Current Research and Capacity Building Projects including Grants 1. Tranexamic acid for reducing postpartum bleeding in women with anaemia: an international, randomised, double-blind, placebo controlled trial (WOMAN-2 trial) (ClinicalTrials.gov Identifier: NCT03475342) Wellcome Trust and Bill & Melinda Gates Foundation. Tranexamic acid (TXA) has been established as an effective treatment for post-partum haemorrhage (PPH), when used within three hours of delivery. This is a multi-centre, multi-country clinical trial that aims to assess the prophylactic use of tranexamic acid for PPH in anaemic women (who are susceptible to blood loss). All women admitted into labour ward for vaginal delivery at the study sites are screened with a hand-held haemoglobin reader (Hemocue). Women with haemoglobin ≤9.5 mg/dL are recruited and given the trial treatment (TXA or placebo) immediately after delivery. Blood loss is measured clinically, follow-up haemoglobin measurements are taken, and a walk test and other parameters to assess anaemia are carried out. Nigeria has four study sites at present and three more sites are being assessed for suitability. I oversee the study at all the Nigerian centres. National coordinating investigator. Professors Haleema Shakur-Still & Ian Roberts, Clinical Trial Unit, London School of Hygiene and Tropical Medicine. 2. Physiologic Mechanisms Underlying Ovarian Follicular Waves During the Menstrual Cycle (ClinicalTrials.gov Identifier: NCT05531357). Royal Hospital University Foundation and MITACS. Fifty healthy women of reproductive age have transvaginal ultrasound scans performed every day of an interovulatory interval to assess follicle counts and diameters. They also have daily finger-prick blood and urine samples to assess pituitary and ovarian reproductive hormones. These are aimed to investigate the multiple ovarian follicle wave theory and to assess the hormonal regulation of the wave phenomenon. It is expected to have clinical applications in assisted conception and hormonal contraception. Co-investigator. Dr Angela Baerwald, University of Saskatchewan. 3. Epidemiologic and Biochemical Profile of Polycystic Ovarian Syndrome in an African Population. TETFund. There is paucity of data on polycystic ovarian phenotypes in the study environment. The study aimed to evaluate anthropometric and biochemical associations with polycystic ovarian morphology identified on transvaginal ultrasound scans. One hundred and forty patients were recruited from gynaecology clinic. Information was obtained on clinical hyperandrogenism and menstrual irregularity to diagnose polycystic ovarian syndrome. Anthropometric measurements were body mass index and waist: hip ratio. Hormonal assays carried out were FSH, LH, AMH, estradiol, fasting glucose, testosterone and sex hormone binding protein. Principal investigator. Ogunbode OO, Morhason-Bello IO, Obajimi OO, Kuti MA. Journal Articles 1. Serwaa D, Bello FA, Osungbade KO, Nkansah C, Osei-Boakye F, Appiah SK, Antwi MH, Danquah M, Buckman TA, and Owusu E. (2021) Prevalence and determinants of low testosterone levels in men with Type 2 diabetes mellitus; a case-control study in a district hospital in Ghana. PLOS Global Public Health. Vol. 1. No. 12: e0000052 Click here 2. Unwaha, E.A., Bello, F.A., Bello, O.O. and Oladokun, A. (2020) Intravenous magnesium sulfate in the management of severe pre-eclampsia: A randomized study of 12-hour versus 24-hour maintenance dose. International Journal of Gynecology and Obstetrics. Vol. 149. No. 1: 37-42.International Journal of Gynecology and Obstetrics. Vol. 149. No. 1: 37-42. click here 3. Akinyotu O. O., Bello F. A., Abdus-Salam R. A. and Arowojolu A. O. (2018) Comparative study of mefloquine and sulphadoxine–pyrimethamine for malaria prevention among pregnant women with HIV in southwest Nigeria.Comparative study of mefloquine and sulphadoxine–pyrimethamine for malaria prevention among pregnant women with HIV in southwest Nigeria. International Journal of Gynecology and Obstetrics. Vol. 142. No. 2: 194-200.International Journal of Gynecology and Obstetrics. Vol. 142. No. 2: 194-200. Click here 4. Bello, F.A., Fawole, B., Oluborode, B., Awowole, I., Irinyenikan, T., Awonuga, D., Loto, O., Fabamwo, A., Guest, P. and Ganatra, B. (2018) Trends in misoprostol use and abortion complications: a cross-sectional study from nine referral hospitals in Nigeria.Trends in misoprostol use and abortion complications: a cross-sectional study from nine referral hospitals in Nigeria. PLoS One. Vol. 13. No. 12: e0209415. Click here 5. WOMAN Trial Collaborators. (2017) Effect of early tranexamic acid administration on mortality, hysterectomy, and other morbidities in women with post-partum haemorrhage (WOMAN): an international, randomised, double-blind, placebo-controlled trial.Publisher: Lancet. Vol. 389. No. 10084: 2105-2116. Click here 6. Bello, F.A., Tsele, T.A. and Oluwasola, T.O. (2015)Bello, F.A., Tsele, T.A. and Oluwasola, T.O. (2015)Title: Decision-Delivery Interval and Perinatal Outcome Following Emergency Caesarean Section in a Nigerian Tertiary HospitalInternational Journal of Gynecology and Obstetrics. Vol. 130. No. 3: 279-283. Click here 7. Fawole, A.O., Bello, F.A., Ogunbode, O., Odukogbe, A.A., Nkwocha, G.C., Nnoaham, K.E., Zondervan, K.T., Akintan, A., Abdus-Salam, R.A. and Okunlola MA. : Endometriosis and associated symptoms among Nigerian women. Endometriosis and associated symptoms among Nigerian women. International Journal of Gynecology and Obstetrics. Vol. 130. No. 2:190-4. Click here 8. Bello, F.A., Ogunbode, O.O., Adesina, O.A., Olayemi, O., Awonuga, O.M. and Adewole, I.F. Bello, F.A., Ogunbode, O.O., Adesina, O.A., Olayemi, O., Awonuga, O.M. and Adewole, I.F. (2011) Acceptability of Counselling and Testing for HIV Infection in Women in Labour at the University College Hospital, Ibadan, Nigeria.Acceptability of Counselling and Testing for HIV Infection in Women in Labour at the University College Hospital, Ibadan, Nigeria. African Health Sciences Vol. 11. No. 1: 30-35. Click here CURRENT STUDENTS Masters Level Project Title: Prevalence of anti-sperm antibodies and the association with semen quality among men attending Biasa Clinic, IVF Centre, Lome, Togo for infertility investigation.Pan African University Life and Earth Sciences Institute (PAULESI), University of Ibadan, 2021; Essolakina Gnoneye Project Title: Condom utilization for sexually transmitted infection prevention and associated factors among pregnant women in Maznini region, Eswatini. Pan African University Life and Earth Sciences Institute (PAULESI), University of Ibadan, 2020; Vuyani Simelane Project Title: Disparities Between Contraceptive Preference and Practice Among Sexually Active Women of Reproductive Age in Ibadan North Local Government Area, Oyo State. University of Ibadan, 2019; Veronica Obiuwevbi
Doctoral Level Project Title:Exclusive breastfeeding in Chad: explanatory factors and impact on infant health, Pan African University Life and Earth Sciences Institute (PAULESI), University of Ibadan, 2021; : Habib Foba Project Title:Serum bisphenol-A level, ovarian reserve, and nuclear receptor gene expression among infertile women in Ibadan, University of Ibadan, 2020; John Odjenimah Project Title:Biochemical and gene expression studies on uterine fibroid patients in Ibadan, Oyo State, Nigeria,Covenant University, Ota, Nigeria, 2019; Mary Okesola
PREVIOUS STUDENTS Masters Level Project Title:The association between seminal plasma copper and magnesium with abnormal and normal semen parameters in adult males in Ibadan, Oyo State, Nigeria. Pan African University Life and Earth Sciences Institute (PAULESI), University of Ibadan, 2021; Uthman Qozeem Ojo Project Title:The association of seminal human papillomavirus and semen parameters in patients referred for seminal fluid analysis in University College Hospital, Ibadan, Nigeria Pan African University Life and Earth Sciences Institute (PAULESI), University of Ibadan 2020; Selasie Ahiatrogah Project Title:Comparison of sex hormone levels among type II diabetic and non-diabetics in Offinso North district, Ghana Pan African University Life and Earth Sciences Institute (PAULESI), University of Ibadan 2019;: Dorcas Serwaa
DOCTORAL LEVEL Fellowship Project Title:Effects of Maternal Ambulation during Labour on Duration and other Labour Outcomes at University College Hospital Ibadan: A Randomised Controlled Trial. West African College of Surgeons 2021; Dr R.E. Takpe Project Title:Twelve hours’ versus Twenty-Four hours Intravenous Magnesium Sulphate in the Management of Severe Pre-Eclampsia at the University College Hospital, Ibadan. West African College of Surgeons 2017; Dr E.A. Unwaha Project Title:Mefloquine versus Sulphadoxine-Pyrimethamine as Intermittent Preventive Treatment for Malaria in HIV Positive Pregnant Women in Ibadan: A Randomized Control Trial. National Postgraduate College of Nigeria 2017; Dr O.O. Akinyotu
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