Profile
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Name: Aduragbenro D. ADEDAPO |
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Designation: Professor |
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Faculty: BASIC CLINICAL SCIENCES |
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| Department: Pharmacology and Therapeutics | ||
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Email: This email address is being protected from spambots. You need JavaScript enabled to view it. Alternate Address 1: This email address is being protected from spambots. You need JavaScript enabled to view it. Alternate Address 2:This email address is being protected from spambots. You need JavaScript enabled to view it. |
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Biography The majority of my research work is in cardiovascular pharmacology from preclinical trials, in animal models using plant extracts to clinical trials and drug utilization concentration of pharmacoepidemiology. We reported the potential toxicity of chlorpheniramine plus chloroquine on respiration during the treatment of malaria in children. Chlorpheniramine was a possible chloroquine resistance reversal agent, but the potential toxicity became a drawback. My epidemiology inquest into disease patterns at the secondary health care facility buttressed the "double disease burden" evident in the developing world. The expenditure on cardiovascular and anti-infective drugs studies in a community pharmacy gave credence to this. Stroke was the leading cause of death highest at 65 years of age and above. The rising trend among females of cardiovascular disease especially hypertension is worrisome. We found that even where hypertension medicines and other medicines are given free, adherence was not optimal until a co-payment option was adopted. Health education and availability of health personnel to interact with patients culminated in improved adherence to medication by patients and an unprecedented level of blood pressure control depicting a “Healthy People”. Health-related quality of life (HRQoL) of patients with hypertension and non-hypertensive controls in south-west Nigeria using the WHO-QoL-BREF questionnaire revealed that hypertensive patients had poorer HRQoL compared with the normal individuals, but blood pressure control had no effect on this. We found that the prescription of antihypertensive drugs to patients did not directly translate to an improved health-related quality of life. Further study, showed that hypertensive heart disease was the most common compelling indication. Angiotensin-converting enzyme inhibitors were most frequently prescribed. Hypertensive patients with compelling indications had very poor blood pressure control with a significant positive correlation with the number of antihypertensive drugs. Plant extracts evaluated in experimental animal models for cardiovascular effects included Adenanthera pavonine, Moringa oleifera, and Phragmanthera incana in L-NAME-induced hypertension in rabbits |
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Research
Completed Research
1. Efficacy and Safety of Two Regimens of Chlorpheniramine plus Chloroquine Combination in the Treatment of Acute Uncomplicated Falciparum Malaria in Children
2. Acute Phase Proteins in Treated and Newly Diagnosed Pulmonary Tuberculosis Patients
3. In vitro Antimalarial Activity of Methylene Blue against Field Isolates of Plasmodium falciparum
4. Host Genetic Factors and Chloroquine Resistance
5. Anti-inflammatory Studies on Adenanthera pavinona Seeds and Anacardium occidentale Stem Bark Extract
6. Medicinal Plants Use among Patients Attending a Secondary Health Care Centre
7. Evaluation of Cardiovascular, Antimicrobial and Antioxidant Effect of Crude Extracts and Chromatographic Fractions of Adenanthera pavonine
8. Microalbuminuria in Type 2 Diabetic Patients
9. Antioxidant Effects of Micronutrients in Diabetic Patients
10. Drug Treatment of Bronchial Asthma and Acid Peptic Disease
11. Assessment of Liver Failure in Sickle Cell Disease using Coagulation Studies and Liver enzymes.
12. Drug Effect on Ocular Pressure
13. Risk Factors for Coronary Heart Disease
14.Halofantrine and Fluconazole Drug Interaction
15. Drug Utilization and Effect on Blood Pressure Control
16. Prescription Quality Indicators and Health-related Quality of Life in Hypertensive Patients
17. Pharmacoeconomics of Treatment Options for Hyperthyroidism
18. Hypolipidemic and antioxidant Effects of Methanolic Stem Bark Extract Anacardium occidentale in triton-x 100 induced hyperlipidemia in rats
19. CREOLE Study: Comparison of Three Combination Therapies in Lowering Blood Pressure in Black Africans. I am a co-investigator in this multicentre, multinational randomized parallel arm superiority clinical trial which determined the best of three combinations of two “free” antihypertensive drugs for Black African hypertensive patients.
20. May Measurement Month for Blood Pressure Screening
21. Cohort study on Adverse Drug Reactio.ns in adults admitted to the medical wards of a tertiary hospital in Nigeria: Prevalence, incidence, risk factors, and fatality
Publications
1. Sowunmi, A., Adedapo, A.D.A., Fehintola, F.A., Sowunmi, C.O., Adedeji, A.A., Falade, A.G. and Oduola, A.M.J. (2000). Comparative Efficacy and Safety of Two Regimens of Chlorpheniramine plus Chloroquine in Acute Uncomplicated Falciparum Malaria in Children. Clinical Drug Investigation Vol. 20. No.5: 317 – 325.
2. Adedapo, A.D.A, Falade, C.O., Kotila, R.T. and Ademowo, O.G. (2007). Age as a Risk Factor for Thrombocytopenia and Anaemia in Children Treated for Acute Uncomplicated Falciparum Malaria. Journal of Vector Borne Diseases Vol. 44: 266-270.
3. Adedapo, A.D.A., Ademowo, O.G., Adedapo, K.S., Demissie, K. and Osinubi, O.Y.O. (2009). Potential Toxicity of Chlorpheniramine plus Chloroquine for the Treatment of Childhood Malaria. Nigerian Journal of Clinical Practice Vol.12. No. 3: 252-257.
4. Adedapo, A.D.A., Osude, Y.O., Adedapo, A.A., Moody, J.O., Adeagbo, A.S., Olajide, O.A. and Makinde, J.M. (2009). Blood Pressure Lowering Effect of Adenanthera pavonina Seed Extract on Normotensive Rats. Records of Natural Products Vol. 3. No. 2: 82-89.
5. Babalola, C.P., Kolade, Y.T., Olaniyi, A.A., Adedapo, A. and Scriba, G.K.E. (2009). Effect of Fluconazole on the Pharmacokinetics of Halofantrine in Healthy Volunteers. Journal of Clinical Pharmacy and Therapeutics Vol. 34: 1-6. (United States of America) (Contribution: 30%).
6. Adedapo, A.D.A., Fawole, O., Bamgboye, A.E., Adedapo, K.S., Demmisie, K. and Osinubi O. (2012). Morbidity and Mortality Patterns of Medical Admissions in a Nigerian Secondary Health Care Hospital. African Journal of Medicine and medical Science Vol. 41: 13-20.
7. Adedapo, A.D.A., Sikuade, O.O., Adeleke, A. and Okechukwu, R.U. (2012). Drug Utilization and Blood Pressure Control in a Population where Aantihypertensives are Given Free: Effect of Policy Change. African Journal of Medicine and medical Science Vol. 41: 349-356.
8. Adedapo, A.D.A., Adeagbo, A.S. and Adedapo, A.A. (2012). Use of Botanical Therapies among Patients in Secondary Health Facilities in Southwest Nigeria: Implications for Medical Education? Recent Progress in Medicinal Plants Vol. 35 (14):299-310.
9. Adedapo, A.D.A., Olayinka, J.N., Abiodun, O.O., Oyagbemi, A.A., Azeez, O.A., Adedapo, A.A., Adeyemi, A.A. and Moody JO (2014). Evaluation of Antimalarial and Antioxidant Activities of the Methanol Seed Extract of Adenanthera pavonina (Linn) in Plasmodium berghei Infected Mice. Asian Journal of Medical Sciences Vol. 5. No. 4: 44-51.
10. Adedapo, A.D.A., Akunne, O. and Adedokun, B. (2015). Comparative Assessment of Determinants of Health-related Quality of Life in Hypertensive Patients and Normal Population in South-West Nigeria. International Journal of Clinical Pharmacology and Therapeutics Vol. 53. No. 3: 265-271.
11. Akunne, O.O., Godman, B., Adedapo, A.D.A, Truter, I. and Fadare, J. (2016). Statin prescribing among hypertensive patients in south-west Nigeria: findings and implications for the future. Journal of Comparative Effectiveness Research Vol. 5. No. 3:281-288. doi: 10.2217/cer.15.65.
12. Adedapo, A.D.A., Adedeji, W.A., Abiola, M.A., Olaremi, J. and Okunola, C. (2016). Antihypertensive drug use and blood pressure control among in-patients with hypertension in a Nigerian Tertiary Healthcare centre. International Journal of Basic & Clinical Pharmacology Vol. 5. No. 3: 696-701.
13. Adedapo, A.D.A., Onyinye, O.O, Oladapo, O. and Salako, B.L. (2017). Drug utilization and blood pressure control in ambulatory hypertensive patients: focus on those with compelling indications. International Journal of Clinical Pharmacology and Therapeutics. Vol. 55. No. 3: 237-245.
14. Adedapo, A.D.A. and Amwe, J.V. (2017). Cost effectiveness and prescription pattern of antidiabetic drugs in patients with diabetes attending a tertiary health facility in south west Nigeria. Journal of Pharmacology and Clinical Toxicology. Vol. 5. No. 3. 1078.
15. Adedapo, A.D.A. (2017). Rising Trend of Cardiovascular Disease among south western Nigerian Female Patients. Nigerian Journal of Cardiology Vol. 14:71-4.
16. Adedapo, A.D.A, and Ogunfowora, O. (2017). Effects of Vitamin D combined with Aspirin or Atorvastatin on plasma lipid profiles and lipid peroxidation in triton-X-induced hyperlipidemia in rats. Journal of Proteomics and Enzymology Vol. 6:2. Doi:10.4172/2470-1289.1000136.
17. Adedapo, A.D.A., Jegede, O.T., Omobowale, T.O., Nabofa, W., Oyagbemi, A.A., Adedapo, A.A. (2018). Safety and efficacy of methanol fraction of Moringa oleifera as antihypertensive in L-NAME induced hypertensive rabbits: bedside to bench, implications for bench back to bedside. Journal of Nutritional Therapeutics Vol.7 No. 2:51-58.
18. Adedapo, A.D.A., Demaki, W.E., Lagunju, I,A,. (2020) Non-dose dependent changes in liver enzymes levels of children with epilepsy on treatment with sodium valproate. Dose Response Vol. 18 No. 2. 1559325820918445.
19. Adedapo, A.D.A., Ajayi, A.M., Ekwunife, N.L., Falayi, O.O., Oyagbemi, A., Omobowale, T.O., Adedapo, A.A. (2020). Antihypertensive effect of Phragmanthera incana (Schum) Balle on NG-Nitro-L-Arginine Methyl Ester (L-NAME) induced hypertensive rats. Journal of Ethnopharmacology Vol. 257:112888.
20. Adedapo, A.D.A., Adedeji, W.A., Adedapo, I.A., & Adedapo, K.S. (2021). Cohort study on adverse drug reactions on adults admitted to the medical wards of a tertiary in Nigeria: prevalence, incidence, risk factors, and fatality. British Journal of Clinical Pharmacology, Vol 87(4): 1878-1889.
Supervision
CURRENT STUDENTS
Masters Level
1. Project Title: Comparison of effect of Rosuvastatin and Atorvastatin on lowering non-HDL Cholesterol.
Student’s Name: Victor Onyenokwe
Examining Body: Pharmacology and Therapeutics, University of Ibadan
Year of Entry: 2020/2021
Doctoral Level
1. Project Title: Impact of Cytochrome P450 2C9 Polymorphism onn glimepiride drug utilization and glycemic control in Patients with Type 2 Diabetes in Ibadan, South-west Nigeria
Student’s Name: Jerry Amwe
Examining Body: Pharmacology and Therapeutics, University of Ibadan
Year of Entry: 2016/2017
Fellowship Level
1. Project Title: Multidrug Resistant Tuberculosis
Student’s Name: Saul Adedapo Adeleke
Examining Body: West African College of Physicians
Year of Entry: 2017
PREVIOUS STUDENTS (Selected)
Masters Level
1. Project Title: Evaluation of hypolipidemic effect of fruits of Chrysophyllum albidum on normal and triton-induced hyperlipidemic rats
Student’s Name: Olu Bunmi Oluwatosin Diya
Year: 2017
2. Project Title: Antidiabetic activity of Chrysophyllum albidum fruit extract: exploring peroxisome proliferator activated receptor ligands
Student’s Name: Bukola Victoria Badaki
Year: 2017
3. Project Title: Evaluation of the changes in serum levels of liver enzymes of children with epilepsy on treatment with sodium valproate
Student’s Name: Winifred Demaki
Year:2018
4. Project Title: Antihypertensive effect of mistletoe leaves Phragmanthera incana (schum) balle on ng-nitro-l-arginine methyl ester (l-name) induced hypertensive rats
Student’s Name: Ekwunife Nancy Losie
Year:2018
5. Project Title: Surveillance of factors that influence adherence and non-adherence to antiretroviral therapy in two tertiary institutions in Ogun State.
Student’s Name: Mobolaji Favour Yomi-Adebanjo
Year: 2019
6. Project Title: Prevalence of malaria in pregnancy: preventive measures in relation to adverse birth outcomes
Student’s Name: Ogundare Omolola
Year:2020
Social Media Handle
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Other Interest/Hobbies
Dr. Aduragbenro D. ADEDAPO loves gardening, care of the elderly, singing, praising God and witnessing Jesus Christ.