Research Gate Profile Email: This email address is being protected from spambots. You need JavaScript enabled to view it. Alternate Email Address 1: This email address is being protected from spambots. You need JavaScript enabled to view it. Biography: I became a Faculty Member at the Department of Biochemistry, Faculty of Basic Medical Sciences, University of Ibadan, Nigeria on the 9th of April 1998. Presently, I am a Professor of Biochemistry since October 1, 2015 and, Head of Department from August 1, 2022 till date. My research interest is in the field of Molecular Drug Metabolism and Toxicology with special interest in Drug Discovery and Development from natural products. I have studied the antioxidative and free radical scavenging effects of some indigenous phytochemicals (Artocarpus altilis, Curcuma longa, Cocos nucifera, Garcinia kola, Xylopia aethiopica, Calliandra portoricensis, etc) in both in vivo and in vitro experiments. In functional experiments, l have studied the underlying mechanism of cardiovascular effects of kolaviron, a biflavonoid complex from Garcinia kola. For the first time, l have shown that kolaviron acts directly on ion channels in vascular beds via blockage of extracellular Ca2+ influx, inhibition of intracellular Ca2+ release and opening of K+ channels that are sensitive to 4-aminopyridine and charybdotoxin. Also, I have worked on the anticancer and anti-angiogenic potentials of Xylopia aethiopica, Calliandra portoricensis, punicalagin, methyl jasmonate, etc in C-33A, MCF-7, PC-3 and LNCaP cancer cells. Presently, l have developed an experimental model of benign prostatic hyperplasia (BPH) in castrated rats. In my laboratory, we have started screening array of bioactive compounds as anti-BPH agents. We have shown for the first time that methyl jasmonate and finasteride synergistically protect against BPH in rats via mechanisms that involve anti-inflammation, induction of apoptosis and inhibition of phase I drug metabolizing enzyme. Also, l have developed experimental animal model of metastatic mammary tumour in female Wistar rats. In my Lab, we have shown that fractions from Calliandra portoricensis, Annona muricata and kolaviron (biflavonoid fraction from Garcinia kola) attenuated inflammation, induced apoptosis and restored cyto-architecture of mammary gland in rats administered N-methyl-N-nitrosourea and benzo(a)pyrene. Research is ongoing to evaluate imparts of fractions from phytochemicals on metastatic cancer cells into distant organs in the malignant rats. Current Research Title: Ameliorative effects of fractions from Calliandra portoricensis on the development of hepatocellular carcinoma (HCC) in metastatic mammary tumour-induced by N-methyl-N-nitrosourea and benzo(a)pyrene in Wistar rats The adverse effects of antihypertensive drugs, such as Ca2+ channel inhibitors, alpha and beta blockers, etc are well documented. The need to protect humans against hypertension and cardiovascular diseases (CVD) using newer and safer class of antihypertensive drugs is important. Therefore, a search of natural products that can protect humans from CVD is a key issue in cardiovascular research. The use of plant products may be beneficial in protecting against CVD since they are less toxic than the synthetic compounds. Recently, soluble epoxide hydrolase (sEH) inhibitors are gaining attention as potent antihypertensive agent. This enzyme converts epoxyeicosatrienoic acids (EETs), a metabolite from arachidonic acid to dihydroxyeicosatrienoic acids. This reaction results in a loss of biological activities of EETs, in particular its ability to mediate in vasodilation as endothelium-derived hyperpolarizing factors. Therefore, agents that can inhibit sEH synthesis will elicit antihypertensive effect. We screened crude extracts from Garcinia kola, Alchornea laxiflora, Alstonia boonei, Morinda lucida, Curcuma longa L, Xylopia aethiopica, Mallotus oppositifolius, etc, as putative inhibitors of sEH. The in vitro high throughput screening of these extracts was achieved using HPLC method. Furthermore, functional studies involving calcium imaging with fluo-4-AM dye were conducted to ascertain the effect of extracts on calcium signals in transfected HEK 293 cells capable of expressing TRPV1 585i ion channel. Selected Publications 1. Kosemani, S., Bakare, A., Adaramoye, O. Fraction from Calliandra portoricensis reduces 7, 12 dimethylbenz(a)anthracene-induced mammary tumors in Wistar rats. Avicenna Journal of Phytomedicine 2022 Mar-Apr;12(2):131-144. doi: 10.22038/AJP.2021.18641. CLICK HERE 2. Folayan A, Akani E, Adebayo OA, Akanni OO, Owumi SE, Tijani AS, Adaramoye OA. Ameliorative effects of hexane extract of Garcinia kola seeds Heckel (Clusiaceae) in cisplatin-induced hepatorenal toxicity in mice. Drug Chem Toxicol. 2022 May;45(3):1098-1108. doi: 10.1080/01480545.2020.1808671. CLICK HERE 4. Adeleke GE, Adaramoye OA. Betulinic acid abates N-nitrosodimethylamine-induced changes in lipid metabolism, oxidative stress, and inflammation in the liver and kidney of Wistar rats. J Biochem Mol Toxicol. 2021 Nov;35(11):e22901. doi: 10.1002/jbt.22901. CLICK HERE 5. Adebayo OA, Akinloye O, Adaramoye OA. Cerium oxide nanoparticles elicit antitumourigenic effect in experimental breast cancer induced by N-methyl-N-nitrosourea and benzo(a)pyrene in female Wistar rats. J Biochem Mol Toxicol. 2021 Apr;35(4):e22687. doi: 10.1002/jbt.22687. CLICK HERE 6. Arowoogun J, Akanni OO, Adefisan AO, Owumi SE, Tijani AS, Adaramoye OA. Rutin ameliorates copper sulfate-induced brain damage via antioxidative and anti-inflammatory activities in rats. J Biochem Mol Toxicol. 2021 Jan;35(1):e22623. doi: 10.1002/jbt.22623. CLICK HERE 7. Adefisan AO, Madu JC, Owumi SE, Adaramoye OA. Calliandra portoricensis ameliorates ovarian and uterine oxido-inflammatory responses in N-methyl-N-nitrosourea and benzo CLICK HERE 9. Adebayo OA, Akinloye O, Adaramoye OA. Cerium Oxide Nanoparticles Attenuate Oxidative Stress and Inflammation in the Liver of Diethylnitrosamine-Treated Mice. Biol Trace Elem Res. 2020 Jan;193(1):214-225. CLICK HERE 11. Adaramoye OA, Oladipo TD, Akanni OO, Abiola OJ. Hexane fraction of Annona muricata (Sour sop) seed ameliorates testosterone-induced benign prostatic hyperplasia in rats. Biomed Pharmacother. 2018 Dec 27;111:403-413. CLICK HERE 12. Adebayo OA, Akinloye O, Adaramoye OA. Cerium oxide nanoparticle elicits oxidative stress, endocrine imbalance and lowers sperm characteristics in testes of balb/c mice. Andrologia. 2018 Apr;50(3). doi: 10.1111/and.12920. CLICK HERE 13. Adaramoye OA, Akanni OO, Abiola OJ, Owumi SE, Akinloye O, Olapade-Olaopa EO. Methyl jasmonate reduces testosterone-induced benign prostatic hyperplasia through regulation of inflammatory and apoptotic processes in rats. Biomed Pharmacother. 2017 Sep 20;95:1493-1503. CLICK HERE 14. Popoola B., Ashefor O., Akanni O., Adaramoye O. Biochemical, hormonal and histological changes in prostate of Wistar rats following long term streptozotocin-induced diabetes mellitus. Niger. J. Physiol. Sci., 2017; 32(1): 85-90. CLICK HERE 16. Adaramoye O, Erguen B, Nitzsche B, Höpfner M, Jung K, Rabien A. (2017) .Punicalagin, a polyphenol from pomegranate fruit, induces growth inhibition and apoptosis in human PC-3 and LNCaP cells. Chemico-Biological Interactactions. pii: S0009-2797(17)30511-2. doi: 10.1016/j.cbi.2017.07.009. CLICK HERE 17. Akanni, O.O., Abiola, O.J. and Adaramoye, O.A. (2017). Methyl Jasmonate Ameliorates Testosterone Propionate-induced Prostatic Hyperplasia in Castrated Wistar Rats. Phytotherapy Research Vol 31, No. 4: 647-656. CLICK HERE 18. Adaramoye, O., Erguen, B., Oyebode, O., Nitzsche, B., Höpfner, M., Jung, K. and Rabien A. (2015). Antioxidant, antiangiogenic and antiproliferative activities of root methanol extract of Calliandra portoricensis in human prostate cancer cells. Journal of Integrative Medicine Vol 13, No. 3, 185-193. CLICK HERE 19. Adaramoye O.A., Sarkar J., Singh N., Meena S., Changkija B., Yadav P.P., Kanojiya S. and Sinha S. (2011). Anti-Proliferative Action of Xylopia aethiopica Fruit Extract on Human Cervical Cancer Cells. Phytotherapy Research Vol. 25, No. 10, 1558-1563. CLICK HERE 20. Adaramoye, O.A., Anjos, R.M., Almeida, M.M., Veras, R.C., Silvia, D.F., Oliveira, F.A., Cavalcante, K.V., Araújo, I.G., Oliveira, A.P. and Medeiros, I.A. (2009): Hypotensive and endothelium-independent vasorelaxant effects of methanolic extract from Curcuma longa L. in rats. Journal of Ethnopharmacology Vol. 124. No. 3, 457-462. CLICK HERE CURRENT STUDENTS S/N Student’s Name Matric. Number Title of Project Degree Year of graduation 1. Adefisan, Adedoyin Omobolanle 168161 Chemopreventive effects of root bark extract of Calliandra portoricensis (Benth) in N-methyl-N-nitrosourea and Benzo(a)pyrene-induced mammary gland and reproductive toxicity in Wistar Rats PhD In-view 2. Adebayo, Olayinka Anthony 166471 Biochemical Evaluation of Peptide-Based Cerium Oxide Nanoparticles on the Structure and Function of Vital Organs in Adult Rodent PhD In-view 3. Oyinlola, Idowu Shakirat 168160 Evaluation of heavy metal content in water samples from rivers around Ewekoro cement factory, Ogun state,Nigeria and it’s effects on biochemical indices in clarias gariepinus. PhD In-view 4. Olatoye, Raphael Segun 173524 Evaluation of antiproliferative and anti-inflammatory effects of diphenyl diselenide in hepatocellular carcinoma (HCC) model: in vivo and in vitro studies PhD In-view 5. Madu, Judith Chizoba 203289 Interactive actions of N-Methyl-N-Nitrosourea and Benzo[a]pyrene-induced oxidative stress in Drosophila melanogaster MPhil In-view 6. Ajibade, Comfort Omokhogbo 169751 Effect of Heavy metals accumulation on biomarkers of oxidative stress and inflammation in the brain, liver and kidney of Clarias gariepinus grown in water samples from Awba Dam MSc In-view 7. Onah, Chijioke Nwangbada 226238 Chemopreventive roles of protocatechuic acid and diphenyl diselenide against 7,12-dimethylbenz[a] anthracene-induced mammary tumorigenesis in female Wistar rats MSc In-view 8. Alli, Adetayo Ajadi 227338 Ameliorative effects of protocatechuic acid and Diphenyl diselenide against Dimethylbenz[a]anthracene (DMBA)- induced uterine toxicity in female Wistar rats MSc In-view 9. Adeniyi, Olola Esther 180048 Combined Cerium and Zinc Oxide nanoparticles-induced hepato-renal damage in rats through oxidative stress mediated inflammation MSc In-view 10. Edema, Adeleye Adegboyega 226875 Biochemical and Pharmacological properties of diphenyl diselenide against 7,12 Dimethylbenz[a] anthracene-induced mammary tumorigenesis in female Wistar rats MSc In-view 11. Olatunde, Opeyemi Bukola 218447 Effect of methyl jasmonate and diphenyl diselenide on diethylnitrosamine and carbon tetrachloride - induced nephrotocixity in male Wistar rats MSc In-view 12. Ayodele, Emmanuel Blessing 218568 Effect of Methyl jasmonate and Diphenyl diselenide on Diethylnitrosamine and Carbon teterachloride- induced testicular toxicity in male Wistar rats MSc In-view 13. Anuoluwa, Abigail 226954 Biochemical and Pharmacological properties of Diphenyl diselenide and Protocatechuic acid against DMBA-induced mammary tumorigenesis in female Wistar rats MSc In-view PREVIOUS STUDENTS (Selected) S/N Student’s Name Matric. Number Title of Project Degree Year of graduation 1. Adeleke, Gbadebo Emmanuel Biochemical and Pharmacological properties of betulinic acid in experimental animals PhD 2018 2. Akanni, Olubukola Oyebimpe 152984 Effects of methyl jasmonate on benign prostatic hyperplasia in Wistar rats PhD 2019 3. Omage, Folorunsho Bright 194925 Chemopreventive effects of Luteolin on Testosterone Propionate-Induced Benign Prostatic Hyperplasia in Castrated Rats MSc 2018 4. Sanni, Monsuru Adetunji 150487 Protective roles of Punicalagin on Testosterone Propionate - Induced Benign Prostatic Hyperplasia in castrated Wistar rats MSc 2018 5. Ibi, Anna Asheahe 202628 Artemisinin improves prostatic health in testosterone propionate-induced benign prostatic hyperplasia in male Wistar rats. MSc 2018 6. Bakare, Aminat Abidemi 169762 Chemopreventive effect of chloroform fraction of Calliandra portoricensis (benth) on 7, 12-dimethylbenz(a)anthracene -induced mammary toxicity in female Wistar rats MSc 2020 7. Olagunju, Abolaji Samson 211156 Effects of Heavy Metals Accumulation on Biomarkers of Hepatic Oxidative Stress and Inflammation in Clarias gariepinus from Rivers Around Ewekoro Cement Factory, Ogun State Nigeria. MSc 2020 8. Akinseye, Ebenezer Ifedayo 166730 Effects of quercetin and protocatechuic acid on diethylnitrosamine and carbon tetrachloride-induced hepatotoxicity in male balb/c Mice MSc 2020 9. Iroko, Toluwanimi Peace 165188 Co-administration of cerium oxide and zinc oxide nanoparticles exert testicular dysfunction in male Wistar rats MSc 2020 10. Kosemani, Samson Oluwapelumi 210402 Fraction from Calliandra portoricensis reduces 7, 12-dimethylbenz(a)anthracene-induced mammary tumorigenesis in female Wistar rats MSc 2020 Facebook: Profile Link My hobbies are reading books, travelling and working out. I also like participating in volunteer activities especially teaching underprivileged kids. I have been associated with a few non-profit organisations (NGOs) like learning new skills. I am interested in exploring different languages as these will help to explore new cultures around the world.Profile
Name:Oluwatosin A. ADARAMOYE
Designation: Professor and Head of Department
Faculty:Basic Medical Sciences
Department: Biochemistry
Phone Number: +234 816 304 7157
Research
Funder: Self
Brief Summary: The study aims to evaluate in a mechanistic term, the role of fractions from Calliandra portoricensis in inhibiting the migration of metastatic cancer cells from cancerous mammary gland to hepatocytes of the animals. Biochemical assays which include Chick Chorioallantoic Membrane assay (angiogenesis), Migration assay (metastasis), NF-kB and IL-1β assays (inflammation), histology of hepatocytes (direct visualization of cancer cells), survival assay, etc will be conducted in this study.
Role: Principal Investigator
Collaborators: Professor Oluyemi Akinloye, Department of Medical Laboratory Science, University of Lagos and Professor Maik Gollasch, Department of Internal Medicine, Charite University of Medicine, Berlin, Germany
Completed ResearchPublications
3. Adefisan AO, Owumi SE, Soetan KO, Adaramoye OA. Chloroform extract of Calliandra portoricensis inhibits tumourigenic effect of N-methyl-N-nitrosourea and benzo(a)pyrene in breast experimental cancer. Drug Chem Toxicol. 2021 Jul 29:1-15. doi: 10.1080/01480545.2021.1957556. CLICK HERE
8. Akanni OO, Owumi SE, Olowofela OG, Adeyanju AA, Abiola OJ, Adaramoye OA. Protocatechuic acid ameliorates testosterone-induced benign prostatic hyperplasia through the regulation of inflammation and oxidative stress in castrated rats. J Biochem Mol Toxicol. 2020 Mar 30:e22502. doi: 10.1002/jbt.22502. CLICK HERE
10. Adefisan A, Owumi S, Adaramoye O. Root bark extract of Calliandra portoricensis (Jacq.) Benth. chemoprevents N-methyl-N-nitrosourea-induced mammary gland toxicity in rats. J Ethnopharmacol. 2019 Dec 29;233:22-33. CLICK HERE
15. Adaramoye OA, Erguen B, Nitzsche B, Höpfner M, Jung K, Rabien A. Antioxidant and antiproliferative potentials of methanol extract of Xylopia aethiopica (Dunal) A. Rich in PC-3 and LNCaP cells. J Basic Clin Physiol Pharmacol. 2017 Jul 26;28(4):403-412. CLICK HERESupervision
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