of indigenous fruits, spices and herbs 2. Interplay between alcohol, alcohol herbal mixture (paraga) abuse, diet and stress on mental health 3. Interplay between stress and immune system activation on malaria complications and efficacy of Artemisinin-based combination drugs SELECTED PUBLICATIONS 1. Olajide, O.A., Ajayi, A.M. and Wright, C.W. (2009). Anti-inflammatory properties of cryptolepine. Phytotherapy Research 23. No. 10: 1421-1425. https://doi.org/10.1002/ptr.2794 2. Ajayi, A.M., Tanayen, J.K., Balogun, S.O., Ibrahim, A., Ezeonwumelu, J.O.C, Kiplagat, D., Oyewale, A.A., Oloro, J.O., Goji, A.D.T. and Adzu, B. (2011). Anti-inflammatory and Analgesic Properties of Ethanolic Stem Bark Extract of Ficus trichopoda in Rats. Pharmacognosy Journal 2. No. 18: 43-47. https://doi.org/10.1016/S0975-3575(11)80024-6 3. Eduviere, A.T., Umukoro, S., Aderibigbe, A.O., Ajayi, A.M. and Adewole, F.A. (2015). Methyl jasmonate enhances memory performance through inhibition of oxidative stress and acetylcholinesterase activity in mice. Life Sciences. 132: 20 -26. https://doi.org/10.1016/j.lfs.2015.04.007 4. Ajayi, A.M., Martins, D.T.O., Balogun, S.O., Oliveira, R.G., Ascencio, S.D., Soares, I.M., Barbosa, R.B., and Ademowo, O.G. (2017). Ocimum gratissimum leaf flavonoid-rich fraction suppress LPS-induced inflammatory response in RAW 264.7 macrophages and peritonitis in mice. Journal of Ethnopharmacology Vol. 204: 169-178. https://doi.org/10.1016/j.jep.2017.04.005 5. Ajayi, A. M., Umukoro, S., Ben‐Azu, B., Adzu, B., & Ademowo, O. G. (2017). Toxicity and Protective Effect of Phenolic‐Enriched Ethylacetate Fraction of Ocimum gratissimum (Linn.) Leaf against Acute Inflammation and Oxidative Stress in Rats. Drug Development Research, Vol. 78 No. 3-4: 135-145. https://doi.org/10.1002/ddr.21384 6. Oyeleke, S.A., Ajayi, A.M., Umukoro, S., Aderibigbe, A.O., Ademowo, O.G. (2018). Anti-inflammatory activity of Theobroma cacao stem bark ethanol extract and its fractions in experimental models. Journal of Ethnopharmacology, Vol. 222: 239-248. https://doi.org/10.1016/j.jep.2018.04.050 7. Omorogbe, O., Ajayi, A. M., Ben-Azu, B., Oghwere, E. E., Adebesin, A., Aderibigbe, A. O., Okubena, O., & Umukoro, S. (2018). Jobelyn® attenuates inflammatory responses and neurobehavioural deficits associated with complete Freund-adjuvant-induced arthritis in mice. Biomedicine & Pharmacotherapy, Vol. 98: 585-593. https://doi.org/10.1016/j.biopha.2017.12.098 8. Ajayi, A.M., Ben-Azu, B., Onasanwo, S.A., Adeoluwa, O., Eduviere, A., Ademowo, O.G. (2019) Flavonoid-Rich Fraction of Ocimum gratissimum attenuates lipopolysaccharide-induced sickness behaviour, inflammatory and oxidative stress in mice. Drug Research 69: 151-158. https://doi. 10.1055/a-0654-5042 9. Alabi, A. O., Ajayi, A. M., Ben-Azu, B., Bakre, A. G., & Umukoro, S. (2019). Methyl jasmonate abrogates rotenone-induced parkinsonian-like symptoms through inhibition of oxidative stress, release of pro-inflammatory cytokines, and down-regulation of immnopositive cells of NF-κB and α-synuclein expressions in mice. Neurotoxicology, Vol. 74, 172-183. https://doi.org/10.1016/j.neuro.2019.07.003 10. Ajayi, A. M., Badaki, V. B., Ariyo, O. O., Ben-Azu, B., Asejeje, F. O., & Adedapo, A. D. (2020). Chrysophyllum albidum fruit peel attenuates nociceptive pain and inflammatory response in rodents by inhibition of pro-inflammatory cytokines and COX-2 expression through suppression of NF-κB activation. Nutrition Research. Vol. 77: 73-84. https://doi.org/10.1016/j.nutres.2020.03.004 11. Ajayi, A. M., Arasi, R. O., Ben-Azu, B., Godson, J. C., Umukoro, S., Aderibigbe, A.O. (2020). Nigerian Psychoactive alcoholic herbal mixture impacts behavioural performance and caused brain biochemical and histopathological alterations in mice. African Journal of Biomedical Research, Vol. 23 No. 2: 255-265 12. Ajayi, A. M., Alabi, A. O., Oyibo, A. O., & Joseph, O. O. (2021). Antioedematogenic and anti-inflammatory actions of Phragmanthera incana (Schum) Balle leaf in carrageenan-induced inflammation models in rats. Advances in Traditional Medicine, 21, 701–711. https://doi.org/10.1007/s13596-020-00480-4 13. Adedapo, A. D., Ajayi, A. M., Ekwunife, N. L., Falayi, O. O., Oyagbemi, A., Omobowale, T. O., & Adedapo, A. A. (2020). Antihypertensive effect of Phragmanthera incana (Schum) Balle on NG-nitro-L-Arginine methyl ester (L-NAME) induced hypertensive rats. Journal of Ethnopharmacology, 112888. https://doi.org/10.1016/j.jep.2020.112888 14. Ajayi, A. M., Adedapo, A. D., Badaki, V. B., Oyagbemi, A. A., & Adedapo, A. A. (2021). Chrysophyllum albidum fruit ethanol extract ameliorates hyperglycaemia and elevated blood pressure in streptozotocin-induced diabetic rats through modulation of oxidative stress, NF-κB and PPAR-γ. Biomedicine & Pharmacotherapy, Vol. 141: 111879. https://doi.org/10.1016/j.biopha.2021.11187 15. Ajayi, A. M., Coker, A. I., Oyebanjo, O. T., Adebanjo, I. M., & Ademowo, O. G. (2022). Ananas comosus (L) Merrill (pineapple) fruit peel extract demonstrates antimalarial, anti-nociceptive and anti-inflammatory activities in experimental models. Journal of Ethnopharmacology, Vol. 282: 114576. https://doi.org/10.1016/j.jep.2021.114576 16. Ajayi, A. M., Ben-Azu, B., Ogunkolade, G. E., Melete, J., Oyedele, A. T., & Umukoro, S. (2022). Repeated social defeat stress exacerbates lipopolysaccharide-induced behavioural deficits in mice: ameliorative role of Chrysophyllum albidum fruit extract through anti-neuroinflammation, antioxidant and neurochemical balance. Metabolic Brain Disease, Vol. 37(7), 2467-2481. https://doi.org/10.1007/s11011-022-01053-x 17. Ajayi, A. M., Melete, J., Ben‐Azu, B., & Umukoro, S. (2022). Aggressive‐like behaviour and neurocognitive impairment in alcohol herbal mixture‐fed mice are associated with increased neuroinflammation and neuronal apoptosis in the prefrontal cortex. Journal of Biochemical and Molecular Toxicology, e23252. https://doi.org/10.1002/jbt.23252 18. Umukoro, S., Ajayi, A. M., Ben-Azu, B., Ademola, A. P., Areelu, J., Orji, C., & Okubena, O. (2023). Jobelyn® improves motor dysfunctions induced by haloperidol in mice via neuroprotective mechanisms relating to modulation of cAMP response-element binding protein and mitogen-activated protein kinase. Metabolic Brain Disease, 38, 2269–2280 (2023). https://doi.org/10.1007/s11011-023-01253-z 19. Ajayi, A. M., Ola, C. B., Ezeagu, M. B., Adeleke, P. A., John, K. A., Ologe, M. O., Ben-Azu, B & Umukoro, S. (2023). Chemical characterization, anti-nociceptive and anti-inflammatory activities of Plukenetia conophora seed oil in experimental rodent models. Journal of Ethnopharmacology, Vol. 305, 116017. https://doi.org/10.1016/j.jep.2022.116017 20. Ajayi, A. M., Adebanjo, I. M., & Ademowo, O. G. (2023). Vitamin C-rich juice co-administration with artemether-lumefantrine ameliorates oxido-inflammatory responses in Plasmodium berghei-infected mice. Parasitology Research, 122, 1841–1850 (2023). https://doi.org/10.1007/s00436-023-07885-5Profile
Designation: Senior Lecturer
Faculty: Basic Clinical Sciences
Department: Pharmacology and Therapeutics
Alternate Email Address: This email address is being protected from spambots. You need JavaScript enabled to view it.
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