Prof. Samuel B. OLALEYE

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	Name: Samuel B. OLALEYE
	Designation: Professor
	Faculty: Basic Medical Sciences
	Department: Physiology
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Biography:
The Revd. Canon Samuel Babafemi Olaleye, Professor of Physiology, was born in Ibadan and was educated at Omolewa Nursery/Primary Institution (1971-1979), Ibadan Grammar School, Ibadan (1980 -1982) and Moremi High School, University of Ife (now OAU) Ile-Ife (1982-1985). He also attended Federal Government College, Ilorin for his A-levels. He obtained his B.Sc., M.Sc. and Ph.D. degrees in 1990, 1992 and 1999 respectively from Ibadan. As a postgraduate student, he won many scholarships, including the Federal Government Postgraduate Scholarship (1991), Oyo State Government Scholarship (1992) and was the first recipient of the M.K.O. Abiola Postgraduate scholarship at UI.

He joined the services of the University of Ibadan in 1996 as a Lecturer grade II having previously worked at the Universities of Maiduguri (1992-1995) and Ilorin (1995 - 1996). He was promoted Lecturer I in 1999, Senior Lecturer in 2002, Reader in 2007 and Professor in 2012.   He was a postdoctoral Fellow at the Department of Pharmacology of the School of Medicine, University of Hong Kong at Sassoon Road, Pokfulam. He was the twelfth Dean of the Faculty of Basic Medical Sciences (August 1, 2018 – July 31 2022). He assumed duty as the 12^th Head of the Department of Physiology on August 1, 2022. He is also the Director, Laboratories for Gastrointestinal Secretion and Inflammation Research in the Department of Physiology.

He has been Visiting Professor to Niger Delta University, Wilberforce Island, Nigeria (2004 – 2005), University of Maiduguri (2010 – 2014), Kampala International University, Uganda (2015-2016). He also served as a W.H.O Teaching consultant and visiting Professor to the University of Sierra Leone (2017 – 2018). He is a recipient of a number of institutional, national and International Fellowships and Grants including MacArthur Foundation Fellowship (2005) and ICGEB (2017, 2019).  He has served as Convener/Facilitator for many workshops and conferences for the Medical Education Partnership Initiative (MEPI), DrosAfrica, Physiological Society of Nigeria and the University of Ibadan.

He is a member of several professional associations, including the American Physiological Society (APS), African Association for Physiological Sciences, the Physiological Society of Nigeria and Nigerian Society for Experimental Biology. A consultant to many Scientific Journals, he is the current Editor-in-Chief of the Nigerian Journal of Physiological Sciences and African Journal of Biomedical Research. He is the President of the African Society for Drosophila Research (ASDR). He has supervised and mentored over 75 BSc, 58 MSc and 15 PhD students. As at September 2022, he has a total of 121 publications and over 40 conference proceedings. in local and international Journals, with an overall h-index score of 20. 

Area of Specialisation
The major forte of his research activities for over 25 years has been in the area of dietary and environmental factors in gastrointestinal inflammation and secretion. His current research is in Gastrointestinal Toxicology, specifically on the role of trace elements in gastrointestinal tract function as well as the efficacy of natural products in pain and ulcer treatments.

Resume

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Research

Current Research and Capacity Building Projects

1. Medicinal plant screening for antiulcer and anti-inflammatory activities along the gastrointestinal tract: I have been involved in screening medicinal plants for possible gastroprotective and antiulcer activities. Several other natural compounds – Buchholzia coriacea, Landolphia owarensis, Occimum gratissimum, Eucalyptus torrelliana, Eucalyptus camauldulensis, Bryophyllum pinnatum, Aspila Africana; Hendrathera barteri, Chrysophyllum albidum and Soybean (Glycine max) and Chasmanthera dependens have bee screened and shown to have potent antiulcer activities. It is also worthy of note that a number of the candidate products found to be anti-ulcerogenic also possess antimicrobial activities. The possibility that the ability of these agents to inhibit Helicobacter pylori (another important ulcerogenic factor) are being investigated. Of all the plants that we have screened in our laboratory, none has received much attention than Garcinia kola, a tropical flowering plant found in western and central Africa. Specifically, we investigated the effect Kolaviron, the active component of G. kola found to be responsible for most of its gastrointestinal effects. Using several animal models (Pylorus ligation, Ethanol, acidified ethanol, indomethacin, ischaemic injury) and cell line models of ulcers, the effectiveness of Garcinia kola in inhibiting inflammatory gastric ulcers was established. Such action was further established using biochemical indices and markers of oxidative and molecular damage to proteins.

2. Antimalaria drugs and ulcer formation and prevention: Prompted by reports of increasing cases of non- prescribed anti-malarial drugs used in malaria-prone areas and the fact that the dosage regimen taken is incorrect in most cases, I started a series of investigations into how various classes of anti-malaria drugs affect gastrointestinal function and inflammation. Results from these studies showed that Chloroquine and amodiaquine worsens gastric lesions produced by both ulcerogens, increased indicators of lipid peroxidation and decreased protein, catalase and mucous content of the gastric mucosal samples. On the other hand, artemisinin ameliorates the effect of indomethacin and may be considered safe to the rat stomach.

3. Age and Ulcer healing: We have reported, through several studies, that age is an important factor in not only ulcerogenesis, but also in the delayed ulcer healing process. Studies from our laboratory further revealed that reduced epithelial cell proliferation and angiogenic activities are responsible for the reduced gastric mucosa healing time observed in aged rats. This conclusion was premised upon the finding that the expression of markers of cell proliferation (KI67 and EGFR) and angiogenesis (factor VIII and CD31) were reduced significantly in the aged rats. Moreso, effective red blood cell circulation is essential in the process of healing of ulcer, since haemoglobin residing in the red blood cell is responsible for the amount of oxygen carried by the blood to be delivered to the tissues.

4. Studies on heavy metals and trace elements and gastrointestinal function: In our laboratory and others in our network, we pioneered studies that showed that excessive exposure to heavy metals and trace elements may be dangerous to gastrointestinal tract functions. Specifically, Lead, Cadmium, Arsenite and Vanadium have been shown to interfere significantly with Saliva, gastric acid, glucose absorption and antioxidative balance of the gastrointestinal system. However, the benefial effects of manganese, cabalt and vanadium at low doses in gut functions have also been reported.

5. Respiratory and gastrointestinal tract effects of cement dust exposure: Due to the previous challenge of not having a known model for experimental exposure to cement dust as previous studies have relied mainly on questionnaires, examination of health/medical records, interviews and case reports, we developed a model for controlled exposure to cement dust. This model was standardized, with the rate of effusion determined mathematically. Although it was developed for use in our cement dust study, it is equally suitable for studies involving exposure to any airborne pollutant. Subsequently, we have reported that cement dust interferes with several aspects of gastrointestinal and respiratory functions

All the studies reported above were carried out successfully by me, with colleagues and with postgraduate students in my laboratory at the Gastrointestinal Physiology and Inflammation Research Laboratories, Department of Physiology, University of Ibadan, Nigeria) as well as with international scientists in established laboratories in Hong Kong, South Africa, Uganda, India and Japan.

Publications

1. Odukanmi A, Ajala OA, Olaleye SB (2022): Short-term acute constipation and not short-term acute diarrhea altered cardiovascular variables in male Wistar rats. Niger J Physiol Sci. 37(1):43-48. CLICK HERE

2. Owonikoko M.W;  Salami A. T.;  Odukanmi A. O.;  Emikpe B. O.; . Olaleye S. B (2022): Hematopoietic toxicity in Wistar rats experimentally exposed to cement dust. Comparative Clinical Pathology. CLICK HERE

3. Owonikoko MW, BO Emikpe, SB Olaleye (2021): Standardized Experimental Model For Cement Dust Exposure; Tissue Heavy Metal Bioaccumulation and Pulmonary Pathological. Toxicology Reports 8, 1169-1178. CLICK HERE

4. Omayone T and S, B. Olaleye (2021): Biochemical and histopathological effects of low dose vanadium in the healing of acetic acid-induced colitis in male Wistar rats. J Basic Clin Physiol Pharmacol. 33(3):273-283. CLICK HERE

5. AT Salami, GE Okotie, PN Echendu, A Uwaifoh, SB Olaleye (2021): Potassium bromate (KBrO3) Modulates Oxidative stress and inflammatory biomarkers in NaOH induced crohn’s colitis in Wistar rats. Canadian Journal of Physiology and Pharmacology. Can J Physiol Pharmacol. 2021 Oct;99(10):989-999. CLICK HERE

6. Omayone TP, Salami AT, Olopade JO, Olaleye SB (2020): Attenuation of ischemia-reperfusion-induced gastric ulcer by low-dose vanadium in male Wistar rats. Life Sciences 259, 118272. CLICK HERE

7.  Odukanmi A, AT Salami, TR Olanrewaju, SB Olaleye (2020): Exposure to Mosquito Coil Smoke Delays Healing of Acetic Acid Induced Gastric Ulcer in Male Wistar Rats. Nigerian Niger J Physiol Sci. 2020 Jun 30;35(1):77-87.

8. Ajayi A.F. and Olaleye S.B. (2020): Age-related changes in haematological parameters and biochemical markers of healing in the stomach of rats with acetic acid induced injury. Toxicol Rep 19; 7:1272-1281. CLICK HERE

9. Namulema J, Nansunga M, Kato CD, Kalange M, Olaleye SB. (2018): Thyroid hormones increase stomach goblet cell numbers and mucin expression during indomethacin induced ulcer healing in Wistar rats. Thyroid Res. 2018 May 25;11:6. CLICK HERE.

10. Omayone, T.P.; Salami, A.T.; Odukanmi, A.O.; Olaleye, S.B. (2018): Diet containing seeds of Buchholzia coriacea accelerates healing of acetic acid induced colitis in rats. Asian Pacific Journal of Tropical Biomedicine.  CLICK HERE

11. Salami, A.T.; Odukanmi, O.A.; Oshode, O.O.; Olaleye, S.B (2018):  Modulatory activities of Chrysophyllum albidum and its fractions on microflora and colonic pump activities during inflammatory phase of colitis healing in experimental mice. Food Bioscience. CLICK HERE

12. Kazeem O. Ajeigbe; Benjamin O. Emikpe; Samuel Babafemi Olaleye (2018): Effects of artemisinin, with or without lumefantrine and amodiaquine on gastric ulcer healing in rat. Journal of Basic and Clinical Physiology and Pharmacology. CLICK HERE

13. Odukanmi OA, AT Salami, OP Ashaolu, AG Adegoke, SB Olaleye (2017): Kolaviron attenuates ischemia/reperfusion injury in the stomach of rats. Applied Physiology, Nutrition, and Metabolism 43 (1), 30-37. CLICK HERE

14. Salami AT, OA Odukanmi, OF Faniyan, TP Omayone, SB Olaleye (2017): Seeds of Buchholzia coriacea in Diet Mitigate Ischemic Reperfusion–Induced Gastric Ulceration in Experimental Rats. Journal of dietary supplements, 1-18.  CLICK HERE

15. Adeniyi, O.S.; Makinde, O.V.; Friday, E.T.; Olaleye, S.B (2017): Effects of quinine on gastric ulcer healing in Wistar rats. Journal of Complementary and Integrative Medicine. CLICK HERE

16. Olaleye, S.B, Adaramoye, O. A., Erigbali, P. P., Adeniyi, O. S. (2007): Lead exposure increases oxidative stress in the gastric mucosa of HCl/ethanol-exposed rats. World J Gastroenterol. 2007 Oct 14;13(38):5121-6. CLICK HERE

17. Olaleye, S. B and Farombi, E. O. (2006): Attenuation of Indomethacin- and HCl/Ethanol-induced oxidative Gastric Mucosa Damage in rats by Kolaviron, A natural biflavonoid of Garcinia kola seed. Phytotherapy Research Volume 20, 14 – 20. CLICK HERE

18. Owoyele VB, CO Wuraola, AO Soladoye, SB Olaleye (2004) Studies on the anti-inflammatory and analgesic properties of Tithonia diversifolia leaf extract Journal of ethnopharmacology 90 (2-3), 317-321. CLICK HERE

19. Olaleye, S. B, Farombi, E.O, Adewoye, E. A, Owoyele, B.V, Onasanwo, S. A and Elegbe, R.A. (2000): Analgesic and anti-inflammatory effects of Kolaviron (A Garcinia kola seed extract). African Journal of Biomedical Research 3 (3): 171 – 174  CLICK HERE

20. Ibironke, G.F; Olaleye, S.B.; Balogun, O and Aremu, D.A (1997): Effect of Diets Containing Seeds of Garcina Kola (Herckel) On Gastric acidity and Experimental Ulceration in Rats. Phytotherapy Research, Vol 11, 312-313.  CLICK HERE

Supervision

CURRENT STUDENTS

S/No.	Names	Titles of Theses/Dissertations	Degree in view	Expected Year of Award
1	Owonikoko Mathew	Gastrointestinal and Respiratory Functions in Rats Experimentally Exposed to Cement Dust	PhD	2022
2	Morakinyo Olanike	Effect of Hexavalent Chromium on Experimental Colitis in Male Wistar Rats	PhD	2022
3	Faniyan Omosola	Effect of Vanadium Treatment on Some Gastrointestinal Functions in Normal and Hyperglycemic Rats	PhD	2022
4	Iyiola Toluwalope	Beta-Adrenergic Modulation of Gastric Ulcer Healing in Experimental Rats	PhD	2022
5	Uwaifoh Akpamu	Age Related Responses to Factors Affecting Gastric Mucosal Cell Functions in Rats	PhD	2022

PREVIOUS STUDENTS (Selected)

S/No.	Names	Titles of Theses/Dissertations	Degree	Years of Award
1	Ige Serah.F	Effect of Kolaviron on experimental Colitis in Rats	M.Phil	2011
2	Ajeigbe Kazeem O	Effects of Chloroquine, Amodiaquine, Sulfadoxine-Pyremethamine and Artesunate on Gastric Acid Secretion in Rats	M.Phil	2011
3	Adeniyi Olasupo S	Effects of Thyroidectomy and Thyroxine Treatment on Gastric Ulcer Healing in Rats	Ph.D	2011
4	Adeleye, Gbenga S	Delayed Healing of Acetic Acid -Induced Ulceration in The Stomach of Lead-Exposed Rats	Ph.D	2013
5	Ebunlomo O.O	Effects of Chloroquine, Arthemeter-Lumenfantrine and Artesunate on Experimental Colitis in Rats	M.Phil	2014
6	Ajayi Ayodeji F	Age Related Changes in Gastric Ulcer Healing in Rats	Ph.D	2014
7	Ige Serah.F	Effects of Kolaviron and The Biflavanones of Garcinia Kola (Heckel) on Acetic Acid-Induced Colitis in Wistar Rats	Ph.D	2015
8	Ajeigbe Kazeem O	Effects of Artemisinin-Based Combination Drugs On Gastric Ulcer Healing in Wistar Rats	Ph.D	2015
9	Morakinyo Olanike	Attenuation of Experimental Gastric Ulceration by Chromium in Rats	M.Phil	2016
10	Odukanmi Adeola O	Effect of Trivalent Chromium on Normal and Injured Gastrointestinal Tract of Laboratory Rodents	Ph.D	2016
11	Omayone Tosan	Effect of Sodium Metavanadate on Gastrointestinal Injury and Inflammation in Rats	PhD	2016
12	Adegoke Gbemisola	Attenuating Effects of Kolaviron on Experimental Colitis in Wistar Rats During Chronic Cadmium Exposure	Ph.D	2017
13	Adebayo Grace I	Reversal of Sodium arsenite-induced delay in ulcer healing in rats by Kolaviron, Vitamin E and Zinc	PhD	2017

Grants

1. 1995-1996: University of Ilorin Senate Research Grant Award (Co-Principal Investigator with Prof. Emudianughe)

2. 1999-2000: University of Ibadan Senate Research Grant Award for Individuals (Principal Investigator)

3. 2006: University of Ibadan Senate Research Grant Award for Multidisciplinary Research Projects; Category C Inter Faculty group researchers (Co-Principal Investigator)

4. 2006: University of Ibadan Senate Research Grant Award (Principal Investigator)

5. 2015: The John D and Catherine T MacArthur Foundation/ University of Ibadan Staff Development Fellowship to the University of Hong Kong (Laboratory of Prof. Chi Hin Cho)

6. 2017: International Centre for Genetic Engineering and Biology (ICGEB) event grant for organizing conference on Drosophila melanogaster in Biomedical Research: Low-Cost and Profitable Venue: University of Ibadan, Ibadan, Nigeria Dates: 17th – 28th JULY 2017 (Principal Investigator, Grant No. NIG1702).

7. 2019: Company of Biology Grant for part sponsorship of a workshop on Molecular Biology of Drosophila melanogaster" September 2019 (Principal Investigator).

8. 2019: International Centre for Genetic Engineering and Biology (ICGEB) Grant for Sponsored DrosAfrica-ICGEB Workshop titled: DrosAfrica-ICGEB Workshop on Drosophila melanogasterin African biomedical research" September 2019 (Principal Investigator, Grant No.. W/NIG19-0).

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