Professor Wuraola A. SHOKUNBI

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 Mofeyisara Omobowale

Name: Wuraola A. SHOKUBI (Nee OLAOFE)
Designation: Professor
Faculty: BASIC CLINICAL SCIENCES
Department: Haematology

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Biography:

Born on the 7th of August, 1953, in Are – Ekiti, Ekiti State. MB.BS (Ibadan); FMCPath (Nigeria); FWACP, (Lab Med); Certificate in Immunology (Ibadan); Certificate in Preventive Measures against HIV (Hokkaido). Her research interests include Coagulation Disorders, particularly Inherited Bleeding Disorders, Haemostasis in Sickle Cell Disease (SCD), Psychosocial issues in SCD, Preventive of HIV and AIDS and Blood Transfusion Medicine. She has also conducted research in the following areas: Lupus anticoagulant, Pattern of bleeding in Nigerian haemophiliacs, FVIIIc level in Neonates and correlation with intra and post circumcision bleeding, Protein C, Von Willebrand factor, and D-Dimer in Sickle Cell Disease and Transfusion Transmissible Infections (TTIs) such as HIV, HBV, and HCV. These have resulted in over 130 publications. She has been a past President of the Nigerian Society for Haematology and Blood Transfusion, President of Ibadan College of Medicine Alumni Association Worldwide, President Medical Women’s Association of Nigeria, Oyo State Branch and Head of the Department of Haematology, UCH Ibadan and first female Chairman, Medical Advisory Committee, Director of Research and Training to the UCH (1998 – 2002).

Apart from mentoring several residents through their postgraduate work, Professor Shokunbi has received several Fellowships and Grants including from the Japanese International Co-operation Agency and MacArthur Grant (as Principal Investigation) for HIV and AIDS Prevention amongst University of Ibadan Students (2005 – 2010). Her current activities include a multi-disciplinary research in Childhood Malaria, in collaboration with MRC, London and Survey of Haemophilia Care in Nigeria.

Resume

Not Available

Research

Current Research and Capacity Building Project including Grants

  1. Indication for admission in the sickle cell disease patients seen at the University College Hospital, UCH Ibadan.

  2. The influence of Absolute Concentration and Relative Distribution of red cell membrane Phospholipids and cholesterol in different Haemoglobin Genotypes on Malaria Parasite Infection and Correlate Findings with Humoral Immunity – in collaboration with Immunology sub-dept.

  3. Childhood Malaria Research Group: External Collaboration MRC, London

  4. Survey of Haemophilia Care in Nigeria: January 2017 to date

Completed Research

  1. Bone marrow changes in Cerebral Malaria Bone marrow examination was performed in 25 children with cerebral Malaria - majority showing Erythroid Dysplasia.

  2. HIV Screening at Autopsy. HIV Screening was done in 100 consecutive autopsies at UCH; one was ELISA positive but could not be confirmed on Western Blot

  3. Factor X activity in adults with Sickle cell Anaemia; FX activities in 50 patients with HbS was significantly lower than in normal controls.

  4. Education for AIDS Prevention in Nigerian old city – in collaboration with African Regional Health Education Centre Project sponsored by American Foundation for AIDS Research (AMFAR).

  5. Multicentre trial of a single sub dermal contraceptive implant (Normegestrol acetate) in patients with Sickle Cell Anaemia. –in collaboration with Obstetrics and Gynaecology Department.

  6. Sexual Behaviour, STDs and HIV transmission among prisoners in Nigerian – in collaboration with the Nigerian Behavioral Research on STD and HIV transmission.

  7. Multicentre study on Roferon A (& - interferon) use in CML; sponsored by Roche. 1996 – 1998

  8. MacArthur Project on Peer Education on HIV-AIDS Prevention among University of Ibadan students (6 yr. Grant): 1st. Phase 2005- 2007; 2nd. Phase 2008-2010.

  9. Psychosocial adjustments in-patients with Sickle Cell Disease and their relatives – in collaboration with Psychiatry Department.

  10. Lupus anticoagulant in-patients with SLE.

  11. Morbidity profile of Sickle Cell Disease seen in UCH, Ibadan, Nigeria.

  12. Pattern of bleeding in Nigerian Haemophiliacs.

  13. IgM levels in SCD patients with Chronic Leg Ulcers.

  14. HIV Seroprevalence in Blood Donors

  15. HIV, HBV and HCV in Haemophiliacs.

Publications

Books:

  1. Adewole I.F., Shokunbi W.A., Inem V. Oye- Adeniran B.A., Ekpo M, Elesha S.O., Abosede O.A.Akinsete I.(1991). Guildelines for Health Workers on HIV infection and AIDS. Nigerian Medical Association Publication March 1-85.

  2. Ajuwon AJ and Shokunbi WA: Women and the risk of HIV Infection in Nigeria: Implications for Control Programs. In Bucanan D & Cernada G (Eds): Progress in Preventing AIDS? Dogma, Dissent and Innovation. Global Perspectives: New York: Baywood publications; 1998: pp 227 – 239

  3. Shokunbi WA, Ajuwon AJ eds. Training Workshop Manual: Peer Education for HIV-AIDS Prevention among UI Students. Publisher: Corporate Graphics (Ibadan) 2008. pp 1-299

  4. Shokunbi WA. Bleed Not, My Son: Inaugural Lecture at the University of Ibadan. Publisher: Ibadan University Press (Ibadan) 2011. pp1-86

  5. Shokunbi WA, Durosinmi MA, Aken’Ova YA, Olatunji OO, Akanmu SA, Wakama TT, Fasola FA, Olaniyi JA, Nwauche CA, Akingbola TS, Mamman A, Enosolease ME, Abjah UMA, Ocheni S, Eteng KII. Lymphoma Treatment Guidelines for Nigeria. Complied by NSHBT.

  6. Awodu OA, Shokunbi WA, Akanmu A. Sulaimon, Ogbe O. Patrick, Bolarinwa Rahman, Yuguda Saleh, Omunakwe H., Okoye Helen C. Guideline for management of Venous Thromboembolism in Nigeria, 2018. Compiled by NSHBT

  7. Shokunbi W.A., Ogundeji S.P., Ogunleye A.I., and Raji O.H. Psychosocial Issues in Patients with Sickle Cell Disease. Booklet (ISBN: 978-978-58950-9-4). Publisher: Tumak Ventures Nigeria Limited (Ibadan) 2023.

Journal Article

1. Nwankwo Anwuli, Shokunbi W.A., Asinobi A.O. Adebamowo E.O. Dairo M.D. Plasma lead levels among children at a Tertiary Health care Institution in Nigeria. Nigerian Journal of Haematology (NJH). 2019 March; 2(1)

2. Biobele J. Brown, Alexander A. Przybylski, Petru Manescu, Fabio Caccioli, Gbeminiyi Oyinloye, Muna Elmi, Michael J. Shaw, Vijay Pawar, Remy Claveau, John Shawe-Taylor, Mandayam A. Srinivasan, Nathaniel K. Afolabi, Adebola E. Orimadegun, Wasiu A. Ajetunmobi, Francis Akinkunmi, Olayinka Kowobari, Kikelomo Osinusi, Felix O. Akinbami, Samuel Omokhodion, Wuraola A. Shokunbi,Ikeoluwa Lagunju, Olugbemiro Sodeinde, Delmiro Fernandez-Reyes. Data-Driven Malaria Prevalence Prediction in Large Densely-Populated Urban Holoendemic sub-Saharan West Africa: Harnessing Machine Learning Approaches and 22-years of Prospectively Collected Data. 2019 18 Jun; 11:25:35 UTC (4,315 KB) Machine Learning (cs.LG); Applications (stat.AP); Machine Learning (stat.ML) https://org/abs/1906.07502 or arXiv:1906.07502v1[cs.LG] 

3. Foluke Atinuke Fasola, Florence Olamide Fowodu, Wuraola Adebola Shokunbi,Taiwo Rachel Kotila. The effect of the coinheritance of Glucose-6-phosphate dehydrogenase deficiency on the severity of sickle cell disease. Nigerian Postgraduate Medical Journal (NPMJ), 2019; 26(2):118-122

4. A Shokunbi, B.J. Brown, M.O. Okunola. T.S. Akingbola, O.W. Aworanti. Mid Shaft Femoral Fracture in a Young Haemophilia A Patient – A Case Report. International Journal of Research and Reports in Hematology, 2019; 2(2): 1-5, Article no. IJR2H.47332

5. Raji Olayinka Habib, Shokunbi Wuraola A., Ajuwon Adedamola J. Knowledge, Experience and coping mechanisms for Priapism among persons with Sickle Cell Disease in Ibadan, Nigeria. West African Journal of Medicine, 2020; 37(1): 32 – 39

6. Biobele J. Brown, Petru Manescu, Alexander A. Przybylski, Fabio Caccioli, Gbeminiyi Oyinloye, Muna Elmi, Michael J. Shaw, Vijay Pawar, Remy Claveau, John Shawe-Taylor, Mandayam A. Srinivasan, Nathaniel K. Afolabi, Geraint Rees, Adebola E. Orimadegun, Wasiu A. Ajetunmobi, Francis Akinkunmi, Olayinka Kowobari, Kikelomo Osinusi, Felix O. Akinbami, Samuel Omokhodion, Wuraola A. Shokunbi,Ikeoluwa Lagunju, Olugbemiro SodeindeDelmiro Fernandez-Reyes. Data-driven malaria prevalence prediction in large densely populated urban holoendemic sub-Saharan West Africa. Scientific Reports, Open Access. www.nature.com/scientificreports. September, 2020.

7. Samuel Eneojo Abah, Florence Burte, Steven A. Howell, Ikeoluwa Lagunju, Wuraola A. Shokunbi, Mats Wahlgren, Olugbemiro Sodeinde, Biobele J. Brown, Anthony A. Holder, Delmiro Fernandez-Reyes. Depleted circulatory complement-lysis inhibitor (CLI) in childhood cerebral malaria returns to normal with convalescence. Malaria Journal, 2020; 19:167. https://doi.org/10.1186/s12936-020-03241-5

8. Aworanti O.W., Anyanwu-Yeiya C., Shonde-Adebola K.B., Olaniyi J.A., Shokunbi W.A. Haematology Consultation in a Tertiary Health Care Centre in Nigeria. West African Journal of Medicine, 2020 November; 37(6): 662 – 665. PMID: 33185263

9. Khadijah B. Shonde-Adebola, Wuraola A. Shokunbi, Mukhtar B. Adebola. Prevalence of von Willebrand Disease among Nigerian Youths in Ibadan, South-Western Nigeria. Open Access Library Journal, August 2021; 8(8).

10. Aworanti O.W., Ogundeji S.P., Adeoye O.A., Shokunbi W.A. Multiple Myeloma with Unexplained Isolated Anaemia in a 24year Old Man – A Case Report. African Health Sciences (Uganda). (Accepted for Publication on 2nd January, 2022)

11. Kotila T.R., Akunwata C.U., Aworanti O.W., Fasola F.A., Olaniyi J.A., Ogundeji S.P., Shokunbi W.A. The Spectrum of Crises among Adult Sickle Cell Disease Patients at a Nigerian Tertiary Hospital. African Journal of Medicine and Medical Sciences. (Accepted for Publication 6th January, 2022)

12. Gbotosho O, Akinpelu O., Shokunbi W, Salawu L. Haemoglobin Levels Regulate Hepcidin Production in Late Pregnancy. Nigerian Journal of Haematology, August 2022; 3(2): 45 – 51.

13. Aworanti O.W., Ogundeji S.P., Adeoye O.A., Shokunbi W.A. Multiple Myeloma with Unexplained Isolated Anaemia in a 24year Old Man – A Case Report. African Health Sciences (Uganda). (Accepted for Publication on 2nd January, 2022)

14. Kotila T.R., Akunwata C.U., Aworanti O.W., Fasola F.A., Olaniyi J.A., Ogundeji S.P., Shokunbi W.A. The Spectrum of Crises among Adult Sickle Cell Disease Patients at a Nigerian Tertiary Hospital. African Journal of Medicine and Medical Sciences. (Accepted for Publication 6th January, 2022)

15. Gbotosho O, Akinpelu O., Shokunbi W, Salawu L. Haemoglobin Levels Regulate Hepcidin Production in Late Pregnancy. Nigerian Journal of Haematology, August 2022; 3(2): 45 – 51.

16. A. Shokunbi, O.W. Aworanti, P.O. Olatunji, M.D. Dairo, E.S. Fakunle, O.T. Ojo, Saleh Yuguda, Leke Ibijola, Kapona Iwara, C.I. Ajuba, F.A. Fehintola. Physicians’ Response on Haemophilia Care in South Western Nigeria. Asian Journal of Medicine and Health, 2023; Vol.21 (11): 75–81.

Supervision

  1. CURRENT STUDENTS (Project Title, Student’s Name, Examining Body and Year of Entry)

Masters Level:           1

Doctoral Level:          No

Fellowship Level:       2

  1. PREVIOUS STUDENTS (Selected)

Masters Level

  1. Full blood count, Platelet count and erythrocyte sedimentation rate in Tuberculosis – October 1989. FMILT Haematology Dissertation by Mr. E. O. Akintunde.

  2. Coagulation profile in Patients with Sickle Cell Anaemia January 1991. Haematology dissertation by Mr. F.I. Buseri.

  3. FVIIIc and fibrinogen levels in cryo-precipitate: December 1996. dissertation by Mr. A.O. Oluokun.

  4. Coagulation Profile in Pregnant Nigerian Women according to the Gestational age. Sc. dissertation by Mr. A.A. Olomu.2000

  5. The frequency of presentation of haematological emergencies in the Haematology Day Care Unit (HDCU) of the University College Hospital (UCH), Ibadan (as Co-Supervisor) – M Sc. Epidemiology and Medical Statistics, dissertation, University of Ibadan. December, 2002 by Dr. J.O. Olabode 2006

  6. Von Willebrand factor antigen as a prognostic index in Sickle Cell Disease, dissertation by Dr Kapoona Iwara (MSc Haematology, University of Ibadan), 2009.

  7. D-dimer levels in Sickkle Cell Disease patients in crises and steady states, dissertation by Dr E E Fakunle (MSc Haematology, University of Ibadan). 2007.

  8. Plasma lead levels in Children presenting at the Department of Paediatrics in the University College Hospital, Ibadan. Dissertation by Nwankwo, Anwuli Frances, (MSc Haematology) 2016.

  9. Knowledge, Experience and Coping Mechanism for Priapism among persons with Sickle Cell Disease in Ibadan. Dissertation by Raji, Olayinka Habib, (MPH) 2016.

Doctoral Level

  1. Cardio-respiratory and Haematological adaptation of Patients with Sickle Cell Anaemia to a twelve-week endurance exercise-training programme PhD Thesis (as co-Supervisor) – June 1998 by Dr. O.O. Alawale.

Fellowship

  1. HbA2 and HbF in Sickle Cell Anaemia patients. May 1997 FMCPath. Dissertation by Dr. T. R. Kotila.

  2. Coagulation profile in Nigerian children with Cerebral Malaria. April 1998. FMCPath dissertation by Dr. T. O. Akingbola.

  3. Lupus anticoagulant in women with poor Obstetric History (as co-Supervisor,). FMCPath dissertation by Dr. Amodu 1998.

  4. Pure Tone Audiometry in SCD – (as co-supervisor). FMCS dissertation by Dr. P. A. Onakoya 2000.

  5. Pre-circumcision factor VIIIC level & other haemostatic parameters in Nigerian neonates & incidence of bleeding associated with circumcision. Dissertation by Dr. Emmanuel Eyitayo Fakunle, 2005.

  6. Evaluation of protein C in Nigerian patients with sickle cell anaemia in steady state. Dr Ibijola Ajayi Adeleke, FMCPath Dissertation, 2010.

  7. Red Cell Antibody Screening and Antibody Identification in Blood Donors and Patients in a Tertiary Hospital in Nigeria. Dr. Kapoona Ibiang Iwara Eteng, FMCPath Dissertation, 2011

  8. CD4+ T-Lymphocyte, Gamma-Interferon, Interleukin-4 and Ultrasonographic Splenic Size in Homozygous Sickle Cell Anaemia Patient. Dr. Omotola Toyin Ojo, FMCPath Dissertation, 2011

  9. Screening and Prevalence of Haemolytic Disease of the Foetus and Newborn. Kapoona Ibiang Iwara Eteng. FWACP Lab Medicine Dissertation, 2012.

  10. Glucose-6-Phosphate Dehydrogenase Activity in Sickle Cell Disease Patients in Ibadan, South-Western Nigeria (in advisory capacity). Florence Olamide Fowodu, FMCPath Dissertation, 2013.

  11. Determination of the Prevalence of Von Willebrand Disease among Nigerian Youths in Ibadan, South Western Nigeria. Dissertation by Khadijah Bolanle Shonde-Adebola. (FMCPath), 2017.

  12. A study of Hepcidin Levels in Anaemia and Non-Anaemia Pregnant Women in Ogbomosho, Oyo State, Nigeria. Gbotosho, Olabisi Abosede. FWACP Lab Medicine Dissertation, 2018.

  13. Plasma Thrombin-Antithrombin Complex in Adult Sickle Cell Anaemia Patients in Steady State and Vaso-Oclusive Crisis at the University College Hospital, Ibadan, Nigeria. Adeoye Olateni Asake. FWACP Lab. Medicine Diseertation, 2023.

Grants

 Current Grant Funding

  1. Title:   Retrospective study in ALL
    Funder:      Self sponsored
    Brief Summary:  The retrospective study will analyse the data obtained on the clinical features, Haematological parameters and response to chemotherapy of ALL patients managed in the department over a 5 year period.
    Role:  PI
    Collaborators: Dr Peter Ogundeji
  1. Title:  Psychosocial Issues in Sickle Cell Disease-0
    Funder:  Self sponsored
    Brief Summary:  The Psychosocial study is a review of psychosocial issues in SCD patients.
    Role:   PI
    Collaborators:  Dr Peter Ogundeji

  2. Title: Strengthening Comprehensive care in 7 Haemophilia Treatment Centres across Nigeria (approved on 23rd May, 2023)
    Funder:       Novo Nordisk Haemophilia Foundation
    Brief Summary: - Improve diagnostic capacity in 7 comprehensive haemophilia treatment centres in Nigeria
    - Develop and strengthen comprehensive care in the management of haemophilia care
    - Improve treatment regimens at the 7 comprehensive haemophilia treatment centres
    - Raise awareness about haemophilia and ensure advocacy effort 
    Role: Investigator at the University College Hospital, Ibadan.          
    Collaborators: Dr. Peter Ogundeji

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Other Interests/Hobbies

Shokunbi1

The focus of my interest is in counselling the Youths particularly on interpersonal relationships and marriage, and this I do through the Catholic Apostolate, Women of Grace, which I belong to. I have a certificate in Basic Theology.

I have also made myself available for private counselling for students and other youths over the years when I was Sub-Dean and Assistant Warden. This apostolate is also engaged in annual Charity work to the less privileged.

My hobbies are cooking and gardening.

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