Profile
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Name: Mayowa O. OWOLABI |
| Designation: Professor | |
| Faculty: Clinical Sciences | |
| Department: Medicine | |
| Phone Number: +2348020775595 | |
| ORCID Profile | |
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Email: This email address is being protected from spambots. You need JavaScript enabled to view it. |
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Biography: Mayowa Ojo Owolabi, MBBS, MSc, DrM, MD, DSc, FMCP, FWACP, FRCP, FANA, FAHA, FAAN, FAAS, FAS, FAMedS, a luminary in the field of neurology and precision medicine, holds an extensive array of academic accolades and leadership roles. As a Professor of Neurology and Director of the Center for Genomic and Precision Medicine at the University of Ibadan, his expertise spans implementation science, translational genomic epidemiology, and the study of hypertension, stroke, and cardiovascular diseases. During his tenure as Dean of the Faculty of Clinical Sciences from 2018 to 2022, Owolabi's impact was felt profoundly. His current role as Principal Investigator in numerous multimillion-dollar internationally funded research projects exemplifies his dedication. Among these are groundbreaking initiatives such as African Rigorous Innovative Stroke Epidemiological Surveillance (ARISES), Stroke Investigative Research and Educational Network (SIREN) - the largest study of stroke on the African continent, and the Systemic Investigation of Blacks with Stroke using genomics (SIBS-Genomics), which focus on stroke epidemiology and genetics, involving a consortium covering over 12 African countries and more than 55,000 subjects.Renowned for his innovative contributions to the medical field, Owolabi has introduced conceptual models like the 'Seed of Life Model' and tools such as the HRQOLISP, a globally accepted quality of life measure for stroke survivors. His work on the 'stroke quadrangle' and 'brain quadrangle' has been instrumental in global interventions against stroke and brain health promotion, earning widespread global acceptance. Owolabi's research breakthroughs extend to identifying both genetic and non-genetic risk factors for stroke in Africa, including the protective effects of green leafy vegetables against stroke and hypertension. Notably, he pioneered the discoveries of the association between APOL1, microRNA, and stroke in Africans. He is among the global top 2% scientists (2023), Owolabi received the 2021 World Stroke Organization Global Award for Outstanding Contributions to Clinical Stroke Research. He is a leader in the fight against stroke, hypertension, and non-communicable diseases, actively leading the implementation of actions against hypertension in Africa in collaboration with esteemed organizations like the World Hypertension League and the World Health Organization. His impact in academia is reflected in over 400 publications in peer-reviewed journals, h-index of 84 and over 122,000 citations. Additionally, he serves as an associate editor of the Stroke journal and several other top journals in neurology. He is the pioneer Regional Vice-President (Africa), and member of the Presidium, World Federation of Neurorehabilitation (Africa); member Board of Directors, World Stroke Organization; African Regional Director, World Hypertension League; Lead Co-Chair, WSO- Lancet Commission on stroke. He is foundation co-chair of the steering committee of African Stroke Organization; and Member/Rapporteur of the WHO Technical Action Group on NCD (Research and Innovation). He is co-Lead of the African Research Universities Alliance- The Guild Universities Cluster of Excellence for non-communicable diseases. Recognized as a Fellow of esteemed institutions such as the American Academy of Neurology, American Heart Association, Royal College of Physicians, Academy of Medical Specialties, and the Nigerian Academy of Science, African Academy of Science and Atria Academy of Science and Medicine, Owolabi's contributions have received widespread acclaim. His significant recognition includes being the fifth individual to receive the Doctor of Science degree from the University of Ibadan, an honor bestowed during the university's 75th anniversary and coinciding with his 50th birthday, marking a pivotal moment in his distinguished career. |
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Research
a. Current Research and Capacity Building Projects including Grants
1. Title: Training Africans to Lead and Execute Neurological Trials Studies (TALENTS) D43TW012030
Funder: NIH/NINDS
Brief Summary: The goal of the Training Africans to Lead and Execute Neurological Trials & Studies (TALENTS) program, within the Chronic, Non-Communicable Diseases & Disorders Across the Lifespan: Fogarty International Research Training D-43 initiative, is to build sustainable neurological research capacity in Africa through partnerships between US institutions, African Institutions, & the African Academy of Neurology (AFAN). We will train & inspire scholars recruited from a cross-national pool of multidisciplinary post-doctoral scholars (PhDs, or Registrar/Fellow Physicians) in Africa in the pedagogy & practice of conducting clinical neurological investigations (including multi-omics) and drug trials, which could build sustainable clinical neuroscience research on the continent, as well as the capacity for Africans to contribute to the advancement of the field of neurology. Using a Multiple PI mechanism, the program will be supported by a multidisciplinary global group with demonstrated expertise in clinical trial leadership and execution, built on an infrastructure of existing funded NIH clinical neuroscience research programs & training grants in Africa. TALENTS is based in part on social science theories, & empirical data. AFAN will freely provide member benefits & support for a rich array of career development activities at their annual meetings. TALENTS will be integrated into Mentor research projects as much as possible. Five scholars will be accepted into the program each year.
Role: MPI
Collaborators: UCSF
2. Title: African Rigorous Innovative Stroke Epidemiological Surveillance (ARISES) R01NS115944
Funder: NIH/NINDS
Brief Summary: The African Rigorous Innovative Stroke Epidemiological Surveillance (ARISES) initiative introduces a groundbreaking Stroke Information and Surveillance System (SISS) through mobile health (mHealth) technology. Its primary goal is to accurately measure and continually track stroke burden in both urban and rural areas of Nigeria while enhancing stroke awareness, early detection, and outcomes.
ARISES leverages prior resources like stroke literacy videos, culturally-tailored dance routines, a pictographic screening tool, and specialized software for precise stroke characterization. Pilot tests involving 1,095 households demonstrated high mobile phone accessibility (99%) and community willingness (over 95%) to engage with the e-Surveillance system for reporting stroke incidents.
To ensure comprehensive data collection and precise population estimates, ARISES will conduct thorough community mappings, update demographic profiles, and utilize a unique "hot and cold pursuit" method, combining traditional and non-traditional healthcare systems for comprehensive case identification.
Furthermore, the initiative plans to integrate SISS into a sustainable care framework to improve stroke outcomes within the surveyed areas. ARISES aims to serve as a scalable model, using novel e-Surveillance, community engagement strategies, and mHealth technology to generate accurate epidemiological data on stroke burden in resource-limited settings. Its broader goal includes enhancing stroke literacy, prevention, early detection, and ultimately improving outcomes, making it a potential blueprint applicable not only in Nigeria but also in various low-resource settings globally, including low- and middle-income countries (LMICs) and the USA.
Role: PI
Collaborators: MUSC
3. Title: Copy number Variation and Stroke (CaNVAS) risk and outcome Study R01NS114045
Funder: NIH/NINDS
Brief Summary: The proposal aims to delve into the complex realm of ischemic stroke (IS) by exploring the uncharted territory of copy number variations (CNVs) within the genetic landscape. IS stands as a formidable cause of mortality and disability, its roots veiled in multifaceted origins. While genome-wide association studies (GWAS) have offered insights into stroke susceptibility, the role of CNVs remains largely unexplored in this context. Leveraging existing datasets encompassing over 24,500 IS cases and 43,500 controls, the research hypothesizes that analyzing CNVs could unravel novel associations shedding light on stroke mechanisms, treatment targets, and outcome predictors.
The study proposes a multi-pronged approach: first, identifying CNVs associated with IS risk across diverse demographics; second, validating these associations in diverse ethnic populations; third, elucidating how identified CNVs influence stroke risk using biomarker data; and fourth, exploring the relationship between CNV burden and stroke outcome at three months. This multifaceted investigation not only seeks to uncover genetic determinants but also establishes a platform for junior investigators, fostering a training network.
By investigating CNVs in IS, this study endeavors to unlock hidden aspects of stroke genetics, potentially revolutionizing stroke pathophysiology understanding. The discovery of novel genes, pathways, and treatment targets holds the promise of transforming stroke prevention, treatment, and patient outcomes.
Role: Co-invetigator, Site PI
Collaborators: University of Maryland Baltimore
4. Title: Systematic Investigation of Blacks with Stroke using Genomics (SIBS Genomics) R01NS107900
Funder: NIH/NINDS
Brief Summary: The prevalence of ischemic stroke, responsible for a significant portion of strokes in the USA, is influenced by intricate genetic and environmental factors, posing a challenge in comprehensively understanding its mechanisms. A considerable portion of stroke-related genetic risk remains unexplained, particularly in African and European Americans, hindering their translation into practical clinical applications. The absence of African populations in genome-wide association studies (GWAS) on stroke, despite their higher stroke heritability and potential for precise mapping, represents a critical gap in stroke genomics.
To address these limitations, the SIBS-Genomics initiative aims to identify, validate, and characterize novel genetic variants associated with ischemic stroke in people of African ancestry. Leveraging various NIH-funded projects in the US and Africa, such as REGARDS, SiGN, COMPASS, and others, SIBS-Genomics intends to significantly advance global efforts in discovering new genetic loci related to ischemic stroke. Key strategies include employing meticulously phenotype subjects with robust datasets, utilizing advanced genomics technology tailored for African ancestry, exploring a population with higher stroke heritability, and conducting comprehensive validation and functional assessments of previously identified variants.
This multi-stage approach involves collaboration among leading global experts to validate known variants in continental Africans, discover new variants in this population, validate in African Americans (the majority having West African ancestry), and conduct trans-ancestry analyses involving diverse American ancestries. The study's outcomes are expected to unveil insights into stroke's molecular mechanisms, leading to the development of targeted biomarkers for prediction, diagnosis, and prognosis, as well as interventions for stroke prevention and treatment. Importantly, this transomics study holds promise for significantly reducing the burden of stroke, especially among African Americans who currently face a disproportionately high incidence.
Role: PI
5. Title: Sub-Saharan Africa Conference on Stroke (SSACS) Conference 1R13NS115395-01A1
Funder: NIH/NINDS
Brief Summary: The Sub-Saharan Africa Conference on Stroke (SSACS) 2020 is the inaugural cross-national scientific gathering focused on cerebrovascular disease in Sub-Saharan Africa (SSA). Set against the backdrop of rising stroke prevalence due to increased risk factors and limited healthcare infrastructure, SSACS aims to bridge critical gaps in stroke research and cultivate a collaborative platform for stakeholders. Scheduled for a one-day symposium in Bahir Dar, Ethiopia, SSACS will feature keynote talks, symposia, poster sessions, and community engagements.
The conference seeks to bring together experts and early career scientists, emphasizing the latter's involvement to foster future advancements in stroke research within SSA. To achieve this, SSACS plans to grant 20 Young Investigator Travel Awards, nurturing a network of committed researchers dedicated to stroke study in the region.
SSACS' specific objectives include identifying research gaps, facilitating interdisciplinary discussions on stroke epidemiology, fostering collaborations among stakeholders, and disseminating acquired knowledge through scientific and public avenues. The conference's success will be gauged by attendee numbers and the achievements of Young Investigator Awardees, aiming to evaluate its impact and effectiveness in advancing stroke research within SSA. Collaborating with esteemed global organizations like the World Stroke Organization and World Federation of Neurology, SSACS aims to leverage their expertise, resources, and experience to maximize the conference's impact on stroke research in the region.
Role: Co-Chair
6. Title: Growing Data-science Research in Africa to Stimulate Progress (GRASP) UE5HL172183
Funder: NIH
Brief Summary: GRASP (Growing Data-science Research in Africa to Stimulate Progress) aims to confront the rising challenge of non-communicable diseases (NCDs), particularly neurological disorders, in Africa by bolstering sustainable research capabilities. Existing programs lack a specific focus on brain health, critical in achieving overall health goals. This initiative endeavors to enhance the data science expertise of selected African scholars to unravel the sociodemographic, dietary, and lifestyle determinants impacting brain health and cardiovascular risk.
The program intends to develop a cohort of researchers adept in data science methodologies, leveraging extensive datasets from SIREN, ARISES, CHAIR, H3Africa, DS-I Africa consortia, and other relevant resources. Five scholars annually will engage in mentored research projects for three years, integrating diverse data sets encompassing sociodemographic, cognitive, neuroimaging, genomic, climate, and geographical information. Their training includes a comprehensive nine-month Postgraduate Certificate program involving online modules and a residency at the University of Ibadan in Nigeria.
GRASP emphasizes skill enhancement in translational data science research with a specific focus on brain health, aiming to identify sociodemographic determinants and patterns across various datasets. The scholars will benefit from mentorship provided by elite mentors, ensuring robust guidance throughout their training. Monitoring the program's success involves assessing the scholars' academic progress, publications, and their ability to secure funding for research projects or career development.
Through GRASP, the initiative envisions cultivating a cadre of skilled researchers capable of addressing the complexities of brain health in African populations, paving the way for tailored interventions and strategies to combat NCDs.
Role: PI
7. Title: Recruitment and Retention for Alzheimer’s Disease Diversity Genetic Cohorts in the ADSP (READD – ADSP) study U19AG074865
Funder: NIH
Brief Summary: The John P. Hussman Institute for Human Genomics (HIHG) at the University of Miami, along with partner institutions, has launched a pioneering five-year initiative funded by a $46 million grant from the National Institute on Aging. This international effort aims to revolutionize Alzheimer’s disease research by expanding genetic studies into African ancestry populations and Hispanic/Latinx groups, historically underrepresented in such studies.
Led by Dr. Margaret A. Pericak-Vance and a team of co-Principal Investigators across various sites, including Case Western Reserve University, Columbia University, Wake Forest University, the University of Pennsylvania, and the University of Ibadan, the initiative seeks to rectify the lack of diversity in Alzheimer’s genetic studies. The primary goal is to establish a comprehensive genetic data resource by recruiting and analyzing a diverse cohort of 5,000 individuals from African countries, 4,000 African Americans, and 4,000 Hispanic/Latinx individuals. This extensive gathering of clinical, phenotypic, genetic, and social determinant data aims to deepen the understanding of Alzheimer’s across diverse populations.
The African Dementia Consortium (AfDC) will oversee recruitment in Africa, involving researchers from nine African nations. This collaboration seeks to enhance the characterization of dementia, particularly Alzheimer’s, within the African context. By exploring genetic factors influencing Alzheimer’s among diverse ancestral backgrounds, the initiative aims to develop more targeted and universally beneficial treatment strategies.
Additionally, the study will investigate the interplay between ancestry and social determinants of health in Alzheimer’s risk and age of onset. Through this initiative’s collaborative efforts and individual participation, it aims to bridge research gaps, tackle disparities, and pave the way for more effective Alzheimer’s treatments and prevention strategies.
Role: Co-Investigator
8. Title: Consortium for Advancement of MRI Education and Research in Africa (CAMERA)
Funder: Silicon Valley Community Foundation (SVCF)
Brief Summary: The Consortium for Advancement of MRI Education and Research in Africa (CAMERA) aims to revolutionize healthcare in Africa by addressing the critical deficit in MRI technology and expertise. Despite facing a considerable burden of non-communicable diseases, African countries encounter limited access to MRI technology and a shortage of skilled personnel proficient in MRI operations.
CAMERA represents a collaborative effort between African MRI experts and global partners, striving to establish a sustainable MRI training and mentorship program across African nations. The initiative's core objectives include training 12 emerging MRI scientists and technologists sourced from Nigeria, Ghana, Uganda, Kenya, and Mozambique. Additionally, it aims to set up an African Chapter of the International Society of Magnetic Resonance in Medicine (ISMRM) to amplify African contributions to global MRI advancements.
To ensure talent retention, CAMERA plans to cultivate a robust mentorship program for early-career MRI scientists, fostering collaborative projects and encouraging their continued presence and impact within the region. An online MRI resource platform will be developed, serving as a repository for virtual education sessions, housing tools for image processing, analysis, and sequence development.
Furthermore, CAMERA will facilitate hands-on training courses for MRI engineers within African countries. These courses intend to equip local engineers with the necessary expertise to sustain and maintain MRI technology, promoting self-sufficiency in MRI operations within the region.
By expanding access to MRI technology, empowering local expertise, and fostering a collaborative and sustainable environment, CAMERA endeavors to significantly enhance healthcare delivery and research capabilities across Africa.
Role: Co-Investigator
b. Completed Research
1. Title: Stroke Investigative Research & Educational Network (SIREN) U54HG007479
Funder: NIH/NINDS, NHGRI
Brief Summary: The Stroke Investigative Research and Education Network (SIREN) aims to address the intricate nature of stroke by establishing a multidisciplinary collaborative network between Sub-Saharan Africa (SSA) and the United States. Stroke, though a distinct medical condition, stems from complex genetic and environmental factors, posing a challenge in analyzing its underlying mechanisms. Particularly in SSA, understanding the unique risk factors for stroke remains limited, hindered by a lack of expertise, infrastructure, and experience in genomics and environmental research.
SIREN's primary goal is to comprehensively investigate the genetic and environmental contributors to stroke among individuals of African ancestry. By establishing three core projects - SIBS-Phenomics, SIBS-Genomics, and SIBS-Bioinformatics - across eight sites in Nigeria, Ghana, and South Africa, SIREN intends to unravel the specific factors influencing stroke in SSA. This initiative involves comparing findings with African American stroke survivors to discern similarities and differences.
Furthermore, SIREN aims to build sustainable capacities in phenomics, biobanking, genomics, biostatistics, and bioinformatics, crucial for future high-level investigations into stroke and other vascular diseases in SSA. Leveraging prior collaborations and ongoing studies in SSA, as well as drawing expertise from successful stroke reduction strategies in the United States, SIREN seeks guidance from established content experts. This collaboration aims to identify stroke risk factors and implement corresponding preventive strategies tailored for SSA, similar to successful strategies employed in the United States. Ultimately, SIREN's efforts aim to fill the knowledge gaps surrounding stroke risk factors in SSA while establishing a foundation for comprehensive stroke research in the region.
Role: MPI
2. Title: African Neurobiobank for Precision Stroke Medicine (ELSI) : U01HG010273
Funder: NIH
Brief Summary: The African Neurobiobank for Precision Stroke Medicine - Ethical, Legal, and Social Implications (ELSI) Project aims to address the critical gaps and uncertainties surrounding stroke biobanking in Sub-Saharan Africa (SSA). Despite the growing biobanking initiatives through the Human, Heredity and Health in Africa (H3Africa) initiative, Africa has been historically underrepresented in this realm.
Stroke incidence rates in SSA are rising, with poorer outcomes and affecting a relatively younger population compared to other ethnicities. To advance precision medicine for stroke in this region, it's crucial to understand the intricate interplay between environmental and genomic risk factors. However, the ethical, legal, and social implications (ELSI) of developing neurobiobanks in an African context remain unclear. This includes addressing unique cultural, linguistic, and belief systems within a global research community that values openness and sharing of biological materials.
The project's primary goal is to identify and tackle the ELSI challenges of stroke biobanking in SSA. Adopting a community-based participatory mixed methods research (CBPR) approach, the project will engage multiple levels of the social ecological model. It aims to develop culturally appropriate interventions and tools to enhance community understanding and participation in stroke biobanking activities. The ultimate objective is to foster enduring trust and fair utilization of biobanking resources for genetic and trans-omics research related to stroke and other neurological disorders.
Role: Co-Investigator
3. Title: SIBS Genomics Genetics Counselling Study (SIBS-Gen-Gen) 3R01NS107900-02S1
Funder: NIH/NINDS
Brief Summary: The SIBS Genomics-Genetic Counselling (SIBS-Gen-Gen) project aims to integrate implementation science into stroke research among individuals of African ancestry. Stroke is a significant cause of disability and mortality, particularly prevalent among people of African descent. While some genetic variants linked to ischemic stroke have been identified in other populations, there's a notable absence of findings among indigenous Africans (IA). The SIBS Genomics study seeks to fill this gap through the first genome-wide association study focused on genetic determinants of stroke among indigenous Africans.
However, before integrating these emerging genetic determinants into clinical practice, validation is essential. This ancillary study, conducted in response to NOT-TW-19-003, will explore the perceptions, preferences, and attitudes of stroke-free individuals regarding the disclosure of genetic test results for stroke. This research aims to understand the implications of disclosing genetic findings related to stroke among individuals and their families, healthcare providers, and the wider community within the socio-ecological model.
The project, SIBS-Gen-Gen, plans to engage stroke-free individuals, their families, healthcare providers, and the community to gauge their understanding and receptivity towards genetic testing disclosure. Additionally, a workshop on genetic counseling will be conducted to equip relevant personnel with the skills necessary for handling genetic test results effectively.
This study intends to generate pilot data for designing a randomized controlled trial focused on the disclosure of stroke genetic test results. Ultimately, the project aims to prepare for the implementation of genetic findings from SIBS Genomics into clinical and community settings by understanding the perceptions and attitudes of the target population towards genetic testing disclosure for stroke.
Role: PI
4. Title: Future Leaders – African Independent Research (FLAIR) Fellowship: African Innovative Genetics of Vascular Cognitive Impairment Study
Funder: African Academy of Sciences, the Royal Society and Global Challenges Research Fund (GCRF)
Role: Mentor
5. Title: Tailored Hospital-based Risk Reduction to Impede Vascular Events after Stroke (THRIVES) U01NS079179
Funder: NIH/NINDS
Brief Summary: The World Health Organization (WHO) underscores the critical impact of stroke in low- and middle-income countries (LMICs), with nearly 86% of stroke-related deaths occurring in these regions, particularly in Africa. As infectious diseases decrease, the burden of stroke is anticipated to significantly rise in LMICs, posing a severe challenge. Hypertension, a leading modifiable risk factor for stroke, is becoming increasingly prevalent in Africa, affecting approximately 37% of Nigeria's population, accentuating the urgency for effective healthcare programs.
Recognizing this urgent need, a tailored chronic care model intervention named Tailored Hospital-based Risk Reduction to Impede Vascular Events after Stroke (THRIVES) is proposed to enhance secondary stroke prevention in Nigeria. THRIVES is designed to address local needs and cultural contexts, aiming to mitigate the dire consequences of stroke through improved management of high blood pressure.
The intervention will begin by gathering insights from stroke patients, caregivers, healthcare providers, and hospital administrators to identify barriers and facilitators to adherence to evidence-based secondary stroke prevention treatments in Nigeria. This data will refine the THRIVES intervention, incorporating tools like stroke patient report cards, provider-initiated text messaging, and in-clinic educational videos.
Subsequently, a randomized controlled trial involving 334 recently discharged stroke patients from four medical facilities in Southwestern Nigeria will assess the efficacy of THRIVES. The primary outcome will focus on systolic blood pressure reduction after 12 months, while a secondary aim involves conducting a cost analysis of THRIVES from the local government's perspective in Nigeria. This cost analysis aims to present valuable data to Nigerian decision-makers, aiding them in understanding the benefits and implications of supporting THRIVES beyond the research period.
Role: Co-PI
6. Title: GCRF-Africa-UK Collaboration for the genetic Epidemiology of Stroke (ACES).
Funder: GCRF
Brief Summary: Academy of Medical Sciences Global Challenges Research Fund Networking Grant Scheme
Role: PI
7. Title: Carotid Doppler ultrasound study in stroke patients to determine the pattern and associations of carotid atherosclerosis in stroke patients.
Funder: 2008 Mac Arthur Foundation Research Grant.
Role: PI
8. Title: Improving neurologic outcome measurement for interventional research in Ibadan. Neurologic outcome Measurement in Research for Intervention and Care (NUMERIC) R25NS080949
Funder: Awarding Body: MEPI-linked R25 grant from NIH
Role: Co-Investigator.
9. Title: Ibadan Brain Bank. Ibadan (Dementia, Ageing and Neurodegeneration) Brain Bank [IBADAN Brain Bank] (College Research and Innovation Management Unit CRIM Grant
Funder: College Research and Innovation Management Unit CRIM Grant
Role: Co-Investigator.
10. Title: Enhancing Capacity for Stroke Recognition, Documentation, Care and Prevention in Nigeria
Funder: World Federation for Neurology/ World Stroke Organisation
Role: Co-Investigator.
11. Title: Stroke information and Surveillance System
Funder: Center for Global Health Pilot Grant
Role: PI
Collaborators: Medical University of South Carolina, USA
12. Title: H3Africa CVD Supplement - green leafy vegetables and cardiovascular diseases
Funder: NIH
Role: PI
13. Title: Pilot grant on Stroke inflammatory protein biomarkers.
Funder: University of Glasgow,
Collaborators: University of Glasgow, UK/University of Ibadan, Nigeria
14. Title: Expanding Global Access to Bioimaging RFA
Funder: The Chan Zukerberg Initiative DAF
Brief Summary: Strengthening Consortium for Advancing MRI Education & Research in Africa (GBI). The study aims to provide researchers and clinicians in Africa the requisite technical support to accelerate and advance Magnetic Resonance Imaging (MRI) education, research and clinical translation.
Role: Co-Investigator
Publications
1. Owolabi, M.O., Platz, T. (2008): Proposing the stroke levity scale: a valid, reliable, simple and time-saving measure of stroke severity. European Journal of Neurology, 15(6):627-633.
2. Owolabi, M.O. (2010): Psychometric properties of the HRQOLISP-40: a novel shortened multi-culturally valid holistic stroke measure. Neurorehabilitation and Neural Repair, 24 (9):814-825 DOI:10.1177/1545968310369113.
3. Owolabi, M. O., Sarfo, F., Howard, V. J., Irvin, M. R., Gebregziabher, M., Akinyemi, R., Bennett, A., Armstrong, K., Tiwari, H. K., Akpalu, A., Wahab, K. W., Owolabi, L., Fawale, B., Komolafe, M., Obiako, R., Adebayo, P., Manly, J. M., Ogbole, G., Melikam, E., Laryea, R., Saulson, R., Jenkins, C., Arnett, D. K., Lackland, D. T., Ovbiagele, B., Howard, G., & SIREN-REGARDS Collaboration (Stroke Investigative Research and Educational Network–Reasons for Geographic and Racial Differences in Stroke). (2017). Stroke in Indigenous Africans, African Americans, and European Americans: Interplay of Racial and Geographic Factors. Stroke, 48(5), 1169-1175. doi: 10.1161/STROKEAHA.116.015937.
4. Sarfo, F., Ovbiagele, B., Gebregziabher, M., Wahab, K., Akinyemi, R., Akpalu, A., Akpa, O., Obiako, R., Owolabi, L., Jenkins, C., & Owolabi, M., on behalf of SIREN. (2018). Stroke Among Young West Africans: Evidence from the SIREN Large Multi-site Case-Control Study. Stroke, 49(5), 1116-1122.https://doi.org/10.1161/STROKEAHA.118.020783
5. Owolabi, M., Sarfo, F., Akinyemi, R., Gebregziabher, M., Akpa, O., Akpalu, A., Wahab, K., Obiako, R., Owolabi, L., & Ovbiagele, B. (2018). Dominant modifiable risk factors for stroke in Ghana and Nigeria (SIREN): a case-control study. The Lancet Global Health, 6(4), e436-e446. doi: 10.1016/S2214-109X(18)30002-0
6. Owolabi, M. O., Gebregziabher, M., Akinyemi, R. O., Akinyemi, J. O., Akpa, O., Olaniyan, O., Salako, B. L., Arulogun, O., Tagge, R., Uvere, E., Fakunle, A., & Ovbiagele, B. (2019). Randomized trial of an intervention to improve blood pressure control in stroke survivors. Circulation: Cardiovascular Quality and Outcomes, 12, e005904. https://doi.org/10.1161/CIRCOUTCOMES.119.005904
7. Sarfo, F. S., Ovbiagele, B., Gebregziabher, M., Akpa, A., Akpalu, A., Wahab, K., Ogbole, G., Akinyemi, R., Obiako, R., Komolafe, M., Owolabi, L., Lackland, D., Arnett, D., Tiwari, H., Markus, H. S., Akinyemi, J., Oguntade, A., Fawale, B., Adeoye, A., Olugbo, O., Ogunjimi, L., Osaigbovo, G., Jenkins, C., Chukwuonye, I., Ajose, O., Oyinloye, L., Mutiso, F., Laryea, R., Calys-Tagoe, B., Salaam, A., Amusa, G., Olowookere, S., Imoh, C., Mande, A., Arulogun, O., Adekunle, F., Appiah, L., Balogun, O., Singh, A., Adeleye, O., Ogah, O., Makanjuola, A., Owusu, D., Kolo, P., Adebayo, O., Agunloye, A., Shidali, V., Faniyan, M., Lakoh, S., Diala, S., Iheonye, H., Efidi, C., Sanya, E., Sunmonu, T., Akintunde, A., & Owolabi, M. (2020). Unraveling the Risk factors for Spontaneous Intracerebral Hemorrhage and its Severity among West Africans. Neurology, 94, e1-e15. doi: 10.1212/WNL.0000000000009056
8. Akpa, O. M., Made, F., Ojo, A., Ovbiagele, B., Adu, D., Motala, A. A., Mayosi, B. M., Adebamowo, S. N., Engel, M. E., Tayo, B., Rotimi, C., Salako, B., Akinyemi, R., Gebregziabher, M., Sarfo, F., Wahab, K., Agongo, G., Alberts, M., Ali, S. A., Asiki, G., Boua, R. P., Gómez-Olivé, F. X., Mashinya, F., Micklesfield, L., Mohamed, S. F., Nonterah, E. A., Norris, S. A., Sorgho, H., Tollman, S., Parekh, R. S., Chishala, C., Ekuro, K., Waddy, S. P., Peprah, E., Mensah, G. A., Wiley, K., Troyer, J., Ramsay, M., & Owolabi, M. O., as members of the CVD Working Group of the H3Africa Consortium. (2020). Regional patterns and association between obesity and hypertension in Africa: Evidence from the H3Africa CHAIR Study. Hypertension, 75(5), 1167-1178. doi:10.1161/HYPERTENSIONAHA.119.14147.
9. Owolabi, M. O., Thrift, A. G., Mahal, A., Ishida, M., Martins, S., Johnson, W. D., Pandian, J., Abd-Allah, F., Yaria, J., Phan, H. T., Roth, G., Gall, S. L., Beare, R., Phan, T. G., Mikulik, R., Akinyemi, R. O., Norrving, B., Brainin, M., Feigin, V. L.(2021).Stroke Experts Collaboration Group. Primary stroke prevention worldwide: translating evidence into action. The Lancet Public Health,
10. Sarfo, F. S., Ovbiagele, B., Akpa, O., Akpalu, A., Wahab, K., Obiako, R., Komolafe, M., Owolabi, L., Ogbole, G., Calys-Tagoe, B., Fakunle, A., Sanni, T., Mulugeta, G., Abdul, S., Akintunde, A. A., Olowookere, S., Uvere, E. O., Ibinaiye, P., Akinyemi, J., Uwanuruochi, K., Olayemi, B., Odunlami, O. A., Abunimye, E., Arulogun, O., Isah, S. Y., Abubakar, S. A., Oladimeji, A., Adebayo, P., Shidali, V., Chukwuonye, I. I., Akpalu, J., Tito-Ilori, M. M., Asowata, O. J., Sanya, E. O., Amusa, G., Onyeonoro, U., Ogunmodede, J. A., Sule, A. G., Akisanya, C., Mensah, Y., Oyinloye, O. I., Appiah, L., Agunloye, A. M., Osaigbovo, G. O., Olabinri, E., Kolo, P. M., Okeke, O., Adeoye, A. M., Ajose, O., Jenkins, C., Lackland, D. T., Egberongbe, A. A., Adeniji, O., Ohifemen Adeleye, O., Tiwari, H. K., Arnett, D., Laryea, R. Y., Olunuga, T., Akinwande, K. S., Imoh, L., Ogah, O. S., Melikam, E. S., Adebolaji, A., Oguike, W., Ogunronbi, O., Adeniyi, W., Olugbo, O. Y., Bello, A. H., Ohagwu, K. A., Ogunjimi, L., Agyekum, F., Iheonye, H., Adesina, J., Diala, S., Dambatta, H. A., Ikubor, J., Singh, A., Adamu, S., Obese, V., Adusei, N., Owusu, D., Ampofo, M., Tagge, R., Efidi, R., Fawale, B., Yaria, J., Akinyemi, R., & Owolabi, M. (2021). Risk Factor Characterization of Ischemic Stroke Subtypes Among West Africans. Stroke, 52, e00-e00. doi: 10.1161/STROKEAHA.120.032072. PMID: 34587795.
11. Akinyemi, R. O., Ovbiagele, B., Adeniji, O. A., Sarfo, F. S., Abd-Allah, F., Adoukonou, T., Ogah, O. S., Naidoo, P., Damasceno, A., Walker, R. W., Ogunniyi, A., Kalaria, R. N., & Owolabi, M. O. (2021). Stroke in Africa: profile, progress, prospects and priorities. Nature Reviews Neurology, 1-23. Advance online publication. https://doi.org/10.1038/s41582-021-00542-4 PMID: 34526674
12. Akpa, O. M., Okekunle, A. P., Asowata, O. J., Chikowore, T., Mohamed, S. F., Sarfo, F., Akinyemi, R., Akpalu, A., Wahab, K., Obiako, R., Komolafe, M., Owolabi, L., Osaigbovo, G. O., Ogbole, G., Tiwari, H. K., Akinyemi, J., Fakunle, A., Uvere, E., Adeoye, A., Lackland, D., Arnett, D. K., Ovbiagele, B., Ramsay, M., & Owolabi, M. (2022). Frequent vegetable consumption is inversely associated with hypertension among indigenous Africans. European Journal of Preventive Cardiology, zwac208. Advance online publication. doi: 10.1093/eurjpc/zwac208. PMID: 36098047
13. Mishra, A., Malik, R., Hachiya, T., ... Owolabi, M. O. (Senior Author), Huffman, J. E., Milani, L., Kamatani, Y., Dichgans, M., & Debette, S. (2022). Stroke genetics informs drug discovery and risk prediction across ancestries. Nature. https://doi.org/10.1038/s41586-022-05165-3
14. Sarfo, F. S., Akpa, O. M., Ovbiagele, B., Akpalu, A., Wahab, K., Obiako, R., Komolafe, M., Owolabi, L., Ogbole, G., Fakunle, A., Okekunle, A. P., Asowata, O. J., Calys-Tagoe, B., Uvere, E. O., Sanni, T., Olowookere, S., Ibinaiye, P., Akinyemi, J. O., Arulogun, O., Jenkins, C., Lackland, D. T., Tiwari, H. K., Isah, S. Y., Abubakar, S. A., Oladimeji, A., Adebayo, P., Akpalu, J., Onyeonoro, U., Ogunmodede, J. A., Akisanya, C., Mensah, Y., Oyinloye, O. I., Appiah, L., Agunloye, A. M., Osaigbovo, G. O., Adeoye, A. M., Adeleye, O. O., Laryea, R. Y., Olunuga, T., Ogah, O. S., Oguike, W., Ogunronbi, M., Adeniyi, W., Olugbo, O. Y., Bello, A. H., Ogunjimi, L., Diala, S., Dambatta, H. A., Singh, A., Adamu, S., Obese, V., Adusei, N., Owusu, D., Ampofo, M., Tagge, R., Fawale, B., Yaria, J., Akinyemi, R. O., & Owolabi, M. O. (2023). Patient-level and system-level determinants of stroke fatality across 16 large hospitals in Ghana and Nigeria: a prospective cohort study. Lancet Global Health, 11(4), e575-e585. https://doi.org/10.1016/S2214-109X(23)00038-4
15. Owolabi, M. O., Leonardi, M., Bassetti, C., Jaarsma, J., Hawrot, T., Makanjuola, A. I., Dhamija, R. K., Feng, W., Straub, V., & Camaradou, J. (2023). Global synergistic actions to improve brain health for human development. Nature Reviews Neurology. Advance online publication. https://doi.org/10.1038/s41582-023-00808-z
16. Feigin, V. L., Owolabi, M. O.; World Stroke Organization–Lancet Neurology Commission Stroke Collaboration Group. (2023). Pragmatic solutions to reduce the global burden of stroke: A World Stroke Organization-Lancet Neurology Commission. The Lancet Neurology. Advance online publication. https://doi.org/10.1016/S1474-4422(23)00277-6
17. Adebayo, O., Akpa, O., Asowata, O. J., Fakunle, A., Sarfo, F. S., Akpalu, A., Wahab, K., Obiako, R., Komolafe, M., Owolabi, L., Osaigbovo, G. O., Okekunle, A. P., Sunmonu, T., Tiwari, H. K., Jenkins, C., Arulogun, O., Appiah, L., Akinyemi, J., Adeoye, A. M., Ogbole, G., Yaria, J., Arnett, D., Adebayo, P., Calys-Tagoe, B., Ogah, O. S., Balogun, O., Ogunjimi, L., Mensah, Y., Agbogu-Ike, O. U., Akinyemi, R., Ovbiagele, B., & Owolabi, M. O. (2023). Determinants of first-ever stroke severity in West Africans: Evidence from the SIREN study. Journal of the American Heart Association, 12(12), e027888. https://doi.org/10.1161/JAHA.122.027888
18. Asowata, O. J., Okekunle, A. P., Akpa, O. M., Fakunle, A. G., Akinyemi, J. O., Komolafe, M. A., Sarfo, F. S., Akpalu, A. K., Obiako, R., Wahab, K. W., Osaigbovo Osawaru, G. O., Owolabi, L. F., Jenkins, C. M., Calys-Tagoe, B. N. L., Arulogun, O. S., Ogbole, G. I., Ogah, O. S., Lambert, A. T., Ibinaiye, P. O., Adebayo, P. B., Singh, A., Adeniyi, S. A., Mensah, Y. B., Laryea, R. Y., Balogun, O., Chukwuonye, I. I., Akinyemi, R. O., Ovbiagele, B., & Owolabi, M. O. (2023). Risk Assessment Score and Chi-Square Automatic Interaction Detection Algorithm for Hypertension Among Africans: Models From the SIREN Study. Hypertension, 80(12), 2581-2590. https://doi.org/10.1161/HYPERTENSIONAHA.122.20572
19. Owolabi, M. O., Kumuthini, J., Sankoh, O., Uvere, E., Abubakar, I., Makani, J.; ABLE Steering Committee and ABLE Team. (2023). Maximising human health and development through synergistic partnerships: The African Biobank and Longitudinal Epidemiological Ecosystem. The Lancet Global Health, 11(9), e1333-e1334. https://doi.org/10.1016/S2214-109X(23)00303-0
20. Owolabi, M., Olowoyo, P., Mocumbi, A., Ogah, O. S., Odili, A., Wahab, K., Ojji, D., Adeoye, A. M., Akinyemi, R., Akpalu, A., Obiako, R., Sarfo, F. S., Bavuma, C., Beheiry, H. M., Ibrahim, M., El Aroussy, W., Parati, G., Dzudie, A., Singh, S., Akpa, O., Kengne, A. P., Okekunle, A. P., de Graft Aikins, A., Agyemang, C., Ogedegbe, G., Ovbiagele, B., Garg, R., Campbell, N. R. C., Lackland, D. T., Barango, P., Slama, S., Varghese, C. V., Whelton, P. K., & Zhang, X. H. (2023). African Control of Hypertension through Innovative Epidemiology and a Vibrant Ecosystem (ACHIEVE): novel strategies for accelerating hypertension control in Africa. Journal of Human Hypertension, March. https://doi.org/10.1038/s41371-023-00828-8.
Supervision
i. CURRENT STUDENTS
1. Water and Land-Based Therapeutic Exercise on Selected Cognitive Function, Cardiorespiratory fitness and Gait Performance of Ischemic Stroke Patients in Ibadan, Oyo State , Nigeria. Abiodun Emman BAMIGBOYE (PhD Thesis) Matric number 125013. From November 2021
2. Assessment of Genetic Polymorphism and Association With Type 2 Diabetes among Stroke Patients in The SIREN Project. 2019. Callistus Akinleye Matric number 129629
ii.PREVIOUS STUDENTS
Doctoral Level
1. Predictors of Delayed Neuroimaging in Acute Stroke (MD Thesis) From Year 2014 Godwin Ogbole.
2. Determinants of Morbidity and Mortality in elderly patients on admission in UCH.. ADEBUSOYE Lawrence. Matric number 49028. (MD Thesis) 2011.
3. Development and Psychometric Testing of Ibadan Stroke Specific pain scale. Oladunni Caroline OSUNDIYA. PhD Thesis Neurophysiotherapy. Matric Number 125722.
4. Efficacy of Cognitive rehabilitation therapy on post-stroke depression among first ever stroke survivors in Ibadan. Olugbemi OLUKOLADE. PhD Thesis Matric No: 136605.
5. A 12-month longitudinal study of interrelationships among motor function, activity, participation and health-related quality of life after stroke (PhD Thesis). Grace PETERS (Matric Number: 86534) .2010.
6. Development and validation of a primary health care physiotherapy protocol for stroke rehabilitation (PhD Thesis) Olubukola A. OLALEYE (Matric number: 69806). 2009.
7. A Study of Stroke in Southern Ghana: Epidemiology, Quality of Life and Community Perceptions. (PhD Thesis) Eric SAMPANE-DONKOR , University of Iceland, Iceland. 2010.
8. An Assessment of Phonological Deficits in Yoruba-English Bilingual Aphasia (PhD Thesis) Folorunsho E. Awoniyi. 2023.
9. Predictors of weight reduction among Nigerian patients with obesity. Adetola M. Ogunbode (MD Thesis, Department of Medicine) From 2011 till 2021 Awarded.. Matric Number 54486.
iii.POST-DOCTORAL FELLOW
1. Onoja Matthew Akpa. H3Africa Cardiovascular Diseases Working Group. Harmonization of tools and phenotypes for the genetic epidemiology of cardiovascular diseases in Africa involving > 55,000 research subjects. (2016 to 2018)
Professional Fellowships Supervised/Co-Supervised
1. Health-related quality of life in adults with Parkinson’s Disease in Nigeria (Part II FWACP Fellowship Dissertation): Dr Olaitan OKUNOYE. 2010.
2. Assessment of Neurocognitive function in patients with chronic kidney disease stages 3 to 5 at the UCH Ibadan (Part II FMCP Fellowship Dissertation): Dr Uduak E. WILLIAMS. 2009.
3. Factors militating against clinic attendance in epileptic patients in Ibadan (Part II FWACP Fellowship Dissertation): Dr Emmanuel O. EZUNU. 2010.
4. The outcome of stroke in Jos University Teaching Hospital (Part II FMCP Fellowship Dissertation): Dr Bertha C. EKEH. 2007.
5. Frequency and effect of dysphagia on 30-day outcome in acute stroke patients at the University College Hospital, Ibadan. Part II FMCP Fellowship Dissertation Dr. Bode OLAJIDE, 2013.
6. Frequency, associated risk factors and pattern of cognitive dysfunction in stroke survivors at three months: a case – control study Dr Funmilola TAIWO Dissertation: FMCP2014
7. The Relationship between Sickle Cell Trait, Stroke Severity and 30- Day Stroke Outcome. Part II FWACP Dissertation, Dr Paul OLOWOYO: 2015
8. Post-stroke Infections (Urinary Tract Infection and Pneumonia) and their Association With Short-Term Stroke Outcomes Dr Tomiwa MAKANJUOLA Part II Dissertation: WACP April 2019
9. Calibration of Clinical History Concerning Seizure Semiology in a Neurology Clinic in Nigeria: National Postgraduate Medical College of Nigeria: Dr Joseph YARIA (Part II FMCP Dissertation) May 2019.
10. Sleep disorders and their effects on quality of life in Parkinson's disease patients in Ibadan. Part II WACP Dissertation Dr Richard OGUNTOYE October 2020.
11. Post-stroke pain: the frequency, profile, determinants, and association with quality of life in stroke survivors seen at UCH Ibadan. WACP Fellowship Dr Ayotunde BISI Dissertation, October 2020
Grants
Current Grant Funding
1. Title: Training Africans to Lead and Execute Neurological Trials Studies (TALENTS) D43TW012030
Funder: NIH/NINDS
Brief Summary: The goal of the Training Africans to Lead and Execute Neurological Trials & Studies (TALENTS) program, within the Chronic, Non-Communicable Diseases & Disorders Across the Lifespan: Fogarty International Research Training D-43 initiative, is to build sustainable neurological research capacity in Africa through partnerships between US institutions, African Institutions, & the African Academy of Neurology (AFAN). We will train & inspire scholars recruited from a cross-national pool of multidisciplinary post-doctoral scholars (PhDs, or Registrar/Fellow Physicians) in Africa in the pedagogy & practice of conducting clinical neurological investigations (including multi-omics) and drug trials, which could build sustainable clinical neuroscience research on the continent, as well as the capacity for Africans to contribute to the advancement of the field of neurology. Using a Multiple PI mechanism, the program will be supported by a multidisciplinary global group with demonstrated expertise in clinical trial leadership and execution, built on an infrastructure of existing funded NIH clinical neuroscience research programs & training grants in Africa. TALENTS is based in part on social science theories, & empirical data. AFAN will freely provide member benefits & support for a rich array of career development activities at their annual meetings. TALENTS will be integrated into Mentor research projects as much as possible. Five scholars will be accepted into the program each year.
Role: MPI
Collaborators: UCSF
2. Title: African Rigorous Innovative Stroke Epidemiological Surveillance (ARISES) R01NS115944
Funder: NIH/NINDS
Brief Summary: The African Rigorous Innovative Stroke Epidemiological Surveillance (ARISES) initiative introduces a groundbreaking Stroke Information and Surveillance System (SISS) through mobile health (mHealth) technology. Its primary goal is to accurately measure and continually track stroke burden in both urban and rural areas of Nigeria while enhancing stroke awareness, early detection, and outcomes.
ARISES leverages prior resources like stroke literacy videos, culturally-tailored dance routines, a pictographic screening tool, and specialized software for precise stroke characterization. Pilot tests involving 1,095 households demonstrated high mobile phone accessibility (99%) and community willingness (over 95%) to engage with the e-Surveillance system for reporting stroke incidents.
To ensure comprehensive data collection and precise population estimates, ARISES will conduct thorough community mappings, update demographic profiles, and utilize a unique "hot and cold pursuit" method, combining traditional and non-traditional healthcare systems for comprehensive case identification.
Furthermore, the initiative plans to integrate SISS into a sustainable care framework to improve stroke outcomes within the surveyed areas. ARISES aims to serve as a scalable model, using novel e-Surveillance, community engagement strategies, and mHealth technology to generate accurate epidemiological data on stroke burden in resource-limited settings. Its broader goal includes enhancing stroke literacy, prevention, early detection, and ultimately improving outcomes, making it a potential blueprint applicable not only in Nigeria but also in various low-resource settings globally, including low- and middle-income countries (LMICs) and the USA.
Role: PI
Collaborators: MUSC
3. Title: Copy number Variation and Stroke (CaNVAS) risk and outcome Study R01NS114045
Funder: NIH/NINDS
Brief Summary: The proposal aims to delve into the complex realm of ischemic stroke (IS) by exploring the uncharted territory of copy number variations (CNVs) within the genetic landscape. IS stands as a formidable cause of mortality and disability, its roots veiled in multifaceted origins. While genome-wide association studies (GWAS) have offered insights into stroke susceptibility, the role of CNVs remains largely unexplored in this context. Leveraging existing datasets encompassing over 24,500 IS cases and 43,500 controls, the research hypothesizes that analyzing CNVs could unravel novel associations shedding light on stroke mechanisms, treatment targets, and outcome predictors.
The study proposes a multi-pronged approach: first, identifying CNVs associated with IS risk across diverse demographics; second, validating these associations in diverse ethnic populations; third, elucidating how identified CNVs influence stroke risk using biomarker data; and fourth, exploring the relationship between CNV burden and stroke outcome at three months. This multifaceted investigation not only seeks to uncover genetic determinants but also establishes a platform for junior investigators, fostering a training network.
By investigating CNVs in IS, this study endeavors to unlock hidden aspects of stroke genetics, potentially revolutionizing stroke pathophysiology understanding. The discovery of novel genes, pathways, and treatment targets holds the promise of transforming stroke prevention, treatment, and patient outcomes.
Role: Co-invetigator, Site PI
Collaborators: University of Maryland Baltimore
4. Title: Systematic Investigation of Blacks with Stroke using Genomics (SIBS Genomics) R01NS107900
Funder: NIH/NINDS
Brief Summary: The prevalence of ischemic stroke, responsible for a significant portion of strokes in the USA, is influenced by intricate genetic and environmental factors, posing a challenge in comprehensively understanding its mechanisms. A considerable portion of stroke-related genetic risk remains unexplained, particularly in African and European Americans, hindering their translation into practical clinical applications. The absence of African populations in genome-wide association studies (GWAS) on stroke, despite their higher stroke heritability and potential for precise mapping, represents a critical gap in stroke genomics.
To address these limitations, the SIBS-Genomics initiative aims to identify, validate, and characterize novel genetic variants associated with ischemic stroke in people of African ancestry. Leveraging various NIH-funded projects in the US and Africa, such as REGARDS, SiGN, COMPASS, and others, SIBS-Genomics intends to significantly advance global efforts in discovering new genetic loci related to ischemic stroke. Key strategies include employing meticulously phenotype subjects with robust datasets, utilizing advanced genomics technology tailored for African ancestry, exploring a population with higher stroke heritability, and conducting comprehensive validation and functional assessments of previously identified variants.
This multi-stage approach involves collaboration among leading global experts to validate known variants in continental Africans, discover new variants in this population, validate in African Americans (the majority having West African ancestry), and conduct trans-ancestry analyses involving diverse American ancestries. The study's outcomes are expected to unveil insights into stroke's molecular mechanisms, leading to the development of targeted biomarkers for prediction, diagnosis, and prognosis, as well as interventions for stroke prevention and treatment. Importantly, this transomics study holds promise for significantly reducing the burden of stroke, especially among African Americans who currently face a disproportionately high incidence.
Role: PI
5. Title: Sub-Saharan Africa Conference on Stroke (SSACS) Conference 1R13NS115395-01A1
Funder: NIH/NINDS
Brief Summary: The Sub-Saharan Africa Conference on Stroke (SSACS) 2020 is the inaugural cross-national scientific gathering focused on cerebrovascular disease in Sub-Saharan Africa (SSA). Set against the backdrop of rising stroke prevalence due to increased risk factors and limited healthcare infrastructure, SSACS aims to bridge critical gaps in stroke research and cultivate a collaborative platform for stakeholders. Scheduled for a one-day symposium in Bahir Dar, Ethiopia, SSACS will feature keynote talks, symposia, poster sessions, and community engagements.
The conference seeks to bring together experts and early career scientists, emphasizing the latter's involvement to foster future advancements in stroke research within SSA. To achieve this, SSACS plans to grant 20 Young Investigator Travel Awards, nurturing a network of committed researchers dedicated to stroke study in the region.
SSACS' specific objectives include identifying research gaps, facilitating interdisciplinary discussions on stroke epidemiology, fostering collaborations among stakeholders, and disseminating acquired knowledge through scientific and public avenues. The conference's success will be gauged by attendee numbers and the achievements of Young Investigator Awardees, aiming to evaluate its impact and effectiveness in advancing stroke research within SSA. Collaborating with esteemed global organizations like the World Stroke Organization and World Federation of Neurology, SSACS aims to leverage their expertise, resources, and experience to maximize the conference's impact on stroke research in the region.
Role: Co-Chair
6. Title: Growing Data-science Research in Africa to Stimulate Progress (GRASP) UE5HL172183
Funder: NIH
Brief Summary: GRASP (Growing Data-science Research in Africa to Stimulate Progress) aims to confront the rising challenge of non-communicable diseases (NCDs), particularly neurological disorders, in Africa by bolstering sustainable research capabilities. Existing programs lack a specific focus on brain health, critical in achieving overall health goals. This initiative endeavors to enhance the data science expertise of selected African scholars to unravel the sociodemographic, dietary, and lifestyle determinants impacting brain health and cardiovascular risk.
The program intends to develop a cohort of researchers adept in data science methodologies, leveraging extensive datasets from SIREN, ARISES, CHAIR, H3Africa, DS-I Africa consortia, and other relevant resources. Five scholars annually will engage in mentored research projects for three years, integrating diverse data sets encompassing sociodemographic, cognitive, neuroimaging, genomic, climate, and geographical information. Their training includes a comprehensive nine-month Postgraduate Certificate program involving online modules and a residency at the University of Ibadan in Nigeria.
GRASP emphasizes skill enhancement in translational data science research with a specific focus on brain health, aiming to identify sociodemographic determinants and patterns across various datasets. The scholars will benefit from mentorship provided by elite mentors, ensuring robust guidance throughout their training. Monitoring the program's success involves assessing the scholars' academic progress, publications, and their ability to secure funding for research projects or career development.
Through GRASP, the initiative envisions cultivating a cadre of skilled researchers capable of addressing the complexities of brain health in African populations, paving the way for tailored interventions and strategies to combat NCDs.
Role: PI
7. Title: Recruitment and Retention for Alzheimer’s Disease Diversity Genetic Cohorts in the ADSP (READD – ADSP) study U19AG074865
Funder: NIH
Brief Summary: The John P. Hussman Institute for Human Genomics (HIHG) at the University of Miami, along with partner institutions, has launched a pioneering five-year initiative funded by a $46 million grant from the National Institute on Aging. This international effort aims to revolutionize Alzheimer’s disease research by expanding genetic studies into African ancestry populations and Hispanic/Latinx groups, historically underrepresented in such studies.
Led by Dr. Margaret A. Pericak-Vance and a team of co-Principal Investigators across various sites, including Case Western Reserve University, Columbia University, Wake Forest University, the University of Pennsylvania, and the University of Ibadan, the initiative seeks to rectify the lack of diversity in Alzheimer’s genetic studies. The primary goal is to establish a comprehensive genetic data resource by recruiting and analyzing a diverse cohort of 5,000 individuals from African countries, 4,000 African Americans, and 4,000 Hispanic/Latinx individuals. This extensive gathering of clinical, phenotypic, genetic, and social determinant data aims to deepen the understanding of Alzheimer’s across diverse populations.
The African Dementia Consortium (AfDC) will oversee recruitment in Africa, involving researchers from nine African nations. This collaboration seeks to enhance the characterization of dementia, particularly Alzheimer’s, within the African context. By exploring genetic factors influencing Alzheimer’s among diverse ancestral backgrounds, the initiative aims to develop more targeted and universally beneficial treatment strategies.
Additionally, the study will investigate the interplay between ancestry and social determinants of health in Alzheimer’s risk and age of onset. Through this initiative’s collaborative efforts and individual participation, it aims to bridge research gaps, tackle disparities, and pave the way for more effective Alzheimer’s treatments and prevention strategies.
Role: Co-Investigator
8. Title: Consortium for Advancement of MRI Education and Research in Africa (CAMERA)
Funder: Silicon Valley Community Foundation (SVCF)
Brief Summary: The Consortium for Advancement of MRI Education and Research in Africa (CAMERA) aims to revolutionize healthcare in Africa by addressing the critical deficit in MRI technology and expertise. Despite facing a considerable burden of non-communicable diseases, African countries encounter limited access to MRI technology and a shortage of skilled personnel proficient in MRI operations.
CAMERA represents a collaborative effort between African MRI experts and global partners, striving to establish a sustainable MRI training and mentorship program across African nations. The initiative's core objectives include training 12 emerging MRI scientists and technologists sourced from Nigeria, Ghana, Uganda, Kenya, and Mozambique. Additionally, it aims to set up an African Chapter of the International Society of Magnetic Resonance in Medicine (ISMRM) to amplify African contributions to global MRI advancements.
To ensure talent retention, CAMERA plans to cultivate a robust mentorship program for early-career MRI scientists, fostering collaborative projects and encouraging their continued presence and impact within the region. An online MRI resource platform will be developed, serving as a repository for virtual education sessions, housing tools for image processing, analysis, and sequence development.
Furthermore, CAMERA will facilitate hands-on training courses for MRI engineers within African countries. These courses intend to equip local engineers with the necessary expertise to sustain and maintain MRI technology, promoting self-sufficiency in MRI operations within the region.
By expanding access to MRI technology, empowering local expertise, and fostering a collaborative and sustainable environment, CAMERA endeavors to significantly enhance healthcare delivery and research capabilities across Africa.
Role: Co-Investigator
15. Title: African Neurobiobank for Precision Stroke Medicine (ELSI) : U01HG010273
Funder: NIH
Brief Summary: The African Neurobiobank for Precision Stroke Medicine - Ethical, Legal, and Social Implications (ELSI) Project aims to address the critical gaps and uncertainties surrounding stroke biobanking in Sub-Saharan Africa (SSA). Despite the growing biobanking initiatives through the Human, Heredity and Health in Africa (H3Africa) initiative, Africa has been historically underrepresented in this realm.
Stroke incidence rates in SSA are rising, with poorer outcomes and affecting a relatively younger population compared to other ethnicities. To advance precision medicine for stroke in this region, it's crucial to understand the intricate interplay between environmental and genomic risk factors. However, the ethical, legal, and social implications (ELSI) of developing neurobiobanks in an African context remain unclear. This includes addressing unique cultural, linguistic, and belief systems within a global research community that values openness and sharing of biological materials.
The project's primary goal is to identify and tackle the ELSI challenges of stroke biobanking in SSA. Adopting a community-based participatory mixed methods research (CBPR) approach, the project will engage multiple levels of the social ecological model. It aims to develop culturally appropriate interventions and tools to enhance community understanding and participation in stroke biobanking activities. The ultimate objective is to foster enduring trust and fair utilization of biobanking resources for genetic and trans-omics research related to stroke and other neurological disorders.
Role: Co-Investigator
16. Title: SIBS Genomics Genetics Counselling Study (SIBS-Gen-Gen) 3R01NS107900-02S1
Funder: NIH/NINDS
Brief Summary: The SIBS Genomics-Genetic Counselling (SIBS-Gen-Gen) project aims to integrate implementation science into stroke research among individuals of African ancestry. Stroke is a significant cause of disability and mortality, particularly prevalent among people of African descent. While some genetic variants linked to ischemic stroke have been identified in other populations, there's a notable absence of findings among indigenous Africans (IA). The SIBS Genomics study seeks to fill this gap through the first genome-wide association study focused on genetic determinants of stroke among indigenous Africans.
However, before integrating these emerging genetic determinants into clinical practice, validation is essential. This ancillary study, conducted in response to NOT-TW-19-003, will explore the perceptions, preferences, and attitudes of stroke-free individuals regarding the disclosure of genetic test results for stroke. This research aims to understand the implications of disclosing genetic findings related to stroke among individuals and their families, healthcare providers, and the wider community within the socio-ecological model.
The project, SIBS-Gen-Gen, plans to engage stroke-free individuals, their families, healthcare providers, and the community to gauge their understanding and receptivity towards genetic testing disclosure. Additionally, a workshop on genetic counseling will be conducted to equip relevant personnel with the skills necessary for handling genetic test results effectively.
This study intends to generate pilot data for designing a randomized controlled trial focused on the disclosure of stroke genetic test results. Ultimately, the project aims to prepare for the implementation of genetic findings from SIBS Genomics into clinical and community settings by understanding the perceptions and attitudes of the target population towards genetic testing disclosure for stroke.
Role: PI
17. Title: Pilot grant on Stroke inflammatory protein biomarkers.
Funder: University of Glasgow,
Collaborators: University of Glasgow, UK/University of Ibadan, Nigeria
18. Title: Expanding Global Access to Bioimaging RFA
Funder: The Chan Zukerberg Initiative DAF
Brief Summary: Strengthening Consortium for Advancing MRI Education & Research in Africa (GBI). The study aims to provide researchers and clinicians in Africa the requisite technical support to accelerate and advance Magnetic Resonance Imaging (MRI) education, research and clinical translation.
Role: Co-Investigator
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Other Interest/Hobbies
Philosophy serves as my compass in navigating life's complex questions, delving into the depths of existence, the universe, human beingness, and spirituality. The pursuit of wisdom and understanding through philosophical discourse brings a profound sense of introspection and intellectual curiosity, shaping my perspective on the world.
Spirituality intertwines seamlessly with my quest for deeper meaning, offering solace and connection to a higher realm. Exploring spiritual teachings, practices, and meditation serves as a pathway to inner peace, mindfulness, and a profound sense of interconnectedness with the universe.
Movies are my gateway to diverse narratives, emotions, and experiences. Whether indulging in thought-provoking classics or immersive blockbusters, the cinematic world fascinates me with its storytelling prowess. Each film offers a unique lens into humanity, evoking emotions, sparking contemplation, and often serving as a source of inspiration.
In the realm of sports, lawn tennis fuels my passion for physical activity and strategic gameplay. The dynamic nature of the sport, its blend of athleticism and mental agility, captivates me. The thrill of each match, the precision in each stroke, and the strategic maneuvers on the court ignite a competitive spirit and a drive for continuous improvement.
These diverse interests harmonize to form the fabric of my life, offering a balanced blend of intellectual exploration, spiritual growth, cultural immersion, and physical vitality. Each pursuit contributes uniquely to my journey, shaping my values, broadening my horizons, and nurturing a holistic approach to experiencing the richness of life.