Profile
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Name: Dr. Taiwo R. KOTILA |
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Designation: Reader |
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Faculty: BASIC CLINICAL SCIENCES |
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Department: Haematology |
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Google Scholar Profile Research Gate Profile ORCID Profile |
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Email Address: This email address is being protected from spambots. You need JavaScript enabled to view it. |
Biography
Taiwo Rachel Kotila
MBBS (Ibadan), MSc Clinical Trials (Lond), FMCPath
Dr Taiwo Kotila is a 1987 graduate of the University of Ibadan and a fellow of the national postgraduate medical college, Nigeria. She had her residency training in Haematology and was awarded the Dr Charles O Majekodunmi prize for the best candidate in Haematology Part II FMCPath examination. She was also awarded the young investigators’ prize of the Nigerian Society for Haematology and Blood Transfusion shortly after becoming a fellow of the National College. She worked briefly at the Federal Medical Centre, Owo where she pioneered the pathology department. She joined the faculty of the University of Ibadan in I998. She obtained a master’s degree in clinical trials from the University of London in 2016. She was a research fellow at the Hadassah Medical centre, Jerusalem in 2009, 2010 & 2015. During her visits to the Hadassah hospital, she learnt the use of molecular methods in the diagnosis of the haemoglobinopathies. She was also exposed on the therapeutic use of stem cell transplantation in haematologic disorders.
Dr Kotila was Sub-Dean undergraduate of the faculty of Basic Medical Sciences from 1998-2002 and the treasurer of the Nigerian Society for Haematology and Blood transfusion during the same period. She is a member of the International Society of Thrombosis and Haemostasis where she served in the Diversity, Equity and inclusion (DEI) and the Guidance and Guidelines (G&G) committees. She was also the Chairman, College of Nigerian Pathologists, Oyo state between 2019-2022. She is currently the Acting Head of Haematology department, a position she also held between 2012-2014.
Area of Specialization
I am a Hematologist with interest in hemoglobinopathies, the majority of my publications are on sickle cell disease (SCD). I have related the clinical features of Nigerian sickle cell disease patients to HbF levels and described features which are associated with a clinically severe course of the disease. I have also shown that chronic pain and psychosocial issues might be reasons why SCD patients get addicted to opioids. Recently, we observed that coinheritance of G6PD could worsen the hemolysis in SCD, a phenomenon that we are currently exploring. I am an advocate of newborn screening for SCD. I have also worked on the thalassaemias, I have used gap PCR in the characterization of alpha thalassaemia among Nigerian. I believe from clinical studies that the prevalence of beta thalassaemia in Nigerians may be higher than previously thought. I am therefore currently working on the molecular characterization of Beta thalassaemia among Nigerians.
Research
Completed Research
Malaria Chemoprophylaxis in Sickle Cell Disease
Pain Management in Sickle Cell Disease
Characterization of Thalassaemia genes (Alpha Thalassaemia)
Research in Progress
i. Interrelationship between B vitamins and homocysteine in Thromboembolism
This is to determine the role of Vitamin B12 and folate in venous thromboembolism and to determine the interplay between these vitamins and homocysteine in the development of venous thromboembolism. Demographics and other descriptive parameters have been published, serum B12 and folate has been analysed and is being prepared for publication.
ii. Characterisation of Thalassaemia genes (Beta Thalassaemia)
This is a second part of the work on the characterisation of the thalassaemia genes, the high prevalence of Beta thalassaemia in Nigerians has been established. This current work is to determine mutations responsible for Beta thalassaemia in Nigerians and its clinical ramification.
iii. Clinical implications of the high prevalence of beta thalassaemia in Nigerians
The hypothesis is that if beta thlaassaemia is highly prevalent as shown then it should have significant impact on the health of Nigerians. Diabetes is a metabolic disorder known to be associated with beta thalassaemia, so my current focus is to find out the role of beta thalassaemia in the pathogenesis of diabetes mellitus. Some biochemical parameters are being analysed from patients with diabetes and presumed healthy controls.
iv. Pharmacogenetics of Opioid Abuse in Sickle cell disease
This is to look into the epidemiology of opioid abuse among SCD patients, describe the pharmacokinetics of pentazocine, the commonly abused opioid in SCD patients. To study the polymorphism of CYP2D6 genes and single nucleotide polymorphisms (SNPs) associated with opioids.
a. Project, Dissertation and Thesis
b. Kotila, T. R. HbA2 and HbF in sickle cell anaemia patients. May, 1997
Publications
A. Articles that have already appeared in Refereed Conference Proceedings:
1. Kotila, T.R., Adediran, K., Olatunji, P.O. (2013) The Need for a Paradigm Shift to Non-Communicable Diseases and Newborn Screening of Common Genetic Disorders in Nigeria. Presented at the 2013 Joint Meeting of the Newborn Screening and Genetic Testing Symposium (NSGTS) and the International Society for Neonatal Screening (ISNS) May 5-10, 2013, Atlanta Georgia, USA 70%
Articles that have already appeared in learned journals
2.Okunade, M.A., Kotila, T. R., Shokunbi, W.A., Aken’Ova, Y.A. (1998): Venous Thromboembolism in Ibadan: A Five Year Experience (1986-1990) Nigerian Quarterly Journal of Hospital Medicine Vol.8.No.2,80-82 (Nigeria) (Contribution: 40%)
3. Kotila,T.R., Fatunade, H.B., Ajakaiye, F., Fadairo, J.K, Fadahunsi, O.A. (1999): Use of bovine brain phospholipids in the determination of partial thromboplastin time in Nigeria. Nigerian Postgraduate Medical Journal. Vol.6.No.1,1-3.(Nigeria)(Contribution: 50%)
4.Kotila, T.R., Adeyemo, A.A., Abbiyesukku, F.M., Shokunbi, W.A. (2000): Betke’s and elution Methods in the Estimation of Haemoglobin F in Sickle Cell Anaemia. East African Medical Journal. Vol.77.No.3,40-43. (Kenya) (Contribution: 60%)
5.Kotila, T.R., Lewis, O.I., Shokunbi, W. A. (2000): Haemoglobin F and clinical severity of sickle cell anaemia among Nigerian adults. African Journal of Medicine & Medical Sciences. Vol.29.No3,229-231.(Nigeria)(Contribution: 70%)
6.Kotila,T.R., Aken’Ova,Y.A., Shokunbi, W.A., Akingbola,T.S., Fasola, F.A. (2001): Hodgkin’s disease after treatment for Burkitt’s lymphoma: case report. East African Medical Journal. Vol.78.No.7,49-51. (Kenya)(Contribution:50%)
7.Kotila, T.R., Shokunbi, W. A. (2001): Survival advantage in female patients with sickle cell anaemia. East African Medical Journal.78.No.7,33-35. (Kenya) (Contribution: 80%)
8. Shokunbi, W. A., Kotila, T. R., Dare, O. A. (2001): Earliest presenting sign and morbidity profile of sickle cell patients attending the adult sickle disease clinic at the UCH, Ibadan, Nigeria. Central African Journal of Medicine. Vol. 47. No.7, 186-7. (Uganda)(Contribution: 40%)
9. Adejumo, O. E., Oseni, O. B., Babalola, C.P., Kotila, T. R., Olaniyi, A. A. (2002). Proguanil versus Pyrimethamine in long and short term malaria chemoprophylaxis in sickle cell anaemia. Nigerian Journal of Pharmaceutical Research. Vol.1,22-25. (Nigeria) (Contribution: 30%)
10. Kotila, T.R., Shokunbi, W. A. (2003). Haemoglobin F levels in health Nigerian adults. West African Journal of Medicine. Vol. 22. No.2:143-145. (Nigeria)(Contribution: 80%)
11. Kotila, T. R., Adedapo, K., Adedapo, A., Oluwasola, A., Fakunle, E., Brown, B. (2005): Liver dysfunction in steady state sickle cell disease. Annals of Hepatology. Vol.4. No.4,261-263. (Brazil) (Contribution: 50%)
12. Kotila, T. R., Fasola, F.A. (2005): The lupus anticoagulant in a population of healthy Nigerian adults. Annals of Ibadan Postgraduate Medicine. Vol.3.No.1,45-48 (Nigeria) (Contribution: 70%)
13. Kotila, T. R., Odukogbe, A.A., Okunlola, M.A., Olayemi,O., Obisesan, K. A. (2005): The pregnant Rhesus negative Nigerian Woman. The Nigerian Postgraduate Medical Journal. Vol.12. No.4,305-307.(Nigeria)(Contribution: 50%)
14. Kotila, T. R. (2005):Management of acute painful crises in sickle cell disease. Clinical Laboratory Haematology. Vol.27,221-223 (United Kingdom) (Contribution:100%)
15. Kotila, T.R. (2006): Automated techniques in Haematology. Nigerian Journal of Medicine: Vol.15.No.1,30-33. (Nigeria)(Contribution: 100%)
16. Kotila, T.R., Ocheni, S. (2006): Acute painful crisis in sickle cell disease: severity assessment. The Internet Journal of Tropical Medicine. Vol.3. No.1 (Internet) (Contribution: 70%)
17. Kotila, T. R., Okesola, A. O., Makanjuola, O. (2006): asymptomatic parasitaemia in sickle cell disease: How effective is chemoprophylaxis? Journal Vector Borne Diseases. Vol.44.No.3, 52-55. (India)(Contribution: 70%)
18. Brown, B.J., Kotila, T. R. (2007): Hodgkin’s lymphoma in a child with sickle cell anaemia. Pediatric Hematology Oncology. Vol.24,531-535. (United States of America)(Contribution: 50%)
19. Adedapo, A.D., Falade, C.O., Kotila, T.R., Ademowo, O.G. (2007): Age as a risk factor for thrombocytopaenia and anaemia in children treated for acute uncomplicated Falciparum malaria. Journal of Vector Borne Diseases. Vol.44.No.4,266-271.(India)(Contribution: 30%)
20. Kotila, T. R. (2007): when the inheritance of two heterozygote states become a diagnostic problem: Misdiagnosis of the sickle cell trait. Nigerian Journal of Medicine. Vol.16.No.2,173-176. (Nigeria) (Contribution: 100%)
21. Fasola, F.A. Kotila, T.R., Akinyemi, J.O. (2008): Trends in transfusion-transmitted viral infections from 2001-2006 in Ibadan, Nigeria. Intervirology. Vol51,427-431 (Switzerland) (Contribution: 40%)
22. Kotila, T. R., Fasola, F.A. (2008): Pattern of blood of blood donation in a Nigerian tertiary hospital: The way forward. African Sanguine. Vol.7.No.219-21 (South Africa)(Contribution: 70%)
23. Fasola, F.A. Kotila, T.R., Shokunbi, W. A. (2009). Audit of the red cell units’ supply of a busy hospital blood bank in Nigeria. Nigerian Journal Clinical Practice. Vol.12.No2,165-168 (Nigeria)(Contribution: 40%)
24. Kotila, T. R., Adeyemo, A. A., Mewoyeka, O.O., Shokunbi, W.A. (2009). Beta thalassaemia trait in Western Nigeria. African Health Sciences.Vol.9.No.1,46-48 (Uganda)(Contribution: 60%)
25. Shapshak, P., Somboonwit, C., Drumright, L., Frost,S., Commins, D., Tellinghsisen, T., Scott, W., Duncan, R., McCoy, C., Page, J., Giunta, B., Fernandez, F., Singer, E., Levine, A., Minagar, A., Oluwadara, O., Kotila, T., Chiappelli, F., Sinnot, J. (2009). Molecular and contextual markers of hepatitis C virus and drug abuse. Molecular Diagnosis &Therapy. Vol.13.No.3,1-27(New Zealand)(Contribution: 30%)
26. Kotila, T. R. (2010): Guidelines for the diagnosis of the haemoglobinopathies in Nigeria. Annals of Ibadan Postgraduate Medicine. Vol. 8. No.1, 25-29 (Nigeria) (Contribution: 100%)
27. Babalola, C. P., Adejumo, O., Ung, D, Xu, Z., Odetunde, A., Kotila, T., Falusi, A.G., Nagar, S. (2010). Cytochrome P450 CYP2C19 genotypes in Nigerian sickle cell disease patients and normal controls. Journal of Clinical Pharmacy & Therapeutics Vol.35,471-477 (United Kingdom) (Contribution: 30%)
28. Kotila, T. R. (2012) Phenotypic and genotypic expression of alpha thalassaemia in Nigeria. African Journal of Medicine and Medical Sciences. Vol.41.No3, 283-287 (Nigeria) (Contribution:100%)
29. Kotila, T. R., Ipadeola, A., Olutogun, T., Aworanti, O. (2012): Steroid induced diabetes mellitus in patients receiving prednisolone for haematological malignancies. African Health Sciences. Vol.13.No.3, 842-844. (Uganda) (Contribution: 60%)
30. Kotila, T. R. (2012): Thalassaemia is a tropical disease. Annals of Ibadan Postgraduate Medicine. Vol.10. No.2,11-15. (Nigeria)(Contribution: 100%)
31. Olutogun, T., Aworanti, O., Kotila, T. R. (2012): Alteration of ABH Blood group antigens in a patient with acute leukaemia. Annals of Ibadan Postgraduate Medicine. Vol.3 No.2,141-143. (Ile-Ife, Nigeria)(Contribution: 70%)
32. Fasola, F. A., Kotila, T. R., Edwin, O. A., Dada, V. O., Oyewumi, T. J. (2013) Assessment of immunoglobulin levels in the cause of false pass rate in the use of copper sulphate (CuSO4) as pre-donation screening test. The tropical Journal of Health Sciences. Vol.20.No.2,8-13 (Nigeria)(Contribution: 30%)
33. Kotila, T. R.,Fasola, F.A., Busari, E. O. (2013): A revisit of thromboembolism. African Journal of Medicine & Medical Sciences.Vol.42.No.2, 177-181. (Nigeria)(Contribution: 70%)
34. Kotila, T.R. (2013): Beta thalassaemia in Nigeria: Myth or Fact?African Journal of Medicine & Medical Sciences. Vol.42.No3,261-264 (Nigeria)(Contribution: 100%)
35. Ogun, G.O., Ebili, H., Kotila, T.R. (2014): Autopsy findings and pattern of mortality in Nigerian sickle cell disease patients. The Pan African Medical Journal. Vol.18,30-35. (South Africa) (Contribution: 20%)
36. Anyanwu-Yeiya, C.C., Sonubi, O., Kotila, T. R. (2015): Targeting females as voluntary non remunerated donors in developing nations. Journal of Blood disorders and transfusion. S4:1-3. (India) (Contribution: 30%)
37.Kotila, T.R., Busari, O.E., Makanjuola, V., Eyelade, O.R. (2015) Addiction or pseudoaddiction in sickle cell disease patients: Time to decide-A case series. Annals of Ibadan Postgraduate Medicine. Vol.13No1,44-47. (Nigeria) (Contribution: 50%)
38.Kotila, T.R., Eyelade, O.R., Makanjuola, V., Busari, O.E. (2015). Pain management in sickle cell disease: What remedy to reduce the risk of opioid abuse? African Journal of Anaesthesia and Intensive Care. Vol.15.No.2, 10-15. (Nigeria) (Contribution: 50%)
39. Fasola, F.A., Shokunbi, W.A., Kotila, T.R. (2015). Blood wastage rate in a Sub-Saharan African Hospital based blood bank. International Blood Research & Review. Vol.4.No.4, 1-6. (Poland) (Contribution: 30%)
40. Fasola, F.A., Kotila, T.R., Ilesanmi, O.S., Busari, O.E. (2015). Antithrombin deficiency in patients with thromboembolic disorders in Nigeria. Nigerian Journal of Hospital Practice. Vol.16. No.4-6,27-32. (Nigeria) (Contribution: 30%)
41. Alagbe, A.E., Akunwata, C.U., Ogundeji, S.P., Aworanti, O.W., Kotila, T.R. (2016). Hypereosinophilic syndrome with severe hypokalaemia in a Nigerian woman: a case report. Nigerian Journal of Medicine. Vol.25.No.1,93-96. (Nigeria) (Contribution: 20%)
42. Adejumo, O.E., Kotila, T.R., Falusi, A. G., Silva, B.O., Nwogu, J.N., Fasinu, P.S., Babalola, C.P. (2016). Phenotyping and genotyping of CYP2C19 using comparative metabolism of proguanil in sickle cell disease patients and healthy controls in Nigeria. Pharmacology Research & Perspective. e00252. (United States of America) (Contribution: 25%)
43. Kotila, T. R. (2016) Sickle cell trait: a benign state? ActaHaematologica. Vol.136. No.3, 147-51. (Switzerland) (Contribution: 100%)
B. Technical Reports and Monographs:
44. Kotila, T. R.(2010)Sickle Cell Disease: that all may be aware published by Ibadan University press ISBN: 978-078-8414-34-6(Nigeria) (Contribution: 100%)
I. Major Conferences Attended with Papers Read (In the last 5 years)
International Conference of the African and South African Societies of Human Genetics, Cape Town, South Africa March 2011
Paper Read: Thalassaemia: The Known but forgotten Genetic disease in tropical Africa.
1.American Society of Human Genetics, San Francisco, USA, Nov 2012
2. Joint Meeting of the Newborn Screening and Genetic Testing Symposium (NSGTS) and the International Society for Neonatal Screening, Atlanta Georgia, USA May 2013.
Paper Read: The need for a paradigm shift to Non-Communicable diseases and Newborn screening of common genetic disorders in Nigeria
1. American Society for Haematology, New Orleans, USA, Dec 2013
2. International Conference on Opioids, Boston, USA, June 2014
Paper Read: Opioid abuse among sickle cell disease patients in Nigeria.
Grants
Current Grant Funding
1. World Bleeding Disorders Registry Research Support Program (WBDR-RSP)
Funder: World Federation of Haemophilia
This grant by the World Federation of Haemophilia is to empower the University College Hospital as a treatment centre for Haemaophilia and to actively recruit and enrol individuals with inherited bleeding disorders into the world bleeding disorder registry
Role: Principal Investigator
Collaborators: Haemophilia Treatment Centers (HTCs) in Nigeria
2. Title: Haemophilia Treatment Centre –Funding Program (HTC-FP)
Funder: World Federation of Haemophilia
This is recurring grant to enable the UCH-HTC create awareness about haemophilia and maintain the registration of individuals with inherited bleeding disoders in the World Bleeding Disorder Registry
Role: Director
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