Dr. Oluwatoyin A. ADEYEMO-SALAMI

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Name: Oluwatoyin A. ADEYEMO-SALAMI

Designation: Senior Lecturer 

Faculty: Basic medical sciences 

Department: Biochemistry

Phone number: +2348077467025

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Biography:                

Oluwatoyin Adenike Adeyemo-Salami (nee Adeyemo) Ph.D, MCSN

I  am Oluwatoyin Adenike Adeyemo-Salami, a senior faculty. Currently, I am a Senior Lecturer in the Department of Biochemistry of the Faculty of Basic Medical Sciences, College of Medicine, University of Ibadan, Oyo State, Nigeria. I obtained my doctoral degree from the same department in October 2017. From my doctoral project, titled ”Antiplasmodial and chemopreventive effects of Paullinia pinnata (Linn.) in ethylene glycol monomethyl ether induced-testicular dysfunction in rodents”, I established a safe margin for the administration of the methanol extract of Paullinia pinnata (Linn.) leaves (an indigenous medicinal plant) and showed that it had antimalarial properties at varying doses but exacerbated the deleterious effect of the infertility model (ethylene glycol monomethyl ether-an industrial solvent) in adult male Wistar rats.

Prior to this, I had obtained my B.Sc (Hons.) in Biochemistry in 1992 and my Masters degree in Industrial Chemistry in 1995 from the Department of Biochemistry and the Department of Chemistry, respectively, both in the University of Ibadan.

My research focus is investigating the biological activities of indigenous herbs as well as exploring the therapeutic potentials of phytonutrients. I also have a keen interest in nutrigenetics, nutrigenomics and nutritional biochemistry.

My area of specialization is investigating the biological activities of medicinal plants and phytonutrients using various experimental models and simulated disease conditions in rodents and Drosophila melanogaster.

During my stay as a visiting scientist to Hussein Ebrahim Jamal (H.E.J.) Research Institute of Chemistry, University of Karachi, Pakistan using the Third World Organization for Women in Science (TWOWS) Postgraduate Sandwich Fellowship, in collaboration with Prof. Muhammad Iqbal Choudhary, we showed that the methanol extract of P.pinnata leaves had phytotoxic activity against Lemna minor (common duck-weed), variably mild antibacterial activity and no leishmanicidal and cytotoxic effect on Artemia salina (brine shrimp). We also reported our observations with these in-vitro models using Anthocleista vogelli (Benth) and Anthocleista nobilis (G.Don). These reports have all been published in international peer-review journals. I have published sixteen publications, a book and one book chapter.

I am an awardee and beneficiary of various prizes, grants and awards institutionally, nationally and internationally. I am a member of learned societies including the Biochemical Society U.K. I am a professional member of the Chemical Society of Nigeria (now Nigerian Chemical Society). Also, I am a member of the Board of Trustees for the Adewuyi Research Animal Foundation Grant. I have attended workshops and conferences both locally and internationally. I have supervised and am currently supervising both undergraduate and postgraduate students. I am happily married and the union is blessed with two lovely children.

Research

Current Research and Capacity Building Projects including Grant

1. Title: Investigating the effect of chlorogenic acid on mitochondrial-mediated apoptosis using in vitro and in vivo models
Brief Summary: Chlorogenic acid is a polyphenol widely distributed in the diet, and it has been shown to have various therapeutic potentials including anti-diabetic, anti-cancer and anti-obesity capacities. Using Swiss mice and the hepatic mitochondria, the effect of chlorogenic acid on apoptosis using different biochemical assays is being conducted. The results will show the capacity of chlorogenic acid to initiate apoptosis and therefore unravel the mechanism of the anti-tumor property.
Role: Principal Investigator
Collaborator: Dr. A.O. Olowofolahan

2. Title: Investigating the haematinic effect of chlorogenic acid
Brief Summary: Using an haematotoxic agent, anemia is being induced in Swiss mice and the animals have been exposed at graded doses to chlorogenic acid (a phytonutrient) to assess the anti-anaemic property. The results will reveal the possible haematinic property of chlorogenic acid.
Role: Principal Investigator
Collaborator: Dr. O. Azeez 

3. Title: Investigating the genotoxic effect of chlorogenic acid in the sperm
Brief Summary: Male Swiss mice are being exposed to graded doses of chlorogenic acid (a phytonutrient) with a gonadotoxicant being the negative control. Biochemical assays, including DNA assays, will be conducted on the organs of the male reproductive system. The results will serve to show if chlorogenic acid affects the DNA in the male gonads. Thus showing its possible effect on fertility.
Role: Principal Investigator
Collaborator: Dr. I.O. Awogbindin

Completed Research

1. Project Title: Acute and Sub-acute toxicity studies of the methanol leaf extract of Paullinia pinnata
Funder: Third World Organization for Women in Science (TWOWS) Postgraduate Sandwich Fellowship
Brief  Summary: The aim of this study was to investigate the toxicological effects of the leaves of Paullinia pinnata (Linn.) in rodents using Wistar albino mice and rats as experimental models. Varing doses of the methanol extract of the leaves were     administered orally for varing duration of time. The effect of the treatment was observed for mortality (in the acute toxicity study) and on the lung, kidney and liver function (sub-acute toxicity study). The treatment did not result in mortality in the acute toxicity study but varying lesions in the liver and lungs for the sub-acute toxicity study suggested that a safe dose would be 200 mg/kg body weight.
Role: Principal Investigator
Collaborators: Prof. Janet M. Makinde and Dr. E.O. Ewuola

2. Project Title: Investigating the phytotoxic effect of Paullinia pinnata methanol leaf extract
Funder: Third World Organization for Women in Science (TWOWS) Postgraduate Sandwich Fellowship
Brief Summary: Paullinia pinnata (Linn.) leaves are employed traditionally as fish poison in certain parts of West Africa. Use of synthetic herbicides have been shown to have varying deleterious effect. Weed management and control is therefore being sought by allelopathy. Therefore the aim of the study was to investigate the possible phytotoxic effect of the leaves of Paullinia pinnata (Linn.). The study showed that the leaves possess good phytotoxic activity.
Role: Principal Investigator
Collaborator: Prof. Muhammad Iqbal Choudhary

3. Project Title: In-vitro toxicological screening of the aqueous ethanol root bark extract of Anthocleista nobilis and Anthocleista vogelli using various experimental models including Leishmania major, Lemna minor, Artemia salina and different bacterial strains
Funder: Third World Organization for Women in Science (TWOWS) Postgraduate Sandwich Fellowship
Brief Summary: Anthocleista vogelli and Anthocleista nobilis are trees whose parts are used traditionally for the treatment and management of diseases in Africa. The aim of this study was to investigate the effects of the aqueous ethanol root bark extracts of Anthocleista vogelli and Anthocleista nobilis against various biological organisms in order to evaluate their toxic potential. From the study, it was concluded that the root bark of A. vogelli can be explored as a source of compounds useful in weed control and management in agriculture while that of A. nobilis may be a target of drug discovery for the treatment of leishmania.
Role: Principal Investigator
Collaborator: Prof. Muhammad Iqbal Choudhary

4. Project Title: Investigation into the antiplasmodial activity of Paullinia pinnata, Anthocleista vogelli and Anthocleista nobilis extracts using various tests and the effects on antioxidant markers
Brief Summary: Paullinia pinnata is known to be used traditionally in the treatment of fever. However, in our previous work, we were not able to establish this at a safe dose. We therefore double the dose and investigated along with the curative test, the suppressive and prophylactic tests. The effect of the methanol leaf extract on the antioxidant system and inflammation in the chloroquine-resistant Plasmodium berghei NK 65 infected mice was also investigated using the liver where malaria invades. At the safe dose varying effect on the prophylactic and suppressive activity was observed with weak curative potential. However this was reversed at the high dose. It was therefore recommended that caution be exercised when ingesting preparations from the leaves of P. pinnata for the treatment of malaria. Anthocleista vogelli and Anthocleista nobilis aqueous ethanol root bark extracts did not show any significant antimalarial effect.
Role: Principal Investigator
Collaborator: Prof O.G. Ademowo

5. Project Title: Sub-acute toxicity study of the effects of ethylene glycol monomethyl ether (EGME) on antioxidant parameters in the male reproductive organs and haematological indices
Funder: a) National Earned Academic Allowance Postgraduate Study Grant
             b) Thomas-Bassir Biomedical Foundation (TBBF) seed grant
Brief Summary: Ethylene glycol monomethyl ether (EGME) is an industrial solvent with wide application. This was a preliminary study in order to determine the working dose for subsequent work by investigating its effect on the antioxidant system of the   reproductive organs of male rats being a gonadotoxicant. Varying doses was administered to Wistar rats orally and the effect on the testes and epididymes was determined. EGME caused perturbations in the antioxidant system of the male organs and there was a survival rate of 90% at 200 mg/kg body weight.
Role: Principal Investigator

6. Project Title: The effect of Paullinia pinnata methanol leaf extract on EGME-induced testicular dysfunction
Funder: National Earned Academic Allowance Postgraduate Study Grant

Brief Summary: One of the folkloric applications of Paullinia pinnata is to help infertility. Using EGME as the experimental model for infertility, Paullinia pinnata methanol leaf extract was administered to male Wistar rats and the chemopreventive potential on perturbations in the hypothalamus-pituitary-gonadal axis was investigated. However, this was not validated in this model rather it was observed that Paullinia pinnata methanol leaf extract exacerbated the deleterious effect of EGME.
Role: Principal Investigator

7. Project Title: Comparison of the nutritive value of Eva F1 hybrid tomato fruit with commercial pastes
Brief Summary: This study was designed to investigate and compare the proximate, phytochemical and micronutrient content of an intermediate hybrid variety of tomato (Eva F1) with five different commercial pastes. They all had varying levels in their content of the parameters and a combination of both in the diet was recommended.
Role: Principal Investigator
Collaborator: Mr. Yusuf Kareem

8. Title: Comparison of the nutritive value of Eva F1 hybrid tomato fruit with commercial pastes
Brief Summary: This study was designed to investigate and compare the proximate, phytochemical and micronutrient content of an intermediate hybrid variety of tomato (Eva F1) with five different commercial pastes. They all have varying levels in their content of the parameters and a combination of both in the diet was recommended.
Role: Principal Investigator
Collaborator: Mr. Yusuf Kareem

9. Title: Ameliorative potential of chlorogenic acid on rotenone-induced neurotoxicity in Drosophila melanogaster model
Brief Summary: Chlorogenic acid, abundantly found in green coffee beans is a phenolic          compound with anti-oxidant and anti-inflammatory properties amongst others. Exposure         to environmental toxicant such as rotenone, a commonly used natural pesticide, induces       Parkinsonism (a type of neurodegeneration) through the induction of mitochondria     dysfunction and oxidative stress. In this research, the ameliorative role of chlorogenic       acid on rotenone-induced toxicity in Drosophila melanogaster was evaluated. Chlorogenic acid extended the lifespan of flies and it ameliorated rotenone-induced           perturbations including the deleterious effect on acetylcholinesterase activity.
Role: Principal Investigator
Collaborator: Dr. A. O. Abolaji

10. Title: An investigation into the chemopreventive potential of Paullinia pinnata (Linn.) methanol leaf extract against toxicity by ethylene glycol monomethyl ether in Wistar rats
Funder: U.I. College of Medicine MBBS/BDS Class of ’88 Research Grant
Brief Summary: Ethylene glycol monomethyl ether (EGME) is a toxicant with wide industrial applications and industrial workers are constantly being exposed to the toxic effects of EGME. Paullinia pinnata (Linn.) is a medicinal plant used in the treatment of various ailments and is sometimes being taken by this group of people. The aim of this study is to investigate the possible chemoprotective effect of the co-administration of Paullinia pinnata methanol leaf extract (PP) and EGME in the liver and the kidneys using rodents.
Role: Principal Investigator

11. Title: Effects of dietary intervention with chlorogenic acid on copper-induced toxicity in Drosophila melanogaster
Brief Summary:  Copper (in the form of copper sulphate) was administered to Drosophila melanogaster as a model of Alzheimer’s disease. Co-treatment of the flies with chlorogenic acid (a phytonutrient) ameliorated the observed neurodegenerative effects. Chlorogenic acid can therefore be used to prevent the onset of Alzheimer’s disease.
Role: Principal Investigator
Collaborator: Dr. A.O. Abolaji

12. Title: Effect of acute exposure of Swiss mice to chlorogenic acid
Funder: Thomas-Bassir Biomedical Foundation (TBBF) seed grant
Brief Summary: Chlorogenic acid, a phytonutrient, is also packaged and administered as food supplements and for therapeutic uses without proper documentation of risk assessment. Swiss mice were exposed to graded doses of chlorogenic acid and various assays, including biochemical assays, were carried out. Chlorogenic acid showed signs of toxicity at the higher doses. Therefore care should be exercised when ingesting at high doses.
Role: Principal Investigator

13. Title: In silico profiling of chlorogenic acid
Brief Summary: Computational prediction of the possible biological activities of chlorogenic acid (a phytonutrient) was conducted usinf chemical absorption, distribution, metabolism, excretion and toxicity (ADMET) software. The compound was predicted to be to have both benign and deleterious capacities.
Role: Principal Investigator
Collaborator: Dr. Funmilayo I.D. Afolayan

14. Title: Bacteriostatic activity of Paullinia pinnata leaf fractions on isolates of treatment-failure wound
Brief Summary: Various strains of gram-positive and gram-negative bacteria isolated from wounds resistant to orthodox treatment were exposed to fractions of Paullinia pinnata Linn. leaf. The most potent fraction to the isolates was the ethyl acetate fraction and would therefore be a source for microbial therapies.
Role: Principal Investigator
Collaborators: Prof. O.M. David and Dr. J.O. Olanlokun

Publications

a.)  BOOK

Oluwatoyin A. Adeyemo-Salami (2023). Paullinia pinnata Linn.: Toxicity studies in Wistar albino mice and Wistar albino rats. Eliva Press: Mauritius. https://www.elivapress.com/en/ book/book-2939831583/.

b.) BOOK CHAPTER

Oluwatoyin Adenike Adeyemo-Salami (2021). Recent trends in ethylene glycol monomethyl ether research. In: New Innovations in Chemistry and Biochemistry. Bhowmik P.K. (Ed.). Vol. 6, Chapter 9, Pgs. 110-123. Book Publishers International: U.K.https://www.bookpi.org/bookstore/product/new-innovations-in-chemistry-and-biochemistry-vol-6/.

c.) JOURNAL ARTICLES

1. Adeyemo- Salami, O.A. and Makinde, J.M. (2013). Acute and sub-acute toxicity studies of the methanol extract of the leaves of Paullinia pinnata (Linn.) in Wistar albino mice and rats. African Journal of Medicine and medical sciences Vol 42. No.1:81-90.      

2.  Adeyemo-Salami, O.A., Farombi, E.O. and Ademowo, O.G. (2014). An investigation into the antimalarial effect of methanolic extract of Paullinia pinnata leaves in Plasmodium berghei infected mice and course of infection. African Journal of Medicine and medical sciences Vol. 43. Suppl.: 93-100.

3. Adeyemo-Salami, O.A. and Ewuola, E.O. (2015). Hematological effects of repeated graded doses of the methanol extract of Paullinia pinnata (Linn.) leaves in Wistar albino rats. Pharmacognosy Research Vol. 7. Suppl. 1: S34-S38.

4. Salami, O.A., Fafunso, M.A., Choudhary, M.I. and Atta-Ur-Rahman (2015). Toxicological screening of the ethanol root bark extracts of two Anthocleista species. World Applied Sciences Journal Vol.33. No.7: 1164-1170.

5.  Salami, O. A. and Fafunso, M. A. (2016). Phytotoxic activity of methanol leaves extract of Paullinia pinnata (Linn.). Nigerian Journal of Natural Products and   Medicine Vol. 20: 1-3.

6.  Adeyemo-Salami, O.A. and Farombi, E.O. (2018). Sub-acute toxicity study of ethylene glycol monomethyl ether on the antioxidant defense system of the testes and epididymes of Wistar rats. Nigerian Journal of Physiological Sciences. Vol. 33. No. 2: 195- 200.

7. Adeyemo-Salami, O.A. and Farombi, E.O. (2019). Exacerbative effect of Paullinia pinnata methanol leaves extract on ethylene glycol monomethyl ether-induced testicular dysfunction in male Wistar rats. Archives of Basic and Applied Medicine Vol. 7. No.1: 47-56.

8. Adeyemo-Salami, O.A., Oyedele, G.T., Oyekan, B.O. and Kareem, Y.O. (2020). Comparison of the nutritive value of Eva F1 hybrid tomato fruit with commercial tomato pastes. Annals. Food Science and Technology Vol. 21. No.1: 117-126.

9. Adeyemo-Salami, O.A., Ademowo, O.G. and Farombi, E.O. (2020). Antioxidant and antiplasmodial activities of methanol leaf extract of Paullinia pinnata. Journal of Herbs, Spices and Medicinal Plants Vol. 26. No. 3: 315-328.

10. Adeyemo-Salami, O.A. (2020). The medicinal properties of Paullinia pinnata Linn. leaves. International Journal of Phytomedicine Vol.12. No. 2: 019-025.

11.  Adeyemo-Salami, O.A. (2020). Ethylene glycol monomethyl ether research- My contribution. Archive of Urological Research Vol. 4. No.1: 068- 070.https://dx.doi.org/10.17352/aur. 000021.

12. Adeyemo-Salami, O.A. (2020). Cystic fibrosis in the intestine and the influence on digestion. Journal of Immunological Sciences Vol. 4. No. 3: 22-32.

13. Adeyemo-Salami, O.A. and Choudhary, M.I. (2021). Cytotoxic, antibacterial and leishmanicidal activities of Paullinia pinnata (Linn.) leaves. Avicenna Journal of Medical Biochemistry Vol. 9. No. 2: 88-92. DOI: 10.34172/ajmb.2021.08.

14. Adeyemo-Salami, O.A. and Farombi, E.O. (2021). The effect of ethylene glycol monomethyl ether on haematological parameters in Wistar rats. Archives of Basic and Applied Medicine Vol. 9: 121-124.

15. Adeyemo-Salami, O.A., Afonja, O.J., Adeleke, O.F., Adedara, A.O. and Abolaji, A.O. (2021). Ameliorative potential of chlorogenic acid on rotenone-induced neurotoxicity in Drosophila melanogaster model. Journal of Public Health International Vol. 4. No. 3: 55-66.

16.  Adeyemo-Salami, O.A. and Mohammad, I.C. (2021). The antifungal activity of the aqueous ethanol extract of the root bark of Anthocleista nobilis G. Don. Tropical Veterinarian Vol. 39. No. 2: 44-51.

Supervision

 

CURRENT STUDENTS

Masters Level

1. Project Title: Acute toxicity study of chlorogenic acid
Name of Students: 1.
Abdullahi Adekunle Amuzat
                               2. Dorcas Abiola Afolabi
                               3.
Omobolanle Abimbola Abiodun
Year of Entry: 2020
Examining Body: Department of Biochemistry, University of Ibadan.

2. Project Title: Copper-induced Alzheimer’s-like disease and dietary intervention with chlorogenic acid in Drosophila melanogaster
Name of Student:
Samuel Oluwadamilare Akano
Year of Entry: 2020
Examining Body: Department of Biochemistry, University of Ibadan.

3. Project Title: Genotoxic manifestations of chlorogenic acid in the male reproductive organ of Swiss mice
Name of Student: 1.
Gladys Furo Dalanbo
                             2.
Esther Ifeoluwa Oluyege
Year of Entry: 2022
Examining Body: Department of Biochemistry, University of Ibadan.

4. Project Title: Haematinic effect of chlorogenic acid in phenyl-hydrazine induced anaemia
Name of Student: Mayokun Akinbode
Year of Entry: 2023
Examining Body: Department of Biochemistry, University of Ibadan.

PREVIOUS STUDENTS (Selected)

Masters Level                                                     

1. Project Title: An investigation into the chemopreventive potential of Paullinia pinnata (Linn.) methanol leaf extract against toxicity by ethylene glycol monomethyl ether in Wistar rats
Name of Students: 1.
Damilola Samuel Kolade
                               2.
Lateefah Oyindamola Akande
Year of Entry: 2019
Examining Body: Department of Biochemistry, University of Ibadan

Grants

Current Grant Funding

Title: Acute toxicity study of chlorogenic acid in mice
Funder: Thomas-Bassir Biomedical Foundation (TBBF) seed grant
Brief Summary: Chlorogenic acid (a phytonutrient) was administered in graded doses to male Swiss mice. After twenty-four hours, the blood, liver and kidneys were collected and assayed for haematological and biochemical parameters. Chlorogenic acid showed signs of toxicity at the higher doses.
Role: Principal Investigator
Collaborators: Nil

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Other Interest/Hobbies

Oluwatoyin A Adeyemo salami Picture2My interest lies in interpreting messages in English to my native language and intercession. I appreciate good Christian music and I dance.


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