Name: Omolola A. Adesanoye Email: This email address is being protected from spambots. You need JavaScript enabled to view it. Alternate Email Address 1: This email address is being protected from spambots. You need JavaScript enabled to view it. Biography: Dr Omolola A. Adesanoye is a researcher and tutor dedicated to building student's confidence and competence in complex biochemical principles and methodologies for improved educational success. I offer expertise in drug metabolism and toxicology research to aid further understanding and development in molecular and biochemical mechanisms of toxicities of environmental pollutants and disease causative agents. I have a great passion and concern to understand the molecular basis of diseases and possible intervention to promote a more healthy society through multidisciplinary approach or research Completed: SELECTED PUBLICATIONS 1. Olusola, A.O., Obodozie, O.O., Nssien, M., Adaramoye, A.O., Adesanoye, O.A., Odama, L.E., Emerole, G.O. (2004): Concentrations of Copper, Iron and Zinc in major organs of the Wistar Albino rats – A comparative study. Biological Trace Elements Research Vol. 98 No. 3, 265-274. PMID: 15131322DOI: 10.1385/BTER:98:3:265 3. Adedara, I.A., Adesanoye, O.A.,Farombi, E.O. (2010): Evaluation of antioxidant properties of Mallotusoppositifolius in in vitro, in vivo and ex-vivo model systems. African Journal of Medicine & medical Sciences Vol. 39, 67-72. PMID: 22416646 CURRENT STUDENTS MastersLevel 1. Evaluating the Protective Effect of Quercetin on Sodium Azide-Induced Toxicity in Drosophila Melanogaster, 2020 2. Evaluating the Protective Effect of Apegenin on Chromium-Induced Oxidative Stress and Inflammation in Drosophila Melanogaster, 2020 3. Evaluating the Protective Effect of Rutin on Lead Acetate-Induced Oxidative Stress in Drosophila Melanogaster, 2020 4. Rescue Role of Curcumin on Mercuric Chloride-Induced Toxicity in Drosophila Melanogaster, 2020Profile
Designation: Senior Lecturer
Faculty: Basic Medical Sciences
Department: Biochemistry
Research
Research Interest
1. Chemopreventive and therapeutic uses of natural products, especially medicinal plant in the amelioration/treatment of drugs and chemical-induced tissue and organ damages.
2. Molecular and biochemical mechanisms of toxicities of environmental toxicants and the possible ameliorative agents.
1. Antioxidant and hepato-protective effects of the methanolic extract of Vernonia amygdalina against CCl4- induced liver damage in rats.
2. Anti-hemolytic effect of Vernonia amygdalina in Human red blood cells.
3. Modulatory effect of Vernonia Amygdalina on some free radical-induced diseases.
4. Antioxidant and Chemoprotective properties of Vernonia amygdalina against 2-AAF-induced organ damage.
5. Structural elucidation of crude methanolic extract of Vernonia amygdalina.
6. In vivo and in vitro antioxidant properties of Vernonia amygdalina.
7. Modulatory effect of Vernonia amygdalina on Allyl Alcohol-induced liver and kidney injuries in rats.
8. Ameliorating potentials of Vernonia amygdalina on toxicological effects of Hydrochlorothiazide (HCT) in rats.
9. Cardio-Renal effect of combined administration of hydrochlorothiazide (HCT) and ethanol in Wistar rats; possible protective effects of Vernonia amygdalina.
10. Toxicological effects of Bisphenol-A in male and female rats; possible ameliorative effects of luteolin and Vernonia amygdalina extract.Publications
2. Adesanoye, O.A., Farombi, E.O. (2010): Hepatoprotective effects of Vernoniaamygdalina (Astereaceae) in rats treated with carbon tetrachloride. Experimental and Toxicologic Pathology Vol. 62, 197-206. https://doi.org/10.1016/j.etp.2009.05.008
4. Ekor, M., Adesanoye, O.A., Farombi, E.O. (2010): N-Acetylcysteine pretreatment ameliorates mercuric chloride-induced oxidative renal damage in rats. African Journal of Medicine & medical Sciences Vol. 39, 153-160. PMID: 22416658
5. Ekor, M., Adesanoye, O.A., Udo, I.E., Adegoke, O.A., Raji, J., Farombi, E.O. (2010): HibiscusSabdariffaethanolic extract protects against dyslipidemia and oxidative stress induced by chronic cholesterol administration in rabbits. African Journal of Medicine & medical Sciences Vol. 39, 161-170. PMID: 22416659
6. Ekor, M., Odewabi, A.O., Kale, O.E., Oritogun, K.S., Adesanoye, O.A., Bamidele, T.O. (2011): Pharmacologic inhibition of the renin-angiotensin system did not attenuate hepatic toxicity induced by carbon tetrachloride in rats.Human & Experimental Toxicology Vol. 30 No. 11, 1840-1848. PMID: 21357630DOI: 10.1177/0960327111401051
7. Adaramoye, O.A., Adesanoye, O.A., Adewumi, O.M., Akanni, O. (2012): Studies on the toxicological effect of nevirapine, an antiretroviral drug, on the liver, kidney and testis of male Wistar rats.Human & Experimental Toxicology Vol. 31 No.7, 676-685.PMID: 22027508DOI: 10.1177/0960327111424304
8. Adaramoye, O, Akanni, O, Adesanoye, O, Labo-Popoola, O, Olaremi, O. (2012). Evaluation of toxic effects of metformin hydrochloride and glibenclamide on some organs of male rats.Nigerian Journal of Physiological Science Vol. 27 No. 2, 137-144. PMID: 23652227
9. Adaramoye, OA, Adewumi, OM, Adesanoye, OA, Faokunla, OO, Farombi, EO. (2012). Effect of tenofovir, an antiretroviral drug, on hepatic and renal functional indices of Wistar rats: protective role of vitamin E.Journal of Basic and Clinical Physiology and Pharmacology Vol. 23 No. 2, 69-75. https://doi.org/10.1515/jbcpp.2011.0042
10. Ekor, M., Odewabi, A.O., Kale, O.E., Adesanoye, O.A., Bamidele, T.O. (2013).Celecoxib, a selective cyclooxygenase-2 inhibitor, lowers plasma cholesterol and attenuates hepatic lipid peroxidation during carbon tetrachloride associated liver injury in rats. Drug and Chemical Toxicology Vol. 36 No. 1, 1-8. PMID: 22168377DOI: 10.3109/01480545.2011.642380
11. Adesanoye, O.A., Molehin, O., Delima, A., Adefegha, A., Farombi, E.O. (2013). Modulatory effect of methanolic extract of Vernonia amygdalina (MEVA) on tert- butyl hydroperoxide-induced erythrocyte hemolysis. Cell Biochemistry and Functions Vol. 31 No. 7, 545-550. https://doi.org/10.1002/cbf.2933
12. Ekor, M., Odewabi, A.O., Kale, O.E., Bamidele, T.O., Adesanoye, O.A.,Farombi E.O. (2013): Modulation of paracetamol-induced hepatotoxicity by phosphodiesteraseisozyme inhibition in rats: a preliminary study.Journal of Basic and Clinical Physiology and Pharmacology Vol. 24 No. 1, 73-79. PMID: 23425627 DOI: 10.1515/jbcpp-2012-0043
13. Adesanoye, O.A.,Adekunle, A.E., Adewale, O.B., Mbagwu, A.E., Delima, A.A., Adefegha, S.A., Molehin, O.R., Farombi, E.O (2013): Chemoprotective effect of Vernonia amygdalina del. (Astereacea) against 2-acetylaminofluorene-induced hepatotoxicity in rats. Toxicology and Industrial Health2016 Jan;32(1):47-58.doi: 10.1177/0748233713498436. Epub 2013 Sep 10(Epub ahead of print).
14. Adesanoye, O.A, Ifezue, A.O.C., Farombi, E.O. (2014): Influence of Chloramphenicol and Amoxicillin on Rat Liver Microsomal Enzymes and Lipid Peroxidation. African Journal of Biomedical Research Vol.17, 135- 142. eISSN: 1119-5096
15. Adesanoye, O.A., Farombi, E. O. (2014): In vitro antioxidant properties of methanolic leaf extract of Vernonia amygdalina. Nigerian Journal of Physiological Science Vol. 29 No. 2, 91-101. ISSN: 0794-859X
16. Abolaji, A.O., Adesanoye, O.A., Awogbindin I., Farombi, E.O. (2016): Endocrine disruption and oxidative stress implications of artemether-lumefantrine combination therapy in the ovary and uterus of rats. Hum ExpToxicol. 2016 Jan 25. pii: 0960327115626580. PMID: 26811345DOI: 10.1177/0960327115626580
17. Adebayo O.A., Adesanoye O.A., Abolaji O.A., Kehinde A.O., Adaramoye O.A. (2018): First-line antituberculosis drugs disrupt endocrine balance and induce ovarian and uterine oxidative stress in rats.J Basic ClinPhysiolPharmacol. 29(2):131-140. doi: 10.1515/jbcpp-2017-0087.
18. Olajuyin A.M., Yang M., Mu T., Tian J., Thygesen A., Adesanoye O.A., Adaramoye O.A., Song A., Xing J. (2018): Enhanced production of succinic acid from methanol-organosolv pretreated Strophanthuspreussii by recombinant Escherichia coli.Bioprocess Biosyst Eng. 2018 Jul 13.doi: 10.1007/s00449-018-1977-1
19. Adesanoye O.A., Abolaji A.O., Faloye T.R., Olaoye H.O., Adedara A.O. (2020): Luteolin-Supplemented diets ameliorates Bisphenol A-Induced toxicity in Drosophila melanogaster. Food and Chemical Toxicology. 142: 111478.PMID: 32504732DOI: 10.1016/j.fct.2020.111478
20. Adesanoye O.A., Farodoye O.M., Adedara A.O., Falobi A.A., Abolaji A.O., Ojo O.O. (2021): Beneficial actions of esculentin-2CHa(GA30) on high sucrose-induced oxidative stress in Drosophila melanogaster. Food and Chemical Toxicology.157 (2): 112620. DOI:10.1016/j.fct.2021.112620Supervision
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