Basic Information
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Name: Prof. Ezekiel O. IWALEWA |
Faculty: BASIC CLINICAL SCIENCES |
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Email: This email address is being protected from spambots. You need JavaScript enabled to view it. |
Department:Pharmacology and Therapeutics | |
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Designation: Professor |
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Brief Biography: |
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Resume
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CURRICULUM VITAE PERSONAL DATA: NAME: IWALEWA, Olugbenga Ezekiel NATIONALITY: Nigerian STATE OF ORIGIN: Ekiti State SENATORIAL DISTRICT: Ekiti North LOCAL GOVERNMENT AREA: Ido-Osi Local Government PERMANENT HOME ADDRESS: Ibagun Village, Kute, beside Exide Battery, Iwofun, Olodo-Ibadan MARITAL STATUS: Married NUMBER & AGES OF CHILDREN: Four: 24, 22, 20 and 16 years NAME & ADDRESS OF SPOUSE: Mrs. Olufunke Iwalewa, University Health Centre, Pharmacy Unit, Obafemi Awolowo University,Ile-Ife. NAME & ADDRESS OF NEXT OF KIN: Mrs Olufunke Iwalewa as above address DATE OF ASSUMPTION OF DUTY: 1st July 2013. STATUS AT FIRST APPOINTMENT: Professor PRESENT POSITION: Professor DATE OF PRESENT APPOINTMENT ANNOUNCEMENT: 19th December 2012. DATE OF CONFIRMATION OF APPOINTMENT: - PRESENT SALARY SCALE: UASS 7; Step 2 FACULTY: Basic Medical Sciences DEPARTMENT: Pharmacology & Therapeutics 1. EDUCATIONAL BACKGROUND:
2. Other Distinctions and Awards with Dates: Research Grants: Obafemi Awolowo University Research Grant, October 1998. Code: 1427ED – Principal Investigator Obafemi Awolowo University Research Grant URC 1427EO - Co-Researcher Post-Doctoral Fellowship Award Department of Paraclinical Sciences (Phytomedicine Programme), Faculty of Veterinary Sciences, University of Pretoria, PB OX4, 0110 Onderstepoort, Pretoria, South Africa. January – December 2007. Bill and Melinda Gates Foundation Global Health Travel Award 2007: to attend the Keystone Symposia B1 Drugs Against Protozoan Parasites Granlibakken Resort, Tahoe City, California USA on Jan 28 – Feb 1, 2007. Post-Doctoral Travel Fellowship Award by GA – Society for Medicinal Plant Research, Munster, Germany: to attend the 55th Annual Meeting of the Society for Medicinal Plant Research, Graz, Austria on 3 – 6 September, 2007. WHO Travel Grant : to attend the 2nd Stakeholders Meetings of ANDI, Cape-Town, South Africa on 3-7 October, 2009. Bill and Melinda Gates Foundation Global Health Travel Award 2012: to attend the Keystone Symposia J1 Drugs Against Protozoan Parasites held at Santa Fe Community Convention Center, Santa Fe, New Mexico, USA on Jan 15 - Jan 20, 2012. WORK EXPERIENCE: 1. Work Experience Outside the University System: (i) Lecturer in Pharmacology, State School of Nursing, Warri, Delta State (Dec. 1983-Nov.1984) N.Y.S.C. (ii) Teacher, Comprehensive High School, Ikare-Akoko, Ondo State (April, 1985 – Dec, 1986). 2. Work Excperience in other University System: (i) Asst. Lecturer, Ahamadu Bello University, Zaria (February 1988 - October 1991) (ii) Lecturer II, Ahamadu Bello University, Zaria (November 1991- October 1994) (iii) Lecturer I, Ahamadu Bello University, Zaria (November 1994 - October 1995) 3. Work Experience in the Obafemi Awolowo University: (i) Lecturer 1, O.A.U, Ile-Ife (December 1995 –September 2003) (ii) Senior Lecturer, O.A.U, Ile-Ife (October 2003 - September 2007) (iii)Associate Professor, O.A.U, Ile-Ife (October 2007- 2010) (iv) Professor, PFQ Case in O.A.U, Ile-Ife (2010) 4. Courses Taught in the Department of Pharmacology: (Undergraduates) PCL 201 & 202 - Anatomy and Physiology of Essential Organs I & II. PCL 301- General Pharmacology I (Principles of Drug Actions: Pharmacodynamics and Pharmacokinetics) PCL 302- General Pharmacology II (Autocoids & Inflammation and Drugs affecting Cardio- Varscular System) PCL 401- General Pharmacology III (Pharmacology of Central Nervous System), PCL-408 – Chemotherapy of Infectious Diseases (Bacterial, Fungi, Parasites, Helminthes, Viral) (Postgraduates) PCL 601- Advances Laboratory Courses and Instrumental Methods in Pharmacology PCL 602- Chemical Mediators and Nervous System Pharmacology PCL 608 – Pharmacological and Biochemical Basis of Therapeutics PCL609- Advanced Chemotherapy, DRP 623 - Advanced Human Biology, DRP 627 - Physiological Basis of Phytomedicine, DRP 629 - Toxicology of Natural Products. Graduate Study Supervision: By Research and year of graduation: 1. Akanmu, M. A: Evaluation of the Toxicity Potential of Cassia podocarpa and Cassia fistula fruits with reference to Senna. M.Sc. (Pharmacology) 1999. 2. Aderibigbe. A.O: Anti-convulsant Property and other Pharmacological Profiles of Aridanin from Tetrapleura tetraptera fruit. M. Phil (Pharmacology) 2004 3. Oyemitan. Idris: Neuro-toxicity of Artemisinin in Rats. M.Sc (Pharmacology) 2004 4. Subair, H.G; The Role of Opioid system in chloroquine-induced excitatory behaviours in rats and mice. M. Sc (Pharmacology) 2004. 5. Ayoka, A.O.; Neuropharmacological effects of Spondias mombin L. (Anacardiaceae) extracts. M. Phil (Pharmacology) 2004 6. Bassi, P.U. Effects of Tetracycline on Halofantrine Pharmacokinetics in Health Human volunteers. M. Sc (Pharmacology) 2004. 7. Omisore, N.O.A. An Evaluation of Anti-trichomonal and associated biological activities of two Dorstenia species. M. Sc (Pharmacology) 2005. 8. Adeyemi.O.I. Effects of malaria parasites infection on Chloroquine-induced Body Scrathing in rats. M. Sc (Pharmacology) 2005. 9. Daniyan O.M. Dispositions and Plasma Protein Binding of Halofantrine in Experimental Diabetic Rats.M.Sc. (Pharmacology) 2006. 10. Oyemitan I.Evaluation of the Dennettia tripetala G.Baker (Annonaceae) for Central Nervous System Activities.M.Phil. (Pharmacology) 2006. 11. Akinpelu L.A.– Toxic and behavioural effects of Harungana madagascariensis stem bark extract in mice infected with Plasmodium yoelii nigeriensis. M.Sc. (Pharmacology) 2008 12. Aderibigbe A.O – Psychopharmacological Effects of Holarrhena floribunda stem bark constituents in mice. . Ph.D. (Pharmacology) 2009 13. Omisore N.O. Antiparasitic Property of Harungana madagariensis LAM. ex POIR. Family: (Clusiaceae) stem bark constituents in malaria and trichomonas infections (Ph.D Pharmacology) 2011 14. Ologe, O. Malaria Chemotherapeutic andPharmacokinetics Studies of Azadirachta indica leaves extract preparations. (M.Phil. Pharmacology) 2011 15. Akinpelu, B. A. Bioactivity of Saponin(s) of Stem Bark of Erythrophleum suaveolens (Gull & Perr) (Ph.D. Biochemistry) 2011 16. Fadare, O.A. Synthesis and Evaluation of the Analgesic, Anti-inflammatory and Antioxidant Activity of (E)-2-Benzylidene-2, 3-dihydroinden-1-ones (1-indanone Chalchones) and their 2,4-dinitrophenylhydrazine derivatives. (M.Sc. Synthetic Chemistry) 2011. 17. Aduloju, Bolanle. Combination of nitric oxide donors and anthraquinones in malaria therapy (M.Sc. Pharmacology) (Defended 2011) By Long Essay: Nil Current Undergraduate Students Supervision: Sixteen students. MEMBERSHIP OF LEARNED/PROFESSIONAL BODIES: (i.) West African Society for Pharmacology (WASP), (1989 - 2007) (ii). Malaria Society of Nigeria, (1990) (iii). Nigerian Society of Neuro-Scientists, (1991 - 2000) (iv) Nigerian Society of Parasitology (1992) (v) Nigerian Society of Pharmacognosy (1995- 2007) (vi) African Union of Pharmacology (1992 - 2007) (vii) South Africa Society of Pharmacology (2007) (viii) Toxicology Society of South Africa (2007) (ix) Society for Medicinal Plants Research (GA). (2007) PROFESSIONAL ACCOMPLISHMENT: As a pharmacologist with a focus on the effects of medicinal plants and natural products on biological systems, the following are some of my professional accomplishments in the area of chemotherapy of parasitic organisms using medicinal plants, natural and synthetic products as antiinfective agents – (anti-malarial, antitrichomonal, antibacterial and antifungal.) against malaria, trichomonads, bacteria and fungi respectively. Related pharmacological activities like anti-inflammatory, antioxidant, analgesic and cytotoxic activities were further explored through ethnopharmacology and toxicology approach. I was involved with, supported and contributed to the development of various organs and societies of this branch of Pharmacology locally (West African Society for Pharmacology and Drug Research), regionally (African Union of Pharmacology, South African Society of Pharmacology, Toxicology Society of South Africa), and internationally (Society for Medicinal Plants Research GA). I have evaluated more than 55 medicinal plants used as herbal remedies that are relevant in ethnomedicine for infections (malaria, trichomonads, bacteria and fungi), pain, inflammation, diabetes, gastro-intestinal and central nervous systems disorders. Some of these plants were found to have pronounced activity. This led to isolation of some compounds, and their structural activity relationship (SAR) and mechanism of actions were determined on either a whole animal (in vivo) or isolated preparations (in vitro). One prominent medicinal plant that has effect on most of these diseases and disorders is Harungana madagascariensis which could be a substitute for synthetic and expensive agents. My findings therefore showed that this Harungana madagascariensisplant is a potential candidate for drug development for various diseases and disorders. CONFERENCES ATTENDED 18th Annual Conference of West African Society for Pharmacology (WASP) in Port-Harcourt, Nigeria, 5-7 April, 1989. 19th Annual Conference of West African Society for Pharmacology in Lagos, Nigeria, 3-7 April, 1990. International Workshop on the current treatment and prevention of malaria in Calabar, Nigeria, 25-28 November 1990 2nd Annual Conference of Nigerian Society of Neuroscientists, Jos, Nigeria, 3-6 December, 1991. 16th Annual Conference of Nigeria Society of Parasitology, Zaria, Nigeria, 22-25 Sept, 1992. Joint 4th Union of African Society for Pharmacology and 21st West African Society for Pharmacology Conference, Lagos, October 6 - 10, 1992. 2nd Annual Conference of Nigerian Association of Academic Pharmacist, Zaria, Nigeria, October 14-17, 1992. 2nd Annual Scientific Conference of West African Society for Pharmacology at Jos, Nigeria, 21-25 October, 1995. National Annual Scientific Conference of Nigerian Society of Pharmacognosy, University of Jos, Jos, 15 -18 October, 1995. National Annual Scientific Conference of Nigerian Society of Pharmacognosy held at Obafemi Awolowo University, Ile-Ife, 3-6 December 1997. 25th Annual Regional Conference of the West African Society for Pharmacology at A.B.U. Zaria, 20 -24th October 1998. 6th International Congress of Ethnopharmacology: International Society of Ethnopharmacology, Zurich, September 2000. International Congress and 49th Annual Meeting of the Society for Medicinal Plant Research, Erlangen, Germany. 2—6 September 2001. 29th Annual Regional Conference of the West African Soeciety for Pharmacology (WASP) & 1st Nigeria Chapter Meeting of the Western Africa Network of Natural Products Research Scientists (WANNPRES) at NIPRD, Abuja, 21st-23rd October 2002. 30th Annual Regional Conference of the West African Society for Pharmacology at Ibadan, October 18 –24th, 2003. 10th Indigenous Plants Use Forum, University of Johannesburg, South Africa, 2 – 5, July, 2007. 55th International Congress and Annual Meeting of the Society for Medicinal Plant Research Graz, Austria. September 2 -6, 2007. The South African Pharmacology and Toxicology Congress 2 – 5 October, 2007 Bufferlspoort Holiday Resort Marikana, North West Province. The 7th Joint Meeting of AFERP, ASP, GA, PSE & SIF, held in Athens, Greece. 3rd -8th August, 2008. The African Network of Drugs Development and Innovations (ANDI), 5th -10th October, 2008 in Abuja, Nigeria. The African Network of Drugs Development and Innovations (ANDI), 4th -7th October, 2009 in Cape-Town, South Africa. The African Network of Drugs Development and Innovations (ANDI), 10th -14th October, 2010 in Nairobi, Kenya. Keystone Symposia J1 Drugs Against Protozoan Parasites to be held at Santa Fe Community Convention Center, Santa Fe, New Mexico, USA on Jan 15 - Jan 20, 2012. OTHER REVELANT INFORMATION: Service within the Department: Acting Head of Department (2004 – Jan 2007) The Coordinator of Pharmacology Department (2002-2003). Coordinator of all the Pharmacology Post graduate courses. (1998-2004) Coordinator of all the Pharmacology 400 Level courses. Service within the Faculty: Member, Faculty Board of Pharmacy Member, Faculty Review Committee Member, Faculty Postgraduate Committee. Member, Faculty Students’ Council Member, Faculty Research Committee. Member, Task Force on Drug Production from Herbal Medicine Leader, Malaria and Inflammatory Research Group, O.A.U, Ile-Ife. Service within the University: Member of Senate representing Faculty of Pharmacy; 2004 -2007 Representing the Dean of Pharmacy as Cognate to the Faculty of Science (2008). Service outside the University: Reviewer for the Nigerian Journal of Natural Products and Medicine 2000 – Date (A Journal of the Nigerian Society of Pharmacognosy). Reviewer for the African Journal of Traditional, Complementary and Alternative Medicines, 2004 – Date Reviewer for the Discovery and Innovation (A Journal of African Academy of Science Nairobi, Kenya). Reviewer for the African Journal of Pharmacy and Pharmacology, 2008 Reviewer for the Pharmaceutical Biology 2008 Reviewer for African Journal of Medicine and Medical Sciences 2006 to date Reviewer for the Journal of Ethnopharmacology, 2013 External Examiner (for both Undergraduate and Postgraduate Students)to the: Department of Pharmacology and Therapeutics, University of Ibadan, Ibadan. Department of Pharmacology, College of Medicine, University of Lagos, Lagos. Department of Pharmacology and Therapeutics, University of Ilorin, Ilorin. Department of Clinical Pharmacology and Therapeutics, University of Maiduguri, Department of Pharmacology, Olabisi Onabanjo University, Shagamu Department of Pharmacology, Lagos State University, Ikeja. A minister (Deacon) in The Redeemed Christian Church of God, and the Former Parish Pastor of Love Assembly, Beside Podo / Odo-Ona Elewe Community Bank Ltd, New-Garage, Ibadan 2005-2006. Parish Pastor in the Redeemed Christian Church of God, Joy Unspeakable Parish, Itasin Street, Modakeke. 2008 till date. Co-Curricular Activities: Sports, Reading, Farming and Music. CONTRIBUTION TO KNOWLEDGE Ethno pharmacology and Toxicology of medicinal plants and natural products has been my major research area of interest. This is with special reference to chemotherapy of infectious diseases (malaria, trichomonads, bacteria and fungi) and related inflammatory disorders, reactive oxidative stress (ROS), pain and fever. I have used basic pharmacology and biochemical tools to explain the possible mechanism of actions of various effects of extracts, fractions and isolated compounds derived from medicinal plants and natural products examined. Therefore, as a pharmacologist with a focus on the effects of medicinal plants and natural products on biological systems so as to justifying the folkloric uses, the following are some of my contributions in the area of chemotherapy of parasitic organisms using these products as anti-infective agents – (anti-malarial, antitrichomonal, antibacterial and antifungal.) against malaria, trichomonads, bacteria and fungi respectively. Related pharmacological activities like anti-inflammatory, antioxidant, analgesic and cytotoxic activities were further explored through ethnopharmacology and toxicology approach, since the foundation of infection is inflammation. The contribution of my research findings to knowledge can be divided into the following major areas: (1). Chemotherapy of malaria, trichomonads, bacteria and fungi –is my main focus with other related activities against inflammation induced disorders; reactive oxidative stress (ROS), pain and fever. (2). Other non-focal published articles on effects of natural products. Chemotherapy of parasitic organisms using medicinal plant, natural and synthetic products with other related activities as anti-malarial, antitrichomonals, antibacterial, antifungal, anti-inflammatory, antioxidants, analgesics and cytotoxic agents: These research papers showed the chemotherapeutic effects of natural products on infections (malaria, bacteria, trichomonads, and fungi) and inflammatory responses that are linked with infection, reactive oxygen species (ROS) generation and pain. The following activities (anti-malarial, antitrichomonals, antibacterial, antifungal, anti-inflammatory, antioxidants, analgesics, and their cytotoxic) were evaluated to prove their folkloric uses. The following plant extracts of Azadiracta indica, Guiera senegalensis, Senna occidentalis and Vernonia cinerea leaves were tested against Plasmodium yoelii nigeriensis in mice and Plasmodium falciparum (in-vitro). Also, extracts from Dorstenia barteri and D. convexa, Murraya koenigii leaves,were tested against Trichomonas gallinae (The papers under this section are indicated in published articles numbers: i, ii, iv, v, vii, viii, xi, xviii, xx, xxi, xxii, xxv, xxvii, xxix, xxxiii, xxxvi). Currently, the various extracts, fractions and isolated compounds from Harungana madagascariensis stem bark were examined on malaria and trichomonads parasites. The varied suppressive and inhibitory activities of these extracts, fractions and isolated compounds were comparable to chloroquine, pyrimethamine and metronidazole (article xxxiii). This, therefore lend credence to their ethnomedical usage in form of decoction. The antipyretic, analgesic and anti-inflammatory properties of these extracts were suggested to have contributed to their anti-infective (antimalarial and antitrichomonads) activities exhibited in various doses as indicated in articles iii, vi, ix, x, xvii, xix, xxiii, xxiv, xxvi, xxviii, xxxi, xxxii, xxxiv, xxxv. In the same vein, some organic extracts (from Dorstenia barteri, D. convexa, Pentaclethra macrophylla, Clausena lansium, Senna occidentalis and 9 medicinal vegetables eaten in South West Nigeria) and some synthetic compounds like acetylsalicylic and anthranillic acid derivatives, chalcones derivatives, bartericin A, 6,8-dipreyleridicytol, quercetrin, 6-prenylapigenin, dorsmainin F, isobavachalcone and stimasterol derived from D. barteri leaves and twigs were examined for their analgesic, anti-inflammatory and antioxidant effects. (The papers under this section are indicated in published articles numbers: vi, ix, x, xvii, xix, xxiii, xxiv, xxvi, xxviii, xxxi, xxxii, xxxiv, xxxv.) The activities exhibited by these organic extracts and isolated / synthetic compounds from their natural sources were subjected into different pharmacological tests in which pain was induced by chemical, mechanical and thermal stimuli, carrageenan induced oedema formation and DPPH scavenging oxygen radicals’ production. The demonstrated activities of these compounds provided scientific explanation for their uses against infections (bacteria, malaria, trichomonads etc), pain and temperature, which were believed to be caused by inflammatory reactions. It was also found out that all these diseases and disorders have been linked with and have a common denominator from inflammatory (cell injury) responses and the generation of oxygen (species) radicals. Recent focus on the pharmacological and toxicological evaluation and activities of Harungana madagascariensis stems bark was actively pursued because of its enormous potentials it has in ethnomedicinal practice. It has been found to possess the following activities, which were examined and justified. The plant has diverse uses in both humans and animals as an antiparasitic / antiplasmodial (in malaria and fever), anti-anaemic (restore the PCV and haemoglobin concentration in anaemic conditions and is a potential substitute for blood transfusion), spasmolytic, antimicrobial activity on strains of bacterial and fungi pathogens, (thus potentially substantiating its use for gastro-intestinal disorders), wound healing agent and to treat skin diseases. Reports have it that 1: 1000 part of the plant parts are to be used as tincture in veterinary homeopathy. Also, it’s anti-hepatotoxic, anti-inflammatory and analgesic properties have been reported while its usefulness in treatment of exocrine pancreatic insufficiency in diabetes has also been documented. All these activities reported in traditional medicine practice show the potential of the plant as a drug candidate. However, data on acute toxicity and these activities of the plant materials are limited and not available. It was on the basis of these informations that the following activities were examined and explored: Antimalarial and antitrichomonal activity (article number xxxiii) Antidiabetic, anti-inflammatory and antioxidant complimentary activities (article number xxxii) Analgesic effects (Manuscripts submitted for Publication) Mechanisms of the toxic effects.The toxic effect exhibited by the plant constituents were found to be due release of nitric oxide and other oxidative enzyme markers (article number xxx) Possible mechanism of the plant inhibiting inflammation, ROS, pain, were examined through various mediators like NO, COX and opioids receptors. It was therefore found out thatinflammation and pain were mediated by NO, COX and opioids receptors.(paper xxxvii) The papers under toxicological effects of natural products are indicated in published articles numbers xii, xiii, xiv, xv, xvi, xxx, xxxvii, xxxviii. These research papers and findings in this area focused on the toxic effects of natural products from plant and animal materials. This is to also explain how safe and toxic the constituents present in the extracts and fractions could be as an index of its potential abilities to damage animal cells and tissues. For example, articles xv revealed the toxic potentials of insect Anaphe venata larvae eaten periodically by people residing in South-West Nigeria. It was found to cause moderate toxicity and the effect was due to CNS depression, enlargement of vital organs/tissues and increase in animal enzymatic activity levels.The level of tolerance in the animals could therefore be ascertained (through the administration of the constituents in the extracts) from their lethal doses. Apart from the lethal dose, effects of natural products on vital organs (kidney, lungs liver, testies) were examined histologically. Mechanisms of toxicosis on antioxidant enzyme markers were used in explaining their toxic potentials. Diabetes and gastrointestinal effects of medicinal plants and natural products: These research findings in this area focused on the effects of medicinal plants and natural products from on other pharmacological and biochemical parameters in various disorders like diabetes, intestinal motilities, effects on the heart and blood pressure (articles numbers: xl, xli, xlii, xliii, xliv, xlv, xlvi, xlvii, l). These plants extracts were examined in order to find an alternatives to agents used in orthodox medicine, which are of low toxicity compared to the synthetic available drugs. For example, the effect of Strophantus sarmentosus seed, which contain cardiac glycoside, was found to produce activity on the heart comparable to digoxin. This was found out to act like digoxin by reducing both the chronotropic and ionotropic contractions of the isolated rabbit heart (article number xl). Likewise, four major plants: Zingiber officinale rhizome, Murraya koenigii leaves, Jatropha tanjorensis leaves and Harungana madagascariensis stem bark showed the anti diabetic properties confirming their ethnomedicinal uses in Asian and African tropical countries (articles numbers: xi, xxxii, xxxvi, xlii, xlvi).The effects of Securidaca logipendaculata, Ocimum gratissimum, Cassia sieberena C. podocarpa and Calotropis procera (articles numbers: iv, xli, xliii, xliv, xlv and xlvii) respectively,indicating a spasmolytic effect on the intestines and bronchi smooth muscles. The spasmolytic actions were mediated through cholinergic, adrenergic and calcium ion channels [Ca2+] systems and direct smooth muscle relaxant activity. This justifies the reasons why they were used in purgation, diarrhea, constipation and asthmatic disorders. I have assisted my colleagues in other Departments in the faculty and outside the faculty in determining pharmacological properties as well as toxicity of medicinal plants and synthetic compounds of interest to them. This is a service that requires my expertise and which I am oblige to give to my colleagues for the progress of medicinal plant research. |
Researches
CURRENT RESEARCH ACTIVITIES
Ethnopharmacology and Toxicology of Medicinal Plants and Natural Products as agents in Chemotherapy of infections and Inflammations:
Identification of active constituents and the pharmacological property of medicinal plants used ethnomedically in infections (bacteria, fungi, malaria and trichomonads) and in inflammatory conditions like: infections, pain, cell membrane integrity and free radical generation.
Evaluating the safety, signs and symptoms of the acute and chronic toxicity of medicinal plant extracts and natural /or synthetic products.
Ethnomedical validation of claims for the use of Harungana madagascariensis plant parts in malaria, trichomonads, inflammatory reactions and pain.
My scientific area of interest is Chemotherapy of infections and Inflammations. The research interest focuses on Inflammation in Malaria and other diseases. Currently, I am exploring the involvement of Nitric oxide (NO) in the pathophysiology/ pathogenesis of malaria and other diseases as potential target of drug action. My current approach involve screening of medicinal plants extracts and pure compound (plant derived or synthetic) for anti-inflammatory, antimalarial, antioxidants and anti-diabetics activities, determining the effects of the extracts/compounds with promising activities on NO, assessing the interaction of NO with proteins (e.g. chaperones – heat shock proteins) at biochemical and molecular levels and the effects of extracts/compounds on such interactions in malaria and other diseases. Both in vitro and in vivo approaches will be used.
The major outputs envisaged from the current research focus will be the advancement of our understanding of the fundamental mechanisms underpinning the activities of NO in malaria and other diseases and the identification of potential novel drug targets. Translating these laboratory investigations into clinical application are my major goal.
Publications
1. Thesis:
(i) “A comparison of Potencies and Affinities of acetylcholine and carbachol on muscarinic receptor sites in the rat gastro-intestinal tract”, M.Sc. Thesis, 1987, University of Ibadan, Ibadan
(ii) “Evaluation of Antimalarial activity and other Pharmacological profiles of Cassia occidentalis and Azadirachta indica leaves” Ph.D. Thesis, 1995, Ahmadu Bello University, Zaria.
2. Books/Monographs: Nil
3. Contribution to Books: Nil
4. Published Journal Articles:
1. Iwalewa, E.O., Lege-Oguntoye, L., Rai, P.P., Iyaniwura, T.T. and Etkin, N.L. (1990). In vitro Anti-malaria activity of leaf extracts of Cassia occidentalis and Guiera senegalensis on Plasmodium yoelii nigeriensis. West African Journal Pharmacology and Drug Research 4 (Suppl.), 19-21.
2. Iwalewa, E.O., Lege-Oguntoye, L., Rai, P.P., Iyaniwura, T.T. (1997) In vivo and in vitro Antimalarial activity of two crude extracts of Cassia occidentalis leaf. Nigerian Journal of Pharmaceutical Sciensis 5, 23 - 28.
3. Iwalewa, E.O., Mohammed, K. and Omotola, O.I.F. (1999) Contributory Pharmacological Effects of Azadirachta indica leaf in the treatment of malaria. Nigerian Journal of Natural Products and Medicine 3, 40-45
4. Orafidiya, O.O; Elujoba, A.A; Iwalewa E.O. and Okeke I. N (2000) Evaluation of Anti diarrhoeal properties of Ocimum gratissimum volatile oil and its activity against Entero aggregative Escherichia coli. Pharmaceutical and Pharmacological Letters. 10 (1) 9-12
5. Isah, A.B., Ibrahim, Y.K.E., Iwalewa, E.O. (2003): Evaluation of the Antimalarial properties and standardization of tablets of Azadirachta indica (Meliaceae) in mice. Phytotherapy Research. 17 (7): 807-810
6. Iwalewa, E. O., Iwalewa, O.J, Adeboye, J. O. (2003) Analgesic, Antipyretic, Anti Inflammatory Activities of the Chloroform, Methanolic and Ether Extracts of Vernonia cinerea leaf. Journal of Ethnopharmacology86, (2-3), 229 – 234.
7. Iwalewa, E O. and Agbani, E.O. (2004) Effect of autacoid inhibitors and of an antagonist on malaria infection in mice. Brazilian Journal of Medical and Biological Research. 37 (8): 1199-1204
8. Oyedapo, O.A., Adewunmi, C.O., Makanju,V.O., Iwalewa, E.O. and Adenowo, T.K (2004) Anti-trichomonal activities of synthetic 1,3-diaryl-2-propen-1-ones on Trichomonas gallinae. African Journal of Traditional, Complementary and Alternative Medicine 1 (1): 55 – 62.
9. Omisore, N.O.A, Adewunmi, C.O., Iwalewa,E.O., Ngadjui, B.T, . Abegaz; B.M., Watchueng, J. and Ojewole,J.A.O. (2004) Antinociceptive and anti-inflammatory effects of Dorstenia barteri (leaves and twigs) extracts in mice. Journal of Ethnopharmacology 95 (1): 7-12
10. Fadeyi, O.O., Obafemi, C.A., Adewunmi, C.O., Iwalewa, E.O. (2004) Antipyretic, Analgesic, Anti-inflammatory and Cytotoxicity Effects of Four Derivatives of Acetylsalicylic acid and Anthranilic acid in mice and rats. African Journal of Biotechnology 3 (8): 426 – 431.
11. Adebajo, A.C., Olayiwola, G.,.Verspohl, J.E, Iwalewa, E.O., Omisore, N.O.A., Bergenthal, D., Kumar, V., Adesina, S.K. (2004) Evaluation of the Ethnomedical Claims of Murraya koenigii. Pharmaceutical Biology 42 (8): 610 – 620.
12. Akanmu, M.A., Iwalewa E.O., Elujoba, A.A., Adelusola, K.A. (2004) Toxicity Potentials ofCassia fistulafruits As Laxative with Reference to Senna. African Journal of Biomedical Research 7 (1): 23-26.
13. Lara. O. Orafidiya, Ejaife. O. Agbani; Ezekiel O. Iwalewa, Kayode A. Adelusola; Oluboade. O. Oyedapo. (2004) Studies on the acute and sub-chronic toxicity of the essential oil of Ocimum gratissimumLinn leaf. Phytomedicine 11 (1): 71-76.
14. Orafidiya, L.O., Agbani, E.O., Adelusola, K.A., Iwalewa, E.O., Adebanji, O.A. Adediran, E.A.F., Agbani, N.T. (2004) A study on the effect of the essential oil of Ocimun gratissimum Linn. on Cyclophosphamide induced inhibited hair growth in pulp rats. International Journal of Aromatherapy 14 (3): 119-128.
15. Iwalewa, E.O., Onayade, O.A., Oyedapo, O.O., Daniyan, O.M. (2005) Sub-acute toxicity and biochemical effects of polar and non-polar extracts of Anaphe venata larvae in mice. African Journal of Biomedical Research 8: 89 – 93.
16. Akanmu, M.A., Iwalewa E.O., Elujoba, A.A., Adelusola, K.A. (2005). Toxicity potential of Senna podocarpa (Guill.et Perr.) Lock pods in rodents. African Journal of Traditional, Complementary and Alternative Medicine 2 (3): 274 – 281.
17. Orafidiya, L.O. Fakoya, F.A. Agbani, E.O., Iwalewa, E.O. (2005)Vascular permeability increasing effect of the leaf essential oil of Ocimum gratissimum Linn as a mechanism for its wound healing property.African Journal of Traditional, Complementary and Alternative Medicine 2 (3):253 – 258.
18. Omisore, N.O.A; Adewunmi,C.O; Iwalewa, E.O., Ngadjui.,B.T; Adenowo.T.K; Abegaz., B.M; Watchuen, J and Ojewole, J.A.O. (2005) Anti-trichomonal and antioxidant activities of Dorstenia barteri and D. convexa Extracts. Brazilian Journal of Medical and Biological Research 38 (7): 1087 – 1094.
19. Iwalewa, E.O., Adewunmi, C.O., Omisore, N.O.A., Adebanji, O.A., Azike, C.K., Adigun, A.O., Adesina, O.A., Olowoyo, O.G. (2005)Pro- and Anti-oxidant effects and Cytoprotectiv potentials of Nine Edible Vegetables in South West Nigeria. Journal of Medicinal Foods 8 (4): 539 – 544.
20. Iwalewa, E.O., Daniyan, O.M., Omisore, N.O. (2006): Methanolic leaf extract of Senna occidentalis in the treatment of malaria. Journal of Tropical Medicinal Plants 7 (1): 11- 16.
21. Adebajo, C.A., Ayoola, O.F., Iwalewa, E.O., Akindahunsi, A., Omisore, N.O.A., Adewunmi, C.O., Adenowo.T.K (2006)Anti-trichomonal, biochemical and toxicological activities of methanolic extract and some carbazole alkaloids isolated from the leaves of Murraya koenigii growing in Nigerian. Phytomedicine13: (4) 246-254.
22. Akomolafe, R.O., Adeoshun, I.O, Fakunle, J.B., Iwalewa, E.O., Ayoka, A.O., Akanji, B.O. (2006) Changes in the visceral functions of Plasmodium berghei infected and uninfected rats following administration of artemether. Clinical and Experimental Pharmacology and Physiology 33 (12): 1180 – 1183.
23. Idowu, T.O., Iwalewa, E.O., Aderogba, M.A., Akinpelu, B., Ogundaini, A.O. (2006) Antinociceptive Anti-inflammatory and Antioxidant activities of Eleagnine: An alkaloid Isolated from Chrysophyllum albidum seed cotyledonsJournal of Biological Sciences 6 (6):1029 – 1034
24. Okorie; C.C., Oparaocha, E.N.T., Adewunmi, C.O., Iwalewa, E.O., Omodara, S.K. (2006)Antinociceptive, Anti-inflammatory and Cytotoxicity Activities of Pentaclethra macrophylla aqueous extracts of the leaf, stem bark, seed and fruit pericap in mice. African Journal of Traditional, Complementary and Alternative Medicine 3 (1):44 – 53.
25. Igbeneghu; O. A., Iwalewa; E.O., Lamikanra, A. (2007) A study of the In Vivo activity of the leaf extract of Alchornea cordifolia against multiply antibiotic resistant S. aureus isolate in micePhytotherapy Research21 (1): 67 – 71.
26. Iwalewa, E.O., Oladimeji, F.A., Adewunmi, C.O., Osoniyi, O.R., Orafidiya, L.O., Adeloye, O., Adeleke, F.B., Omodara, S.K. (2007) Suppression / Involvement of Nitric oxide in the Anti-Inflammatory and Analgesic Effects of Lippia multiflora Leaf Essential Oil Emulsion formulation International Journal of Essential Oil Therapeutics. 1: 126-134
27. Aladesanmi, A.J., Iwalewa, E.O., Adebajo, A.C., Akinkunmi, E.O., Taiwo, B.J., Olorunmola, F.O., Lamikanra, A. (2007): Antimicrobial and Antioxidant Activities of Ten Medicinal Plants. African Journal of Traditional, Complementary and Alternative Medicine 4 (2): 173 – 184
28. Iwalewa, E.O., McGaw, L.J., Naidoo, V., Eloff, J.N. (2007) Inflammation: the foundation of diseases and disorders. A review of phytomedicines of South African origin used to treat pain and inflammatory conditions. African Journal of Biotechnology 6 (25): 2868-2885.
29. Adeyemi.O.I., Iwalewa, E.O., Akanmu, M.A., Ukponmwan.O.E (2007). Malaria Parasite infection and chloroquine-induced pruritus: The role of opioids peptides West African Journal of Pharmacology and Drug Research 22 & 23: 31-38.
30. Iwalewa, E.O., Daniyan, O.M., Osoniyi, O.R., Adetogun, G.E., McGaw, L.J., Naidoo, V., Eloff, J.N. (2007). Mechanisms of the toxic effect of Harungana madagascariensis stem bark in vivo and in-vitro. Journal of Tropical Medicinal Plants 8 (2): 184-192.
31. Oyedapo, O.A., Adewunmi, C.O., Iwalewa, E.O., Makanju, V.O. (2008) Analgesic, Antioxidant and Anti- inflammatory Related activities of 21-hydroxy-2,41- dimethoxychalcone and 4–hydroxychalcone in mice. Journal of Biological Sciences8 (1):131-136.
32. Iwalewa, E.O., Adewale, I.O., Taiwo, B. J, Arogundade, T., Osinowo, A., Daniyan, O.M., Adetogun, G.E. (2008) Effects of Harungana madagascariensis stem-bark extracts on the anti-oxidant markers in alloxan-induced diabetics and carrageenan induced inflammatory disorders in rats. Journal of Complimentary and Intergrative Medicine 5 (1): 1-18.
33. Iwalewa, E.O., Omisore, N. O., Adewunmi, C.O., Gbolade, A. A., Ademowo, O.G., Nneji, C., Agboola, O.I., Daniyan, O.M. (2008) Anti-protozoan activities of Harungana madagascariensis stem bark extract on trichomonads and malaria. Journal of Ethnopharmacology 117: 507–511.
34. Olayinka. O. Adegbehingbe , Adejimi. S. Adesanya , Thomas. O. Idowu , Oluwakemi. C. Okimi, Oyesiku. A. Oyelami , Ezekiel. O. Iwalewa. (2008) Clinical effects of Garcinia kola in knee osteoarthritis Journal of Orthopaedic Surgery and Research, 3:34
35. Oyemitan, I. A., Iwalewa, E. O., Akanmu, M. A., Olugbade, T. A. (2008) Antinociceptive and antiinflammatory effects of essential oil of Dennettia tripetala G.Baker (Annonaceae) in rodents. African Journal of Traditional, Complementary and Alternative Medicines 5 (4): 355-362
36. Adebajo, A.C., Iwalewa, E.O., Obuotor, E.M., Ibikunle, G.F., Omisore, N.O., Adewunmi, C.O., Obaparusi, O.O., Schmidt, T.J., Klaes, M., Verspohl, E.J. (2009) Pharmacological properties of the extract and some isolated compounds of Clausena lansium stem bark: Anti-trichomonal, antidiabetic, anti- inflammatory, hepatoprotective and antioxidant effects.Journal of Ethnopharmacology 122: 10-19
37. Iwalewa, E.O., Naidoo, V., Bagla, V., Eloff, J.N.(2009)Nitric oxide producing effect of six extracts from Harungana madagascariensis stem bark. African Journal of Pharmacy and Pharmacology 3 (1): 14 – 21.
38. Iwalewa, E.O., Omisore, N.O., Daniyan, O.M., Adewunmi, C. O., Taiwo, B. J., Fatokun, O.A., Oluborode, I.O. (2009) Elemental composition and anti- anaemic property of Harungana madagascariensis stem-bark extracts in rats. Bangladesh Journal of Pharmacology 4: 115- 121
39. Iwalewa, E.O., Suleiman, M. M., Mdee, L.K., Eloff, J.N. (2009) Antifungal and antibacterial activities of six different extracts from Harungana madagascariensis stem bark. Pharmaceutical Biology 47 (9): 878–885
40. Iwalewa, E.O., Gbolade,A. A., Omisore, N.O., Nneji, C. M., Ademowo, O.G. (2009) Antiplasmodial and antipyretic effects of Six Nigerian essential oils in mice. Nigerian Journal of Pharmaceutical Research 7 (1): 64- 77.
41. Iwalewa, E.O., Omisore, N.O., Adewunmi, C. O., Adebajo, A. C., Akinpelu, L.A., Obuotor, E.M., Oyedapo, O.O., Akinpelu, B.A. Ngadjui, B. T., Kouam, S.F., Yapna, D. B. (2009) Fractions and isolated compounds of Harungana madagascariensis stem bark: Mechanisms of the antimalarial and anti-trichomonal actions Nigerian Journal of Natural Products and Medicine 13: 59-70.
Other published articles
42. Iwalewa, E.O. and Oriowo, M. A. (1993) Classification of Muscarinic receptor sub-types along the rat gastro intestinal tract. Nig. J. Neuroscience, 4 (1) 43-49.
43. Owonubi, M.O., Iwalewa, E.O. and Shok, M. (1997). Cardio-activity of Sarmentoside - A from Strophanthus sarmentosus seeds (Family Apocynaceaae). Nig J. Nat. Prod. Med., 1, 16-19.
44. Owonubi, M.O; Anuka, J.A; Ibinola, T; Alawode,S and Iwalewa, E.O. (1998) Some Pharmacological Effects of the Root Extract of Securidaca logipendiculata. West. Afr. J. Pharmacol. Drug.Res.14 (1&2), 22-26.
45. Kalejaiye. O.F; Iwalewa. E.O: Omobuwajo O.R; Oyedapo. O.O. (2002) Hypoglycaemic Effects of Nigerian Zingiber officinalerhizome on Experimental Diabetic Rats. Nig. J. Nat Prod-Med. 6, 33—35.
46. Akomolafe, R.O., Adeoshun, I.O., Elujoba,A.A., Iwalewa E.O., Ayoka. A.O. (2003) In-Vitro effects of Cassia sieberiena leave extracts on the intestinal motility of rats. African Journal of Biomedical Research. 6 (1) 141 – 145.
47. Akomolafe, R. O., Adeoshun, I. O., Elujoba, A. A., Ayoka, A. O., and Iwalewa, E.O. (2004) An in-vitro study of the effect of Cassia podocarpa fruits on the intestinal motility of rats. Phytomedicine 11 (2-3): 249-254.
48. Akomolafe, R. O., Adeoshun, I. O., Elujoba, A. A., Iwalewa, E.O. and Ayoka, A. O. (2004) :Effects of Cassia podocarpa leaves extracts on Rat Ileum and Colon. (in-vitro) Bulletins of Latin American and Carrebean Medicinal and Aromatic Plants.(BLACPMA) 3 (3): 52 – 57.
49. Olayiwola, G., Iwalewa, E.O., Omobuwajo, O.R.,. Adebajo, A.C, Adeniyi, A.A., Verspohl, J.E. (2004) Anti-diabetic Potentials of Jatropha tanjorensis leaves. Nigerian Journal of Natural Products and Medicine. 8: 37 – 40.
50. Iwalewa, E.O., Elujoba, A.A.and Bankole, O.A. (2005) In-vitro Spasmolytic Effect of Aquoeus extract of Calotropis procera (leaf and stem) on Guinea-pig trachea smooth muscle chain. Fitoterapia 76 (2): 250 - 253.
51. Ayoka, A.O., Akomolafe, R.O., Iwalewa, E.O., Ukponmwan, O.E. (2005) Studies on the anxiolytic effect of Spondias mombin L. (Anacardiaceae) extracts. African Journal of Traditional, Complementary and Alternative Medicine 2 (2): 153 – 165.
52. Ayoka, A.O., Akomolafe, R.O., Iwalewa, E.O., Akanmu, M.A., Ukponmwan, O.E. (2006) Sedative, antiepileptic and antipsychotic effects of Spondias mombin in mice. Journal of Ethnopharmacology 103: 166 -175.
53. Iwalewa, E.O., Idowu, T.O., Aderogba, M.A., Akinpelu, B., Ogundaini, A.O.(2006).Biochemical and Behavioural Effects of Eleagnine from Chrysophyllum albidum seed cotyledons. Journal of Tropical Medicinal Plants.7 (1): 55-61.
54. Oyemitan, I.A., Iwalewa, E.O., Akanmu, M.A., Asa, S.O., Olugbade, T.A. (2006) The abusive potential of habitual consumption of the fruits of Dennentia tripetala G.Baker (Annonaceae) among the people in Ondo township (Nigeria). Nigerian Journal of Natural Products and Medicine. 10: 55 – 62.
55. Aderibigbe, A.O., Iwalewa, E.O., Adesina, S.K., Adebanjo, A.O., Ukponmwan, O.E. (2007) Anticonvulsant, Analgesic and Hypothermic Effects of Aridanin isolated from Tetrapluera tetraptera fruit in mice. Journal of Biological Sciences 7 ( 8 ):1520 – 1524.
56. Oyemitan, I.A., Iwalewa, E.O., Ukponmwan, O.E., Akomolafe, R.O., Daniyan, O.M. (2007) The Involvement of Serotonin in Artemether-induced Behavioural Activities in Rats. Journal of Biological Sciences 7 (3): 575 – 578
57. Aderibigbe, A.O., Iwalewa, E.O., Adesina, S.K., Ukponmwan, O.E., and Adebanjo, A.O (2007) Neuropharmacological evaluation of aridanin, a glycoside isolated from Tetrapleura tetraptera fruit in mice. Discovery and Innovation 19 (3): 177-181.
58. Michael O. Daniyan, Sharon I. Omoruyi, Cyprian O. Onyeji, Ezekiel O. Iwalewa, Efere M. Obuotor (2008) Pharmacokinetic changes of halofantrine in experimentally-induced diabetes mellitus following oral drug administration African Journal of Biotechnology 7 (9), 1226 1234.
59. Oyemitan, I.A., Iwalewa, E.O., Akanmu, M.A., Olugbade, T.A. (2008) Sedative, Hypothermic and Muscle relaxant effects of the essential oils of Dennentia tripetala G.Baker (Annonaceae) and its mechanisms in mice. Ife Journal of Science 10 (1): 1- 9.
60. Oyemitan, I.A., Iwalewa, E.O., Akanmu, M.A., Gbolade, A.A. Olugbade, T.A. (2009) Behavioural Effects and Mechanisms of Essential Oils of Dennentia tripetala G.Baker (Annonaceae) in mice. West African Journal of Pharmacology and Drug Research 25: 15-22
61. Aderibigbe, A.O.; Iwalewa, E.O.; Adesina, S.K. (2010) Anxiolytic effect of Aridanin isolated from Tetrapleura tetraptera in mice. Bioresearch Bulletin 1: 1-6
62. Aderibigbe, A.O., Iwalewa, E.O., Adesina, S.K., Agboola O.I. (2010) Studies of Behavioural and Neural Mechanism of Aridanin, isolated from Tetrapleura tetraptera fruit in mice. International Journal of Pharmacology 6 (4): 480-486.
63.Akomolafe, R.O., Adeoshun, I.O., Fakunle J.B., Iwalewa, E.O., Ayoka, A.O., Ajayi, O.E., Odeleye, O.M., and Akanji, B.O. (2011) Effects of artemether on the plasma and urine concentrations of some electrolytes in rats. African Journal of Biotechnology 10 (20): 4226-4233,
64.Akanmu, M. A., Adeloye, A.O., Obuotor, E. M., Adelusola, K.A., Iwalewa, E.O., Ukponmwan, O.E., Lamikanra, A. (2011) Neuropharmacological effects of Alchornea cordifolia (Schumach. & Thonn.) Mull. Arg. (Euphorbiaceae) in mice. International Journal of Biological and Chemical Sciences 5 (6): 2250-2262.
65. Rufus O. Akomolafe, Kayode D.S Bamitale, Ezekiel O. Iwalewa, Olasupo S. Adeniyi, Abiodun O Ayoka, Isaac O. Adeoshun. (2011) Effects of aqueous Anaphe venata extract on fecal pellet output in mice. International Journal of Biological and Chemical Sciences Volume 5 (6):2371-2381
66. Akinpelu B. A.., Oyedapo, O. O.., Iwalewa E. O., Shode, F. (2012) Biochemical and histopathological profile of toxicity induced by saponin fraction of Erythrophleum suaveolens (Guill. & Perri.) bark extract. Phytopharmacology 3(1) 38-53
67. Craig A. Obafemi, Festus O. Taiwo, Ezekiel O. Iwalewaand David A. Akinpelu (2012). Synthesis, antibacterial and anti-inflammatory activities of some 2-phenylglyoxylic acid derivatives. International Journal of Life Science and Pharma Research Vol 2(2): 22 – 36.
68. Akinpelu B. A.., Dare, C. A., Adebesin, F. I., Iwalewa E. O., Oyedapo O. O. (2012) Effect of stem bark of Erythrophleum suaveolens (Guill. & Perri.) saponin on fresh water snail (Lanistes lybicus) tissues. African Journal of Environmental Science and Technology Vol 6 (11) 446-451.
69. Adebajo, A.C., Odediran, S.A., Aladesanmi A.J., Iwalewa, E.O., Olugbade, T.A., Nneji, C. M., Ademowo, O.G., Schmidt, T.J., Klaes, M., Verspohl, E.J. (2013) Evaluation of Ethnomedicinal Claim IIa: Antimalarial activities of Gongronema latifolium root and stem Journal of Herbs, Spices and Medicinal Plants 19: 1-22
70. Tsholofelo Abednego Mokoka, Lyndy Joy McGaw, Ladislaus Kakore Mdee, Victor Patrick Bagla, Ezekiel Olugbenga Iwalewa and Jacobus Nicolaas Eloff (2013) Antimicrobial activity nd cytotoxicity of triterpenes isolated from leaves of Maytenus undata (Celastraceae) BMC Complementary and Alternative Medicine, 13:111
71. E.O. Iwalewa., T. Roland, B. O. Aduloju, M. O. Ologe, A. O. Adepiti, S.A. Odediran, O. J. Iwalewa, E.M. Obuotor, J. I. Olawuni. (2013). Antimalarial effect of anthraquinone, nitric oxide donor (sodium nitroprusside) its inhibitor (L-NAME) and their combinations on Plasmodium berghei in mice. International Journal of Pharmacy and Pharmacology.2 (7), 117-124
72. Akinpelu B. A. Igbeneghu O. A. Awotunde A. I., Iwalewa E. O., and Oyedapo O. O.(2014) Antioxidant and antibacterial activities of saponin fractions of Erythropheleum suaveolens (Guill. and Perri.) stem bark extract Academic Journals Vol. 9(16), pp. xxx-xxx, 30 August, 2014
73. E. F. Aransiola, M.O. Daramola, E. O. Iwalewa, A. M. Seluwa, O. O. Olufowobi (2014) Anti- Diabetic Effect of Bryophyllum pinnatum Leaves International Journal of Biological, Food, Veterinary and Agricultural Engineering Vol:8, No:1: 51-55
Papers published after the last promotion
Edited and Referred Conference Proceeding Published Paper
1. Iwalewa, E.O., Lege-Oguntoye, L., Rai, P.P., Iyaniwura, T.T. and Etkin, N.L.(1992). Effect of cardiogenic and sterol extracts of Azadirachta indica leaves on Plasmodium yoelii nigeriensis infection in mice In:Proc. Nigerian Assoc. Academic Pharmacist (October 1992), Vol. 2, 167-172.
2. Iwalewa, E. O. (2000):The efficacy and safety of phytomedicines in the treatment of malaria and sexual transmitted diseases. In: Phytomedicines in Malaria and Sexually Transmitted Disease: Challenges for the New Millennium. Eds: C.O. Adewunmi & S. K. Adesina. pp 51-57.
Manuscripts Accepted for Publication:
1. Akomolafe, R. O., Adeoshun, I. O., Fakunle, J. B., Iwalewa, E. O., Ayoka A. O., Ajayi O. E., Odeleye O. M. and Akanji, B.O. (2012). Changes in some biochemical parameters of kidney functions of Plasmodium berghei infected rats administered with some doses of artemether. African Journal of Biotechnology 2012 (in press)
Non- Referred Conference Proceedings: Nil
Manuscripts Submitted for Publication:
1. Iwalewa, E.O., Akinpelu, L.A., Ilesanmi, O. R.,Daniyan, O.M., Fatuna, O.A.,. Fasina, B.A. Analgesic effect of Harugana madagascariensis stem bark extracts using four experimental models of nociception(Involvement of COX and Opioids mechanisms) (Indian Journal of Pharmacology)
2. Iwalewa, E.O., Akinpelu, L.A., Ilesanmi, O.R.S., Obuotor, E.M, Olawuni, I. J. Role of acetylcholinesterase and nitric oxide in the behavioural changes of Harugana madagascariensis extract in mice infected with Plasmodium berghei(Methods and Findings in Experimental and Clinical Pharmacology)
Creative Works: None
Technical Reports: None
Papers and Works in Preparation
Papers in Preparation
1. M.O. Ologe, E.O. Iwalewa, C.O. Onyeji. An in-vivo Chemotherapeutic Studies of Azadirachta indica leaves extract preparations complexed with (2-Hydroxypropyl)-beta-cyclodextrin and polyvinylpyrollidone (PVP) on Plasmodium berghei in mice.
2. Omisore, N.O., Iwalewa, E.O., Adewunmi, C. O. Antidiarrhoeal, anthelminthic, antipyretic, anti- ulcer effects of aqueous ethanolic extract from Harungana madagascariensis stem bark.
4. Ihediora., O..Obafemi C.A., Iwalewa, E.O., Omodara, S.K.: Anti-inflammatory and antinociceptive activities of 3-Quinoxalinone-2-hydrazone and its Transition- metal Complexes in mice.
5. Fadare, O.A., C.A. Obafemi., E.O. Iwalewa, S. K. Omodara: Synthesis and evaluation of antinociceptive and anti-inflammatory properties of some 3-hydrazino-Quinoxalin-2 (1H)-one derivatives in mice.
Works in Preparation
Fadare, O.A., Obafemi, C.A., Iwalewa, E.O., Omodara, S.K., Antimalarial, analgesics, anti- inflammatory, and cytotoxicity activities of ten (10) synthetic 1- indanone-chachones in mice.
CONTRIBUTION TO JOINT PUBLICATIONS
PAPERS
1. The paper was the preliminary study in order to choose the plants for my Ph.D. programme. I carried out all the pharmacological work, I wrote the paper and others authors as my supervisors made their contributions
2. The paper is another portion of my Ph.D., sequel to the outcome of paper1. The detailed in vivo and in vitro studies were carried out for one of the plants used for the Ph.D. programme. I carried out the pharmacological work, I wrote the paper.
3. Some of the results that emanated form my Ph.D. work. There are additional results from another project I initiated which were added to show the complimentary effect of extract of Azadirachta indica in malaria.. I processed the manuscript for publication all alone. The other authors carried out the experimental methods.
4. Professors Orafidiya with Elujoba initiated this project. I carried out the detailed pharmacological aspect of the work on diarrhea and we processed the manuscript together for publication.
5. This work is a master degree project initiated by Y.K.E. Ibrahim and I co-supervised the project by evaluating the anti-malarial properties of the tablets. This work was done in my laboratory at A.B.U., Zaria. We all contributed to the publication of the manuscript.
6. I initiated this project, which was carried out, in my laboratory. All the pharmacological experiments were carried out by me. I processed the manuscript for publication.
7. I initiated the study as a follow-up to the work I carried out from my Ph.D. work. I carried out all the pharmacological work, Agbani and I wrote and processed the paper.
8. A master degree project initiated by Prof. Adewunmi. I co-supervised the study, Oyedapo and I carried out the experimental work, Makanju, synthezied the compounds, while Adenowo cultured and isolate the Trichomonas gallinae. I wrote and processed the paper for publication with Adewunmi.
9. A master degree project initiated by Prof. Adewumi while I was the co-supervisor. Ngadjui, Abegaz, Watchueng supplied the synthetic compounds from Dorstenia barteri while the Pharmacological work was carried out by Omisore. Prof. Adewumi and I processed the papers.
10. The work was initiated by Obafemi in the Department of Chemistry, I supervised the pharmacological work. I wrote and processed the paper with other authors.
11. Dr. Adebajo initiated the project, did the isolation of the plant materials; Dr. Bergenthal did the spectral analysis of the isolates. Dr. Olayiwola, Omisore and Prof. Verspohl did the Pharmacological experiments. Prof. Kumar supplied the Sri-Lanka plant materials I and Adebajo wrote the manuscript, and while other authors made substantial contributions as the paper was processed for publication.
12. Prof. Elujoba and I jointly initiated the master degree project. We supervised the study. Both the pharmacological and the toxicological parts were conducted by the student and me. I wrote the paper and Elujoba made his contribution.
13. Prof. Orafidiya initated the study, the Pharmacological and the toxicological work were done by Agbani and I, the biochemical work was done by Prof. Oyedapo, while Adelusola examined the histopathological effect. We wrote and processed the paper together.
14. A study initiated by Prof. Orafidiya, the Pharmacological work were carried out by me, Adebanji, Agbani, while the histopathological assessment was carried out by Adelusola and Adediran, Prof. Orafidiya, Agbani and myself wrote and processed the paper.
15. Onayade and Adamolekun initiated the project; I carried out all the pharmacology experiments and single handedly wrote and processed the paper for publication.
16. Prof. Elujoba and I jointly initiated the master degree project. We supervised the study. Both the pharmacological and the toxicological parts were conducted by the student and me. Akanmu wrote the paper and Elujoba and I made our contribution to process the paper together.
17. In sequel to Papers 12 and 13, Prof. Orafidiya initated the study, the Pharmacological work was done by Agbani, Fakoya and I. We wrote and processed the paper together.
18. This paper is sequel to paper 9. It was a master degree project initiated by Prof. Adewumi while I was the co-supervisor. Ngadjui, Abegaz, Watchueng supplied the synthetic drugs from Dorstenia barteri and D. convexa while the Pharmacological work was carried out by Omisore. Prof. Adewumi and I processed the papers.
19. The project was initiated by Prof. Adewunmi, I and other authors’ carries out the pharmacological investigation. Prof. Adewunmi and I wrote and process the paper.
20. I initiated this project, the pharmacological work was done by me and I processed the paper for publication with the approval of the other authors..
21. Dr. Akindahunsi and Ayoola initiated the Master project, Dr. Adebajo supplied the plant extract used, Omisore, Adewunmi and Adenowo were involved in Trichomonads cultures and experiment, I and Adebajo wrote and processed the manuscript.
22. This is Akomolafe Ph.D. work that was intiated and suggested by Adeosun and I. My contribution was in malaria passaging and the methodology. We all contributed to the write- up and the processing of the paper.
23. The project was initiated by the authors, I and other authors’ carries out the pharmacological investigation. Prof. Ogundaini supervised the isolation of eleaginine, Idowu, Aderogba, Akinpelu and I wrote and process the paper.
24. A master degree project initiated by Oparaocha from Michael Okpara University. Okorie came to our laboratory for the pharmacological experiment, which was carried out by me and the student. Prof. Adewunmi and I wrote and process the paper for publication.
25. The paper emanated from Igbeneghu’s M.Sc. work that was intiated by Prof. Lamikanra. I co-supervised the project, involved in the preparation and the processing of the manuscript for publication.
26. The paper came from the project initiated by Prof. Adewunmi, all the pharmacological works were performed by me, Adeloye, Adeleke and Omodara. The essential oil extraction and preparation were done by Oladimeji and Orafidiya. The biochemical parameters were assessed by Osoniyi. The writing and the processing of the paper for publication were done by Iwalewa, Oladimeji, Osoniyi and Orafidiya.
27. A project initiated by Prof. Aladesanmi and coordinated by me. Anti-microbial activities were carried out by Akinkunmi and Olorunmola, supervised by Lamikanra. Antioxidant effect was determined by Taiwo, while the preparation and the processing of the manuscript were done by Aladesanmi, Lamikanra, Akinkunmi, Iwalewa and Adebajo.
28. This is a review paper initiated and written by me. Other authors made their contributions while myself and Eloff processed the paper for publication.
29. This is an M.Sc project for Mr. Adeyemi, it was initiated by Prof. Ukponmwan and co-supervised by me. Adeyemi and Iwalewa carried out the pharmacological works, the paper was written and processed for publication by Adeyemi, myself and Ukponmwan.
30. The paper was initiated by me, the toxicological assessment was done by Iwalewa, Daniyan, Adetogun, the biochemical parameters were done by Osoniyi, all other in-vitro toxicity were done in the laboratories of McGaw, Naidoo and Eloff, who also contributed to the processing and the write-up of the manuscript.
31. Sequel to paper 8, this paper was derived from a master degree project initiated by Prof. Adewunmi. I co-supervised the study, Oyedapo and I carried out the experimental work, Makanju, synthezied the compounds. I wrote and processed the paper for publication with Adewunmi.
32. The paper was initiated by me; the pharmacological (anti-diabetic) assessment was done by Iwalewa, Daniyan, Arogundade, Osinowo, the biochemical evaluation was done by Adewale, the antioxidant work was examined by Taiwo, while the write-up and the processing of the manuscript was done by Iwalewa, Daniyan, Adetogun, Adewale and Taiwo.
33. This paper emanated from Omisore Ph.D. work which I initiated and co-supervised by Prof. Adewunmi.Extraction of the plant materials were done by Gbolade and Agboola, in-vitro culture and assessment were carried out in the laboratory of Ademowo and supervised by Nneji. Iwalewa, Omisore, Adewunmi, Gbolade, Ademowo and Daniyan contributed to the writing and processing the manuscript.
34. Adegbehingbe conceived of the study, participated in its design and coordination. Adesanya actively involved in the study design and coordination and manuscript writing. Idowu characterized the chemistry of G. kola and participated in study coordination. Okimi participated in the design and study coordination. Oyelami involved in the design and study coordination. Iwalewa was involved in the study design and coordination .All authors read and approved the final manuscript.
35. This paper came from Oyemitan M.Phil.project that was supervised by me and Olugbade as co-supervisor. The collection of data and analysis was done by Oyemitan, the write –up of the manuscript and the process for publication was done by Oyemitan, Olugbade and I.
36. The idea of this project was conceived by me. The in vivo pharmacological (hepatoprotective) assessment was done by Iwalewa, Obaparusi, the in-vitro pharmacological (anti-diabetic) assessment was done by Adebajo, Schmidt, Klaes, Verspohl, the chemical isolates were produced by Adebajo, the biochemical evaluation of the extract was conducted by Obuotor, while the anti-trichomonal activity was performed by Ibikunle, Adewunmi, Omisore. All authors except Obaparusi contributed to the write-up and processing of the paper and approved the final manuscript.
37. The idea of this project was conceived by me. The pharmacological work was done by Iwalewa, in the laboratory of Dr. Naidoo, while the toxicity and viability test was conducted by Bagla, The paper was processed and written by me and Eloff.
38. The idea of this project was initiated by me. The elemental composition was done by Taiwo while the anti- anaemic pharmacological property was assessed by Iwalewa, Omisore, Daniyan, Fatokun and Oluborode. The paper was processed and written by Iwalewa, Taiwo and Daniyan.
39. The idea of this project was initiated by me. The extraction of plant materials, the pharmacological experiments (antifungal and antibacterial activities) was done by Iwalewa, Suleiman and Mdee. The paper was processed and written by Iwalewa, Suleiman, Mdee and Eloff.
40. The idea of this project was initiated by Gbolade. The extraction and preparation of the essential oils were done by Gbolade, while the antiplasmodial activity was performed by Omisore in the laboratory of Ademowo under the supervision of Nneji. The paper was written and processed by Iwalewa, Gbolade, Ademowo.
41. The idea of this project was initiated by me. This paper emanated from Omisore Ph.D. work which I initiated and co-supervised by Prof. Adewunmi. The synthetic isolated compounds were supplied by Ngadjui, Kouam and Yapna, The experimental work was carried out by Omisore and Akinpelu under the supervision of Iwalewa and Adewunmi. The biochemical aspect of the work were done by Obuotor, Oyedapo and Akinpelu . The paper was written and processed by Adebajo and Iwalewa.
42. The paper is from my M.Sc. thesis under the supervision of Prof. Oriowo. I carried out the work. I wrote and processed the manuscript.
43. Owonubi initiated the work/projects; it was carried out by our students in the Department of Pharmacology, A.B.U, Zaria. I wrote and processed the paper
44. Owonubi initiated the work/projects; it was carried out by our students in the Department of Pharmacology, A.B.U, Zaria. I wrote and processed the paper.
45. I initiated this project, identification and extract preparation done by Omobuwajo, biochemical analysis done by Oyedapo while the Pharmacological work was done by me and Kalejaiye. I processed the paper for publication.
46. This is Mr Akomolafe M.Sc. degree project initiated by Adeoshun and Elujoba. I co-supervised the project. All the pharmacological in-vitro studies were carried out in my laboratory with the project student. We all processed the manuscripts together for publication.
47. This is another paper from Mr Akomolafe M.Sc. degree project initiated by Adeoshun and Elujoba. I co-supervised the project. All the Pharmacological in-vitro studies were carried out in my lab with the project student. We all processed the manuscripts together for publication.
48. This is yet another paper from Mr Akomolafe M.Sc degree project initiated by Adeoshun and Elujoba. I co-supervised the project. All the Pharmacological in-vitro studies were carried out in my lab with the project student. We all processed the manuscripts together for publication.
49. Omobuwajo initiated the project. Olayiwola, Adeniyi and I carried out the anti-dabetic experimental work. We were all involved in the process of writing the manuscript for publication.
50. The project was initiated by Prof. Elujoba, I carried out the Pharmacological experiment in my laboratory with Olarenwaju. The manuscript was written and processed by me and Prof. Elujoba.
51. This is the M.Phil project of Mr Ayoka initiated by Prof. Ukponmwan which was co-supervised by me. The manuscript was written and processed by all authors
52. Sequel to the paper 51 above, this is another paper from the M.Phil project of Mr Ayoka initiated by Prof. Ukponmwan which was co-supervised by me. The manuscript was also written and processed by Ayoka, Iwalewa and Ukponmwan.
53. The project was initiated by the authors, I and other authors’ carries out the pharmacological investigation. Prof. Ogundaini supervised the isolation of eleaginine, Idowu, Aderogba, Akinpelu and I wrote and process the paper.
54. Sequel to article 35, this paper came from Oyemitan M.Phil.project that was supervised by me and Olugbade as co-supervisor. The collection of data and analysis was done by Oyemitan, the write –up of the manuscript and the process for publication was done by Oyemitan, Olugbade and I.
55. The paper emanated from Aderibigbe’s M.Phil work that was intiated and supervised by me. The preparation and the processing of the manuscript was done by Iwalewa, Aderibigbe, Adesina and Ukponmwan .
56. The paper emanated from Oyemitan M.Sc work that I initiated and supervised. I and Oyemitan prepared the manuscript while other authors made their contribution towards the publication.
57. Sequel to article 55 above, the paper emanated from Aderibigbe’s M.Phil work that was intiated and supervised by me. The preparation and the processing of the manuscript were done by Iwalewa, Aderibigbe, Adesina and Ukponmwan.
58. This article came from the M.Sc. thesis of Mr. Daniyan which Prof Onyeji brought the idea and I served as co-supervisor. All the anti-diabetic experimental works was done by Daniyan and me. The pharmacokinetics analysis of plasma was carried out by Daniyan and Omoruyi. The biochemical parameters were assessed by Obuotor, while the write-up and the process of the manuscript was done by all.
59. Sequel to article 35 and 54, this is yet another paper that came from Oyemitan M.Phil.project that was supervised by me and Olugbade as co-supervisor. Tthe write –up of the manuscript and the process for publication was done by Oyemitan, Olugbade and I.
60. Sequel to article 35, 54 and 59 this paper emanated from Oyemitan M.Phil.project that was supervised by me and Olugbade as co-supervisor. The write –up of the manuscript and the process for publication was done by Oyemitan, Olugbade
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