Dr. Miles-Dei B. OLUFEAGBA

Profile

Biography:  

Miles-Dei Benedict Olufeagba is a Lecturer and Doctoral Research Fellow in the Genetics and Molecular Sciences Unit of the Institute of Child Health, College of Medicine, University of Ibadan. He holds a Master of Science degree in Public Health Biotechnology, specializing in Genetics and Molecular Sciences, from the same Institute, where he now teaches and conducts research.

His research interests lie in Hematological Genetics, with a current focus on the population genetics and molecular characterization of hemoglobinopathies and hemoglobin variants in the Southwestern Nigerian population. His doctoral work aims to determine the genetic epidemiology and molecular characterization of known and novel variants relative to global datasets and to explore the development of a rapid, cost-effective diagnostic protocol for their identification.

Miles-Dei possesses advanced expertise in genetic and quantitative research methodologies and maintains a strong academic interest in the etiopathogenesis of communicable and non- communicable diseases prevalent in tropical sub-Saharan Africa. Over the past five years, he has made significant contributions to his field, completing his pre-field PhD milestones, co- authoring nine publications with several others under review, and submitting three genetic sequences to the National Center for Biotechnology Information (NCBI), USA.

He is a recipient of the Consortium for Advanced Research Training in Africa (CARTA) Doctoral Fellowship, awarded in recognition of his scholarly potential and commitment to advancing biomedical research in Africa. He has also actively participated in domestic and international scientific conferences in Ibadan, Lagos, Uganda, and South Africa, where he has been involved in research dissemination and collaborative networking.

Miles-Dei is an active member of several national and international scientific associations and plays an integral role in teaching and mentoring graduate students in the Genetics and Molecular Sciences Unit of the Institute of Child Health. His overarching goal is to bridge molecular genetics and public health by translating genetic research findings into practical solutions that improve disease prevention, diagnosis, and management within African populations.              

Resume

Not Available

Research

Ongoing Research

Title: Population Genetics and Molecular Characterization of Hemoglobinopathies and Hemoglobin Variants in Ibadan, South-West Nigeria.
Summary: The study is expected to generate a comprehensive genetic profile of hemoglobinopathies and hemoglobin variants in the Southwestern Nigerian population by identifying and characterizing known and novel HBB gene variants, defining their distribution, and establishing genotype–phenotype correlations. It will contribute new data to global genomic databases, elucidate haplotype and linkage patterns, and support the development of a rapid, cost-effective molecular diagnostic protocol for early detection and clinical management of hemoglobinopathies. The findings will strengthen local capacity in molecular genetics and bioinformatics, inform national newborn screening and genetic counseling programs, and provide evidence-based guidance for public health policy on inherited blood disorders in Nigeria.

Completed Research

1. Awareness of the Importance of Proper Management of Hypertension in Already Diagnosed Individuals; A Case Study- Staff of Ilorin East Local Government Area of Kwara State.

2. Association of Polymorphisms of Toll-Like Receptor-9 and Interleukin-17 with Clinical Falciparum Malaria in Children under Age 5 in Ibadan, South-West Nigeria.

3. Effects of Riboflavin on Indomethacin-Induced Peptic Ulcer Disease in Wistar Rats.

4. Association of NOS2 and IL-22 polymorphisms and malaria phenotypes among children under five in Ibadan Southwest Nigeria.

5. Association of Selected Toll Like Receptor Polymorphisms with Clinical Outcome of Malaria Among Children in Ibadan, Southwest Nigeria.

6. Association of Interleukin-1 (Il-1α and Il-1β) Polymorphism with Plasmodium falciparum Malaria Among Under Five Children in Ibadan, Nigeria.

7. Knowledge Attitude and Perception of Nigerians about Keloids.

8. Genetic Variability of CYP2B6 Polymorphisms (785AG, 64CT & 516GT) in Southwest Nigerian Population: Implications for Malaria Treatment.

9. Association of Selected Toll-Like Receptor Polymorphisms with Clinical Outcome of Malaria Among Children in Ibadan, Southwest Nigeria.

10. Antibiotics as Antimalaria; Is There an Emergence of Plasmodium falciparum Drug Resistance in Ibadan, Southwest Nigeria?

11. Association of Anticoagulant Bottles with Genomic DNA Yield and the Effects of Dried Blood Spots and Stored Whole Blood Samples on DNA Yield.

12. Incidence of Dengue Fever-predisposing SNP (oas1-rs 10774671) Among School-aged Children Infected with Malaria in Ibadan Southwest Nigeria.

13. ABO Blood Group Determination: A rs8176719 Genotyping Method.

14. Production of Biodegradable Wrappers using Tuber Crop (Potatoes, Yams and Cassava) Peels.

15. Utilization of Crustacean Waste in the Production of Chitin and Chitosan.

Publications

1. Bamikole OJ, Olajide TH, Adedeji BA, Ademola SA, Fayehun AF, Bukoye NO, Olufeagba MB, Amodu OK. Drug Use Practices and Self-treatment for Suspected Malaria in Ibadan, Nigeria. Am J Trop Med Hyg. 2023 Apr 17:tpmd220489. doi: 4269/ajtmh.22-0489. Epub ahead of print. PMID: 37068754.

2. Bamikole OJ, Olufeagba MDB, Soge ST, Bukoye NO, Olajide TH, Ademola SA, Amodu OK (2019) Genetics of J Neurol Neurophysiol 10: 488.

Sequence submission to NCBI database

3. Olajide,T.H., Ajileye,A.O., Bamikole,O.J., Olufeagba,M.-D.B., Adedeji,B.A., Ademola,S.A. and Amodu,O.K (2022) Poecilobdella manillensis isolate ICH-COMUI 15.8S ribosomal RNA gene and internal transcribed spacer 2, partial sequence. Ascension number ON209372. NIH, NLM, NCBI

4. Olajide,T.H., Ajileye,A.O., Bamikole,O.J., Olufeagba,M.-D.B., Adedeji,B.A., Ademola,S.A. and Amodu,O.K (2022) Poecilobdella manillensis isolate ICH-COMUI 2 5.8S ribosomal RNA gene, partial sequence; Internal transcribed spacer 2, complete sequence; and large subunit ribosomal RNA gene, partial sequence. Ascension number NIH, NLM, NCBI

5. Olajide,T.H., Ajileye,A.O., Bamikole, J.,   Olufeagba,M.-D.B., Adedeji,B.A., Ademola,S.A. and Amodu,O.K (2022) Poecilobdella manillensis isolate ICH-COMUI 3 5.8S ribosomal RNA gene and internal transcribed spacer 2, partial sequence. Ascension number ON209374.NIH, NLM, NCBI

Supervision

Not Available

Grants

Consortium for Advanced Research Training in Africa (CARTA) – March 2025 to 2028

Social Media Handle

Other Interest/Hobbies

Reading, Driving, Traveling, Cooking, Listening to Music, and Fixing Machines.