Prof. Yinusa RAJI

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	Name: Yinusa RAJI
	Designation: Professor
	Faculty: Basic Medical Sciences
	Department: Physiology
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Biography: Professor Raji holds B.Sc. (Hons.), M.Sc. and Ph.D. degrees in Physiology from the University Ibadan and a Fellowship in International Medical Education and Research from FAIMER Institute Philadelphia United States of America (F. Med. Ed. Philad, USA). He joined the Department of Physiology as a Teaching Assistant in 1990, re-appointed an Assistant Lecturer in 1991 and was promoted Professor in 2010. Professor Raji delivered the 444th University Inaugural Lecture on 20th September, 2018. The major area of Professor Raji’s research is Reproductive Physiology and Developmental Programming. The molecular mechanism of action of medicinal plant extracts, drugs and environmental pollutants on reproductive functions as well as on developmental programming are investigated with appropriate interventions. Professor Raji has over one hundred and thirty publications in peer review journals. He also has considerable expertise and interest in Medical Education with emphasis on Lecturing Skills, Curriculum Development, Assessments, Programme and Institution Evaluation and Accreditation. He is a member of several professional societies including, Physiological Society of Nigeria (PSN), African Association of Physiological Society (AAPS), African Association of Biomedical Scientists (AABS), The American Physiological Society (APS), Federation of American Society for Experimental Biology (FASEB), International Society for Developmental Origins of Health and Disease (DOHaD), Physiological Society of the UK and Public Responsibility in Medicine and Research (PRIM&R) USA. Professor Raji has been presented the Favourite Lecturer of the year award many times by the University of Ibadan Medical (UIMSA), Dental (UADS) and Physiology (UIPSA) Students’ Associations. Professor Raji has served and still serving as an external examiner (undergraduate and postgraduate programmes) and external Professorial assessor to many Universities within and outside Nigeria. He is a resource person to National Universities Commission (NUC) on resource verification and accreditation exercises for both undergraduate and postgraduate programmes. He has served as an Assistant Editor-in-Chief of the African Journal of Medicine and Medical Sciences, and Hall Master of AbdulSalami Abubakar Postgraduate Hall, University of Ibadan. Professor Raji served as the tenth Head of Department of Physiology from 1st August, 2016 to 31st July, 2020. During his tenure, and through concerted efforts, the Department of Physiology witnessed monumental development in human capacity and material resources, including expansion of facilities, with the rehabilitation of laboratories, seminar room, animal house, construction of vertical extension of the main Physiology building. The first “Exercise Physiology and Performance Laboratory” was also established and fully equipped. The students’ information handbook and practical manual were comprehensively revised with appropriate inclusion of, the MBBS/BDS and new postgraduate curricula, list of past Heads of Department and practical sessions in exercise physiology among others. Under his leadership, the Department was awarded the Best Department of the year (Face of Pre-Clinicals) by the University of Ibadan Medical Students’ and Dental Students’ Associations.

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Research

CURRENT RESEARCH
1. Title: Molecular mechanisms of action of phytoestrogens, medicinal plant alkaloids, synthetic alkaloids and antimicrobial drugs on male reproductive activities:
Brief Summary: The testes and epididymes from Azadirachta indica induced phenotypically infertile rats were probed for special sperm motility related proteins such as HongrES1, rBD-15, Bin1b, ESC7 and rBD42 using Western blot analyses with 1D and 2D Gel Technologies and analyses of miRNA and mRNA expressions. So far, the results revealed that most medicinal plants with negative impact on male reproduction possess phytoestrogens in variable concentrations.
Role: PI and Postgraduate Supervisor
Collaborators: Postgraduate Students

2. Title: Reproductive Programming effects and mechanisms of different foods, drugs, environment toxicants, medicinal plants and sleep-deprivation, in male and female Wistar rats:
Brief Summary: The fetal programming hypothesis presupposes that a stimulus or insult acting during critical periods of growth and development may permanently alter tissue structure and function. Programming is now known to be an important underlying feature of many systemic adult diseases. While it is clear that fetal programming is not simply the effects of genes passed on through generations, the phenotype of offspring subjected to a variety of intrauterine challenges is determined by lifelong gene expression patterns set into motion during critical windows of development and that in some instances these phenotypes may pass on their effects to future generations. It is in realization of this that studies were designed to investigate the fetal programming effects of the antimalarial and antibiotic drugs and medicinal plants extracts with these activities on reproduction, using rats as the animal model. Currently Quassia amara, Ricinus communis, Sphenocentrum jollyanum, Artesunate, antihypertensive drugs and caffeine are being investigated. Sleep deprivation effects and mechanisms on programming of different aspects of fetal Physiology are also being investigated.
Role: PI and Postgraduate Supervisor
Collaborators: Postgraduate Students

3. Title: Survey and biological evaluation of acclaimed aphrodisiac medicinal plants in selected locations of South Western Nigeria:
Brief Summary: This study is a prelude to detailed laboratory investigation of these natural products from some of which we have generated preliminary data. This is a pioneering work that is expected to show case some of the aphrodisiac agents of medicinal plants origin with the possibility of comparing their efficacy and side effects with those of the synthetic aphrodisiac drugs.
Role: PI and Postgraduate Supervisor
Collaborators: Postgraduate Students

COMPLETED RESEARCH
1. Effects and mechanisms of action of some antimicrobial medicinal plants such as Quassia amara, Azadirachta indica, Alstonia boonei, Morinda lucida, Ricinus communis and Cnestis ferruginea on male reproductive functions in rats

2. Effects and mechanisms of some synthetic antimicrobial drugs such as ampiccilin, cloxacillin, tetracycline, chloroquine, mefloquine, arthemeter and sulphadoxine- pyrimethamine on male reproductive functions in mammalian species

3. Gastrointestinal handling of some medicinal plant extracts (Azadirachta indica, Entandrophragma angolense, Piper guineense, Irvingia gabonensis, Tylophora conspicua and Quassia amara) with reproductive activities

4. Effects and mechanism of action of Proguanil, Dapsone and Artesunate on male reproductive functions.
Role:  PI and Postgraduate Supervisor
Collaborators:  Postgraduate Students

Publications

 SELECTED PUBLICATIONS

1. Njar V. C. O, Alao T. O, Okogun J. I, Raji Y, Bolarinwa AF and Nduka EU (1995): Antifertility activity of Quassia amara: Quassin inhibits the steroidogenesis in rats Leydig cells in vitro. Planta Medica 61: 180-182 https://www.thieme-connect.com/products/ejournals/abstract/10.1055/s-2006-958044

2. Njar V.C.O, Adesanwo J. K and Raji Y (1995): Methyl angolensate. The antiulcer agent of the stem bark of Entandrophragma angolense. Planta Medica 61: 91-92 PMID: 7701005 DOI: 10.1055/s-2006-958015

3. Raji Y and Bolarinwa A. F (1997): Antifertility activity of Quassia amara in male rats- In vivo study. Life Sciences 61: 1067-1074 PMID: 9307052 DOI: 10.1016/s0024-3205(97)00615-2

4. Oyebola D. D. O, Adewoye O. E, Iyaniwura J. O, Alada A. R. A, Fasanmade A. A and Raji Y (2000): A comparative study of students’ performance in preclinical physiology assessed by multiple choice and short essay questions. African Journal of Medicine and Medical Sciences 29: 201-205 https://europepmc.org/article/med/11713989

5. Raji Y, Ogunwande I. A, Adesola J. M and Bolarinwa A. F (2001): Anti-diarrhegenic and anti-ulcer properties of Irvingia gabonensis in rats. Pharmaceutical Biology 39: 340-345 https://doi.org/10.1076/phbi.39.5.340.5890

6. Raji Y, Udoh U. S, Mewoyeka O. O, Ononye F. C and Bolarinwa A. F (2003): Implication of reproductive endocrine malfunction in male antifertility efficacy of Azadirachta indica extract in rats. African Journal Medicine and Medical Sciences 32: 159-165 https://europepmc.org/article/med/15032463

7. Raji Y, Ogunwande IA, Osadebe CA and John G (2004): Effects of Azadirachta indica extract on gastric ulceration and acid secretion in rats. Journal of Ethnopharmacology 90: 167-170 https://doi.org/10.1016/j.jep.2003.09.020

8. Raji Y, Akinsomisoye O. S and Salman T. M (2005): Antispermatogenic activities of Morinda lucida extract in male albino rats. Asian Journal of Andrology 7: 405-410 https://doi.org/10.1111/j.1745-7262.2005.00051.x

9. Raji Y, Oloyo A. K and Morakinyo A. O (2006): Effect of methanol extract of Ricinus communis seed on reproduction of male rats. Asian Journal of Andrology 8: 115-121 https://doi.org/10.1111/j.1745-7262.2006.00055.x

10. Raji Y, Akinsomisoye O. S and Azeez M. O (2006): Impact of the malaria parasite on reproductive indices of male mice. Reproductive Medicine and Biology 5: 201-209 https://doi.org/10.1111/j.1447-0578.2006.00142.x

11. Akinsomisoye O. S and Raji, Y (2011): Prolonged administration of proguanil induces reproductive toxicity in male rats. Journal of Toxicological Sciences 36 (5): 587-599 https://www.jstage.jst.go.jp/article/jts/36/5/36_5_587/_pdf

12. Oyeyipo I. P, Raji Y and Bolarinwa A. F (2014): Antioxidant profile changes in reproductive tissues of rats treated with nicotine. Journal of Human Reproductive Science 7(1): 41-46 https://doi.org/10.4103%2F0974-1208.130823

13. Salami S. A and Raji Y (2015): Generational reproductive outcomes in Wistar rats maternally exposed to Ricinus communis oil at different stages of gestation. Journal of Developmental Origins of Health and Disease 6(5): 443-453 https://doi.org/10.1017/s2040174415001245

14. Salami S. A, Omidiran J. O, Balogun M. E and Raji Y (2015): Testicular and epididymal histomorphometric assessment in F1 male Wistar rats after gestational Ricinus communis oil exposure. Journal of Morphological Sciences 32(3):187-191 http://dx.doi.org/10.4322/jms.088715

15. Olopade F. E., Adaramoye O. A., Raji Y., Fasola A. O and Olapade-Olaopa E. O (2016): Developing a competency-based medical education curriculum for the core basic medical sciences in an African Medical School. Advances in Medical Education and Practice. 7: 389-398 https://www.researchgate.net/publication/305418628_Developing_a_competency-based_medical_education_curriculum_for_the_core_basic_medical_sciences_in_an_African_Medical_School

16. Jeje S.O and Raji Y (2017): Maternal treatment with dexamethasone during gestation alters sexual development markers in the F1 and F2 male offspring of Wistar rats. Journal of Developmental Origin of Health and Diseases. 8(1): 101-112 https://doi.org/10.1017/S2040174416000453

17. Salami S. A., Salahdeen H. M., Ugbebor E. C., Murtala B. A and Raji Y (2018): Effects of aqueous leaf extract of Tridax procumbens on contractile activity of corpus cavernosum in N-nitro-L-arginine methyl ester-induced hypertensive male rats. Journal of Integrative Medicine, 16: 51-56 https://doi.org/10.1016/j.joim.2017.11.001

18. Ogunwole E, Kunle-Alabi O. T, Akindele O. O and Raji Y (2019): Adverse Effects of Saccharum officinarum Molasses on Rat Testicular Cells. Advances in Toxicology and Toxic Effects 3(1): 001-008. DOI: https://dx.doi.org/10.17352/atte

19. Ogunwole E, Kunle-Alabi O. T, Akindele O. O and Raji Y (2020): Saccharum officinarum Molasses Adversely Alters Reproductive Functions in Male Wistar Rats. Toxicology Reports 7: 345-352 https://doi.org/10.1016%2Fj.toxrep.2020.02.005

20. Oduyemi O. A, Salami S. A, Salahdeen H. M, Muritala B. A and Raji Y (2020): Mechanisms of inhibitory activity of root extract of Carpolobia lutea G. Don on in vitro contractile responses of rabbit corpus carvernosum. Revista Internacional de Andrologia. https://doi.org/10.1016/j.androl.2020.04.003. 2611-2618

Supervision

CURRENT STUDENTS
Master’s of Science (M.Sc.) Level
1. Islamiyah Motunrayo OLORUNTELE (Matric No : 225436): Effects of N-acetylcysteine on Carbamazepine-induced reproductive toxicity in female Wistar rats- Year of Admission: 2020/2021

2. Olusegun Ayo ALAWODE (Matric No:227815): Effects of Ocimum gratissimum on testicular energy metabolism in male Wistar rat- Year of Admission: 2020/2021

3. Henry UGOMMA (Matric No: 227669): Effects of early administration of levonorgestrel on fertility index in female Wistar rat- Year of Admission: 2020/2021

4. Iyobosasere Osadebamwen IYAMU (Matric No: 226397): Effects of chronic exposure to sodium arsenite on fertility index in male Wistar rats- Year of Admission: 2020/2021

5. Osamede Pearl OSAWARU (Matric No: 226399): Effect of chronic exposure to sodium arsenite on testicular energy metabolism in male Wistar rats- Year of Admission: 2020/2021

6. Zainab Oluwabukola AIGORO (Matric No: 226461): Effects of Ocimum gratissimum on corpus cavernosum response to peripheral tone modulators in dexamethasone induced metabolic syndrome in Wistar rats in vitro- Year of Admission: 2020/2021

7. Tolulope ADENIJI-KESTER (Matric No: 184425): Protective Effect of N-acetylcystiene on Carbamazepine induced infertility in male Wistar rats- Year of Admission: 2020/2021

Doctoral (Ph.D.) Level
1. Damilare Hakeem ADEYEMI (Matric No: 174429): Mechanisms of erectile impairment in reserpine-induced depression-like behaviour with or without fluoxetine treatment in New Zealand rabbits- Year of Admission: 2016/2017

2. Jessica Edem AKPAN (Matric No: 180642): Effects of maternal consumption of Piper guineense and piperine during lactation on reproductive functions of offspring of Wistar rat- Year of Admission:2017/2018

3. Latif Opeyemi ADEGBITE (Matric No: 148976): Modulatory activities of Allium cepa Linn. juice on uterine functions in Wistar rats- Year of Admission: 2018/2019

4. Abiodun OYERINDE (Matric No: 180646): Effects of paternal sodium arsenite exposure on F1- Year of Admission: 2018/2019

5. Uyai Edidiong FRANCIS (UDOFIA) (Matric No: 166973): Effects of administration of crude extract of Buchholzia coriacea and some of its pure active compounds on the reproductive system of male rats prenatally exposed to hyperglycemia- Year of admission: 2019/2020

6. Great Oluwamayokun ALABI (Matric No: 201153): Alternative treatment of Polycystic ovarian syndrome and its related conditions- Year of Admission: 2020/2021

7. Afsat Motunrayo BUSARI (Matric No: 181412): Uterotonic effect of aqueous leaf extract of Annona muricate- Year of Admission: 2021/2022

8. Aminat Tope SALAUDEEN (Matric No: 159625): Mechanisms of action and structural activity relationship of Bryophyllum pinnatum effect on uterine function- Year of Admission: 2021/2022

9. Oluwatosin Aisha ODUYEMI (Matric No: 127253): Effects of Carpolobia lutea G. Don Roots extract on rabbit corpus cavernous smooth muscle in vitro- Year of Admission 2021/2022

PREVIOUS STUDENTS (Selected)
Master’s of Science (M.Sc.) Degree Programmes:
I have successfully supervised 80 M.Sc. students in Physiology
I have successfully supervised 1 M.Sc., Biomedical Education dissertation

Master’s of Philosophy Degree (M. Phil) in Physiology:
1. ODUYEMI, Oluwatosin Aisha, MPhil (Ibadan) 2019: “In vitro assessment of methanol extract of Carpolobia lutea G. DON root in rabbit corpus cavernosum smooth muscle”

2. OYAWALE, Mogboluwa Tosin, MPhil (Ibadan) 2019: “Comparison of male reproductive functions in offspring of glucose-, sucrose- and fructose-fed Wistar rats”

Doctoral (Ph.D.) Students Successfully Supervised with titles of Theses (Selected):
1. OLAYEMI, Funsho Olakitike, Ph.D. Physiology (Ibadan), 2007: Evaluation of the reproductive and toxic effects of Cnestis ferruginea (de Candolle) root extract in male rats

2. AKINSOMISOYE, Olumide Stephen, Ph.D. Physiology (Ibadan), 2010: Effects of proguanil, dapsone and artesunate on male reproductive activities in mammals

3. SALAMI, Shakiru Ademola, Ph.D. Physiology (Ibadan), 2012: Effects of maternal exposure to Ricinus communis oil on generational reproductive indices in Wistar rats

4. OYEYIPO, Ibukun Peter, Ph.D. Physiology (Ibadan), 2014: Effects of NG Nitro-L-Arginine Methyl Ester on Nicotine -Induced Infertility in Male Wistar Rats.

5. OBEMBE, Olawale Olaleye, Ph.D. Physiology (Ibadan) 2014: Effects of Quassia amara and quassin in epididymal functions and hormonal profiles in rats and their offsprings

6. OYEKUNLE, Olanrewaju Akinloye, Ph.D. Physiology (Ibadan) 2015: Erectogenic and spermiologic effects of stem bark extracts of Nauclea latifolia (Smith) in rabbits

7. JEJE, Sikirullahi Olatunde, Ph.D. Physiology (Ibadan) 2015: Effects of maternal treatment with dexamethasone on male reproductive functions in F1 and F2 offsprings of Wistar rats

8. KUNLE-ALABI, Olufadekemi, Ph.D. Physiology (Ibadan) 2017: Effects of Cocos nucifera Linn. Water on maternal high fat diet-induced metabolic and reproductive changes in offsprings of Wistar rats

9. AKINDELE, Oreofe Opeyemi, Ph.D. Physiology (Ibadan) 2017: Effects of maternal sleep deprivation on reproductive functions of male offsprings in Wistar rats

10. OYEYEMI, Adekunle Wahab, Ph.D. Physiology (Ibadan) 2018: Amendment of lead acetate-induced reproductive toxicity in male Wistar rats using methanol extract of Sida corymbose R. F. Fries leaves and Palmitic acid, ethyl ester.

11. AKINOLA, Adeniran, Ph.D. Physiology (Ibadan) 2018: Amelioration of Cadmium-induced reproductive toxicity in male Wistar rats using methanol extract of Carpolobia lutea G. DON root, Palmitic acid and Nonanoic acid

12. OGUNWOLE, Eunice, Ph.D. Physiology (Ibadan) 2019: Assessment of reproductive functions in male Wistar rats treated with Saccharum officinarum Molasses

13. ADELEYE, Olushola Emmanuel, Ph.D. (Ibadan) 2020: Aqueous extract of Allium cepa L. scaly leaf ameliorates reproductive dysfunctions in sodium chloride-induced hypertensive male Wistar rats

14. ADEDOTUN, Oore-Oluwapo Iretioluwa, Ph.D. (Ibadan) 2021: Methanol extract of Parquetina nigrescence and squalene ameliorate arsenic trioxide induced reproductive toxicity in male Wistar rats

15. AHMED, Taofiqat Tosin, Ph.D. (Ibadan) 2021: Maternal administration of Citrus limon Linn. Juice, oleic, palmitic and stearic acids reduce placental efficiency and foetal morphometry in Wistar rats

16. SHITTU, Seyyid Alli-Sisse, Ph.D. (Ibadan) 2022: Erectogenic activities and mechanism of action of aqueous extract of Ocimum gratissimum Linn. leaf and thymol on penile tissue in Wistar rats

17. HART, Victor Opuada, Ph.D. (Ibadan) 2023: Ameliorative effects of Dennettia tripetala Baker F. seed and linoleic acid on hyperglycaemia-induced testicular dysfunction in male Wistar rats

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