Profile
Biography:
Dr Taye J. Lasisi graduated with a bachelor of dental surgery (BDS) in 2003 and a Master’s degree in physiology in 2007 from the University of Ibadan. She had residency training in Oral Pathology in Nigeria obtaining Fellowship of the National Postgraduate Medical College in 2011 and West African College of Surgeons, in 2012. She obtained PhD in Oral Physiology from the University of Ibadan in 2018.
Dr Lasisi has a joint appointment as a senior lecturer in the department of Oral Pathology, Faculty of Dentistry, University of Ibadan. She also works as an honorary Consultant Oral Pathologist in University College Hospital, Ibadan, Nigeria. Dr Lasisi does research in Dentistry and Physiology. Her research encompasses salivary secretion in health and diseases; pathophysiology of oral and systemic diseases; hearing and deafness. Her work also includes clinical and laboratory diagnosis of oral and maxillofacial diseases.
Dr Lasisi has won many scholarships, prizes and grants including University of Ibadan Travel Support (2013 and 2017), MEPIN Mentored Research Award (2014), Best Early Career Physiologist (2014), Thomas Bassir Biomedical Foundation Grant (2015), Best outstanding COMUI iResearch (2016), Tertiary Education Trust Fund (TETFUND) Grant (2017), Gordon Research Conferences Travel Support to attend Gordon Research Conference on Salivary Glands and Exocrine Biology in Galveston, Texas, USA (2019).
Dr Lasisi serves as a reviewer for many local and international journals. She has collaboratively published over 50 articles in peer-reviewed journals.
Area of Specialisation:
Dr Taye Lasisi’s research activities have focused mainly on salivary secretion in health and diseases. In that regard, she has studied the effect of various conditions such as pregnancy, exercise, aging, nutritional status, diabetes mellitus, oral squamous cell carcinoma, malaria, chronic kidney disease and sleep deprivation on salivary secretion in human and animal models. Her research has found that diabetes as well as malaria is associated with reduced salivary flow rate which has also been implicated in some oral complications of these conditions. Her research on pregnancy and salivary secretion has found that pregnant women are predisposed to higher caries incidence due to reduced salivary pH and bicarbonate concentrations. Furthermore, from her work on the role of salivary cytokines and antimicrobial proteins in pregnancy-induced oral changes, correlations were found between salivary IFN-gamma along with TNF-alpha and periodontal indices. Thus, indicating the contributions of these salivary factors to the pathophysiology of pregnancy-induced periodontal inflammation. Her studies on salivary immunoglobulin classes in cancer patients found that serum IgA appeared to be better index than salivary IgA whereas salivary IgG may be a useful biomarker in patients with head and neck squamous cell carcinoma. Her study on salivary secretion in patients with chronic kidney disease won the best outstanding iresearch Award of the College of Medicine, University of Ibadan in 2016. Some of the findings were that analysis of salivary urea and creatinine in patients with CKD showed good sensitivity and specificity (86% and 94% respectively, for urea and 93% and 85% respectively, for creatinine) and that saliva also reflected the plasma levels of biochemical factors in the pre and post dialysis states. Hence, saliva could be an alternative to blood in monitoring patients with CKD undergoing dialysis. Her work on salivary secretion and sleep deprivation in animal models for the first time reported that total sleep deprivation was associated with reduced salivary flow rate, secretion rate of IgA as well as increased amylase activity. From her work on nutritional status and salivary secretion in animal model, it was reported for the first time that diet-induced obesity as well as kwashiorkor, resulted in impairments of salivary secretion which were reversed by returning to normal diet. Her study for the first time has demonstrated that kwashiorkor caused significant reduction in salivary secretion through reduction of nitric oxide level and aquaporin5 expression in the submandibular salivary glands.
Research
Current Research and Capacity Building Projects including Grants
1. Title: Effect of sleep deprivation on salivary secretion
Funder: Self
Brief Summary: Some of the findings have shown that total sleep deprivation is associated with impaired salivary function in animal models. We are currently investigating the mechanisms underlying impaired salivary secretion associated with sleep deprivation.
Role: Principal investigator
2. Title: Influence of different regime of intermittent fasting on salivary secretion.
Funder: Self
Brief Summary: This study aims at assessing the effect of different regime of intermittent fasting on salivary secretion and their mechanisms.
Role: Principal investigator
Completed Research
1. Evaluation of salivary secretion and composition in pregnant and non-pregnant women.
2. Age-related changes in salivary secretion and composition in rats.
3. Oral health and salivary secretion in diabetic patients.
4. Association of Langerhans cells with histological grade of oral squamous cell carcinoma.
5. Serum and salivary immunoglobulin profile of UCH patients with orofacial carcinoma.
6. Association between oral health, salivary cytokines and growth hormones among sports and non-sports persons in selected sports settings in Ibadan.
7. Oral and salivary changes in patients with chronic kidney disease.
Publications
1. Lasisi, T.J., Shittu, S.T., Kolade, B.A., Akobi, M.A., Usman, A.A. (2022). Differential effect of short- and long-term caffeine administration on salivary flow rate, amylase, IgA and C-reactive protein in male Wistar rats. Archives of Basic and Applied Medicine Vol. 10. No 1: 15-21. CLICK HERE
2. Shittu, S.T., Lasisi, T.J., Shittu, S.A., Adeyemi, A., Adeoye T.J. and Alada, A.R.A. (2021). Ocimum gratissimum enhances insulin sensitivity in male Wistar Rats with Dexamethasone- induced Insulin Resistance. Journal of Diabetes and Metabolic Disorders Vol. 74. No. 1-2: 10-17. CLICK HERE
3. Yusuf, A.T., Raji, Y.R., Lasisi, T.J., Daniel, A., Bamidele, O.T., Fasunla, A.J., Lasisi, A.O. (2021). Predictors of taste dysfunction and its severity among patients with chronic kidney disease. Ear Nose Throat Journal Vol.100. No. 1:19-25. CLICK HERE
4. Lasisi, T.J., Shittu, S.T., Abeje, J.I., Ogunremi, K.J., Shittu, S.A. (2021). Paradoxical sleep deprivation induces oxidative stress in the submandibular glands of Wistar rats. Journal of Basic and Clinical Physiology and Pharmacology Vol. 32. No 1: 1-6. CLCIK HERE
5. Lasisi, T.J. (2020). COVID-19 diagnosis: how reliable is saliva test? Nig Dent J. Vol. 28: 93-100. CLICK HERE
6. Lasisi, T.J., Lawal F.B. (2019). Preference of saliva over other body fluids as samples for clinical and laboratory investigations among healthcare workers in Ibadan, Nigeria. Pan Afr Med J. Vol. 34: 191. CLICK HERE
7. Lasisi, T.J., Shittu, S.T. and Alada, A.R. (2018). Switching to normal diet reverses kwashiorkor-induced salivary impairments via increased nitric oxide level and expression of aquaporin 5 in the submandibular glands of male Wistar rats. Applied Physiology, Nutrition, and Metabolism. Applied Physiology, Nutrition, and Metabolism Vol. 44 No. 4: 365-372. CLICK HERE
8. Lasisi, T.J. and Abdussalam, A.R. (2018). Pregnancy-induced periodontal inflammation: influence of salivary cytokines and antimicrobial proteins. Saudi Dental Journal Vol. 30. No 3: 306-311. CLICK HERE
9. Lasisi, T.J., Shittu, S.T. and Alada, A.R. (2018). Re-establishing normal diet following high fat diet-induced obesity reverses altered salivary composition in Wistar rats. Journal of Basic and Clinical Physiology and Pharmacology Vol. 30. No 1: 111-120. CLICK HERE
10. Lasisi, T.J. and Abimbola, T.A. (2017). Clinico-pathologic review of biopsied tongue lesions in a Nigerian tertiary hospital. Annals of Ibadan Postgraduate Medicine Vol. 15. No. 2: 109-113. CLICK HERE
11. Lasisi, T.J., Shittu, S.T., Meludu, C.C. and Salami, A.A. (2017). Differential effects of total and partial sleep deprivation on salivary factors in Wistar rats. Archives of Oral Biology Vol. 73. 100-104. CLICK HERE
12. Denise, Y., Tekin, D., Bademci, G., Foster, II J., Cengiz, F.B., Kannan-Sundhari, A., Guo, S., Mittal, R., Zou, B., Grati, M., Kabahuma, R.I., Kameswaran, M., Lasisi, T.J., Adedeji, W.A., Lasisi, O.A., Menendez, I., Herrera, M., Carranza, C., Maroofian, R., Crosby, A.H., Bensaid, M., Masmoudi, S., Behnam, M., Mojarrad, M., Feng, Y., Duman, D., Alex, M.M., Alex, S.N., Blanton, S.H., Liu, X. and Tekin, M. (2016). Spectrum of DNA variants for non-syndromic deafness in a large cohort from multiple continents. Human Genetics Vol. 135. No 8: 953-961. CLICK HERE
13. Lasisi, T.J. and Adeniyi, F.A. (2016). Effects of acute exercise on salivary free Insulin-like Growth Factor 1 and Interleukin 10 in sportsmen; African Health Sciences Vol. 16. No 2, 560-566. CLICK HERE
14. Lasisi, T.J., Raji, Y.R. and Salako, B.L. (2016). Salivary creatinine and urea analysis in patients with chronic kidney disease: A case control study. BMC Nephrology Vol. 17. No 10, 1-6. CLICK HERE
15. Lasisi, T.J., Duru, M.E. and Lawal, B.B. (2015). Salivary secretion and composition in malaria: A case control study. Nigerian Journal of Physiological Sciences Vol. 30. No. 1-2, 119-123. CLICK HERE
16. Lasisi, T.J. and Alada, A.R. (2015). Effects of induced-kwashiorkor on salivary parameters in Wistar rat. African Journal of Medicine and Medical Sciences Vol. 44. No. 2, 125-132. CLICK HERE
17. Lasisi, T.J. and Ngwuadu, P.N. (2014). Pregnancy related changes in human salivary secretion in a Nigerian population. African Journal of Medicine and Medical Sciences Vol. 43. No. 4, 347-351. CLICK HERE
18. Lasisi, T.J., Oluwasola, O.A., Lasisi, O.A. and Akang, E.E. (2013). Association between Langerhans cells population and histological grade of oral squamous cell carcinoma. Journal of Oral and Maxillofacial Pathology Vol. 17. No. 3:329-333. CLICK HERE
19. Lasisi, T.J. and Fasanmade, A.A. (2012). Saliva composition in diabetic and non-diabetic patients. Nigerian Journal of Physiological Sciences Vol.27. No. 2, 79-82. CLICK HERE
20. Lasisi, O.A., Olaniyan, F.A., Muibi, S.A., Azeez, A.I., Idowu, K.G, Lasisi, T.J., Imam, Z.K., Yekini, T.O. and Olayemi, O. (2007). Clinical and demographic risk factors associated with chronic suppurative otitis media. International Journal of Pediatric Otorhinolaryngology Vol. 71. No. 10:1549-1554. CLICK HERE
Supervision
CURRENT STUDENTS
Masters Level(MSc.)
1. Project Title: Anti amnestic potential of bromelain in scopolamine induced memory impairment in Swiss mice
Student’s Name: Lawal Sodiq Olamide
Examining Body: University of Ibadan
Year of Entry: 2020
2. Project Title: Effect of ocimum gratissimum extract on salivary growth factors in Streptozotocin-induced diabetic male Wistar rats
Student’s Name: Lawal Sodiq
Examining Body: University of Ibadan
Year of Entry: 2020
Fellowship Level
3. Project Title: Clinical oral findings and salivary adipokines in type 2 diabetes mellitus patients attending the University College Hospital, Ibadan
Student’s Name: Dr Aminat Ogunlayi
Examining Body: National postgraduate Medical College, Nigeria
Year of Entry: 2020
4. Project Title: Correlation between salivary fructosamine and serum glycated haemoglobin in diabetic patients with or without oral mucosal lesions attending the University College Hospital, Ibadan
Student’s Name: Dr Aminat Ogunlayi
Examining Body: West African College of Surgeons
Year of Entry: 2020
PREVIOUS STUDENTS
Masters Level(MSc.)
1. Project Title: Effect of paradoxical sleep deprivation on salivary secretion: role of inflammation
Student’s Name: Abeje Jude Ijuo
Examining Body: University of Ibadan
Year of Entry: 2018
2. Project Title: Mechanism of hyposalivation in streptozotocin-induced diabetes in Wistar rats
Student’s Name: Asafa Olayinka Olawale
Examining Body: University of Ibadan
Year of Entry: 2018
3. Project Title: Salivary secretion and oxidative stress under different regimen of intermittent fasting in male Wistar rats
Student’s Name: Bolarinwa Bimpe
Examining Body: University of Ibadan
Year of Entry: 2018
Grants
NOT AVAILABLE
Social Media Handle
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Other Interests/Hobbies
I have keen interest in enjoining good and forbidding evil. I have been invited on several occasions to give lectures to different groups of people including students (secondary school, undergraduate and postgraduate), women societies and non-governmental organizations. I have served as executive member of many organizations that promote calling to righteousness including the Muslim Students Society of Nigeria, Dawah Front of Nigeria and Federation of Muslim Women Association of Nigeria. I also love to assist people especially the elderly and the less privileged. I enjoy staying home to do ibadah (worship) and care for my family.