Prof. Catherine O. FALADE

Basic Information

 Akinlosotu

Name: Prof. Catherine O. FALADE

 Faculty: BASIC CLINICAL SCIENCES

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  Department:Pharmacology and Therapeutics

 Designation: Professor

Brief Biography:

Resume

CURRICULUM VITAE

I         (a) Name:                        FALADE Catherine Olufunke (Nee   FALODUN)      

          (b) Department:              Pharmacology and Therapeutics

          (c) Faculty:                     Basic Medical Sciences

          (d) College:                     College of Medicine, University of Ibadan, Nigeria

II         (a) First Academic Appointment:                     May 28th 1994

           (b) Present post: Senior Lecturer                    October 1st 1997

           (c) Acting Head of Department                        March 2004 to August 2006

           (d) Acting Head of Department                        August 2010 to date.

III      EDUCATIONAL TRAINING

INSTITUTION/LOCATION

DEGREE

MM/YY

FIELD OF STUDY

University of Ibadan, Ibadan 

MB.BS

1969 - 1975

Medicine & Surgery

University of Ibadan, Ibadan 

M.Sc

1999 - 2001

Pharmacology

 

IV        Academic qualifications (with dates and granting bodies)

Academic Qualifications

Granting Institution

Dates

MB.BS (with distinction in Pediatrics)

University of Ibadan.

1975 June

M.Sc Pharmacology

University of Ibadan

2001 February

                   

V          Professional qualifications and Diplomas

Professional Qualifications

Granting Institutions

    Dates

FWACP

West African Postgraduate Medical College

    1989

FMCP (Physic)

National Postgraduate Medical College of

Nigeria

    1990

 VI       Scholarships, Fellowships and Prizes

Federal Government Scholar, University of Ibadan, Ibadan                  1970 – 1975

Distinction in Pediatrics                                                                    1974

Glaxo Prize in Pediatrics                                                                  1975

Departmental Prize in Pediatrics                                                       1975

Catherine & Frank D Mac Arthur Fellowship                                       1997

VIIa    HONOURS, DISTINCTIONS AND MERITS

Consultant Clinical Pharmacologist, U. C. H., Ibadan          1995 to Date

            Head Department of Clinical Pharmacology, UCH   2004 Mar - Aug 2006

Member, University of Ibadan Senate                               2004 to date

Member, College of Medicine Academic Board                 2005 to date

Member/ Faculty representative, UI/UCH IRC                  2003 to date

Member CDA Independent Data and Safety

Management Committee                                            2006 Oct to 2009

Pediatric ACT Advisory Committee of Medicine for

Malaria Venture (MMV)                                              Sept 2007 to date

Examiner, National Postgraduate Medical College            2006 to date

Resource person, West African College of Physicians       2000 to date

Examiner, West African College of Surgeons                     2006 to date

            External examiner in Pharmacology University of Lagos   1999 -2003, 2007 to date    

External examiner, Department of Pharmacology:

Ladoke Akintola University of Technology, Ogbomosho     2002 -2005   

External examiner in Pharmacology, Olabisi Onabanjo     

University, Shagamu                                                      2005 to date

External examiner in Pharmacology: OAU, Ile Ife             2002 – 2005

External examiner in Pharmacology, Ambrose Alli

University, Ekpoma                                                       2005 to date

External examiner Pharmacology, Ahmadu Bello            

University, Zaria (MB.BS & MSc. Pharmacology)             2006 to date

External examiner in Pharmacology, College of Health

Sciences, University of Ilorin, Ilorin                              2008 to date

VIIb    MEMBERSHIP OF LEARNED SOCIETIES

Member-International Network for the Rational

            Use of Drugs (INRUD) Nigeria Core Group                               1995

Member, Nigerian Medical Association                                                1975

Fellow, West African College of Physicians                                         1989

Fellow, National College of Physicians of Nigeria                                 1990

Member, Association of Physicians of Nigeria                                     1989

Member, West African Society of Pharmacologists                              2002

Member, American Society for Tropical Medicine and Hygiene              2003

Fellow, Royal Society of Tropical Medicine and Hygiene UK                 2004

VIII    DETAILS OF TEACHING AT THE UNIVERSITY LEVEL

  1. Course:            Core Lectures: Therapeutics in Medicine          1996 to 2006

       Class:              Medical Students (MB.BS) 600 Level

      Course content: Dosage forms and drug prescriptions, Drug interactions, clinical significance, monitoring of adverse drug reactions and interactions, influence of disease on drug effects and interactions. Introduction to clinical Pharmacokinetics and pharmacodynamics

  1. Course:            Introduction to pharmacology, Blocks I and II     1995 to Date

                                       Postings in Pharmacology

                Class:               Medical Students (MB.BS) and Dental students (BDS)

                Course content:  Principles of drug action autonomic pharmacology,Diuretics and antihypertensive drugs, chemotherapy of bacterial                                       infections, chemotherapy of parasitic diseases, cardiovascular pharmacology, drugs used in the treatment of duodenal ulcer, Bronchial asthma etc

  1. Course:            Pharmacology in B. Pharm Program                      1994 to date

                Class:               Pharmacy Students (B. Pharm.) 300, 400, 500 Level students

                Course content:  Cardiac glycosides, antiarrhythmic drugs, anti-anginal drugs, vasodilators, pharmacology of the autonomic nervous system,

                                      adrenergic and cholinergic drugs, anticholinesterases and neuromuscular blockers.

  1. Course:            Pharmacy in BNSc Nursing and B. Physiotherapy     ‘99–date

                Class:               BNSc nursing students,

  1. Physiotherapy students

                Course content: Basic pharmacology, principles of chemotherapy and antihypertensive therapy.

  1. Course:            Pharmacology in M. Sc Nursing                                1996 to date

                Class:               M. Sc nursing students

                Course content:  Cardiovascular Pharmacology

  1. Course:PHA 704                                                                                2001 to 2005

                Class:               M. Sc Pharmacology 

                  Course content:   Clinical evaluation of drugs in man                       

  1. Course:PHA 706                                                                               2001 to 2005

                Class:                  M. Sc Pharmacology

              Course content:    Putative neurotransmitters in the Central Nervous System       

  1. Course: PHA 711                                                                              2000 to 2006

                 Class:              M. Sc Pharmacology

              Course content:   M. Sc project work supervision

                                      I have supervised four (4) students to date

  1.  Supervision of     I have supervised more than 10 B. Pharm projects 1998 to date

           B.Pharm 

           Students  

  1. Supervision of M. Sc Pharmacology  Students

I have supervised 5 M. Sc Pharmacology students     

  1. Residency Training

Supervision of residents in clinical pharmacology 2004 to

Supervision of the training and projects (5) for the Fellowship of Postgraduate Medical Colleges (National and West African Colleges)

Resource Person for Peer Review Journals

Peer Reviewer - American Journal of Tropical Medicine and Hygiene

Peer Reviewer - Bulletin of the World Health Organization

Peer Reviewer - Journal of Pediatric Infectious Disease

Peer Reviewer - African Journal of Medicine and Medical Sciences

Peer Reviewer - West African Journal of Medicine

Peer Reviewer - African Journal of Biomedical Sciences

Peer Reviewer - Nigerian Journal of Pediatrics

Peer Reviewer – Malaria Journal

Researches

  1. Comparative efficacy and tolerance of halofantrine, pyrimethamine sulfadoxine and chloroquine in acute uncomplicated malaria in Nigerian children.

Principal investigator: Prof. L.A. Salako

Funding agency: SmithKlineBeecham

  1. Evaluation of non-microscopic techniques for determination of prevalence of malaria infection.

Principal investigator: Prof. A. M. J. Oduola

Funding agency: WHO/TDR

  1. Novel approach to sequential or combination therapy of falciparum malaria

Principal investigator: Prof. A. Sowunmi

Funding agency: WHO/TDR

  1. Research group development grant: Inter-institution collaboration and studies on combination therapy: drug resistance, immunology and vaccine for malaria.

Principal investigator: Prof. A.M.J. Oduola

Funding agency: WHO/TDR

  1. An open label comparative study to determine the safety and efficacy of  atovaquone/proguanil (Malarone™) versus chloroquine in the treatment of acute plasmodium falciparum malaria in children > 5kg and < 11kg in weight in Nigeria

Principal Investigator: Prof. L.A. Salako

Funding agency: GlaxoWellcome

  1. A multi center double blind phase III study comparing the safety and efficacy of chlorproguanil-dapsone (LapDap™) versus sulfadoxine- pyrimethamine (Fansidar™) in the treatment of uncomplicated falciparum malaria in children in Africa.

Principal Investigator: Dr. C. O. Falade

Funding agency: WHO/TDR

  1. Open label, multicenter study for the evaluation of safety and efficacy of Coartem™ (artemether-lumefantrine) tablets (6-dose regimen) in African infants and children in the treatment of acute uncomplicated malaria.

Principal investigator: Dr.  C. O.  Falade

Funding agency: WHO/TDR

       8.    Incorporating socio-cultural and economic characteristics of mothers     and care        givers in the home management of malaria in children

Principal Investigator: Prof J. D. Adeniyi

Funding agency: MIM/TDR

       9.    A multicenter, randomized, parallel group study to assess the efficacy, safety and tolerability of a single 400mg PO dose of oxibendazole suspension versus a single 500mg PO dose of mebendaxole tablet in the treatment of intestinal helminthic infections in children (2 – 17yrs).

          Principal Investigator: Dr. C. O. Falade

          Funding agency: GlaxoSmithKline

      10.Identification of potential antimalaria compounds from Nigeria     phytomedicine compendium.

Principal investigator: Dr. Edith Ajaiyeoba

          Funding agency: MIM/TDR      

     11.Evaluation of dihydroartemisinin (Cotecxin™) suppositories in the management of severe non-cerebral malaria in children from southwestern Nigeria

            Principal Investigator: Dr. C. O. Falade

          Funding agency: ChurchBells Pharmaceuticals Ltd

       12.Epidemiology of congenital malaria in Nigeria: A multi-center study

National coordinator & PI (Ibadan Center): Dr. C. O. Falade

Funding Agency: USAID

  1. Antimalaria drug resistant network: defining and monitoring drug resistant Plasmodium falciparum infections in southwest Nigeria.

Comments

Principal Investigator: Dr. G.O. Gbotosho

CO-PI: Dr. C. O. Falade

Funding agency: WHO/TDR

  1. Evaluation of the safety and efficacy of two artemisinin containing combinations in the management of acute uncomplicated malaria in Children from southwestern Nigeria

Principal Investigator: Dr. C. O. Falade

  1. Improving home management of malaria using artemether-lumefantrine (Coartem™) in the home management of malaria

            Principal Investigator: Dr. IkeOluwapo Ajayi

Funding agency: MIM/TDR

  1. Evaluation of the effectiveness of unsupervised artemether-lumefantrine (Coartem™) in home management of malaria

Principal Investigator: Dr. IkeOluwapo Ajayi

Funding agency: MIM/TDR

        17.Global Health and Geo-resource Management in Nigeria

Principal investigator:  Prof Airhihenbuwa (Penn State University)

Role: Nigeria project leader 

Funding Agency: Forgaty/NIH

18.Evaluation of Audiometric changes during treatment of malaria with Artemisinin Containing Combination Therapies      in Nigerian Children

            Principal investigator: Dr. Catherine Falade 

Funding Agency: Senate Research Grant 2007

DISSERTATIONS AND THESIS

Falade C.O.   “Evaluation of Plasmodium falciparum lactate dehydrogenase activity in isolates ofPlasmodium falciparum during in-vitro culture” (2001)

M.Sc Pharmacology dissertation, University of Ibadan

Falade C.O. “Pattern of Hypertensive Disease in the Nigerian African As Seen At the University College Hospital, Ibadan” (1989)

                                 Dissertation for the Fellowship the West African Postgraduate Medical College of Physicians, (F.W.A.C.P.) Faculty of Internal Medicine

Falade C.O. “A Casebook in Physic” (1990)

Dissertation for the Fellowship of the National Postgraduate Medical College of Nigeria (F.M.C.P) Faculty of Internal Medicine

Focus of Research

My research efforts have focused on malaria in children, the sub-segment of the population of malaria endemic areas that takes the brunt of the infection. By a conservative estimate about two million deaths result from malaria annually and over 70% of these deaths occur in sub-Saharan Africa. Contrary to earlier beliefs, malaria has acquired the status of a pandemic and no longer a disease of tropical endemic areas of the world only. My research into malaria is a holistic one which covers many areas of Malariology  in an effort to contribute in some way to the control of this parasitic infection. I have worked on the evaluation of various treatment modalities and improving the management of malaria, an infection that is responsible for more deaths than the dreaded HIV/AIDS.   

My collaborators and I work in active collaboration with the Malaria Control Units of both the State and Federal Ministries of Health so that our research findings can be made available and also be  meaningfully incorporated into policy for the benefit of children in malaria endemic areas in general and Nigerian children in particular. My research focus can be broadly summarized into five subgroups as follows: 

  1. Diagnosis and Management of Malaria
  2. Chemotherapy of Malaria
  3. Malaria in Pregnancy and the newborn
  4. Epidemiology of malaria among HIV positive patients.
  5. Antimalarial Compounds from Nigerian Phytomedicine Compendium

Publications

 

  1. Sowunmi A., Ohaeri J.U., Falade C.O 1995:  Falciparum malaria presenting as psychosis: A case, Report. Tropical. Geographical.  Medicine.  5: 218 –219. [United Kingdom].
  2. Sowunmi, A., Abohweyere, A.E.J., Akindele, J.A., Ilesanmi, A.O., Falade C.O., and Oduola, A.M.J. (1996):  Comparison of the incision and aspiration methods for the diagnosis of placental malaria infection. Journal of Obstetrics and Gynecology 16 : 316-320. [United Kingdom].
  3. Sowunmi A., Ilesanmi A.O., Akindele J.A., Abohweyere A.E.J., Fawole A.O., Falade C.O. Oduola A.M.J (1996):  Placenta falciparum infection and outcome of pregnancy in West African mothers from an endemic area. Journal of Obstetrics and Gynecology. 16 : 211-216. [United Kingdom].
  4. Oduola, A.M.J., Omitowoju, G.O., Sowunmi, A., Makler, M.T., Falade C.O., Kyle, D.E., Fehintola, F.A., Ogundahunsi, O.A.T., Piper, R.C., Schuster, B.G. and Milhous, W.K. (1997):  Plasmodium falciparum: evaluation of lactate dehydrogenase in monitoring therapeutic responses to standard antimalarial drugs in Nigeria.  Experimental.  Parasitology; 87: 283-289. [United Kingdom].
  5.  Falade C.O., Salako L.A., Sowunmi A., Oduola A.M.J. and Larcier P. (1997): Comparative efficacy of halofantrine, chloroquine and suphadoxine-pyrimethamine in the treatment of acute uncomplicated falciparum malaria in Nigerian children.  Transactions of the Royal Society of Tropical. Medicine and Hygiene 91: 85-62. [United Kingdom].
  6. Sowunmi, A., Oduola A.M.J., Ogundahunsi, O.A.T, Falade C.O., Gbotosho, G.O., Salako L.A (1997):  Enhanced efficacy of chloroquine-chlorpheniramine combination in acute uncomplicated falciparum malaria in children.  Transactions of the Royal Society of Tropical Medicine and Hygiene 91: 63-67 [United Kingdom].
  7. Sowunmi A., Falade C.O., Oduola A.M.J, Ogundahunsi O.A.T., Fehintola F. A., Gbotosho G. O., Lacier P, Salako L.A. (1998): Cardiac effects of halofantrine in children suffering from acute uncomplicated Plasmodium falciparum malaria.  Transactions of the Royal Society of Tropical. Medicine and Hygiene 92: 446-448. [United Kingdom].
  8.  Sowunmi A., Ogundahunsi O.A.T., Falade C.O., Gbotosho G.O. & Oduola A. M. J. (2000): Gastrointestinal manifestations of acute falciparum malaria in children.  Acta Tropica 74; 73-76 [Sweden].
  9. Sowunmi, A., Fehintola, F.A., Adedeji, A.A., Falade A.G., Falade C.O., Akinyinka, O.O., Oduola, A.M.J (2000): Comparative efficacy of chloroquine plus chlorpheniramine alone and in sequential combination with sulfadoxine-pyrimethamine for the treatment of acute uncomplicated falciparum malaria in children. Annals of Tropical Medicine & Parasitology. 94 (3); 209-217 [United Kingdom].
  10. Sowunmi, A., Falade, C. O., Adedeji, A. A., Happi. T. C., Sowunmi, C. O., Ofi, A. B., Okanlawon, F. A. & Oduola, A. M. J. (2000): Pattern of change in electrocardiogram after halofantrine treatment of acute falciparum malaria in children. Clinical Drug Investigation 20 (4) 229-235. [United Kingdom].
  11.  Sowunmi, A., Adedeji, A.A., Sowunmi. C.O., Falade, C.O., Falade A. G., Ohaeri, B., Happi. T.C. & Oduola, A.M.J (2001): Clinical characteristics of and disposition kinetics of the hepatomegaly associated with acute uncomplicated Plasmodium falciparum malaria in children. Annals of Tropical Medicine and Parasitology. 95:7-18  [United Kingdom].
  12.  Sowunmi A., Falade, A.G., Adedeji A.A. & Falade C.O. (2001): Comparative clinical characteristics and responses to oral 4-Aminoquinoline therapy of malarious children who did and did not develop 4-Aminoquinoline-induced pruritus. Annals of Tropical Medicine & Parasitology 95:  549-558 [United Kingdom].
  13. Sowunmi, A., Ayede, A. I., Falade, A. G., Ndikum, V. N., Sowunmi C. O., Adedeji, A. A, Falade C.O., Happi, T. C. & Oduola, A. M. J. (2001): Randomized comparison of chloroquine and amodiaquine in acute uncomplicated malaria Annals of Tropical Medicine & Parasitology. 96: 409-418. [United Kingdom].
  14. Ajaiyeoba E.O., Osowole O.S., Oduola O.O., Ashindi J.S., Akinboye D.O., Gbotosho G.O., Falade C.O., Ogundahunsi O.A.T., Fawole O.I., Bolaji O. M., Falade M.O., Oladepo O.O., Itiola O.A. and Oduola A.M.J. (2002): Nigerian antimalarial ethnomedicine 2: Ethnobotanical surveys of herbal remedies in the treatment of febrile illnessess in the middle belt of Nigeria. Journal of Phytomedicine and Therapeutics 7: 26-39 [Nigeria].
  15. El Setouhy M, Agbenyega T, Anto F, Clerk CA, Koram K, English M, Molyneux  C, Peshu N, Juma R, Mfutso-Bengu J, Molyneux M, Taylor T, Diarra DS, Maiga S, Youssuf D, Falade CO,  Gbadegesin S, Lie R, Mugusi F, Ngassapa D, Ecuru J,  Talisuna A, Emmanuel E, Grady C, Wendler D, Higgins E, Plowe C, Sugarman J(2002) Fair benefits for research in developing countries Science. 298:2133-2134 [USA].
  16.  Ajayi I. O., Falade C.O., Adeniyi J.D., Bolaji M.O. (2003): Role of patent medicine sellers in home management of childhood malaria: A situational analysis of experience in rural Nigeria. (2002-2003) International Quarterly of Community Health Education; 21 (3). 271-281. [USA].
  17. Ajaiyeoba, E.O; Oladepo O., Fawole O.I., Bolaji O.M., Akinboye D.O., Ogundahunsi O.A.T., Falade C.O., Gbotosho G.O, Itiola O.A., Happi T.C., Ebong O.O., Ononiwu I.M., Osowole O.S., Oduola O.O., Ashidi J.S. and Oduola A.M.J. (2003): Cultural categorization of febrile illnesses in corellation with herbal remedies for treatment in southwestern Nigeria. Journal of Ethnopharmacology 85: 179-185 [The Netherlands].
  18. Happi T.C., Thomas S.M., Gbotosho G.O., Falade C.O., Akinboye D.O., Gerena L, Hudson T, Sowunmi A., Kyle D.E., Milhouse W., Wirth D.F. and Oduola A.M.J. (2003): Point mutations in the pfcrt and pfmdr-1 genes of Plasmodium falciparum and clinical response to chloroquine among malaria patients from Nigeria. Annals of Tropical Medicine & Parasitology 97 (5): 439-451 [United Kingdom].
  19.  Happi C. T., Gbotosho G. O., Sowunmi A., Falade C. O., Akinboye D. O., Oladepo O., Oduola A. M. J. (2004): Malaria Diagnosis: false negative ParaSightTM tests in falciparum malaria patients in Nigeria. African Journal of Medicine and Medical Science.33: 15-18 [Ibadan Nigeria].
  20.  Sowunmi A., Fehintola F. A., Adedeji A. A., Gbotosho G. O., Falade C. O., Fateye B. A., Happi T. C. and Oduola A. M. J. (2004): Open randomized study of pyrimethamine-sulfadoxine versus pyrimethamine-sulfadoxine plus probenecid for the treatment of uncomplicated falciparum malaria in children. Tropical Medicine and International Health: 9: (5) 606-614 [United Kingdom].
  21. Alloueche A, Bailey W, Barton S, Bwika J, Chimpeni P, Falade C.O, Fehintola F. A, Horton J, Jaffar S, Kanyok T., Kremsner P.G, Kublin JG, Lang T, Missinou M.A, Mkandala C, Oduola A.M.J, Premji Z, Robertson L, Sowunmi A, Ward S.A, Winstanley P.A (2004): A double-blind randomized comparison of chlorproguanil-dapsone with sulfadoxine-pyrimethamine for the treatment of uncomplicated falciparum malaria in young African children. Lancet 363: 1843 -1848 [United Kingdom].
  22. Ajaiyeoba E.O., Falade C.O., Fawole O.I., Akinboye D.O., Gbotosho G.O., Bolaji O.M., Ashidi J.S., Abiodun O.O., Osowole O.S., Itiola O.A., Oladepo O., Sowunmi A. and Oduola A.M.J. (2004): Efficacy of herbal remedies used by herbalists in Oyo State Nigeria for treatment of Plasmodium falciparum infections – a survey and an observation. African Journal of Medicine and Medical Sciences.33, 115-119 [Nigeria].
  23. Ajaiyeoba E., Ashindi J, Abiodun O., Okpako L., Ogbole O., Akinboye D., Falade C., Bolaji O., Gbotosho G., Falade M., Itiola O., Houghton P., Wright C. and Oduola Ayoade (2004): Antimalaria ethnobotany: In vitro antiplasmodial activity of seven plants in the Nigerian middle belt. Pharmaceutical Biology: 42, 588-91. [Hawaii].
  24. Fehintola F.A.Olayemi O. Oshungbade K. Tongo O. Olomu S.A. Falade C.O., Salako B.L. Sowunmi A. (2004): Profile of Chloroquine-induced pruritus in Nigerian children resident in Ibadan, Nigeria.  African Journal of Biomedical research.;7: 97-101 [Nigeria].
  25. Oduola O. O., Happi T. C., Gbotosho G. O., Ogundahunsi O. A. T., Falade C. O., Akinboye D. O., Sowunmi A. and Oduola A. M. J. (2004): Plasmodium berghei: efficacy and safety of combinations of chloroquine and promethazine in chloroquine resistant infections in Gravid mice. African Journal of Medicine and Medical Sciences. 33: 77-81 [Nigeria].
  26. Happi C.T., Gbotosho G.O.,Sowunmi A, Falade C.O, Akinboye D.O., Hudson T, Gerena L, Kyle DE, Milhous W, Dyann F Wirth and Oduola AMJ (2004): Molecular analysis of Plasmodium falciparum in recrudescent malaria infections treated with chloroquine in Nigeria. American Journal of Tropical Medicine and Hygiene.  70 (1) 20-26. [USA].
  27. Dada-Adegbola H. O., Falade C. O., Oluwatoba O. A. & Abiodun O. O. (2004): Gastrodiscoides hominis infection in a Nigerian – A case report. West African Journal of Medicine 23 (2): 185-186 [Nigeria].
  28. Falade C. O., Osowole O.S., Adeniyi J.D., Oladepo O.O. and Oduola A.M.J.(2004) Attitude of health care workers to the involvement of alternative healthcare providers in the home management of childhood malaria: International Quarterly of Community Health Education23(2): 169-180 [USA].
  29. El Setouhy M, Agbenyega T, Anto F, Clerk CA, Koram K, English M, Mfutso-Bengu J, Molyneux M, taylor T, Diarra DS, Maiga S, Youssuf D, Falade CO,  Gbadegesin S, Lie R, Mugusi F, Nbassapa D, Ecuru J,  Talisunma A, Ezek et al (2004). Moral standards for research in developing countries from “Reasonable availability” to “Fair benefits”. The Hastings Center Report 34[3]: 17-27[USA].
  30. Falade C, Makanga M, Premji Z, Ortmann E, Stockmeyer M and Ibarra de Palacios P. (2005): Efficacy and safety of artemether-lumefantrine (Coartem®) tablets (six-dose regimen) in African infants and children with acute uncomplicated malaria. Transactions of the Royal Society of Tropical. Medicine and Hygiene 99: 459-467. [United Kingdom].
  31. Ajaiyeoba E.O., Bolaji O.M., Akinboye D.O., Falade C.O., Gbotosho G.O., Ashindi J.S., Okpako L.C., Oduola O.O., Falade M.O., Itiola O.A., Houghton P.J., Wright C.W., Ogundahunsi O.A.T and Oduola A.M.J. (2005): In vitro anti-plasmodial and cytotoxic activities of plants used as antimalaria agents in the southwest Nigeria ethnomedicine. Journal of Natural Remedies. 51; 1-6 [India].
  32. Osowole, O., Ajaiyeoba, E., Bolaji, O., Akinboye, D., Fawole, O., Gbotosho, C. G., Ogbole, O., Ashidi, J., Abiodun, O., Falade, C., Sama, W., Oladepo, O., Itiola, I., Oduola, A. (2005). A survey of treatment practices for febrile illnesses among traditional healers in the Nigerian Middle belt zone. Afric. J. Trad. Compl & Alternate Med 2005 (Vol. 2) (No. 3) 337-344  [Nigeria].
  33. Ebong O. O., Ajaiyeoba O, Ononiwu I. M., Eteng M. J., Akinboye D. O., Gbotosho G. O., Falade C. O., Bolaji O. M., Oladepo O., Osowole O. S., Happi C., Fawole O. F., Ogundahunsi O. A. T., Agbadwa I. M., Oduola O., & Oduola A. M. J.  (2005) Contribution of indigenous health care givers to the herbal management of febrile illnesses in Rivers State, South-South Nigeria. West African Journal of Pharmacology and Drug Research:21; 48-54 [Nigeria].
  34. Dada-Adegbola H. O., Oluwatoba O. A., Falade C. O., (2005) The prevalence of multiple intestinal helminths among children in a rural  community. African Journal of Medicine and Medical Sciences. 34: 263-267 [Nigeria].
  35. Makanga M, Premji Z, Falade C, Karbwang J, Mueller EA, Andriano K, Hunt P, De Palacios PI (2006) Efficacy and safety of the six-dose regimen of artemether-lumefantrine in pediatrics with uncomplicated Plasmodium falciparum malaria: a pooled analysis of individual patient data. American Journal of Tropical Medicine & Hygiene 74(6):991-8 [USA].
  36. Ajayi I. O., Falade C. O. (2006) Pre-hospital treatment of febrile illness in children attending the General Outpatients Clinic, University College Hospital, Ibadan, Nigeria. African Journal of Medicine and Medical Sciences. 35(1):85-91. [Nigeria].
  37. Falade C. O., Ogundiran M. O., Bolaji M. O., Ajayi I. O., Akinboye B. O., Oladepo O., Adeniyi J. D. (2006) The influence of cultural perception of causation, complications and severity of childhood malaria on determinants of treatment and preventive pathways. International Quarterly of Community Health Education24(4): 347-363 [USA].
  38. Falade C. O., Oladoyinbo S. O., Elemile T. T., Ajayi I. O, Fawole O. I., Adeniyi J. D. (2006) How well equipped are healthcare facilities to manage childhood malaria? The situation in selected local government areas in South Western Nigeria. African Journal of Medicine and Medical Sciences, 35:329-335. [Nigeria].
  39. Falade C.O., Fadero F. F. Aiyede I, Happi T.C. Dada-Adegbola H.O., Gbotosho G.O., Falade A.G., Oduola A.M.J. and Salako L.A. (2007): Comparative efficacy of dihydroartemisinin suppository versus intramuscular artemether followed by oral sulfadoxine-pyrimethamine in the management of moderately severe malaria in Nigerian children American Journal of Tropical Medicine & Hygiene 76:1; 1-6[USA].
  40. Fehintola F. A., Falade C. O., Sowunmi A. (2006) Intravascular hemolysis following treatment of malaria with halofantrine: case report. Nigerian Journal of Clinical Practice. 9(2):174-5. [Nigeria].
  41. Ogundele S. O. Falade C. O. (2006) Good clinical practice in Nigeria: the way forward Annals of Ibadan Postgraduate Medicine 4: (1) 28-32 [Nigeria
  42. Falade C.O., Ogundahunsi O.A.T., Ajayi I., Oduola A.M.J (2007) Effectiveness, of the use of chloroquine plus Chlorpheniramine in the management of acute  uncomplicated malaria. Nigerian Medical Journal 49:2; 34-38[Nigeria]Nigerian Medical Journal[Nigeria].
  43. Falade C, Mokuolu O, Okafor H, Orogade A, Falade A, Adedoyin O, Oguonu T, Maman A, Davidson H,Michael Callahan (2007) Epidemiology of congenital malaria in Nigeria: A multi-centre study. Tropical Medicine & International Health  12 (11); 1279 – 1287 [UK].
  44. Falade C. O., Yusuf BO, Fadero FF, Mokuolu OA, Hamer DH, Salako LA (2007). Intermittent preventive treatment with sulfadoxine-pyrimethamine is effective in preventing maternal and placental malaria in Ibadan, south-western Nigeria. Malaria Journal. 2007 Jul 6;6: 88 doi:10.1186/1475-2875-6-88  [UK].
  45. Enwere OO, Falade C. O.,Salako BL (2007) Drug prescribing pattern at the medical outpatient clinic of a tertiary hospital in southwestern Nigeria. Pharmacoepidemiology & Drug Safety, 6 (11) 1244-1249  [UK].
  46. Falade CO, Olayemi O, Dada-Adegbola HO, Aimakhu CO, Ademowo OG, Salako L (2008) Prevalence of Malaria at Booking among Antenatal Patients in a Secondary Health Care Facility in Ibadan, Nigeria. African Journal of Reproductive Health 12[2]: 141 -152 [Nigeria].
  47. Adedapo ADA, Falade CO*, Kotila RT, Ademowo OG (2007) Age as a risk factor for thrombocytopenia and anaemia in children treated for acute uncomplicated falciparum malaria. Journal of Vector Borne Diseases44,266–270  *Corresponding author[INDIA].
  48.  Enwere OO, Salako BL, Falade CO (2006) Prescription and Cost Consideration at a Diabetic Clinic in Ibadan, Nigeria: A Report. Annals of Ibadan Postgraduate Medicine. 4: (2): 35-39 [Nigeria].
  49. Falade CO, Michael SO, Oduola AMJ (2008) Enhanced Efficacy of Amodiaquine and Chlorpheniramine Combination over Amodiaquine alone in the Treatment of Acute Uncomplicated Plasmodium falciparum Malaria in Children. Medicine Principles and Practice. 17 (3): 197 -201  [Sweden].
  50. Falade CO, Ogundele SO, Yusuf SM, Ladipo SM and Ademowo OG (2008) High Efficacy of Two Artemisinin Based Combinations (Artemether-Lumefantrine and Artesunate Plus Amodiaquine) For Acute Uncomplicated Malaria in Ibadan, Nigeria. Tropical Medicine & International Health – 13 (5): 635 -643 [United Kingdom].
  51. Ajayi IO, Falade CO, Bamgboye EA, Oduola AMJ, Kale OO. (2008) Assessment of a treatment guideline to improve home management of malaria in children in rural south-west Nigeria. Malaria Journal2008, 7:24 doi:10.1186/1475-2875-7-24 [United Kingdom].
  52. Ajayi IO, Falade C. O., Olley BO, Yusuf B, Gbotosho S, Iyiola O, Olaniyan OJ, Happi C, Munguti K, Pagnoni F. (2008) A qualitative study of the feasibility and community perception on the effectiveness of artemether-lumefantrine use in the context of home management of malaria in south-west Nigeria. BMC Health Services Research. 2008 Jun 1;8(1):119.doi:10.1186/1472-6963-8-119 [United Kingdom].
  53. Orogade AA, Falade CO, Okafor HU, Mokuolu OA, Mamman AI, Ogbonu TA, Ogunkunle OO, Ernest SK,Callahan MV, Hamer DH. (2008) Clinical and Laboratory Features of Congenital Malaria in Nigeria. Pediatric Journal of Infectious Disease. 3(3):1-7 Accepted for publication; May 2008[The Netherlands].
  54. Yusuf OB, Dada-Adegbola HO, Ajayi IO and  *Falade CO.(2008) Malaria prevention practices among mothers delivering in an urban hospital in southwest Nigeria. Journal of Vector Borne Diseases :45: 217 - 224 [India].
  55. Fawole O, Akinboye DO, Falade CO, Arulogun OS, Adeniyi JD (2007-2008) Case Management of Childhood Fever by Traditional Healers in South West Nigeria: Identification of Training and Collaborative needs International Quarterly of Community Health Education 28 (4) 319-335 [USA].
  56.  Yusuf BO, Falade CO, Ajayi IO, et al (2008-2009). Community effectiveness of ACT in rural Nigeria. International Quarterly of Community Health Education 29(1):45-56.[USA].
  57. Ajayi IO, Browne EN, Bateganya F, Yar D, Happi C, Falade CO, Gbotosho GO, Yusuf B, Boateng S, Mugittu K, Cousens S, Nanyunja M and Pagnoni F. Effectiveness of artemisinin-based combination therapy used in the context of home management of malaria: A report from three study sites in sub-Saharan Afri
  58. caMalaria Journal 2008, 7:190 doi:10.1186/1475-2875-7-190 [United Kingdom].
  59. Ajayi IO, Oladepo O, Falade CO, Bamgboye EA, Kale O (2009) The development of a treatment guideline for childhood malaria in rural Southwest Nigeria using participatory approach. Patient Educational Counseling, 75(2):227-37 [United Kingdom].
  60. Falade CO, Ogunkunle OO, Dada-Adegbola HO, Falade AG, Ibarra de Palacios P, Hunt P, Virtanen M, Oduola AM, Salako LA. (2008) Evaluation of the efficacy and safety of artemether-lumefantrine in the treatment of acute uncomplicated Plasmodium falciparum malaria in Nigerian infants and children. Malaria Journal. 2008 Nov 27;7(1):246. [United Kingdom].
  61. Premji ZG, Abdulla S, Ogutu B, Ndong A, Falade CO, Sagara I, Mulure N, Nwaiwu O, Kokwaro G. The content of African diets is adequate to achieve optimal efficacy with fixed-dose artemether-lumefantrine: a review of the evidence. Malaria Journal 2008 Nov 25;7: 244. [United Kingdom].
  62. Mokuolu OA, Falade CO, Orogade AA, Okafor HU, Adedoyin OT, Oguonu TA,  Dada-Adegbola HO, Oguntayo OO, Ernest SK, Harmer DH and Callahan MV  (2009) Malaria at Parturition in Nigeria: Current Status and Delivery Outcome. Infectious Diseases in Obstetrics and Gynecology, 2009:473971.
  63. Falade
  64. Akinleye S, Falade COand Ajayi IO (2009) Intermittent preventive treatment among pregnant women attending antenatal clinics in primary health care centers in a rural Local Government Area in southwest, Nigeria: A cross-sectional study. BMC Pregnancy and Child birth,9:28. [United Kingdom].
  65. Falade C, Manyando C. (2009) Safety profile of Coartem: the evidence base. Malaria Journal 8 Suppl 1:S6. [United Kingdomhttp://www.ncbi.nlm.nih.gov/pubmed/21153838">Antimalarial and antioxidant activities of methanolic extract of Nigella sativa seeds (black cumin) in mice infected with Plasmodium yoelli nigeriensis. Parasitol Res. 2010 Dec 14. [DOI 10.1007/s00436-010-2204-4http://www.ijddr.in
  66. Ogunkunle OO, Fehintola FA, Ogungbamigbe TO, *Falade CO (2011) Comparative cardiac effects of chlorproguanil/dapsone and chloroquine during treatment of acute uncomplicated falciparum malaria infection in Nigerian childrenAfrican Journal of Biomedical research.; 14; 161 -167
  67. Akerele A, Yusuf OB, Falade CO, Ajayi IO, Pagnoni F (2011) Factors associated with use of guideline in home management of malaria in children in rural south-west Nigeria. Malaria Research and Treatment Volume 2011, Article ID 701320, doi:10.4061/2011/701320
  68. Makanga M, Bassat Q, Falade CO, Premji ZG, Krudsood S, Hunt P, Walter V, Beck HP, Marrast AC, Cousin M, Rosenthal PJ (2011). Efficacy and Safety of Artemether-Lumefantrine in the Treatment of Acute, Uncomplicated Plasmodium falciparum Malaria: A Pooled Analysis.Am J Trop Med Hyg. Nov;85(5):793-804.
  69. Ogunleye O. O., Adebayo A. K., Adebiyi A., Falade C. O., Falase A. O. (2010) Tolerability of ramipril in high doses and its comparative effects (in combination with hydrochlorothiazide) with felodipine extended release on mild to moderate hypertension in Nigerian Africans. West African Journal of Pharmacology Drug Research. 26:23-28
  70. Rabiu OR, Kosoko AM, Falade CO, Ademowo OG (2012) Evaluation of the Performances of Two Rapid Diagnostic Tests (Cyscope- mini and Paracheck-Pf) in the Diagnosis of Malaria among Febrile Children in Southwest Nigeria. Medical Principle Practice DOI: 10.1159/000345642.
  71. Ajayi IO, Jegede AS, Falade CO (2012). Sustainability of Intervention for Home Management of Malaria: The Nigerian Experience. J Community Med Health Educ 2012, 2:8; http://dx.doi.org/10.4172/2161-0711.1000175
  72. Okoror TA, Falade CO, Olorunlana A, Walker EM, Okareh OT (2013)login=This email address is being protected from spambots. You need JavaScript enabled to view it.&;lid=20130207" target="_blank">Exploring the Cultural Context of HIV Stigma on Antiretroviral Therapy Adherence Among People Living with HIV/AIDS in Southwest Nigeria.AIDS Patient Care STDS; 27, 55.
  73. Nneji CM, Adaramoye OA, Falade CO, Ademowo OG (2013). Effect of chloroquine, methylene blue and artemether on red cell and hepatic antioxidant defence system in mice infected with Plasmodium yoelii nigeriensis. Parasitology Research. 2013 Jul; 112 (7):2619-25.
  74. Falade CO, Adesina-Adewole B, Dada-Adegbola HO, Ajayi IO, Akinyemi JO, Ademowo OG, Adewole IF, Kanki P (2013) Evaluation of Paracheck-Pf™ RapidMalaria Diagnostic Test for the Diagnosis of malaria at point of care among HIV-positive patients in Ibadan, south western Nigeria. Pathogens and Global Health – 107; 69-77.
  75. Ajayi IO., Jegede AS., Falade CO. & Sommerfelds J. (2013) Assessing resources for implementing a Community Directed Intervention (CDI) strategy in delivering multiple health interventions in urban poor communities in Southwestern Nigeria: A qualitative study. Accepted for publication inJournal of Infectious Disease of Poverty.
  76. Dada-Adegbola HO, Oluwatoba OA, Falade CO (2013) Asymptomatic malaria and intestinal helminth co-infection among children in a rural community in Southwest Nigeria Malaria World Journal, 4:18.
  77. Olorunda DO, Ajayi IO, Falade CO,. (2013) Do frequent antenatal care visits ensure access and adherence to intermittent preventive treatment of malaria in pregnancy in an urban hospital in south west Nigeria?
  78. Akerele A, Yusuf OB, Ajayi IO, Falade CO (2013). Treatment decision-making in the home management of malaria among children in south west Nigeria. Discourse Journal of Malaria Research and Reviews; 1 (4):182-189
  79. Nneji CM, Adaramoye OA, Falade CO, Ademowo OG (2013). Effect of chloroquine, methylene blue and artemether on red cell and hepatic antioxidant defence system in mice infected with Plasmodium yoelii nigeriensis. Parasitology Research. 2013 Jul;112 (7):2619-25.
  80. Falade CO, Dada-Adegbola HO, Ogunkunle OO, Oguike MC, Nash O, Ademowo OG (2014) Evaluation of the Comparative Efficacy and Safety of Artemether-Lumefantrine, Artesunate-Amodiaquine and Artesunate-Amodiaquine-Chlorpheniramine (Artemoclo TM ) for the treatment of acute uncomplicated malaria in Nigerian children. Medicine Principle and Practice DOI: 10.1159/000360578.
  81. Falade CO, Ajayi IO, Yusuf OB, Pagnoni F. (2014) High acceptance of artemisinin-based combination therapy for the home management of malaria in rural communities in southwest Nigeria MWJ 2014, 5:5.
  82. Venkatesan M, Gadalla NB, Stepniewska K, Dahal P, Nsanzabana C, Moriera C, Price RN, Maårtensson A, Rosenthal PJ, Dorsey G, Sutherland CJ, Guérin P, Timothy M. E. Davis, Ménard D, Adam I, Ademowo G, Arze C, Baliraine FN, Berens-Riha N, Bj?rkman A, Borrmann S, Checchi F, Desai M, Dhorda M, Djimde´ AA , El-Sayed BB, Eshetu T, Eyase F, Falade C, Faucher J, Fr?berg G, Grivoyannis A, Hamour S, Houzé S , Johnson J, Kamugisha E, Kariuki S, Kiechel J, Kironde K, Kofoed P, LeBras J, Malmberg M, Mwai L, Ngasala N, Nosten F, Nsobya SL, Nzila A, Oguike M, Otienoburu SD, Ogutu B, Ouédraogo J, Piola P, Rombo L, Schramm B, Somé AF , Thwing J, Ursing J, Wong RPM, Zeynudin A, Zongo I, Plowe CV, and Sibley CH* for the WWARN AL and ASAQ Molecular 91(4), 2014, pp. 833–843 USA.
  83. WWARN Artemether-lumefantrine Dose Impact Group (2013). The effect of dose on the antimalarial efficacy of AL: a pooled analysis of individual patient data. The Lancet. Accepted for publication Dec 2014.
  84. Jegede AS, Ajayi I, Oshiname FO, Falade CO, Chandramohan D, Prudence Hamade, Webster J & Baba E. (2015) Qualitative Assessment of Rural Health Workers’ Management of Malaria in Sick Children in Niger State, Nigeria. Malaria World Journal 14:14 2015.

    XI        Major Conferences and training Workshops attended in the last 5 years Papers Presented at Conferences (2006 to 2010)

    1. The American Society for Tropical Medicine and Hygiene Annual Conference, Atlanta Georgia USA: 12th – 16th November 2006. I made a presentation titled “Cardiac effects of artemether-lumefantrine and artesunate plus amodiaquine during treatment of acute uncomplicated malaria in Nigeria Children” 
    2.  The American Society for Tropical Medicine and Hygiene Annual Conference, Atlanta Georgia USA: 12th – 16th November 2006. I made a presentation titled “Comparative efficacy and safety of two artemisinin containing combination therapies for acute uncomplicated malaria”   
    3.  The American Society for Tropical Medicine and Hygiene Annual Conference, Atlanta Georgia USA: 12th – 16th November 2006. I made a presentation titled “Epidemiology of congenital malaria in Nigeria: A multicentre study”.
    4. European and Developing Country Clinical Trial Partnership 4th Forum in Ouagadougou Burkina Faso: 22ND -24TH October 2007. Intermittent preventive therapy with sulfadoxine-pyrimethamine is effective in preventing maternal and placental malaria in Ibadan, South-Western Nigeria. 
    5. Unibadan Conference of biomedical research, Ibadan Nigeria 26th -29th August 2008. Evaluation of plasmodium falciparum lactate dehydrogenase activity in isolates of plasmodium falciparum during in-vitro culture.
    6. African Health Research Organization- International malaria symposium Accra, Ghana. 12th to 14th August 2008.Intermittent Preventive Treatment (IPT) with Sulfadoxine/Pyrimethamine (SP) as effective strategy to prevent maternal and placental malaria.
    7. ASTMH pre-meeting course, Malaria Eradication: Calibrating Aspirations, Technology and Commitment, held December 6-7, 2008 at the Sheraton New Orleans in New Orleans, Louisiana.
    8. The American Society for Tropical Medicine and Hygiene Annual Conference, New   Orleans Louisiana USA: 7th – 11th December 2008. I made a presentation titled “Evaluation of malaria parasitemia in blood banking in an endemic area”
    9. Cochrane Collaboration workshop on writing systematic review; 15-16th January 2009, Department of Obstetrics & Gynecology, University College Hospital, Ibadan, Nigeria.
    10. Pediatric Association of Nigeria Annual Conference, Ibadan Nigeria. 20th – 24th January 2009. I made a presentation titled Fat content of typical African diets and efficacy of artemether-lumefantrine. 
    11. The American Society for Tropical Medicine and Hygiene Annual Conference, Atlanta Georgia USA:  November 2009. I made a presentation titledAntimalarial drug dispensing among community drug providers in Ibadan Nigeria: a cross-sectional survey.
    The American Society for Tropical Medicine and Hygiene Annual Conference, Atlanta Georgia USA: 3rd 16th November 2010. I made two oral presentations titled Burden of malaria in HIV positive women in Ibadan, Nigeria and Utility of Paracheck in the diagnosis of malaria among HIV positive patients at point of care in Ibadan, SW Nigeria.

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