Professor Solomon UMUKORO

Basic Information

 Akinlosotu

Name: Solomon UMUKORO

 Faculty: BASIC CLINICAL SCIENCES

Email:This email address is being protected from spambots. You need JavaScript enabled to view it.

  Department:Pharmacology and Therapeutics

 Designation: Professor

Brief Biography:

Resume

Basic information

 Name:  Solomon Umukoro                                                         Faculty: Basic Medical Sciences

Email:    This email address is being protected from spambots. You need JavaScript enabled to view it., This email address is being protected from spambots. You need JavaScript enabled to view it.   Department:    Pharmacology  

                                                                                                       and Therapeutics

Resume

Name:   Solomon Umukoro                                       

Faculty: Basic Medical Sciences

 Department:    Pharmacology and Therapeutics  

Unit:  Neuropharmacology

Email:      This email address is being protected from spambots. You need JavaScript enabled to view it., This email address is being protected from spambots. You need JavaScript enabled to view it.  

 Phone Numbers:  +2348156485031; +2348130897439

Professional links:

https://scholar.google.com/citations?user=akPfGJwAAAAJ&hl=en&oi=sra

 

 https://www.researchgate.net/profile/Umukoro_Solomon

University Education and qualifications (with dates)

  1. University of Lagos    B.Sc. (Hons.) (Pharmacology) 1989 - 1994
  2. University of Lagos    M.Sc. (Pharmacology)             1996 - 1997
  3. University of Lagos    Ph.D (Pharmacology)             1998 - 2006

Present academic position (with date): Associate Professor (01 October 2013)

Previous Academic Positions (with dates)

  • Senior Lecturer (01 October 2008)
  • Lecturer 1 (01 October 2005)
  • Lecturer II (27 May 2002)

Membership of Learned Society

  • West African Society for Pharmacology (WASP) 1994
  • University of Lagos Postgraduate bursary award 1996
  • International Brain research organization (IBRO) 2012
  • International Society for Neurochemistry (ISN) 2013
  • Nigerian Society of Neuroscience (NSN) 2013
  • European College of Neuro-psychopharmacology (ECNP) 2016

 Awards and Travel Grants

  • University of Lagos Postgraduate bursary award 1998
  • Travel grant to attend African network for drugs and Diagnostic innovation Conference in South Africa 2009
  • Travel grant to attend the 6th IBRO Teaching Tools workshop in Rabat,

Morocco                                                                                          2013               

  • University of Ibadan Conference Support grant to attend Conference in India 2014
  • Telfund travel grant to attend Conference in Baltimore, USA 2015
  • Economic Developing Countries (EDC) grant to attend European College of Neuro- psychopharmacology Congress (ENCP) in Vienna, Austria 2016
  • Travel grant to attend 10th International Brain Research Organization (IBRO) Congress in Daegu, South Korea 2018

Teaching and supervision

I am involved in the teaching and supervision of both undergraduate and postgraduate students. I also mentor younger colleagues in the Department and other departments of Pharmacology outside the University of Ibadan

Administrative Experience

  • Departmental Coordinator MBBS/BDS and 300 Level B. Pharmacy practical classes 2002-2011
  • Secretary: Local Organizing Committee, West African Society for Pharmacology (WASP L.O. C) Conference 2003
  • Member: Representative of the Dean of FBMS at Postgraduate School Executive Committee Meetings 2012 to 2015
  • Departmental Postgraduate Coordinator: Faculty of Basic Medical Sciences Postgraduate Committee 2010 to 2015
  • Member: Senate, University of Ibadan 2011 to 2013
  • Member: Local Organizing Committee for the International Brain research Organization (IBRO) Neuroscience Course 2016
  • Chairman: Central Animal House, University of Ibadan 2015 to 2018

 Community Services

  • External Examiner: Department of Pharmacology and Therapeutics, Lagos State University 2012-2013
  • External Examiner: Department of Pharmacology and Therapeutics, Olabisi Onabanjo University, Shagmu, Ogun State 2012, 2015 to date
  • External Examiner: Department of Pharmacology, Therapeutics and Toxicology, University of Lagos, Lagos 2015 to date
  • External Examiner: Department of Pharmacology and Therapeutics, University of Ilorin, Ilorin 2018 to date
  • External Examiner: Department of Pharmacology and Therapeutics, Ondo University of Medical Sciences, 2019.
  • Internal/External Examiner: Oral examination of PhD theses (Department of Physiology, University of Ibadan 2015 to date
  • Assessor for Promotion of Academic Staff from Lecturer 1 to Senior Lecturer:
  • Review articles for Pharmacology, Biochemistry and Behavior 2013 to 2015
  • Have reviewed articles for Journal of Basic and Clinical Physiology and Pharmacology 2014 to 2016 and also for Brain Research Bulletin 2014 to 2018
  • Have reviewed articles for Clinical and Human Toxicology 2013 to 2015
  • Reviewed articles for Physiology & Behavior 2014
  • Review articles for Archives of Basic and Applied Medicine 2015 to date
  • Have Review articles for African Journal of Health Sciences 2012
  • Reviewed articles for Toxicology and Industrial Health 2013
  • Regular reviewer of articles for Nigerian Journal of Physiological Sciences 2012 to date
  • Have reviewed articles for African Journal of Biomedical Research 2012 to 2014
  • Regular reviewer for Drug Metabolism and Personalized Therapy

Regular Reviewer for Drug Research and  African Journal of Medicine and medical Review research proposals for University of Ibadan Animal Care and Use Research Ethics Committee (UIACUREC)

Researches

Research Interest/area of specialization

Neuropharmacology/neurotoxicology and Biochemical Pharmacology                                  

Current research studies

  • The major focus of my current research is centered on the interplay between psychopathologic derangements and biochemical/molecular perturbations induced by chronic stress in laboratory animals
  • Development of an adaptogenic formular from variety of botanicals that might be of benefit in combating the deleterious effects of stress

Screening of food supplements with antioxidant/neuroprotective and anti-inflammatory properties for possible ability to mitigate the pathological insults involved in ischemic stroke   with the view of improving its debilitating outcomes.

Publications

  1. Ashorobi, R.B and Umukoro, S. (1999). The Anticonvulsant Potential of Blue Stone and its Correlation with Motor Incoordination in Mice. West African Journal of Pharmacy 13: 9-11.
  2. Ashorobi, R.B and Umukoro, S. (2001). The Role of GABAergic System in the Convulsant Effect of the Leaf Extract of Gymnema sylvestre in Mice. Nigeria Quarterly Journal of Hospital Medicine 11: 12-15.
  3. Ashorobi, R.B and Umukoro, S. (2001). Evaluation of the Anti-microbial Effect of Eugenia caryophyllata, Eurphorbia hirta and Allium Sativum Journal of Pharmaceutical Science and Pharmacy Practice Vol. 7: 8-9.
  4. Umukoro, S and Ashorobi, R.B. (2001). Effect of Aframomum melegueta Seed Extract on Thermal Pain and Carrageenin-induced Oedema. Nigeria Quarterly Journal of Hospital Medicine 11: 33-35.
  5. Umukoro, S and Ashorobi, R.B. (2003). Comparative Study of the Anti-bacterial Activities of the Fresh and Dry Fruit of Capsicum species. Nigerian Journal of Health and Biomedical Sciences 2: 90-93.
  6. Umukoro, S and Ashorobi, R.B. (2003). Pharmacological Evaluation of the Anti-diarrhoeal Activity of Aframomum melegueta Seed Extract. West African Journal of Pharmacology and Drug Research 13: 23-27.
  7. Umukoro, S and Ashorobi, R.B. (2005). Further Evaluation of the Anti-inflammatory Activity of Aframomum melegueta Seed Extract and its Possible Mechanism of Action. Nigerian Journal of Health and Biomedical Sciences 4: 35-39.
  8. Umukoro, S and Ashorobi R.B. (2005). Pharmacological Evaluation of the Central Nervous System Activity of Aframomum melegueta Seed Extract in Mice. Journal of Natural Remedies 5: 192-196.
  9. Umukoro, S and Ashorobi, R.B. (2005). Anti-stress Potential of the Seed Extract of Aframomum melegueta in Mice. African Journal of Biomedical Research 8: 119-121.
  10. Umukoro, S and Ashorobi, R.B. (2006). Evaluation of Anti-inflammatory and Membrane Stabilizing Property of Aqueous Leaf Extract of Momordica charantia in rats. African Journal of Biomedical Research 9: 119-124.
  11. Umukoro, S., Ashorobi, R.B and Essein, E.E. (2006). Anticonvulsant and Anxiolytic Effects of Calcium Channel Blockers in Mice. Journal of Medical Science 6: 1021-1024.
  12. Umukoro, S and Ashorobi, R.B. (2006). Evaluation of the Anti-inflammatory and Membrane-stabilizing Effects of Eupatorium odoratum. International Journal of Pharmacology 2: 509-512.
  13. Umukoro, S and Ashorobi, R.B. (2007). Further Studies on the Antinociceptive Action of Aqueous Seed Extract of Aframomum melegueta. Journal of Ethnopharmacology 109: 501-504.
  14. Umukoro, S and Ashorobi, R.B. (2008). Further Pharmacological Studies on Aqueous Seed Extract of Aframomum melegueta in Rats. Journal of Ethnopharmacology 115: 489-493.
  15. Umukoro, S and Ashorobi, R.B. (2008). Effects of the Methanol Leaf Extract of Sanseviera liberica on the Central Nervous System in Mice. Journal of Natural Remedies 8: 242-246.
  16. Umukoro, S and Aladeokin, A.C (2010). Evaluation of the Anti-stress and Anticonvulsant Activity of Leaf Extract of Alchornea cordifolia in Mice. Journal of Ethnopharmacology 127: 769-770.
  17. Umukoro, S and Aladeokin, A.C. (2011). Nuts & Seeds In Health and Disease Prevention. Preedy, V.R., Watson, R.R. (Eds). , Therapeutic Effects of Grain of Paradise (Aframomum melegueta) Seeds. , pp 535-543., ISBN: 978-0-12-375688, United Kingdom.
  18. Umukoro, S., Alabi, A.O and Aladeokin, A.C. (2011). Antidepressant Activity of Methyl Jasmonate, a Plant Stress Hormone in Mice. Pharmacology, Biochemistry and Behavior 98: 8-11.
  19. Umukoro, S., Bakre, T.O and Onwuchekwa, C. (2010). Antipsychotic and Sedative Effects of Calcium Channel Blockers in Mice. African Journal Medicine and Medical Sciences 39: 61-66.
  20. Aladeokin, A.C and Umukoro, S. (2011). Psychopharmacological Properties of an Aqueous Extract of Tetracarpidium conophorum Hutch& Dalziel in Mice. Journal of Natural Medicines 65: 411-416.
  21. Umukoro, S and Olugbemide, A.S. (2011). Antinociceptive Effects of Methyl Jasmonate in Experimental Animals. Journal of Natural Medicines 65: 466-470.
  22. Majekodunmi, S.O., Oyagbemi, A.A., Umukoro, S and Odeku, O.A. (2011). Evaluation of the Anti-diabetic Properties of Mucuna pruriens Seed Extract. Asian Pacific Journal of Tropical Medicine 8: 632-636.
  23. Sonibare, M.A., Umukoro, S and Shonibare, E.T (2012). Antipsychotic Property of Aqueous and Ethanolic Extracts of Lonchocarpus cyanescense (Schumach and Thornn.) Benth. (Fabaceae) in Rodents. Journal of Natural Medicines 66: 127-132.
  24. Umukoro, S., Eduviere, A.T and Aladeokin, A.C. (2012). Anti-aggressive Activity of Methyl Jasmonate and the Probable Mechanism of its Action in Mice. Pharmacology, Biochemistry and Behavior 101: 271-277.
  25. Umukoro, S., Eduviere, A.T and Aladeokin, A.C. (2013). Aggressive Behavior: A Comprehensive Review of its Neurochemical Mechanisms and Management. Aggression and Violent Behavior 18: 195-203.
  26. Umukoro, S., Ugbomah, A., Aderibigbe, A.O and Omogbiya, A.I (2013). Antioxidant Property of Jobelyn as the Possible Mechanism Underlying its Anti-amnesic Effect in Rodents. Basic and Clinical Neuroscience 4: 42-49.
  27. Umukoro, S., Omogbiya, A.I and Eduviere, A.T. (2013). Effect of Jobelyn on Intruder and Isolation-induced Aggressive Behavior in Mice. Basic & Clinical Physiology & Pharmacology 24: 263-269.
  28. Omogbiya, A.I., Umukoro, S., Aderibigbe, A.O and Bakre, G.A. (2013). Jobelyn® Pretreatment Attenuates Symptoms of Psychosis in Experimental Models. Basic & Clinical Physiology & Pharmacology 24: 331-336.
  29. Umukoro, S., Omogbiya, A.I and Eduviere, A.T. (2013). Evaluation of the Effect of Jobelyn® on Chemoconvulsant-induced Seizure in Mice. Basic and Clinical Neuroscience 4:19-23.
  30. Umukoro, S., Eduviere, A.T., Ogunbiyi, R and Adeoluwa, O.A. (2014). Pharmacological Evaluation of the Analgesic and Anxiolytic Activities of Jobelyn® in Mice. Basic & Clinical Physiology & Pharmacology 25: 439-444.
  31. Umukoro, S., Eduviere, A.T., Aladeokin, A.C and Olugbemide, A.S. (2014). Antidepressant-like Property of Jobelyn®, an African Unique Herbal Formulation, in Mice. Drug Research 64: 146-150.
  32. Arowona, I.T., Sonibare, M.A and Umukoro, S. (2014). Antipsychotic Property of Solvent-partitioned Fractions of Lonchocarpus cyanescens leaf extract in Mice. Journal of Basic and Clinical Physiology and Pharmacology 25: 235-240.
  33. Umukoro, S., Adewole, F.A., Aderibigbe, A.O and Onwuchekwa, C. (2014). Free Radical Scavenging Effect of Donepezil as the Possible Contribution to its Memory Enhancing Activity in Mice. Drug Research 64: 236-239.
  34. Annafi, O.S., Umukoro, S and Eduviere A.T. (2014). Evaluation of the Anticonvulsant and Anxiolytic Potentials of Methyl Jasmonate in Mice. Scientia Pharmaceutica 82: 643-654.
  35. Ibironke, G.F., Umukoro, S and Ajonijebu,D.C. (2014). Central Nervous System Activity of the Ethanol Leaf Extract of Sida acuta in Rats. African Journal of Medicine and Medical Sciences 43: 11-16.
  36. Afolabi, M.O.S and Umukoro, S. (2015). Encyclopedia Of Global Bioethics. Have, T. (Ed.)., Addiction., pp 1-6., ISBN 978-3-319-09483-0, Dordrecht: Springer, United States of America.
  37. Eduviere, A.T., Umukoro, S., Aderibigbe, A.O., Ajayi, A.M and Adewole, F.A. (2015). Methyl Jasmonate Enhances Memory Performance through Inhibition of Oxidative Stress and Acetylcholinesterase Activity in Mice. Life Sciences 132: 20-26.
  38. Aluko, O.M., Umukoro, S., Annafi, O.S., Adewole, F.A and Omorogbe, O. (2015). Effects of Methyl Jasmonate on Acute Stress Responses in Mice Subjected to Forced Swim and Anoxic Tests. Scientia Pharmaceutica 83: 635-644.
  39. Umukoro, S., Oluwole, O.G., Eduviere, A.R., Omogbiya, I.A and Ajayi, A.M. (2015). Jobelyn® Exhibited Anti-inflammatory, Antioxidant, and Membrane-stabilizing Activities in Experimental Models. Basic & Clinical Physiology & Pharmacology 26: 501-508.
  40. Umukoro, S., Oluwole, O.G., Egbewunmi, H., Eduviere, A.T and Omogbiya, A.I. (2015). Effect of Monosodium Glutamate on Behavioral Phenotypes, Biomarkers of Oxidative Stress in Brain Tissues and Liver Enzymes in Mice. World Journal of Neuroscience 5: 339-349.
  41. Umukoro, S., Omorogbe, O., Aluko, O.M., Eduviere, T.A., Owoeye, O and Oluwole, O.G. (2015). Jobelyn, a Sorghum-based Nutritional Supplement Attenuates Unpredictable Chronic Mild Stress-induced Memory Deficits in Mice. Journal of Behavioral and Brain Science 5: 586-597.
  42. Sonibare, M.A., Onda, E.E., Ajayi, A.M and Umukoro, S. (2015). In Vitro Antioxidant and Membrane Stabilization Activities of the Fruit Extract and Fractions of Tetrapleura tetraptera (Schumach & Thonn.) Taub. Journal of Pharmacy and Bioresources 12: 95-105.
  43. Umukoro, S. (2016). Review of the Challenges Facing Management of Patients with Psychotic Disorder and the Need for Mental Health Policies in Nigeria. British Journal of Education, Society & Behavioral Science 12: 1-10.
  44. Umukoro, S., Aluko, O.M., Eduviere, A.T and Owoeye, O. (2016). Evaluation of Adaptogenic-like Property of Methyl Jasmonate in Mice Exposed to Unpredictable Chronic Mild Stress. Brain Research Bulletin 121: 105-114.
  45. Ben-Azu, B., Omogbiya, A.I., Adeoluwa, A.O., Ajayi, A.M., Aderibigbe, A.O., Umukoro, S., Iwalewa, E..O., Ejebe, D., Oloche, J.J., Eneni, A.O and Eranga, O. (2016). Amelioration of Chronic Unpredictable Mild Stress Induced Behavioural Perturbations by Noni Juice in Mice: Possible Involvement of Antioxidant System. European Journal of Medicinal Plants 17: 1-17.
  46. Eduviere, A.T., Umukoro, S., Adeoluwa, O.A. , Omogbiya, I.A and Aluko, O.M. (2016). Possible Mechanisms Involved in Attenuation of Lipopolysaccharide-induced Memory Deficits by Methyl Jasmonate in Mice. Neurochemical Research 41: 3239–3249.
  47. Ben-Azu, B., Omogbiya, A.I., Aderibigbe, A.O., Umukoro, S., Ajayi, A.M., Eneni, A.O and Iwalewa, E.O. (2016). Doxycycline Ameliorates Schizophrenia-like Behaviors in Experimental Models in Mice by Targeting Underlying Oxidative Stress. Journal of Behavioral and Brain Science 6: 539-562.
  48. Oluwole, O.G., Ologe O., Alabi A., Yusuf, GT. and Umukoro, S (2017). Anti- inflammatory Effects and Anti-oxidant Capacity of Myrathius arboreus (Cecropiaceae) in Experimental Models. Journal of Basic and Clinical Physiology and Pharmacology 28: 521-529.
  49. Umukoro, S., Ogboh, S.I., Omorogbe, O., Adekeye, A.A and Olatunde, O.M. (2017). Evidence for the Involvement of Monoaminergic Pathways in the Antidepressant-like Activity of Cymbopogon citratus in Mice. Drug Research 67: 1-6.
  50. Umukoro, S., Alabi, A.O., Eduviere, A.T., Ajayi, A.M and Oluwole, O.G (2017). Anti-inflammatory and Membrane Stabilizing Properties of Methyl Jasmonate in Rats. Chinese Journal of Natural Medicines 15: 0202–0209.
  51. Umukoro, S and Eduviere, A.T. (2017). Methyl Jasmonate Attenuates Memory Dysfunction and Decreases Brain Levels of Biomarkers of Neuroinflammation Induced by Lipopolysaccharide in Mice. Brain Research Bulletin 131: 33–141.
  52. Annafi, O.S., Aluko, O.M., Eduviere, A.T., Omorogbe, O and Umukoro, S. (2017). Probable Mechanisms Involved in the Antipsychotic-like Activity of Methyl Jasmonate in Mice. Naunyn Schmiedeberg Archive of Pharmacology 390: 883-889.
  53. Ajayi, A.M., Umukoro, S., Ben-Azu, B., Adzu, B and Ademowo, O.G. (2017). Toxicity and Protective Effect of Phenolic-enriched Ethylacetate Fraction of Ocimum gratissimum (Linn.) Leaf against Acute Inflammation and Oxidative Stress in Rats. Drug Development Research 78: 135–145.
  54. Adebesin, A., Adeoluwa, O.A,, Eduviere, A.T and Umukoro, S. (2017). Methyl Jasmonate Attenuated Lipopolysaccharide-induced Depressive-like Behaviour in Mice. Journal of Psychiatric Research 94: 29-35.
  55. Eduviere, AT., Omorogbe, O and Umukoro, S. (2017). Methyl Jasmonate Ameliorates Memory Deficits in Mice Exposed to Passive Avoidance Paradigm. International Journal of Neuroscience Research 1: 0001-0007.
  56. Umukoro, , Adebesin, A., Agu, G., Omorogbe, O and Asehinde, S.B. (2018). Antidepressant-like Activity of Methyl Jasmonate Involves Modulation of Monoaminergic Pathways in Mice. Advances in Medical Sciences Vol. 63: 36-42.
  57. Omorogbe, , Ajayi, A.M., Ben-Azu, B., Oghwere, E.E., Adebesin, A., Aderibigbe, A.O., Okubena, O and Umukoro, S. (2018). Jobelyn® Attenuates Inflammatory Responses and Neurobehavioural Deficits associated with Complete Freund-Adjuvant-induced Arthritis in Mice. Biomedicine and Pharmacotherapy Vol. 98:585-593.
  58. Ben-Azu, B., Omogbiya, I.A., Aderibigbe, A.O., Umukoro, S., Ajayi, A.M and Iwalewa, E.O. (2018). Doxycycline Prevents and Reverses Schizophrenic-like Behaviors induced by Ketamine in Mice via Modulation of Oxidative, Nitrergic and Cholinergic Pathways. Brian Research Bulletin 139: 114-124.
  59. Adebesin, A., Ajayi, A.M., Olonode, E.O., Omorogbe, O and Umukoro, S. (2018). Methyl Jasmonate Ameliorates Unpredictable Chronic Mild Stress-induced Behavioral and Biochemical Alterations in Mouse Brain. Drug Development Research 78: 381-389.
  60. Ojo, E.T., Aluko, O.M and Umukoro, S. (2018). Psychopharmacological Evaluation of Antidepressant-like Activity of Ethanol Seed Extract of Grains of Paradise (Aframomum melegueta Schum.) in Mice. Journal of Food Biochemistry Vol. 12528: 1-12.
  61. Ben-azu, , Aderibigbe, A.O., Ajayi, A.M., Eneni, A.O., Umukoro, S and Iwalewa, E.O. (2018). Involvement of GABAergic, BDNF and Nox-2 Mechanisms in the Prevention and Reversal of ketamine-induced Schizophrenia-like Behavior by Morin in Mice. Brian Research Bulletin Vol. 139: 292-304.
  62. Oyeleke, S.A., Ajayi, A.M., Umukoro, S., Aderibigbe, A.O and Ademowo, O.G. (2018). Anti-inflammatory Activity of Theobroma cacao L. Stem Bark Ethanol Extract and its Fractions in Experimental Models. Journal of Ethnopharmacology 222: 239-248.
  63. Umukoro, S., Adeyinka, A.H., Ben-Azu and Ajayi, A.M. (2018). Lemon Grass Tea Enhanced Memory Function and Attenuated Scopolamine-Induced Amnesia in Mice via Inhibition of Oxidative Stress and Acetyl-cholinesterase Activity. Journal of Herbs, Spices & Medicinal Plants 24: 407-420.
  64. Umukoro, , Kalejaye H.A., Ben-Azu, B and Ajayi, A.M. (2018).
    Naringenin Attenuates Behavioral Derangements induced by Social Defeat Stress in Mice via Inhibition of Acetylcholinesterase Activity, Oxidative Stress and Release of Pro-inflammatory Cytokines. Biomedicine and Pharmacotherapy Vol. 105:714-723.
  65. Ben‑Azu, B., Aderibigbe, A.O., Eneni, A.O., Ajayi, A.M., Umukoro, S and Iwalewa, E.O. (2018). Morin Attenuates Neurochemical Changes and Increased Oxidative/nitrergic Stress in Brains of Mice Exposed to Ketamine: Prevention and Reversal of Schizophrenia-like Symptoms. Neurochemical Research 43:1745-1755.
  66. Asehinde, S., Ajayi, A.M., Bakre, A.G., Omorogbe, O., Umukoro, S. (2018). Effects of jobelyn on isoniazid-induced seizures, biomarkers of oxidative stress and glutamate decarboxylase activity in mice. Basic and Clinical Neuroscience 9: 389-396.
  67. Ilechukwu, C.E., Sonibare, M.A., Oluwole, O.G., Ajayi, A.M and Umukoro, S. (2018). Antioxidant and in vitro membrane stabilization activities of leaf extract of Gossypium barbadense (Malvaceae). West African Journal of Pharmacy Vol. 29: 116-126.
  • Ben-Azua, B., Nwoke E.E., Aderibigbe, A.O., Omogbiya, I.A., Ajayi, A.M., Olonode, ET., Umukoro, S and Iwalewa, O. (2019). Possible Neuroprotective Mechanisms of Action Involved in the Neurobehavioral Property of Naringin in Mice. Biomedicine and Pharmacotherapy Vol. 109: 536-546.
  • Umukoro, S., Oghwere, E.E., Ben-Azu, B., Owoeye O; Ajayi, A.M., Omorogbe, O and Okubena, O. (2019). Jobelyn® Ameliorates Neurological Deficits in Rats with Ischemic Stroke through Inhibition of Release of Pro-inflammatory Cytokines and NF-kB Signaling Pathway. Pathophysiology 26: 77-88.
  • Ajayi, A.M., Ayodele, E.O., Ben-Azu, B., Aderibigbe, A.O., and Umukoro, S. (2019). Evaluation of Neurotoxicity and Hepatotoxicity Effects of Acute and Sub-acute Oral Administration of Unripe Ackee (Blighia sapida) Fruit Extract. Toxicology Reports 6: 656-665.
  • Alabi, A.O., Ajayi, A.M., Ben-Azu, B.,  Bakre, G., and Umukoro, (2019). Methyl Jasmonate Abrogates Rotenone-induced Parkinsonian-like Symptoms through Inhibition of Oxidative Stress, Release of Pro-inflammatory Cytokines, and Down-regulation of Immnopositive Cells of NF-κB and α-synuclein expressions in mice. Neurotoxicology Vol. 74:172-183.
  • Umukoro, S., Apara, M., Ben-Azu, B., Ajayi, AM., and Aderibigbe, A.O. (2019). Neurobiological Effects of Prolonged Exposure to Solid Air Freshener in Mice. Iranian Journal of Toxicology 13: 45-51.
  • Ojo, E.S., Ishola, I.O., Ben-Azu, B., Afolayan, O.O., James, A.B., Ajayi, A.M., Umukoro, S and Adeyemi, O.O. (2019). Ameliorative Influence of Cnestis ferruginea vahl ex DC (Connaraceae) Root Extract on Kainic Acid-induced Temporal Lobe Epilepsy in Mice: Role of Oxidative Stress and Neuroinflammation. Journal of Ethnopharmacology 243:112-117.
  • Ben-Azu, B., Aderibigbe A.O., Ajayi, A.M., Umukoro, S and Iwalewa, E.O. (2019). Involvement of L-arginine-nitric Oxide Pathway in the Antidepressant and Memory Promoting Effects of Morin in Mice. Drug Development Research 80:1071-1079.
  • Alabi, A.O., Ajayi, A.M., Omorogbe, O and Umukoro, (2019). Anti-nociceptive and anti-inflammatory effects of an aqueous extract of blended leaves of Ocimum gratissimum and Psidium guajava. Clinical Phytoscience Vol. 5: 34-42.
  • Alabi, A.O., Ajayi, A.M., Ben-Azu, B., Omorogbe, O and Umukoro, (2019). Methyl Jasmonate Reverses Motor Deficits Induced by Rotenone via Increased Tyrosine Hydroxylase Activity, Dopamine Concentrations and Dendritic Arborisation in Specific Brain Regions of Rats. Metabolic Brain Disease Vol. 34: 1723-1736.
  • Afighor, M., Ben-Azu, B., Ajayi1 A.M., Umukoro, S. (2019). Role of Cytochrome C and Tumor Necrosis Factor-Alpha in Memory Deficit Induced by High Doses of a Commercial Solid Air Freshener in Mice. Journal of Chemical Health Risks Vol. 9: 263-274.
  • Umukoro, S., Ben-Azu, B., Iyiola, A.O., Adeboye, B., Ajayi, A.M., Adebesin, A and Omorobge, O. (2019). Evaluation of the anticonvulsant and anxiolytic-like activities of aqueous leaf extract of Cymbopogon citratus in mice. Journal of Basic and Clinical Physiology and Pharmacology Vol. 31: 20190100. DOI: https://doi.org/10.1515/jbcpp-2019-0100
  • Ben-Azu, B., Aderibigbe, A.O., Ajayi, A.M., Eneni, A.O., Omogbiya, A.I., Owoeye, O., Umukoro, S and Iwalewa, E.O. (2019). Morin decreases cortical pyramidal neuron degeneration via inhibition of neuroinflammation in mouse model of schizophrenia. International Immunopharmacology Vol. 70: 338-353.
  • Emokpae, O., Ben-Azu, B., Ajayi, M and Umukoro, S. (2020). D-ribose-L-cysteine attenuates lipopolysaccharide-induced memory deficits through inhibition of oxidative stress, release of proinflammatory cytokines and nuclear factor-kappa B expression in mice. Naunyn Schmiedebergs Arch Pharmacol. Vol. 393:909-925.
  • Emokpae, O., Ben-Azu, B., Ajayi, M and Umukoro, S. (2020). D‐ribose‐L‐cysteine enhances memory task, attenuates oxidative stress and acetyl‐cholinesterase activity in scopolamine amnesic mice. Drug Development Research Vol. 81: 620-627.
  • Ajayi, A.M., Arasi, R.O., Ben-Azu, B., Godson, J.C., Umukoro, S and Aderibigbe A.O. (2020). Nigerian psychoactive alcoholic herbal mixture impacts behavioural performance and caused brain biochemical and histopathological alterations in mice. J. Biomed. Res. 23:255-265.
  • Ben-Azu, B., Emokpae, O., Ajayi, A.M., Jarikre, T.A., Orhode, V., Aderibigbe, A.O., Eneni, A.O., Omogbiya, A.I., Owoeye, O., Umukoro, S and Iwalewa, E.O. (2020). Repeated psychosocial stress causes glutamic acid decarboxylase isoform- 67, oxidative-Nox-2 changes and neuroinflammation in mice: Prevention by treatment with a neuroactive flavonoid, morin. Brain Research Vol. 1744: 146917.
  • Umukoro, S., Ben-Azu, B., Ajayi, A.M., Adebesin, A and Emokpae, O. (2020). Cymbogogon citratus aqueous leaf extract attenuates neurobehavioral and biochemical changes induced by social defeat stress in mice. Chinese Herbal Medicine Vol. 12: 303-309.
  • Umukoro, S., Okoh, L,, Igweze, C.S., Ajayi, A.M and Ben-Azu, B. (2020). Protective effect of Cyperus esculentus (Tiger nut) extract against scopolamine-induced memory loss and oxidative stress in mouse brain. Drug Metabolism & Personalized Therapy
  • Ajayi, A.M., Alabi, A.O., Adebesin, A., Ben-Azu, B and Umukoro, S. (2020). Aqueous extract of dry powder blend of seeds and leaves of Picralima nitida (Stapf) T. & H. Durand reduce pain and inflammation in animal models. J Basic Clin Physiol Pharmacol 20190212
  • Akinluyi, E., Aderibigbe A.O., Adeoluwa, O., Ben-Azu, B., Eduviere., T.A., Ajayi, A.M and Umukoro, S (2020). Morin hydrate attenuates chronic stress-induced memory impairment and degeneration of hippocampal subfields in mice: The role of oxidative, nitrergic and neuroinflammatory pathways. Metabolic Brain Diseases https://doi.org/10.1007/s11011-020-00595-2.
  • Aluko, O.M and Umukoro, S. (2020). Methyl jasmonate reverses chronic stress-induced memory dysfunctions through modulation of monoaminergic neurotransmission, antioxidant defense system, and Nrf2 expressions. Naunyn-Schmiedeberg's Archives of Pharmacology https: //doi.org/10.1007/s00210-020-01939-6
  • Ajayi, A.M., Chidebe, E.O., Ben-Azu, B and Umukoro, S. (2020).
    Chrysophyllum albidum (African star apple) fruit-supplemented diet
    enhances cognitive functions and attenuates lipopolysaccharide-induced memory impairment, oxidative stress, and release of proinflammatory cytokines. Nutrire 45:20.
  • Olonade, E., Aderibigbe A.O., Adeoluwa, O., Ajayi, A.M., Eduviere., T. A., Bakre, A.G Ben-Azu, B., Umukoro, S (2020). Morin Hydrate Reverses Neurodegeneration via Inhibition of Neuroinflammation in Mice Exposed to Unpredictable Chronic Stress. IBRO Reports 7 (Supplement): 23-24.

Contact Information

 Phone: 08130897439  Address:  Email: This email address is being protected from spambots. You need JavaScript enabled to view it.
 Facebook: Profile Link  LinkedIn: Profile Link  Twitter: Profile Link
 Instagram: Profile Link  YouTube: Profile Link
Pinterest: Profile Link

Quick Links

Social Links

Get In Touch