Name: John O. OGUNBIYI Google Scholar Profile Email: This email address is being protected from spambots. You need JavaScript enabled to view it. Alternative Email Address 1: This email address is being protected from spambots. You need JavaScript enabled to view it. Alternative Email Address: This email address is being protected from spambots. You need JavaScript enabled to view it. Brief Biography: I graduated MBBS from the University of Lagos, Nigeria (1983). I undertook residency training at the University College Hospital Ibadan and obtained the Fellowship of the West African Postgraduate Medical College (FWACP (Lab Med)) in 1990. I joined the College of Medicine of the University of Ibadan as Faculty member (Lecturer I) in December 1990 and was appointed honorary Consultant Pathologist to the University College Hospital at the same time. I did a one-year Postdoctoral Research Fellowship at the W.H.O.’s International Agency for Research in Cancer, Lyon France (1992) and was Visiting Research Scientist at the Eccles Institute of Human Genetics of the University of Utah, Salt Lake City, USA both in 1993 and in 1995. I became full Professor in Anatomical Pathology Oct 1999. I have therefore worked as an undergraduate lecturer and a postgraduate resident trainer since December 1990. In the course of time I served as Sub-dean Undergraduate Studies and Sub-dean Postgraduate studies in the Faculty of Basic Medical Sciences for periods of 4 years each and as Head of Department twice also for 4 year periods each time. Additional Certificate Courses undertaken include the Certificate of Immunology of the CMUI/UCH, Certificate in Radiation Safety of the University of Utah, as well as the following from the University of Washington Global Health Programme: Leadership and Management in Health (2018), Project Management in Global Health (2019), and Fundamentals of Implementation Science (2020). I was awarded the International Fellowship of the College of American Pathologists (IFCAP), as well as the Fellowship of the East Central and Southern African College of Pathologists [FCPath (ECSA)]. I am the Foundation President of the West African Division of the International Academy of Pathology (WADIAP, now AWADIAP), am a Foundation fellow of the Nigerian Academy of Medicine (FNAMed) and a Foundation Fellow of the Academy of Medicine Specialties of Nigeria (FAMedS). My research interests are in Genetic Epidemiology of Prostate cancer and I keep a continuing keen interest in Lung, Liver and colon pathology. More recently I am trying to find grounds in knowledge of pathology informatics and application for Nigeria. I worked as Visiting Professor and Consultant Pathologist at the College of Medicine and Allied Health Sciences (COMAHS) of the University of Sierra Leone, Kwame Nkrumah University of Science and Technology (KNUST), Kumasi, Ghana and at the Sultan Qaboos University (SQU), Muscat, Oman. During these times and subsequently, I have served as external examiner in Pathology for both local and regional medical schools and Colleges and have examined for the West African College of Physicians in Laboratory Medicine, West African College of Surgeons in Pathology, and the Nigerian National Postgraduate Medical College in Pathology. I also examined for the Ghana College of Physicians and Surgeons in Pathology. was a member of the advisory board of the West African Journal of Medicine. As the West African health community evolved into the WAHO, it became necessary to ensure equivalencies of the qualifications obtained in all West African training programme. 1. Aken’Ova Y.A, Olasode B.J, Ogunbiyi JO and Thomas J.O. (1993). Hepatobiliary changes in Nigerians with sickle cell anaemia. Annals of Tropical Medicine and Parasitology 87(6): 603-606. 2. Oshima H, Bandaletova TY, Brouet I, Bartsch H, Kirby G, Ogunbiyi F,VatanasaptV, and Pipitgool V (1994). Increased nitrosamine and nitrate biosynthesis mediated by nitric oxide synthase induced in hamsters infected with liver fluke (Opistorchis viverrini). Carcinogenesis 15(2): 271-75. 3. Ogunbiyi JO (1997) Metastatic Tumours in the Liver: A 10-year biopsy study. Qt. J. Hosp. Med. 7 (3): 220 – 223. 4. Ogunbiyi JO (2001). Hepatocellular carcinoma in the developing world. Seminars in Oncology, 28(2): 179-187. 5. Akinyinka OO, Falade AG, Ogunbiyi O, Johnson AOK (2001). Hepatocellular carcinoma in Nigerian children. Annals of Tropical Paediatrics 21: 165-168 6. Ndububa DA, Yakicier CM, Ojo OS, Adeodu OO, Rotimi O, Ogunbiyi O, and Ozturk M (2001). P53 codon 249 mutation in hepatocellular carcinomas from Nigeria. J. Med. med. Sci. 30: 125-127. 7. Lawan AI and Ogunbiyi JO (2013). Aetiological and histopathological correlates of Liver cirrhosis in Nigeria. Nig. J Gastroeneterol Hepatol 5(1): 7-12. 8. Irabor D, Oluwasola OA, Ogunbiyi OJ, Ogun OG, Okolo CA, Melas M, Gruber SB, Shi C and Raskin L (2017). Microsatellite Instability Is Common in Colorectal Cancer in Native Nigerians. Anticancer Research 37: 2649-2654. doi:10.21873/anticanres.11612 9. Ezenkwa US, Ogun GO, Bamiro OO, Mashor MI, Okolo CA, Adegoke OO, Ogunbiyi OJ (2020). Pattern and Significance of Tumour Budding in Colorectal Carcinoms using the ITBCC Guidelines: A low resource setting practice observation. Journal of Gastrointestinal Cancer. Jan 22. Doi 10.1007/s12029-020-00365-4 10. Ogunbiyi, J.O. (1995). Lung cancers at the University College Hospital, Ibadan. Nigeria. Afr. J. Med 14: 50-55. 11. Ogunbiyi JO, Ogun GO, and Okani CO (2012). Dendriform pulmonary ossification with lymphocytic thyroiditis in a young Nigerian woman: original report of an association. J. Med. med. Sci. 41, 97-101. 12. Rotimi C, Cooper R, Ogunbiyi O, Morrison L, Ladipo M, Tewksbury D, Ward R. (1997) Hypertension, serum angiotensinogen and molecular variants of the angiotensinogen gene among Nigerians. Circulation 95: 2348 - 2350. 13. Guo X, Rotimi C, Cooper R, Luke A, Elston RC, Ogunbiyi O, and Ward R. (1999) Evidence of a major gene effect for angiotensinogen among Nigerians. Hum. Genet. 63: 293-300. 14. Ogunbiyi JO (1998). Epidemiology of Cancer in Ibadan: Tumours in adulthood. Archives of Ibadan Medicine, U.K 1 (2): 9-12 15. Ogunbiyi JO and Shittu OB (1999). Increased incidence of prostate cancer in Nigeria.J Natl. Med Assoc. 91(3):159 – 164. 16. Olapade-Olaopa EO, Moscatello DK, MacKay EH, Ogunbiyi JO, Shittu OB, Terry TR, Okeke LI, Wong AJ, Habib FK. (2007). A variant epidermal growth factor receptor protein is similarly expressed in benign hyperplastic and carcinomatous prostatic tissues in black and white men. West Afr J Med.26:42-7. 17. Okolo CA, Akinosun OM, Shittu OB, Olapade-Olaopa EO, Okeke LI, Akang EEU, Ogunbiyi JO (2008). Correlation of Serum PSA and Gleason Score in Nigerian Men with Prostate Cancer. J. Urol 14: 15-22. 18. Allemani C, Weir KH, Carriera H, Harewood R, Spika D, Wang X-S, Bannon F, Ahn JV, et al (2014): THELANCET-D-14-07220R1, Global surveillance of cancer survival 1995-2009: analysis of individual data for 25,676,877 patients from 279 population-based registries in 67 countries (CONCORD-2). 19. Allemani C, Matsuda T, Di Carlo V, Harewood R, Matz M, Nikšic Ḿ, Bonaventure A, Valkov M, Johnson CJ, Estève J, Ogunbiyi OJ, Azevedo e Silva G, Chen W-Q, …… Coleman MP, CONCORD Working Group* (2018). Global surveillance of trends in cancer survival 2000–14 (CONCORD-3): analysis of individual records for 37 513 025 patients diagnosed with one of 18 cancers from 322 population-based registries in 71 countries (17)33326-3. Click here 20. Joko-Fru WY, Jedy-Agba E, KorirA, Ogunbiyi O,Dzamalala CP, Chokunonga E, Wabinga H, Finesse A, Somdyala N, Liu BJemal A, Bray F, Parkin DM (2020). The evolving epidemic of breast cancer in sub-Saharan Africa: Results from the African Cancer Registry Network. Int. J. Cancer, 147:2131–2141. Cancer Epidemiology DOI: 10.1002/ijc.33014 CURRENT STUDENTS Fellowship Level 1. Title: Prognostic Utility of KI-67 expression in low grade Prostate Adenocarcinomas at the University College Hospital, Ibadan. PREVIOUS STUDENTS 1. Title: - VenusCancer Study 2. Title: Genomic Diversity of Prostate Cancer Across the African Diaspora (MADGAP) Network (Men of Africa Decent Carcinoma of the Prostate) 3. Title: Improving Population Level Stage of Diagnosis and Estimation of Cancer Survival in Nigerian Cancer Registries (IMPACT) Facebook: Profile Link LinkedIn: Profile Link Twitter: Profile Link Instagram: Profile Link YouTube: Profile Link Pinterest: Profile LinkProfile
Designation: Professor
Faculty: BASIC CLINICAL SCIENCES
Department: Pathology
Publications
Supervision
Student's Name: Ifeayin Nwanji
Year: October, 2022.
Fellowship Level
Student's Name: Dr. A. O. Oluwasola
Year: October, 1998
Student's Name: Dr. Martin A Nzegwu
Year: September, 2004.
Student's Name: Dr. Clement Abu Okolo
Year: 2004.
Student's Name: Dr. A. O. Adeoye
Year: October, 2007.
Student's Name: Dr. Michael E. Onwukamuche
Examination Body: National Postgraduate Medical College of Nigeria
Year: 2010.
Student's Name: Dr. Chukwudi O. Okani
Examination Body: National Postgraduate Medical College of Nigeria
Year: 2012
Student's Name: Dr. Taiwo Olabimpe Babatunde
Year: October, 2013.
Student's Name: Dr. Adesoji Ebenezer Adetona
Year: April, 2015.
Student's Name: Dr. Gbadegesin Junaid Oladapo
Year: April, 2018.
Student's Name: Dr. Uchenna Simon Ezenkwa
Year: June 2019.
Student's Name: Dr. Mbwas Isaac Mashor
Year: October, 2019.
Student's Name: Dr. Mbwas Isaac Mashor
Year: October, 2019.
Student's Name: Dr. Ezenkwa, Uchenna Simon
Year: May, 2020.
Student's Name: Dr. Francis Akarovyo Onakpoma
Year: October, 2020
Student's Name: Dr. John Ifeanyi Nwadiokwu
Year: April, 2021.Grants
Funder: European Research Council. (Grant 772345 ERC 2017-COG, EPNCZNB53)
Brief Summary: The main thrust of this project is to do a worldwide comparison of survival outcomes in female cancers by comparing stage at diagnosis with the therapy provided to these patients.
Role: Subcontractor
Collaborators: Allemani et al, London School of Health and Tropical Medicine.
Funder: National Institutes of Health, USA. (RO1CA259200)
Brief Summary: Cancer registration is often neglected in sub-Saharan Africa owing to competing demands for resources for healthcare. Cancer registries therefore often encounter key challenges to their activities, which hinder their ability to expand cancer registration coverage and improve data completeness and accuracy. Yet cancers in Nigeria are often underdiagnosed or diagnosed at late stages and very few SSA countries have functional population-based cancer registries (PBCRs) that provide accurate data on stage at diagnosis at the population- level even for the most common cancers (breast, cervix, colon-rectum and prostate). Currently, cancer staging information is not routinely collected in Nigeria cancer registries and status of patient is often not recorded in cancer registry databases making it difficult to conduct any meaningful cancer survival analyses. Characterizing the actual burden of cancers and accurately determining survival from cancer across Africa is mostly speculative, based on information from highly selective cases series, or simply estimated. This study aims to investigate stage at diagnosis and cancer survival for the four most commonly diagnosed cancers in Nigeria using data from five population-based cancer registries with the overarching goal to provide new information on stage at diagnosis and cancer survival (by stage) in these 4 cancers, and to identify the determinants and factors associated with survival in Nigeria. Data generated should result in an improvement in overall cancer registry data quality (completeness, accuracy and timeliness). It will be critical in decision making and will inform the development of cancer prevention and control strategies in the country’s subsequent cancer control plans.
Role: Site Investigator
Collaborators: Dr Elima Jeddy-Agba, Institute of Human Virology Abuja + the African Cancer Registry Network. Elima Jedy Agba- Institute of Human Virology, Nigeria, Dr. Festus Igbinoba - National Hospital Abuja, Nigeria, Dr. Abidemi Omonisi - Federal Medical Centre Ado Ekiti, Prof. Ima Ekanem - University of Calabar Teaching Hospital, Cross River, Prof. Emmanuel Ezeome - University of Nigeria Teaching Hospital Enugu and the African Cancer Registry Network (AFCRN).Social Media Handle