Name: Fatai A. FEHINTOLA Email: This email address is being protected from spambots. You need JavaScript enabled to view it. Alternate Email Address 1: This email address is being protected from spambots. You need JavaScript enabled to view it. Alternate Email Address 2: This email address is being protected from spambots. You need JavaScript enabled to view it. Biography:
Research, Mentoring Activities I have conducted studies on chemotherapy of acute uncomplicated malaria in children and pregnant women, the two population groups most affected by this parasitic infection in endemic sub-Saharan Africa. A few of these studies were funded, and I played the role of Principal Investigator or Co-PI. My research efforts in malaria chemotherapy span well over two decades beginning with in the era of monotherapy to the present combination chemotherapy including the use of Artemisin-based Combination Therapy, ACT. I have also explored Cotrimoxazole, a commonly used antibacterial, as an antimalarial drug and its apparent influence in the seeming delay in the emergence of drug resistance in malaria in Nigeria, given the widespread use with antimalarial drugs. Some of these studies contributed to the body of knowledge on the use of ACTs in Nigeria. Indeed, one of such publications was referenced in the 2011 National Malaria Control Programme of the Federal Government of Nigeria. I acknowledge University of Ibadan Senate Research Grant I also received a NIH-Fogarty In-Country Seed Grant which enabled me and international collaborators to explore pharmacokinetics and pharmacodynamic interactions between antimalarial and anti-retroviral drugs. It is believed that outcome of drug-drug interactions of antimicrobial medications will improve the management of these conditions, and positively impact public health globally. Over the years, particularly in the last one decade I have also devoted substantial efforts to the study of pharmacodynamic drugs, for example, efficacy and tolerability of anti-hypertensive drugs, and I am currently studying aspects of pharmaco-epidemiology and pharmacovigilance. In addition to the highlighted specific research thrust, I: 1. Served as Consultant to the WHO, and MAPS-USAID at various times. 2. Recently served on the Technical Expert Group of the United Nations Office on Drugs and Crimes (UNODC)-Federal Government of Nigeria (FGN) Project for the Review of Curriculum of Medical, Pharmacy and Nursing Schools on the Rational Use of Controlled Medicines. 3. Played pivotal role in the establishment of pharmacovigilance committee in the University College Hospital, Ibadan as the hospital management’s decision was premised on my report which was prompted by the establishment of National Pharmacovigilance Centre in September 2004. Supervised/supervise: 1. Residency Programme – Postgraduate Medical Training 2. PhD/MD Degree (Pharmacology) 3. MSc Degree (Pharmacology & Therapeutics) 4. Provide mentorship to some professional and academic colleagues within and outside University of Ibadan/University College Hospital, Ibadan since well over a decade. Notably, one of Mentees is in receipt of NIH-K43 Grant. Selected Publication Professorial Inaugural Lecture 1. Fehintola F. A. Good for Goose; Grave for Gander: selective toxicity in the service of man. The 404th University of Ibadan Inaugural Lecture Delivered on 23rd March 2017 at the Trenchard Hall, University of Ibadan. Chapter in Book 2. Adedeji WA, Balogun ST, Fehintola FA, Morse GD. Drug-Drug Interactions of Antimalarial Drugs In: Drug Interactions in Infectious Diseases: Antimicrobial Drug Interactions. Ed: Pai, et al, 4th Edition. ISBN 978-3-319-72415-7. Springer International Publishing AG, part of Springer Nature 2018 3. Fehintola FA. Clinical Pharmacology In: Handbook of Medical Emergencies. (In press) Articles published in learned journals 4. Oduola, A.M.J., Omitowoju, G.O., Sowunmi, A., Makler, M.T., Falade, C.O., Kyle, D.E., Fehintola, F.A., Ogundahunsi, O.A.T., Piper, R.C., Schuster, B.G. and Milhous, W.K. (1997): Plasmodium falciparum: evaluation of lactate dehydrogenase in monitoring therapeutic responses to standard antimalarial drugs in Nigeria. Experimental Parasitology; 87: 283-289. 5. Sowunmi, A., Falade, C.O., Oduola, A.M.J., Ogundahunsi, O.A.T., Fehintola, F.A., Gbotosho, G.O., Larcier, P. and Salako, L.A. (1998): Cardiac effects of halofantrine in children suffering from acute uncomplicated falciparum malaria. Trans. R. Soc. Trop. Med. Hyg. 92: 446-448. 6. Sowunmi, A., Fehintola, F.A., Ogundahunsi, O.A.T., Arowojolu, A.O. and Oduola, A.M.J. (1998): Efficacy of chloroquine plus chlorpheniramine in chloroquine resistant falciparum malaria during pregnancy in Nigerian women: a preliminary study. J. Obst. Gynae. 18: 524-527. 7. Salako, B.L., Kadiri, S., Walker, O. and Fehintola, F.A. (1998): An evaluation of lacidipine (a calcium antagonist) in the treatment of hypertension in black African people: A double-blind comparison with hydrochlorthiazide. Afr. J. Med. Med. Sci. 27: 73-75 8. Sowunmi, A., Oduola, A.M.J., Ogundahunsi, O.A.T., Fehintola, F.A., Ilesanmi, O.A., Akinyinka, O.O. and Arowojolu, A.O. (1998): Randomised trial of artemether versus artemether and mefloquine for treatment of chloroquine or sulphadoxine-pyrimethamine-resistant falciparum malaria. J. Obst. Gynae. 18(4): 322-327 9. Sowunmi, A., Fehintola, F.A., Ogundahunsi, O.A.T. and Oduola, A.M.J. (1998): Comparative efficacy of chloroquine plus chlorpheniramine and halofantrine in acute uncomplicated falciparum malaria in Nigerian children. Trans. R. Soc. Trop. Med. Hyg. 92: 441-445 10. Salako, B.L., Kadiri, S., Fehintola, F.A. and Akinkugbe, O.O. (1999): The effect of anti-hypertensive therapy on urinary albumin excretion in Nigerian hypertensives. West Afr. J. Med. 18(3): 170-174. 11. Michael OS, Sogaolu OM, Fehintola FA, Ige OM, Falade CO. Adverse events to the firstline anti-tuberculosis drugs in patients co-infected with HIV and Tuberculosis. Ann. Ib. Postgrad. Med. 2016; 14 (1): 21-29 12. Abdus-Salam RA, Bello FA, Fehintola FA, Arowojolu AO. A comparative study of azithromycin and sulphadoxine-pyrimethamine as prophylaxis against malaria in pregnancy. National Postgraduate Medical Journal. 2016; 23: 57-61 13. Adedeji WA, Igbinoba SI, Fakeye TO, Oladosu IA, Fehintola FA, Ma Q, Morse GD. CYP2D6 phenotype in the Yoruba Nigerian Population. Expert Review in Clinical Pharmacology. 2017; 10 (10): 1145-1152 14. Michael OS, Adedapo ADA, Fehintola FA. Blueprint for healthcare security in Nigeria by 2050: ensuring access, promoting adherence and safe use of medicines. Afr. J. Med. Med. Sc. 2019; 48 (suppl): 105-109 15. Usman Y, Aderibigbe AO, Beneth BA, Fehintola FA. Antipsychotic effects of ethanolic extract of Blighia saphida stembark on pharmacological models of psychosis in Swiss mice. Afr J Med med Sc. 2019; 48 (2): 151 - 160 16. Adedeji WA, Dairo MD, Oyemakinde A, Nguku P, Fehintola FA. Pattern and predictors of antibiotics use among adults in rural and urban communities, Oyo State, Nigeria. Afr J Med med Sc. 2020; 49: (In press) 17. Okpako DT, Fehintola FA. Dinah Mary James, OBE: Tribute to an Amazon of Pharmacology. Archives of Basic and Applied Medicine. 2020; 8 (1): 1-1 18. Adedeji WA, Adegoke AB, Fehintola FA. Adverse drug reactions reporting practice and associated factors among community health extension workers in public health facilities, southwest Nigeria. Pan Afr. Med. J. 2021; 40: 165. DOI: 10.11604/pamj.2021.40.165 19. Okunlola C, Adedeji WA, Balogun ST, Fehintola FA. Assessment of Adherence to IPTp-SP among Pregnant Woemn using lignin test: A preliminary report. Afr. J. Med. Med. Sc. 2021 20. Adedeji WA, Dairo MD, Nguku P, Oyemakinde A, Fehintola FA. Pattern and predictors of medication use among adults in southwestern Nigeria – A cross-sectional study. 2022; Pharmacology Res Perspect. DOI: 10.1002/prp2.1027 MBBS/BDS I have been involved in the teaching of the MBBS/BDS students for more than six years at their various levels of their programme, that is, Introductory, Block I and Block II postings. Some of the lecture topics include: Autacoids, Antihypertensive drugs, Pharmacology of Asthma, Peptic Ulcer Disease, Anti-histamine drugs, Analgesics, Chemotherapy, Drug Interactions and Adverse Drug Reactions. B. Pharm I have been involved in the teaching of Pharmacology Courses at the 300, 400 and 500 Levels for the Pharmacy students since 1999. Courses taught include: Autacoids and Inflammation, Autonomic Pharmacology, Anti-inflammatory drugs, Antihistaminic drugs, Drug metabolism and drug interactions. Other lectures (B. Nursing Science. and B. Physio) The Pharmacology lectures for Physiotherapy and Nursing students is also undertaken by our Department and I have duly involved in the teaching of these health professionals and topics include: chemotherapy of infections, drug treatment of hypertension and asthma as well as antiseptic drugs. Research and Training Supervision I have been actively involved in the supervision of projects/research at both undergraduate and postgraduate levels. Postgraduate Research and Training Supervision I have co-supervised/trained and currently co-supervising/training many candidates for postgraduate academic and/or professional dissertation/thesis since 2005 to date: MSc Candidates’ Supervision/Training Notable MSc Degree Dissertation supervised by me include the under-listed: 1. A. O. Ajala, 2005 - Interaction between Anti-Hypertensive and Non-Steroidal Anti-Inflammatory Drugs: Implication in Management of Osteoarthritis and Opinion on a Compromise Therapy. Department of Physiotherapy, Faculty of Clinical Sciences 2. Yusuf Usman, 2016 - Antipsychotic effect of ethanol extract of Blighia sapida stem bark on pharmacological models of psychosis in Swiss mice. Department of Pharmacology & Therapeutics, Faculty of Basic Medical Sciences, College of Medicine, University of Ibadan 3. Cecilia Okunlola, 2018 - Assessment of adherence to Intermitent Preventive Treatment with Sulphadoxine-pyrimethamine (IPTp- SP) in a selected population of Nigerian Pregnant women. Department of Pharmacology & Therapeutics, Faculty of Basic Medical Sciences. 4. L. O. Ogunjinmi, 2018 - Comparison of hormonal and cognitive effect carbamazepine monotherapy and Levetiracetam monotherapy on adult females with epilepsy. Department of Pharmacology and Therapeutics, Facuty of Basic Medical Sciences, College of Medicine, University of Ibadan. 5. W. A. Adedeji, 2014 - Pattern of antimicrobial prescription and adverse drug reactions reporting among doctors in the Oyo State public health facilities. Department of Pharmacology & Therapeuticss, Faculty of Basic Medical Sciences, College of Medicine. 6. D. A. Adebayo, 2022 – Assessment of Adherence to Intermittent Preventive Treatment in Pregnancy with Sulphadoxine-pyrimethamine using Lignin Test. Department of Pharmacology Therapeutics, Faculty of Basic Medical Sciences 7. Taiwo Omotoso, 2023 – Concomittant use of antituberculosis drugs and other antimicrobial drugs among tuberculosis patients in two selected hospitals in Ibadan. Department of Pharmacology & Therapeutics, Faculty of Basic Medical Scoences 8. Oluwatonilola Akinbami, 2023 – Concomittant use of Anti-hypertensive drugs and antituberculosis drugs the University College Hospital and Jericho Specialist hospital, Ibadan. Department of Pharmacology & Therapeutics, Faculty of Basic Medical Sciences MD/PhD Theses/Dissertations I supervised/co-supervised the following MD/PhD Candidates 1. T. Balogun, PhD (University of Maiduguri, June 2014) 2. O. Ogunjimi, MD (University of Ibadan, September 2023) Postgraduate Medical Fellowship Training/Supervision I contributed substantially to the fellowship training/supervision of the following Candidates (Fellows): 1. Obaro S. Michael Title: Adverse Drug Reactions in Patients with and without HIV/AIDS on Treatment for Tuberculosis at the University College Hospital Ibadan, Nigeria. [NPMCN, 2009] 2. Dr Emmanuel Tunde OSINUGA 3. Dr Adeola R. ABDUS-SALAM 4. Dr Waheed A. Adedeji MD/PhD Examinations I served as Examiner and/or Chairman during the defence of the MD/PhD Degree Theses of the under-listed Candidates: 1. Sulayman Tunde BALOGUN, PhD, University of Maiduguri, June 2014 2. Mathew Olugbenga AJULO, PhD, Faculty of Pharmacy, 2015 3. Emmanuel Olagboye TAIWO, MD, Faculty of Clinical Sciences, April 2016 4. Segun Johnson SHOWANDE, PhD, Faculty of Pharmacy, February 2017 5. Oritoke Modupe ALUKO, PhD, Faculty of Basic Medical Sciences, March 2020 6. Itievere Adrian OMOGBIYA, PhD, Faculty of Basic Medical Sciences, January 2021 7. Akinyinka Oladapo ALABI, PhD, Faculty of Basic Medical Sciences, March 2021 8. Rasidat Olufunke TIJANI, PhD, Faculty of Basic Medical Sciences, March 2021 9. Ayaebi Okubo ENENI, PhD, Faculty of Basic Medical Sciences, March 2021 10. Gladys Onyinye AGU, PhD, Faculty of Basic Medical Sciences, July 2021 11. Oluwakemi Omolade ARIYO, PhD, Faculty of Basic Medical Sciences, July 2021 12. Abimbola Sadiat OLUGBEMIDE, PhD, Faculty of Basic Medical Sciences, Nov. 2021 13. Jeremiah John OLOCHE, PhD, Faculty of Basic Medical Sciences, November 2021 14. Akinniyi Akinbiyi AJE, PhD, Faculty of Pharmacy, February 2022 15. Luqman Opeyemi OGUNJIMI, MD, Faculty of Basic Medical Sciences, Sep. 2023 Fellowship Examinations (Examiner/Chairman) – National Postgraduate Medical College of Nigeria (NPMCN) I served on the team of examiners and/or as Chairman during the fellowship examinations in Internal Medicine/Clinical Pharmacology & Therapeutics (CPT) for the following Candidates (Fellows): 1. Adedayo F. Asalu, FMCP, May 2006 - NPMCN 2. Peter E. Akhideno, FMCP (CPT), May 2011 - NPMCN 3. Nwani Paul Osemeke, FMCP (CPT), May 2011 – NPMCN 4. Abimbola OLOWOFELA, FMCP (CPT) November 2011 - NPMCN 5. Stephen A. Ayinbuomwan, FMCP (CPT), November 2011 - NPMCN 6. Joseph Ogirima OVOSI, FMCP (CPT), November 2014 - NPMCN 7. Waheed A. Adedeji, FMCP (CPT), November 2016 - NPMCN 8. Oluwafunmibi Enitan Anjorin, FMCP (CPT), 2019 - NPMCN 9. Olaleken Agede, FMCP (CPT), 2019 - NPMCN Undergraduate supervision B. Pharm. I supervised more than a dozen B. Pharm Projects.Profile
Designation: Professor
Faculty: Basic Clinical Sciences
Department: Pharmacology and Therapeutics
ORCID Profile
Research
Publications
Supervision
Title: Assessment of Antimalarial susceptibility of Plasmodium falciparum isolates to selected antimalarial drugs in Maiduguri, Norstheast, Nigeria
Title: Evaluation of beneficial effects of Levetiracetam and Carbamazepine in Post-Stroke Epilepsy
Title: Cross-sectional survey of Malaria Parasitaemia amongst Pregnant Women attending Antenatal Booking Clinic at Adeoyo Maternity Hospital, Ibadan, Nigeria [WACS, 2011]
Title: Prevalence of Malaria parasitaemia among pregnant Women attending Antenatal Clinic at University College Hospital, Ibadan [NPMCN, 2011]
Title: A Comparative Study of Azithromycin and Sulphadoxine-Pyrimethamine as Prophylaxis against Malaria in Pregnancy [NPMCN, 2013]
Title: Evaluation of CYP2D6 Phenotype in the Yoruba-Nigerian Population [National Postgraduate Medical College of Nigeria, NPMCN, November 2016]Social Media Handle
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