Profile
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Name: Omowumi M. FEMI-AKINLOSOTU |
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Designation: Senior Lecturer |
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Faculty: Basic Medical Sciences |
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Department: Anatomy |
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Email: This email address is being protected from spambots. You need JavaScript enabled to view it. Alternate Email Address 1: This email address is being protected from spambots. You need JavaScript enabled to view it. Alternative Email Address 2: This email address is being protected from spambots. You need JavaScript enabled to view it. |
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Biography:
Dr. Omowumi Femi-Akinlosotu holds a Bachelor of Dental Surgery (BDS), Master of Science degree in Anatomy and a PhD in Neurobiology. Her research interest is in the basic and applied neuroanatomy, craniofacial and dental anatomy as well as forensic anatomy. She is a member of the Nigeria Medical Association (NMA), Nigeria Dental Association (NDA), Medical Women Association of Nigeria (MWAN), International Brain Research Organization (IBRO), International Society for Neurochemistry (ISN), Society for Neuroscience (SfN) and Society of Neuroscientists of Africa (SONA).
She has carried out several researches on hydrocephalic states in rodent and swine models focusing on the neuronal networks in the sensorimotor and visual cortices, hippocampus and cerebellum. Her skills in neurobiology research has endeared collaboration with other colleagues consequently leading to publication of several peer-reviewed articles on neurotoxic effects of fluoride, the role of extracellular regulated signaling proteins in neurodevelopment and plant extracts used in neurological conditions as well as effect of stroke on the neuronal population in different parts of the rodents’ brain.
Her background in Dentistry has given her an impetus to channel her basic science research acumen towards dental anatomy and craniometry in different animal species. Hence publishing articles on the dental abnormalities in rodents, cattles, camels, bats, duikers and pigs. Using both clinical and basic anatomy skills, data have been generated which are relevant to head and neck surgical manipulations and maneuvers.
Apart from her specialty in neuroscience, and craniofacial and dental anatomy, she is very passionate about girl-child education and mentorship, this has earned her a position on the Board of Directors of Global Youth Leadership & Girl Child Foundation, a non-profit, non-governmental organization focused on providing solutions to the challenges faced by the girl child in Nigeria and other African countries. Her passion for teaching has been rewarded several times by her students as best female lecturer in the pre-clinical school of the College of Medicine. She has won both local and international awards some of which are Young (Early Career) Women Academics in West Africa (2018), International Society for Neurochemistry Travel Grant (2018, 2022) and International Brain Research Organization Travel Grant (2019).
Dr. Omowumi Femi-Akinlosotu has published several articles in peer reviewed journals and written chapters in books on neuroscience and girl-child education. She is married with children and enjoys travelling and watching documentaries.
Resume
Not Available
Research
Current Research and Capacity Building Projects including Grants
Title: Lead neurotoxicity in rodents
Funder: Departmental Research Grant
Brief Summary: Lead neurotoxicity poses a significant threat to brain health, particularly in relation to synaptic connections in the sensorimotor cortex, cerebellum, and hippocampus leading to alterations in synaptic efficacy, structural morphology, cognitive and neurological impairments. However, the specific problems caused by lead neurotoxicity and the underlying mechanisms of lead-induced toxicity on synaptic connections at different stages of rat brains development in the sensorimotor cortex, cerebellum, and hippocampus has not been well elucidated. Conversely, there is limited knowledge on lead-induced synaptic neuroplasticity at different developmental stages of rat brain.
This animal research study will involve the use of lead acetate to induce neurotoxicity in the experimental groups and investigate its effect on the synaptic neuroplasticity in different brain regions at different developmental stages and their corresponding neurobehaviors.
Role: Principal Investigator
Collaborators: Dr. Olumayowa Igado, Dr. Funmilayo Olopade, Prof. J.O. Olopade, Prof. M.T. Shokunbi
Publications
Selected Publications
1. Omotoso G.O., Ibitolu J.O., Femi-Akinlosotu O.M., Akinola O.B., Enaibe B.U. (2013) Morphological and neurohistological changes in adolescent rats administered with nicotine during intrauterine life. Nigerian Journal of Physiological Sciences 28:147–151
2. Adejuwon S.A., Femi-Akinlosotu O.M., Omirinde J.O., Owolabi O.R., Afodun A.M. (2014). Launaea taraxacifolia ameliorates cisplastin-induced hepato-renal injury. European Journal of Medicinal Plants 4(5):528-541
3. Adejuwon S.A., Aina O. O., Femi-Akinlosotu O.M., Omirinde J. O. (2014). Anti- Clastogenic effects of Launaea Taraxacifolia leaf extract on Cisplastin-Induced micronuclei in bone marrow erythrocytes. Journal of Biological Innovation 3(2): 86-92.
4. Adejuwon S.A., Femi-Akinlosotu O.M., Omirinde J.O. (2014). Cisplastin-induced testicular dysfunction and its amelioration by Launaea taraxacifolia leaf extract. Andrologia. 47(5): 553-559 DOI: 10.1111/and.12302
5. Omotoso G.O., Adekeye M., Femi-Akinlosotu O., Akinola O.B., Enaibe B.U. (2015). Histoenzymic evaluation of the frontal cortex of young Wistar rats following prenatal nicotine administration. Rawal Medical Journal 40(1):96-100
6. Omotoso G.O., Alabi A.S., Femi-Akinlosotu O., Akinola O.B., Enaibe B.U. and Ezekiel A. Caxton-Martins (2015). Gestational nicotine exposure alters oligodendrocyte morphology and axonal myelination in the lateral prefrontal cortex of young wistar rats. Nigerian Journal of Neuroscience 7(1): 24-29. (Nigeria)
7. Femi-Akinlosotu O.M. and Shokunbi M.T. (2015). Persistence of medial edge epithelium in the palate of neonatal mice following brief in-utero hyperthermia. Archives of Basic and Applied Medicine 3:1 – 8
8. Owoeye O., Femi-Akinlosotu O.M., Adejuwon S.A. (2015). Launaea taraxacifolia Aqueous Extract Attenuates Cisplatin-Induced Neurotoxicity by Decreasing Oxidative Stress and Neuronal Cell Death in Rats. Archives of Basic and Applied Medicine 3: 71 – 78
9. Femi-Akinlosotu O., Olopade F.E., Omirinde J.O. (2015). Prevalence of Missing Palmaris Longus Muscle in the Arm of Secondary School Children in Ibadan, Nigeria. Archives of Basic and Applied Medicine 3:89 – 92
10. Gambo B.G., Yahaya A., Femi-Akinlosotu O., Olopade J.O. (2015). Investigation into dental abnormalities in Kuri cattle. Sahel Journal of Veterinary Sciences 14(1): 33-41
11. Shallie P.D., Koya A. K., Shallie O. F., Femi-Akinlosotu O., Alese O.O. and Alese M.O (2017). Green Tea confers Protection on the Retina in MPTP Mice Model of Parkinson’s Disease. Annual Research & Review in Biology 13(5): 1-11.
12. Ajani R. S., Femi-Akinlosotu Omowumi (2017). Cadaveric assessment of kidney dimensions among Nigerians - a preliminary report. Anatomy Journal of Africa. 6(2): 957 -962
13. Arigbede O.A., Adeyemi F.B., Femi-Akinlosotu O. (2017). Relative biocompatibility of micro-hybrid and nano-hybrid light-activated composite resins. Journal of Dental Research, Dental Clinics, Dental Prospects. 11(1):1-6
14. Ajani R.S., Femi-Akinlosotu Omowumi (2017). Congenital solitary functioning kidney; an incidental cadaveric dissection finding in an adult male Nigerian: Case report. African Journal of Medical Sciences 46:509-514
15. Igado O., Femi-Akinlosotu O., Omobowale T., Ajadi R., Nottidge H. (2018). Dental Formula and Dental Abnormalities Observed in the Eidolon helvum (Fruit Bat) Captured from the Wild. African Journal of Biomedical Research 21: 223-22
16. Femi-Akinlosotu O.M., Shokunbi M.T. and Thajasvarie Naicker (2019). Dendritic and Synaptic Degeneration in Pyramidal Neurons of the Sensorimotor Cortex in Neonatal Mice with Kaolin-Induced Hydrocephalus. Front. Neuroanat. CLICK HERE
17. Omotosho G.O., Kadir R.E., Alabi A.S., Olayaki L.A., Femi-Akinlosotu O. (2019). Alterations in the levels of female sex hormones following administration of nicotine to Wistar rats. Centrepoint Journal (Science Edition); 25(1):156-162
18. Femi-Akinlosotu O.M., Ogundoyin O.O., Akintola M.A. (2020). The r ole of floride on eruption of mandibular molars of albino rats. Anatomy Journal of Africa. 9(1):1752-1761 doi:10.4314/aja.v9i1.15. issn; 2305-9478
19. Femi-Akinlosotu O.M., Shokunbi M.T. (2020). Changes in neuronal density of the sensorimotor cortex and neurodevelopmental behaviour in neonatal mice with kaolin-induced hydrocephalus. Pediatric Neurosurgery doi:10.1159/000510603
20. Femi-Akinlosotu O.M., Olopade FE, Obiako J, Olopade JO, Shokunbi MT. (2023). Vanadium improves memory and spatial learning and protects the pyramidal cells of the hippocampus in juvenile hydrocephalic mice. Front Neurol. doi: 10.3389/fneur.2023.1116727. PMID: 36846142; PMCID: PMC9947794
Supervision
CURRENT STUDENTS
Masters Level
1. Project Title: Histomorphometric analysis of the neural tissue of the enteric system in a bat model
Student’s Name: Obi, Ndubuisi Paris
Examining Body: The Postgraduate School, University of Ibadan
Year of Entry: 2023
2. Project Title: Synaptic Neuroplasticity of Rat Brains Exposed To Lead Neurotoxicity
Student’s Name: Idepefo, Samson Adetope
Examining Body: The Postgraduate School, University of Ibadan
Year of Entry: 2023
Doctoral Level: 1
Project Title: Analysis of neural stem cells in kaolin-induced hydrocephalic rats
Student’s Name: Idris Olanrewaju Oderinde
Examining Body: The Postgraduate School, University of Ibadan
Year of Entry: 2021
PREVIOUS STUDENTS (Selected)
Masters Level
1. Project Title: Vanadium attenuates the morphological and functional alterations in the pyramidal neurons in the Hippocampus of Juvenile Hydrocephalic Mice
Student’s Name: Obiako Jane
Examining Body: Postgraduate College, University of Ibadan
Year of Completion of Study: 2022
Masters Level
1. Project Title: Neurotoxic effects of lead on the pyramidal neurons of the sensorimotor and purkinje neurons of the cerebellar cortices of juvenile albino mice
Student’s Name: Oladejo, Taofiquat
Examining Body: Postgraduate College, University of Ibadan
Year of Completion of Study: 2023
Masters Level
1. Project Title: Neuronal Integrity of Pyramidal Neurons of the Prefrontal Cortex and Hippocampus of Lead-Induced juvenile mice
Student’s Name: Joshua, Rebecca Nnasefia
Examining Body: Postgraduate College, University of Ibadan
Year of Completion of Study: 2023
Fellowship: 1
1. Project Title: Growth hormone assay and histological changes in the pituitary gland of rats with post-natally induced hydrocephalus
Student’s Name: Festus Ayobami Oshunpidan
Examining Body: West African College of Surgeons
Year of Completion of Study: 2022
Grants
Current Grant Funding
1. Title: Phytochemical modulation of aquaporin-4 (aqp-4) as potential therapeutic target for non-surgical treatment of childhood hydrocephalus
Funder: Tertiary Education Trust Fund (TETFUND)
Brief Summary: Hydrocephalus, a common childhood disorder in which cerebrospinal fluid (CSF) accumulates in the cerebral ventricles. It impairs cognition and sensorimotor activities and reduces the quality of life. It contributes significantly to the global burden of surgical diseases in young children, especially in low and medium countries where infections dominate the causation of the disorder. Presently, pharmacological therapy for hydrocephalus has proved to be ineffective. Aquaporin-4 (AQP-4) is a recently identified water channel protein that regulates CSF and extracellular brain water circulation and serves as a modulator of neuroinflammation. There is evidence that it is upregulated in hydrocephalic mice, suggesting a role in this disease. The unexplored linkage between hydrocephalic brain injury, neuroinflammation and AQP-4 provides an opportunity to investigate whether modulation of AQP-4 expression will reverse the biochemical, morphological and functional sequelae of hydrocephalic brain injury. Quercetin, a phytochemical present in leafy vegetables and fruits and have been found to be neuroprotective in several neurological disorders in experimental animals, through modulation of AQP-4 expression and may hold promise for investigation in hydrocephalus. Therefore, we aim to explore the possibility of quercetin reversing the biochemical, structural and functional sequelae of hydrocephalus through modulation of brain AQP-4, using piglets as experiment animals.
Role: Co-Investigator
Collaborators: Prof. M.T. Shokunbi, Dr. Funmi Olopade
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